{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:13:36Z","timestamp":1791922416296,"version":"4.3.4"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["Grant No. 2023D01C116"],"award-info":[{"award-number":["Grant No. 2023D01C116"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-05740-4","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:10:23Z","timestamp":1751382623000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploring the toxicological effects of DOTP exposure on periodontitis by combining molecular docking and molecular dynamics simulations"],"prefix":"10.1038","volume":"15","author":[{"given":"Junjie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"1","key":"5740_CR1","doi-asserted-by":"publisher","first-page":"6064","DOI":"10.1038\/s41467-023-41765-x","volume":"14","author":"W Xu","year":"2023","unstructured":"Xu, W. et al. Biomimetic single Al\u2013OH site with high acetylcholinesterase-like activity and self-defense ability for neuroprotection. Nat. Commun. 14(1), 6064. https:\/\/doi.org\/10.1038\/s41467-023-41765-x (2023).","journal-title":"Nat. Commun."},{"issue":"4","key":"5740_CR2","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1093\/ije\/dyac082","volume":"51","author":"WC Lo","year":"2022","unstructured":"Lo, W. C. et al. Long-term exposure to ambient fine particulate matter (PM2.5) and associations with cardiopulmonary diseases and lung cancer in Taiwan: A nationwide longitudinal cohort study. Int. J. Epidemiol. 51(4), 1230\u20131242. https:\/\/doi.org\/10.1093\/ije\/dyac082 (2022).","journal-title":"Int. J. Epidemiol."},{"issue":"11","key":"5740_CR3","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum, N. J. et al. Global burden of severe periodontitis in 1990\u20132010: A systematic review and meta-regression. J. Dent. Res. 93(11), 1045\u20131053. https:\/\/doi.org\/10.1177\/0022034514552491 (2014).","journal-title":"J. Dent. Res."},{"issue":"Suppl 1","key":"5740_CR4","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou, P. N. et al. Periodontitis: Consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J. Periodontol. 89(Suppl 1), S173\u2013S182. https:\/\/doi.org\/10.1002\/JPER.17-0721 (2018).","journal-title":"J. Periodontol."},{"issue":"1","key":"5740_CR5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis, G. Periodontitis: From microbial immune subversion to systemic inflammation. Nat. Rev. Immunol. 15(1), 30\u201344. https:\/\/doi.org\/10.1038\/nri3785 (2015).","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"5740_CR6","doi-asserted-by":"publisher","first-page":"e1700782","DOI":"10.1126\/sciadv.1700782","volume":"3","author":"R Geyer","year":"2017","unstructured":"Geyer, R., Jambeck, J. R. & Law, K. L. Production, use, and fate of all plastics ever made. Sci. Adv. 3(7), e1700782. https:\/\/doi.org\/10.1126\/sciadv.1700782 (2017).","journal-title":"Sci. Adv."},{"key":"5740_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.129064","volume":"265","author":"HT Tran","year":"2021","unstructured":"Tran, H. T. et al. Bacterial community progression during food waste composting containing high dioctyl terephthalate (DOTP) concentration. Chemosphere 265, 129064. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.129064 (2021).","journal-title":"Chemosphere"},{"key":"5740_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.124217","volume":"355","author":"DFMS Mohamed","year":"2024","unstructured":"Mohamed, D. F. M. S., Tarafdar, A., Lee, S. Y., Oh, H. B. & Kwon, J. H. Assessment of biodegradation and toxicity of alternative plasticizer di(2-ethylhexyl) terephthalate: Impacts on microbial biofilms, metabolism, and reactive oxygen species-mediated stress response. Environ. Pollut. 355, 124217. https:\/\/doi.org\/10.1016\/j.envpol.2024.124217 (2024).","journal-title":"Environ. Pollut."},{"key":"5740_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.112984","volume":"164","author":"P Harmon","year":"2022","unstructured":"Harmon, P. & Otter, R. A review of common non-ortho-phthalate plasticizers for use in food contact materials. Food Chem. Toxicol. 164, 112984. https:\/\/doi.org\/10.1016\/j.fct.2022.112984 (2022).","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"5740_CR10","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41370-021-00392-8","volume":"32","author":"L Edwards","year":"2022","unstructured":"Edwards, L. et al. Phthalate and novel plasticizer concentrations in food items from U.S. fast food chains: A preliminary analysis. J. Expo Sci. Environ. Epidemiol. 32(3), 366\u2013373. https:\/\/doi.org\/10.1038\/s41370-021-00392-8 (2022).","journal-title":"J. Expo Sci. Environ. Epidemiol."},{"key":"5740_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2025.179080","volume":"972","author":"W Wei","year":"2025","unstructured":"Wei, W. et al. Plasticizer sources and concentrations in indoor environments in Europe: A systematic review of existing data. Sci. Total Environ. 972, 179080. https:\/\/doi.org\/10.1016\/j.scitotenv.2025.179080 (2025).","journal-title":"Sci. Total Environ."},{"issue":"2","key":"5740_CR12","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41370-022-00441-w","volume":"33","author":"E Dom\u00ednguez-Romero","year":"2023","unstructured":"Dom\u00ednguez-Romero, E. et al. Time-trends in human urinary concentrations of phthalates and substitutes DEHT and DINCH in Asian and North American countries (2009\u20132019). J. Expo Sci. Environ. Epidemiol. 33(2), 244\u2013254. https:\/\/doi.org\/10.1038\/s41370-022-00441-w (2023).","journal-title":"J. Expo Sci. Environ. Epidemiol."},{"issue":"4","key":"5740_CR13","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/10937400903094091","volume":"12","author":"JL Lyche","year":"2009","unstructured":"Lyche, J. L. et al. Reproductive and developmental toxicity of phthalates. J. Toxicol. Environ. Health B Crit. Rev. 12(4), 225\u2013249. https:\/\/doi.org\/10.1080\/10937400903094091 (2009).","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"5740_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.117864","volume":"291","author":"F Cao","year":"2025","unstructured":"Cao, F., Guo, C. & Guo, J. Deciphering CSU pathogenesis: Network toxicology and molecular dynamics of DOTP exposure. Ecotoxicol. Environ. Saf. 291, 117864. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117864 (2025).","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"5740_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/prd.12342","volume":"84","author":"FSC Sczepanik","year":"2020","unstructured":"Sczepanik, F. S. C. et al. Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way. Periodontol. 2000 84(1), 45\u201368. https:\/\/doi.org\/10.1111\/prd.12342 (2020).","journal-title":"Periodontol. 2000"},{"key":"5740_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108851","volume":"190","author":"M Teng","year":"2024","unstructured":"Teng, M. et al. Effects of BBIBP-CorV vaccine on gut microbiota and short-chain fatty acids in mice exposed to bis (2-ethylhexyl) phthalate and dioctyl terephthalate. Environ. Int. 190, 108851. https:\/\/doi.org\/10.1016\/j.envint.2024.108851 (2024).","journal-title":"Environ. Int."},{"issue":"1","key":"5740_CR17","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1186\/s12967-023-04559-9","volume":"21","author":"X Ye","year":"2023","unstructured":"Ye, X. et al. Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: Insights from a two-sample Mendelian randomization study. J. Transl. Med. 21(1), 674. https:\/\/doi.org\/10.1186\/s12967-023-04559-9 (2023).","journal-title":"J. Transl. Med."},{"issue":"9","key":"5740_CR18","doi-asserted-by":"publisher","first-page":"5142","DOI":"10.3390\/ijms23095142","volume":"23","author":"M Di Stefano","year":"2022","unstructured":"Di Stefano, M. et al. Impact of oral microbiome in periodontal health and periodontitis: A critical review on prevention and treatment. Int. J. Mol. Sci. 23(9), 5142. https:\/\/doi.org\/10.3390\/ijms23095142 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"5740_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.167904","volume":"905","author":"S Huang","year":"2023","unstructured":"Huang, S. Efficient analysis of toxicity and mechanisms of environmental pollutants with network toxicology and molecular docking strategy: Acetyl tributyl citrate as an example. Sci. Total Environ. 905, 167904. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.167904 (2023).","journal-title":"Sci. Total Environ."},{"issue":"18","key":"5740_CR20","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.3390\/ijms20184331","volume":"20","author":"L Pinzi","year":"2019","unstructured":"Pinzi, L. & Rastelli, G. Molecular docking: Shifting paradigms in drug discovery. Int. J. Mol. Sci. 20(18), 4331. https:\/\/doi.org\/10.3390\/ijms20184331 (2019).","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt A","key":"5740_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134824","volume":"405","author":"X Hu","year":"2023","unstructured":"Hu, X. et al. Molecular dynamics simulation of the interaction of food proteins with small molecules. Food Chem. 405(Pt A), 134824. https:\/\/doi.org\/10.1016\/j.foodchem.2022.134824 (2023).","journal-title":"Food Chem."},{"issue":"1","key":"5740_CR22","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1038\/s41467-022-29331-3","volume":"13","author":"J Zhu","year":"2022","unstructured":"Zhu, J., Wang, J., Han, W. & Xu, D. Neural relational inference to learn long-range allosteric interactions in proteins from molecular dynamics simulations. Nat. Commun. 13(1), 1661. https:\/\/doi.org\/10.1038\/s41467-022-29331-3 (2022).","journal-title":"Nat. Commun."},{"issue":"W1","key":"5740_CR23","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina, A., Michielin, O. & Zoete, V. SwissTargetPrediction: Updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res. 47(W1), W357\u2013W364. https:\/\/doi.org\/10.1093\/nar\/gkz382 (2019).","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"5740_CR24","doi-asserted-by":"publisher","first-page":"W726","DOI":"10.1093\/nar\/gkac297","volume":"50","author":"K Gallo","year":"2022","unstructured":"Gallo, K., Goede, A., Preissner, R. & Gohlke, B. O. SuperPred 3.0: Drug classification and target prediction-a machine learning approach. Nucleic Acids Res. 50(W1), W726\u2013W731. https:\/\/doi.org\/10.1093\/nar\/gkac297 (2022).","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"5740_CR25","doi-asserted-by":"publisher","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","volume":"49","author":"S Kim","year":"2021","unstructured":"Kim, S. et al. PubChem in 2021: New data content and improved web interfaces. Nucleic Acids Res. 49(D1), D1388\u2013D1395. https:\/\/doi.org\/10.1093\/nar\/gkaa971 (2021).","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"5740_CR26","doi-asserted-by":"publisher","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","volume":"51","author":"UniProt Consortium","year":"2023","unstructured":"UniProt Consortium. UniProt: The universal protein knowledgebase in 2023. Nucleic Acids Res. 51(D1), D523\u2013D531. https:\/\/doi.org\/10.1093\/nar\/gkac1052 (2023).","journal-title":"Nucleic Acids Res."},{"key":"5740_CR27","doi-asserted-by":"publisher","first-page":"baq020","DOI":"10.1093\/database\/baq020","volume":"2010","author":"M Safran","year":"2010","unstructured":"Safran, M. et al. GeneCards Version 3: The human gene integrator. Database (Oxford). 2010, baq020. https:\/\/doi.org\/10.1093\/database\/baq020 (2010).","journal-title":"Database (Oxford)."},{"issue":"Database issue","key":"5740_CR28","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett, T. et al. NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41(Database issue), D991\u2013D995. https:\/\/doi.org\/10.1093\/nar\/gks1193 (2013).","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"5740_CR29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43(7), e47. https:\/\/doi.org\/10.1093\/nar\/gkv007 (2015).","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"5740_CR30","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"Sherman, B. T. et al. DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 50(W1), W216\u2013W221. https:\/\/doi.org\/10.1093\/nar\/gkac194 (2022).","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"5740_CR31","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk, D. et al. The STRING database in 2023: Protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 51(D1), D638\u2013D646. https:\/\/doi.org\/10.1093\/nar\/gkac1000 (2023).","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"5740_CR32","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13(11), 2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303 (2003).","journal-title":"Genome Res."},{"key":"5740_CR33","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1265\/ehpm.24-00095","volume":"29","author":"Z Yu","year":"2024","unstructured":"Yu, Z. et al. Identification of hub genes and key pathways in arsenic-treated rice (Oryza sativa L.) based on 9 topological analysis methods of CytoHubba. Environ. Health Prev. Med. 29, 41. https:\/\/doi.org\/10.1265\/ehpm.24-00095 (2024).","journal-title":"Environ. Health Prev. Med."},{"key":"5740_CR34","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2105-4-2","volume":"4","author":"GD Bader","year":"2003","unstructured":"Bader, G. D. & Hogue, C. W. An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinform. 4, 2. https:\/\/doi.org\/10.1186\/1471-2105-4-2 (2003).","journal-title":"BMC Bioinform."},{"issue":"5","key":"5740_CR35","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","volume":"24","author":"D Seeliger","year":"2010","unstructured":"Seeliger, D. & de Groot, B. L. Ligand docking and binding site analysis with PyMOL and Autodock\/Vina. J. Comput. Aided Mol. Des. 24(5), 417\u2013422. https:\/\/doi.org\/10.1007\/s10822-010-9352-6 (2010).","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"24","key":"5740_CR36","doi-asserted-by":"publisher","first-page":"5121","DOI":"10.1093\/bioinformatics\/btz459","volume":"35","author":"Y Zhang","year":"2019","unstructured":"Zhang, Y. & Sanner, M. F. AutoDock CrankPep: Combining folding and docking to predict protein-peptide complexes. Bioinformatics 35(24), 5121\u20135127. https:\/\/doi.org\/10.1093\/bioinformatics\/btz459 (2019).","journal-title":"Bioinformatics"},{"issue":"8","key":"5740_CR37","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","volume":"61","author":"J Eberhardt","year":"2021","unstructured":"Eberhardt, J., Santos-Martins, D., Tillack, A. F. & Forli, S. AutoDock Vina 1.2.0: New docking methods, expanded force field, and python bindings. J. Chem. Inf. Model. 61(8), 3891\u20133898. https:\/\/doi.org\/10.1021\/acs.jcim.1c00203 (2021).","journal-title":"J. Chem. Inf. Model."},{"issue":"5","key":"5740_CR38","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1111\/cbdd.14038","volume":"99","author":"X Wu","year":"2022","unstructured":"Wu, X., Xu, L. Y., Li, E. M. & Dong, G. Application of molecular dynamics simulation in biomedicine. Chem. Biol. Drug Des. 99(5), 789\u2013800. https:\/\/doi.org\/10.1111\/cbdd.14038 (2022).","journal-title":"Chem. Biol. Drug Des."},{"key":"5740_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114653","volume":"190","author":"D Yu","year":"2024","unstructured":"Yu, D. et al. Application of the molecular dynamics simulation GROMACS in food science. Food Res. Int. 190, 114653. https:\/\/doi.org\/10.1016\/j.foodres.2024.114653 (2024).","journal-title":"Food Res. Int."},{"issue":"2","key":"5740_CR40","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/jcpe.12803","volume":"45","author":"D Polak","year":"2018","unstructured":"Polak, D. & Shapira, L. An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J. Clin. Periodontol. 45(2), 150\u2013166. https:\/\/doi.org\/10.1111\/jcpe.12803 (2018).","journal-title":"J. Clin. Periodontol."},{"key":"5740_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113216","volume":"213","author":"MM Madkour","year":"2021","unstructured":"Madkour, M. M., Anbar, H. S. & El-Gamal, M. I. Current status and future prospects of p38\u03b1\/MAPK14 kinase and its inhibitors. Eur. J. Med. Chem. 213, 113216. https:\/\/doi.org\/10.1016\/j.ejmech.2021.113216 (2021).","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"5740_CR42","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2174\/138920009787048347","volume":"10","author":"KL Kirkwood","year":"2009","unstructured":"Kirkwood, K. L. & Rossa, C. Jr. The potential of p38 MAPK inhibitors to modulate periodontal infections. Curr. Drug Metab. 10(1), 55\u201367. https:\/\/doi.org\/10.2174\/138920009787048347 (2009).","journal-title":"Curr. Drug Metab."},{"issue":"1","key":"5740_CR43","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1172\/JCI11830","volume":"107","author":"PP Tak","year":"2001","unstructured":"Tak, P. P. & Firestein, G. S. NF-kappaB: A key role in inflammatory diseases. J. Clin. Investig. 107(1), 7\u201311. https:\/\/doi.org\/10.1172\/JCI11830 (2001).","journal-title":"J. Clin. Investig."},{"issue":"2","key":"5740_CR44","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1365-2249.2007.03342.x","volume":"148","author":"MR Milward","year":"2007","unstructured":"Milward, M. R. et al. Differential activation of NF-kappaB and gene expression in oral epithelial cells by periodontal pathogens. Clin. Exp. Immunol. 148(2), 307\u2013324. https:\/\/doi.org\/10.1111\/j.1365-2249.2007.03342.x (2007).","journal-title":"Clin. Exp. Immunol."},{"issue":"15","key":"5740_CR45","doi-asserted-by":"publisher","first-page":"12097","DOI":"10.3390\/ijms241512097","volume":"24","author":"C Lin","year":"2023","unstructured":"Lin, C., Liu, M., Guo, J. & Jia, R. Cryotherapy attenuates inflammation via the lncRNA SNHG1\/miR-9-5p\/NFKB1 regulatory axis in periodontal ligament cells. Int. J. Mol. Sci. 24(15), 12097. https:\/\/doi.org\/10.3390\/ijms241512097 (2023).","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"5740_CR46","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1002\/jcb.27487","volume":"120","author":"SM Haftcheshmeh","year":"2019","unstructured":"Haftcheshmeh, S. M., Mohammadi, A., Soltani, A., Momtazi-Borojeni, A. A. & Sattari, M. Evaluation of STAT1 and Wnt5a gene expression in gingival tissues of patients with periodontal disease. J. Cell Biochem. 120(2), 1827\u20131834. https:\/\/doi.org\/10.1002\/jcb.27487 (2019).","journal-title":"J. Cell Biochem."},{"issue":"9","key":"5740_CR47","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1177\/0022034519858063","volume":"98","author":"W Wei","year":"2019","unstructured":"Wei, W. et al. Activation of the STAT1 pathway accelerates periodontitis in Nos3-\/- mice. J. Dent. Res. 98(9), 1027\u20131036. https:\/\/doi.org\/10.1177\/0022034519858063 (2019).","journal-title":"J. Dent. Res."},{"issue":"7","key":"5740_CR48","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1093\/rheumatology\/keaa794","volume":"60","author":"AH Schneider","year":"2021","unstructured":"Schneider, A. H. et al. Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation. Rheumatology (Oxford) 60(7), 3461\u20133473. https:\/\/doi.org\/10.1093\/rheumatology\/keaa794 (2021).","journal-title":"Rheumatology (Oxford)"},{"issue":"13","key":"5740_CR49","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.7150\/ijbs.86492","volume":"19","author":"E Mart\u00edn-V\u00e1zquez","year":"2023","unstructured":"Mart\u00edn-V\u00e1zquez, E., Cobo-Vuilleumier, N., L\u00f3pez-Noriega, L., Lorenzo, P. I. & Gauthier, B. R. The PTGS2\/COX2-PGE2\u00a0signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus. Int. J. Biol. Sci. 19(13), 4157\u20134165. https:\/\/doi.org\/10.7150\/ijbs.86492 (2023).","journal-title":"Int. J. Biol. Sci."},{"key":"5740_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.07.028","author":"W Qiu","year":"2024","unstructured":"Qiu, W. et al. Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity. J. Adv. Res. https:\/\/doi.org\/10.1016\/j.jare.2024.07.028 (2024).","journal-title":"J. Adv. Res."},{"key":"5740_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114215","volume":"159","author":"X Liu","year":"2023","unstructured":"Liu, X., Yang, L. & Tan, X. PD-1\/PD-L1 pathway: A double-edged sword in periodontitis. Biomed. Pharmacother. 159, 114215. https:\/\/doi.org\/10.1016\/j.biopha.2023.114215 (2023).","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"5740_CR52","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1136\/gutjnl-2015-309897","volume":"66","author":"V Blasco-Baque","year":"2017","unstructured":"Blasco-Baque, V. et al. Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. Gut 66(5), 872\u2013885. https:\/\/doi.org\/10.1136\/gutjnl-2015-309897 (2017).","journal-title":"Gut"},{"key":"5740_CR53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2025.01.011","volume":"229","author":"W Ye","year":"2025","unstructured":"Ye, W. et al. Dectin-2 depletion alleviates osteoclast-induced bone loss in periodontitis via Syk\/NOX2\/ROS signaling. Free Radic. Biol. Med. 229, 13\u201329. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.01.011 (2025).","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"5740_CR54","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3109\/10408444.2011.623149","volume":"42","author":"GL Ball","year":"2012","unstructured":"Ball, G. L., McLellan, C. J. & Bhat, V. S. Toxicological review and oral risk assessment of terephthalic acid (TPA) and its esters: A category approach. Crit. Rev. Toxicol. 42(1), 28\u201367. https:\/\/doi.org\/10.3109\/10408444.2011.623149 (2012).","journal-title":"Crit. Rev. Toxicol."},{"key":"5740_CR55","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijsu.2019.10.015","volume":"72","author":"NB Robinson","year":"2019","unstructured":"Robinson, N. B. et al. The current state of animal models in research: A review. Int. J. Surg. 72, 9\u201313. https:\/\/doi.org\/10.1016\/j.ijsu.2019.10.015 (2019).","journal-title":"Int. J. Surg."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05740-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05740-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05740-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:10:24Z","timestamp":1751382624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05740-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5740"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-05740-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"18 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20915"}}