{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:58:04Z","timestamp":1783641484499,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-05796-2","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:20:04Z","timestamp":1751383204000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bacterial infections in pediatric oncology patients- a single center experience"],"prefix":"10.1038","volume":"15","author":[{"given":"Joanna","family":"Klepacka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szymon","family":"Skocze\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Wojtaszek-G\u0142\u00f3wka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacper","family":"\u017burek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Czoga\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Kwieci\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzanna","family":"Zakrzewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"5796_CR1","doi-asserted-by":"publisher","first-page":"e604","DOI":"10.1016\/S1470-2045(15)00197-7","volume":"16","author":"S Alexander","year":"2015","unstructured":"Alexander, S. et al. Classification of treatment-related mortality in children with cancer: A systematic assessment. Lancet. Oncol. 16, e604\u2013e610 (2015).","journal-title":"Lancet. Oncol."},{"key":"5796_CR2","volume-title":"Lanzkowsky\u2019s Manual of Pediatric Hematology and Oncology","author":"P Lanzkowsky","year":"2016","unstructured":"Lanzkowsky, P., Lipton, J. & Fish, J. D. Lanzkowsky\u2019s Manual of Pediatric Hematology and Oncology 6th edn. (Elsevier, 2016).","edition":"6"},{"issue":"4","key":"5796_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3816\/SCT.2006.n.018","volume":"3","author":"S Moon","year":"2006","unstructured":"Moon, S., Williams, S. & Cullen, M. Role of prophylactic antibiotics in the prevention of infections after chemotherapy: A literature review. Support. Cancer Ther. 3(4), 207\u2013216 (2006).","journal-title":"Support. Cancer Ther."},{"key":"5796_CR4","doi-asserted-by":"crossref","unstructured":"Wolf J.; Allison KJ.; Tang L. et al. No evidence of benefit from antibiotic lock therapy in pediatric oncology patients with central line-related bloodstream infection: results of a retrospective matched cohort study and review of the literature. Pediatr Blood Cancer. 2014, Oct;61(10), 1811\u20135.","DOI":"10.1002\/pbc.25101"},{"key":"5796_CR5","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1093\/cid\/ciz319","volume":"70","author":"G Martinez-Nadal","year":"2020","unstructured":"Martinez-Nadal, G. et al. Inappropriate empirical antibiotic treatment in high-risk neutropenic patients with bacteremia in the Era of multidrug resistance. Clin. Infect. Dis. 70, 1068\u20131074 (2020).","journal-title":"Clin. Infect. Dis."},{"key":"5796_CR6","unstructured":"Global Antimicrobial Resistance and Use Surveillance System (GLASS). Early Implementation Report. Available online at: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/332081\/9789240005587-eng.pdf (2020)."},{"key":"5796_CR7","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3390\/jcm11030880","volume":"11","author":"D Mattei","year":"2022","unstructured":"Mattei, D. et al. Characteristics and outcomes of bloodstream infections in a tertiary-care pediatric hematology-oncology unit: A 10-year study. J. Clin. Med. 11, 880 (2022).","journal-title":"J. Clin. Med."},{"issue":"9","key":"5796_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/INF.0000000000000326","volume":"33","author":"P Agyeman","year":"2014","unstructured":"Agyeman, P. et al. A prospective multicenter study of microbiologically defined infections in pediatric cancer patients with fever and neutropenia: Swiss pediatric oncology group 2003 fever and neutropenia study. Pediatr. Infect. Dis. J. 33(9), 219\u2013225 (2014).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"5796_CR9","unstructured":"Lee E., & Anjum F.. Staphylococcus epidermidis infection. In: StatPearls [Internet]. (Treasure Island (FL), StatPearls Publishing 2023)."},{"issue":"9","key":"5796_CR10","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1128\/AAC.43.9.2200","volume":"43","author":"J Carratal\u00e0","year":"1999","unstructured":"Carratal\u00e0, J. et al. Randomized, double-blind trial of an antibiotic-lock technique for prevention of gram-positive central venous catheter-related infection in neutropenic patients with cancer. Antimicrob. Agent. Chemother. 43(9), 2200\u20132204 (1999).","journal-title":"Antimicrob. Agent. Chemother."},{"issue":"5","key":"5796_CR11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1017\/ice.2022.87","volume":"43","author":"N Buetti","year":"2022","unstructured":"Buetti, N. et al. Strategies to prevent central line-associated bloodstream infections in acute-care hospitals: 2022 Update. Infect Control. Hosp. Epidemiol. 43(5), 553\u2013569 (2022).","journal-title":"Infect Control. Hosp. Epidemiol."},{"issue":"9","key":"5796_CR12","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1080\/23744235.2018.1451917","volume":"50","author":"S Morioka","year":"2018","unstructured":"Morioka, S., Ichikawa, M., Mori, K. & Kurai, H. Coagulase-negative staphylococcal bacteraemia in cancer patients. TIME to positive culture can distinguish bacteraemia from contamination. Infect. Dis. (Lond). 50(9), 660\u2013665 (2018).","journal-title":"Infect. Dis. (Lond)."},{"key":"5796_CR13","doi-asserted-by":"crossref","unstructured":"Al Battashi A.; Al Harrassi B.; Al Maskari N.; Al Hashami H.; Al Awaidy S. Alarming Antibiotic Resistance in Pediatric Oncology Patients: A Three-Year Prospective Cohort Study from Oman. Infect Drug Resist. 25(15), 3939\u20133947. Erratum in: Infect Drug Resist. 2022, 30(15), 4961\u20134962 (2022).","DOI":"10.2147\/IDR.S369909"},{"issue":"3","key":"5796_CR14","doi-asserted-by":"publisher","first-page":"226","DOI":"10.4103\/2141-9248.157520","volume":"5","author":"NH Ahmed","year":"2015","unstructured":"Ahmed, N. H., Baruah, F. K. & Grover, R. K. Staphylococcal blood stream infections in cancer patients. Ann. Med. Health Sci. Res. 5(3), 226\u2013227 (2015).","journal-title":"Ann. Med. Health Sci. Res."},{"key":"5796_CR15","unstructured":"WHO Regional Office for Europe\/European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2022 \u2013 2020 data. Copenhagen: WHO Regional Office for Europe (2022)."},{"issue":"3","key":"5796_CR16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1053\/j.spid.2006.06.006","volume":"17","author":"KM Butler","year":"2006","unstructured":"Butler, K. M. Enterococcal infection in children. Semin. Pediatr. Infect. Dis. 17(3), 128\u2013139 (2006).","journal-title":"Semin. Pediatr. Infect. Dis."},{"issue":"1","key":"5796_CR17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jiac.2022.09.003","volume":"29","author":"K Soneda","year":"2023","unstructured":"Soneda, K. et al. Clinical characteristics and treatment of IMP-type carbapenemase-producing Enterobacteriaceae bacteremia: Case series and literature review. J. Infect Chemother. 29(1), 26\u201332 (2023).","journal-title":"J. Infect Chemother."},{"issue":"5","key":"5796_CR18","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.ijantimicag.2017.01.008","volume":"49","author":"ME Flokas","year":"2017","unstructured":"Flokas, M. E., Karageorgos, S. A., Detsis, M., Alevizakos, M. & Mylonakis, E. Vancomycin-resistant enterococci colonisation, risk factors and risk for infection among hospitalised paediatric patients: A systematic review and meta-analysis. Int. J. Antimicrob. Agent. 49(5), 565\u2013572 (2017).","journal-title":"Int. J. Antimicrob. Agent."},{"issue":"6","key":"5796_CR19","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1002\/pbc.21250","volume":"49","author":"AF Reilly","year":"2007","unstructured":"Reilly, A. F. & Lange, B. J. Infections with viridans group streptococci in children with cancer. Pediatr. Blood Cancer. 49(6), 774\u2013780 (2007).","journal-title":"Pediatr. Blood Cancer."},{"issue":"3","key":"5796_CR20","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1053\/j.spid.2006.06.008","volume":"17","author":"L Bruckner","year":"2006","unstructured":"Bruckner, L. & Gigliotti, F. Viridans group streptococcal infections among children with cancer and the importance of emerging antibiotic resistance. Semin. Pediatr. Infect Dis. 17(3), 153\u2013160 (2006).","journal-title":"Semin. Pediatr. Infect Dis."},{"issue":"2","key":"5796_CR21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1097\/QCO.0000000000000038","volume":"27","author":"EM Trecarichi","year":"2014","unstructured":"Trecarichi, E. M. & Tumbarello, M. Antimicrobial-resistant Gram-negative bacteria in febrile neutropenic patients with cancer: current epidemiology and clinical impact. Curr. Opin. Infect Dis. 27(2), 200\u2013210 (2014).","journal-title":"Curr. Opin. Infect Dis."},{"issue":"4","key":"5796_CR22","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jinf.2013.12.006","volume":"68","author":"M Mikulska","year":"2014","unstructured":"Mikulska, M. et al. Fourth european conference on infections in leukemia group (ECIL-4), a joint venture of EBMT, EORTC, ICHS, ELN and ESGICH\/ESCMID. Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients. J. Infect. 68(4), 321\u2013331 (2014).","journal-title":"J. Infect."},{"key":"5796_CR23","unstructured":"Hryniewicz, W.; Kuch, A.; Wanke-Rytt, M.; \u017bukowska, A. (red.). Pa\u0142eczki Enterobacterales wytwarzaj\u0105ce karbapenemazy (CPR). Epidemiologia, diagnostyka, leczenie i profilaktyka zaka\u017ce\u0144. 2022. Warszawa: Narodowy Instytut Lek\u00f3w."},{"issue":"1","key":"5796_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1089\/mdr.2019.0393","volume":"27","author":"O Zajac-Spychala","year":"2021","unstructured":"Zajac-Spychala, O. et al. Prevalence, epidemiology, etiology, and sensitivity of invasive bacterial infections in pediatric patients undergoing oncological treatment: A multicenter nationwide study. Microb. Drug Resist. 27(1), 53\u201363 (2021).","journal-title":"Microb. Drug Resist."},{"key":"5796_CR25","unstructured":"WHO bacterial priority pathogens list, 2024: Bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance 9789240093461-eng.pdf (2024)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05796-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05796-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05796-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:20:07Z","timestamp":1751383207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-05796-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5796"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-05796-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"15 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study protocol was approved by institutional ethical committee: Bioethics Committee of the Jagiellonian University. The informed consent was waived by institutional ethical committee: Bioethics Committee of the Jagiellonian University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"All authors declare consent for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"20976"}}