{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:26:55Z","timestamp":1787754415953,"version":"build-2784847793"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Science and Technology Foundation of Guizhou Province","award":["J-[2024]1Y367"],"award-info":[{"award-number":["J-[2024]1Y367"]}]},{"name":"the Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) of China","award":["2025ZYYB004"],"award-info":[{"award-number":["2025ZYYB004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-05502-2","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:24:14Z","timestamp":1751383454000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and potential mechanisms of jatrorrhizine on MNNG-induced chronic atrophic gastritis in rats based on serological metabolomics and molecular docking"],"prefix":"10.1038","volume":"15","author":[{"given":"Zong-ge","family":"Sha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-liang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-tao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"5502_CR1","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1053\/j.gastro.2015.05.059","volume":"149","author":"P Tan","year":"2015","unstructured":"Tan, P. & Yeoh, K. G. Genetics and molecular pathogenesis of gastric adenocarcinoma. Gastroenterology 149, 1153-1162.e1153. https:\/\/doi.org\/10.1053\/j.gastro.2015.05.059 (2015).","journal-title":"Gastroenterology"},{"key":"5502_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-230x-14-21","volume":"14","author":"Y Du","year":"2014","unstructured":"Du, Y. et al. Chronic gastritis in China: A national multi-center survey. BMC Gastroenterol. 14, 21. https:\/\/doi.org\/10.1186\/1471-230x-14-21 (2014).","journal-title":"BMC Gastroenterol."},{"key":"5502_CR3","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1136\/gut.2009.192757","volume":"59","author":"DY Graham","year":"2010","unstructured":"Graham, D. Y. & Fischbach, L. Helicobacter pylori treatment in the era of increasing antibiotic resistance. Gut 59, 1143\u20131153. https:\/\/doi.org\/10.1136\/gut.2009.192757 (2010).","journal-title":"Gut"},{"key":"5502_CR4","doi-asserted-by":"publisher","first-page":"5903","DOI":"10.3748\/wjg.v20.i19.5903","volume":"20","author":"YJ Kong","year":"2014","unstructured":"Kong, Y. J., Yi, H. G., Dai, J. C. & Wei, M. X. Histological changes of gastric mucosa after Helicobacter pylori eradication: A systematic review and meta-analysis. World J. Gastroenterol. 20, 5903\u20135911. https:\/\/doi.org\/10.3748\/wjg.v20.i19.5903 (2014).","journal-title":"World J. Gastroenterol."},{"key":"5502_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/878164","volume":"2015","author":"Y Wei","year":"2015","unstructured":"Wei, Y. et al. Huangqi Jianzhong tang for treatment of chronic gastritis: A systematic review of randomized clinical trials. Evid. Based Complement. Altern. Med. 2015, 878164. https:\/\/doi.org\/10.1155\/2015\/878164 (2015).","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"5502_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284411","volume":"18","author":"L Wang","year":"2023","unstructured":"Wang, L. et al. Efficacy and safety of Weifuchun tablet for chronic atrophic gastritis: A systematic review and meta-analysis. PLoS ONE 18, e0284411. https:\/\/doi.org\/10.1371\/journal.pone.0284411 (2023).","journal-title":"PLoS ONE"},{"key":"5502_CR7","doi-asserted-by":"publisher","first-page":"19575","DOI":"10.1038\/s41598-019-56149-9","volume":"9","author":"S Wang","year":"2019","unstructured":"Wang, S. et al. Jatrorrhizine balances the gut microbiota and reverses learning and memory deficits in APP\/PS1 transgenic mice. Sci. Rep. 9, 19575. https:\/\/doi.org\/10.1038\/s41598-019-56149-9 (2019).","journal-title":"Sci. Rep."},{"key":"5502_CR8","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/ptr.1517","volume":"18","author":"L Slobodn\u00edkov\u00e1","year":"2004","unstructured":"Slobodn\u00edkov\u00e1, L., Kost\u2019\u00e1lov\u00e1, D., Labudov\u00e1, D., Kotulov\u00e1, D. & Kettmann, V. Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. Phytother. Res. 18, 674\u2013676. https:\/\/doi.org\/10.1002\/ptr.1517 (2004).","journal-title":"Phytother. Res."},{"key":"5502_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.684358","volume":"12","author":"Y Lyu","year":"2021","unstructured":"Lyu, Y. et al. Blood-glucose-lowering effect of Coptidis Rhizoma extracts from different origins via gut microbiota modulation in db\/db mice. Front. Pharmacol. 12, 684358. https:\/\/doi.org\/10.3389\/fphar.2021.684358 (2021).","journal-title":"Front. Pharmacol."},{"key":"5502_CR10","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.2174\/1871527314666150821104455","volume":"14","author":"W Jiang","year":"2015","unstructured":"Jiang, W. et al. Jatrorrhizine protects against okadaic acid induced oxidative toxicity through inhibiting the mitogen-activated protein kinases pathways in HT22 hippocampal neurons. CNS Neurol. Disord. Drug Targets 14, 1334\u20131342. https:\/\/doi.org\/10.2174\/1871527314666150821104455 (2015).","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"5502_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202300751","volume":"47","author":"R Wang","year":"2024","unstructured":"Wang, R. et al. Integrated ultra-high-performance liquid chromatography coupled with quadrupole-orbitrap mass spectrometry-based components analysis and network pharmacology strategy of Gancao Xiexin Decoction in treating gastric ulcer. J. Sep. Sci. 47, e2300751. https:\/\/doi.org\/10.1002\/jssc.202300751 (2024).","journal-title":"J. Sep. Sci."},{"key":"5502_CR12","doi-asserted-by":"publisher","first-page":"591","DOI":"10.22034\/apjcp.2018.19.3.591","volume":"19","author":"AR Yusefi","year":"2018","unstructured":"Yusefi, A. R., Bagheri Lankarani, K., Bastani, P., Radinmanezsh, M. & Kavosi, Z. Risk factors for gastric cancer: A systematic review. Asian Pac. J. Cancer Prev. 19, 591\u2013603. https:\/\/doi.org\/10.22034\/apjcp.2018.19.3.591 (2018).","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"5502_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.chroma.2017.07.046","volume":"1513","author":"M Lashgari","year":"2017","unstructured":"Lashgari, M., Yamini, Y., Basheer, C. & Lee, H. K. Ordered mesoporous carbon as sorbent for the extraction of N-nitrosamines in wastewater and swimming pool water. J. Chromatogr. A 1513, 35\u201341. https:\/\/doi.org\/10.1016\/j.chroma.2017.07.046 (2017).","journal-title":"J. Chromatogr. A"},{"key":"5502_CR14","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.3390\/cells10112832","volume":"10","author":"Q Jin","year":"2021","unstructured":"Jin, Q. & Ma, R. C. W. Metabolomics in diabetes and diabetic complications: INSIGHTS from epidemiological studies. Cells 10, 2832. https:\/\/doi.org\/10.3390\/cells10112832 (2021).","journal-title":"Cells"},{"key":"5502_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154150","volume":"102","author":"Y Kang","year":"2022","unstructured":"Kang, Y. et al. Hirsutine, a novel megakaryopoiesis inducer, promotes thrombopoiesis via MEK\/ERK\/FOG1\/TAL1 signaling. Phytomedicine 102, 154150. https:\/\/doi.org\/10.1016\/j.phymed.2022.154150 (2022).","journal-title":"Phytomedicine"},{"key":"5502_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153619","volume":"91","author":"JX Wen","year":"2021","unstructured":"Wen, J. X. et al. Therapeutic effects and potential mechanism of dehydroevodiamine on N-methyl-N\u2032-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis. Phytomedicine 91, 153619. https:\/\/doi.org\/10.1016\/j.phymed.2021.153619 (2021).","journal-title":"Phytomedicine"},{"key":"5502_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.644638","volume":"12","author":"Y Tong","year":"2021","unstructured":"Tong, Y. et al. Berberine attenuates chronic atrophic gastritis induced by MNNG and its potential mechanism. Front. Pharmacol. 12, 644638. https:\/\/doi.org\/10.3389\/fphar.2021.644638 (2021).","journal-title":"Front. Pharmacol."},{"key":"5502_CR18","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.3390\/nu14142848","volume":"14","author":"A Gunes-Bayir","year":"2022","unstructured":"Gunes-Bayir, A. et al. Anti-inflammatory and antioxidant effects of carvacrol on N-methyl-N\u2032-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis in wistar rats. Nutrients 14, 2848. https:\/\/doi.org\/10.3390\/nu14142848 (2022).","journal-title":"Nutrients"},{"key":"5502_CR19","doi-asserted-by":"publisher","first-page":"587","DOI":"10.12688\/f1000research.10625.1","volume":"6","author":"D Finlay","year":"2017","unstructured":"Finlay, D., Teriete, P., Vamos, M., Cosford, N. D. P. & Vuori, K. Inducing death in tumor cells: Roles of the inhibitor of apoptosis proteins. F1000Research 6, 587. https:\/\/doi.org\/10.12688\/f1000research.10625.1 (2017).","journal-title":"F1000Research"},{"key":"5502_CR20","doi-asserted-by":"publisher","first-page":"6578","DOI":"10.1038\/s41467-022-34253-1","volume":"13","author":"H Ning","year":"2022","unstructured":"Ning, H. et al. Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity. Nat. Commun. 13, 6578. https:\/\/doi.org\/10.1038\/s41467-022-34253-1 (2022).","journal-title":"Nat. Commun."},{"key":"5502_CR21","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/821043","volume":"2014","author":"B Sangiuliano","year":"2014","unstructured":"Sangiuliano, B., P\u00e9rez, N. M., Moreira, D. F. & Beliz\u00e1rio, J. E. Cell death-associated molecular-pattern molecules: Inflammatory signaling and control. Mediat. Inflamm. 2014, 821043. https:\/\/doi.org\/10.1155\/2014\/821043 (2014).","journal-title":"Mediat. Inflamm."},{"key":"5502_CR22","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1172\/jci128322","volume":"130","author":"L Mao","year":"2020","unstructured":"Mao, L. et al. Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1\u03b2-mediated colitis. J. Clin. Investig. 130, 1793\u20131807. https:\/\/doi.org\/10.1172\/jci128322 (2020).","journal-title":"J. Clin. Investig."},{"key":"5502_CR23","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1136\/gut.42.2.227","volume":"42","author":"I Beales","year":"1998","unstructured":"Beales, I. & Calam, J. Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut 42, 227\u2013234. https:\/\/doi.org\/10.1136\/gut.42.2.227 (1998).","journal-title":"Gut"},{"key":"5502_CR24","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4149\/neo_2009_01_63","volume":"56","author":"DS Arici","year":"2009","unstructured":"Arici, D. S., Tuncer, E., Ozer, H., Simek, G. & Koyuncu, A. Expression of retinoblastoma and cyclin D1 in gastric carcinoma. Neoplasma 56, 63\u201367. https:\/\/doi.org\/10.4149\/neo_2009_01_63 (2009).","journal-title":"Neoplasma"},{"key":"5502_CR25","first-page":"12929","volume":"13","author":"Y Zhou","year":"2021","unstructured":"Zhou, Y. & Wang, S. Efficacy of Jianpiyangxue granule on gastrointestinal autonomic nerve dysfunction and its impact on adverse reactions. Am. J. Transl. Res. 13, 12929\u201312938 (2021).","journal-title":"Am. J. Transl. Res."},{"key":"5502_CR26","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5265444","volume":"2021","author":"X Guo","year":"2021","unstructured":"Guo, X., Xu, Y., Tan, H., Wang, X. & Xiao, L. The key ingredient acacetin in Weishu decoction alleviates gastrointestinal motility disorder based on network pharmacology analysis. Mediat. Inflamm. 2021, 5265444. https:\/\/doi.org\/10.1155\/2021\/5265444 (2021).","journal-title":"Mediat. Inflamm."},{"key":"5502_CR27","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3498310","volume":"2022","author":"S Niu","year":"2022","unstructured":"Niu, S. et al. Jatrorrhizine alleviates DSS-induced ulcerative colitis by regulating the intestinal barrier function and inhibiting TLR4\/MyD88\/NF-\u03baB signaling pathway. Evid. Based Complement. Altern. Med. 2022, 3498310. https:\/\/doi.org\/10.1155\/2022\/3498310 (2022).","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"5502_CR28","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1002\/jcp.22906","volume":"227","author":"L Zhu","year":"2012","unstructured":"Zhu, L. et al. Zearalenone induces apoptosis and necrosis in porcine granulosa cells via a caspase-3- and caspase-9-dependent mitochondrial signaling pathway. J. Cell. Physiol. 227, 1814\u20131820. https:\/\/doi.org\/10.1002\/jcp.22906 (2012).","journal-title":"J. Cell. Physiol."},{"key":"5502_CR29","doi-asserted-by":"publisher","first-page":"4884","DOI":"10.1038\/s41467-021-25221-2","volume":"12","author":"K de Haan","year":"2021","unstructured":"de Haan, K. et al. Deep learning-based transformation of H&E stained tissues into special stains. Nat. Commun. 12, 4884. https:\/\/doi.org\/10.1038\/s41467-021-25221-2 (2021).","journal-title":"Nat. Commun."},{"key":"5502_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153743","volume":"92","author":"YY Wei","year":"2021","unstructured":"Wei, Y. Y. et al. Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1\/NF-\u03baB pathway. Phytomedicine 92, 153743. https:\/\/doi.org\/10.1016\/j.phymed.2021.153743 (2021).","journal-title":"Phytomedicine"},{"key":"5502_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175331","volume":"935","author":"J Wang","year":"2022","unstructured":"Wang, J. et al. Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics. Eur. J. Pharmacol. 935, 175331. https:\/\/doi.org\/10.1016\/j.ejphar.2022.175331 (2022).","journal-title":"Eur. J. Pharmacol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05502-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05502-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05502-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:24:15Z","timestamp":1751383455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05502-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5502"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-05502-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"6 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animal procedures were carried out by following the Guide for the Care and Use of Laboratory. The research was approved by the Chongqing Academy of Animal Science Animal Ethics Committee (Approval ID: XKY-20240820). This study is reported following ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"21018"}}