{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:35:19Z","timestamp":1785929719116,"version":"3.56.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Center of Excellence in Stem Cell Research and Innovation, Thammasat University"},{"name":"Thailand Science Research and Innovation Fundamental Fund fiscal year 2024, Thammasat University","award":["TUFF 52\/2567"],"award-info":[{"award-number":["TUFF 52\/2567"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-06454-3","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T23:16:49Z","timestamp":1751411809000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High glucose inhibits proliferation, migration, and osteogenic differentiation of human placenta-derived mesenchymal stem cells"],"prefix":"10.1038","volume":"15","author":[{"given":"Supawadee","family":"Duangprom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakpoom","family":"Kheolamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chairat","family":"Tantrawatpan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirikul","family":"Manochantr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"6454_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s13287-022-03054-0","volume":"13","author":"R Margiana","year":"2022","unstructured":"Margiana, R. et al. Clinical application of mesenchymal stem cell in regenerative medicine: A narrative review. Stem. Cell Res. Ther. 13, 366. https:\/\/doi.org\/10.1186\/s13287-022-03054-0 (2022).","journal-title":"Stem. Cell Res. Ther."},{"key":"6454_CR2","doi-asserted-by":"publisher","first-page":"194","DOI":"10.2478\/abm-2024-0027","volume":"18","author":"M Kurniawan","year":"2024","unstructured":"Kurniawan, M. et al. Mesenchymal stem cells therapy for chronic ischemic stroke-a systematic review. Asian Biomed. (Res. Rev. News) 18, 194\u2013203. https:\/\/doi.org\/10.2478\/abm-2024-0027 (2024).","journal-title":"Asian Biomed. (Res. Rev. News)"},{"key":"6454_CR3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.jaci.2024.06.013","volume":"154","author":"HM Seo","year":"2024","unstructured":"Seo, H. M. et al. Phase 1\/2 trials of human bone marrow-derived clonal mesenchymal stem cells for treatment of adults with moderate to severe atopic dermatitis. J. Allergy Clin. Immunol. 154, 965\u2013973. https:\/\/doi.org\/10.1016\/j.jaci.2024.06.013 (2024).","journal-title":"J. Allergy Clin. Immunol."},{"key":"6454_CR4","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1007\/s13577-024-01084-9","volume":"37","author":"D D'Arrigo","year":"2024","unstructured":"D\u2019Arrigo, D., Salerno, M., De Marziani, L., Boffa, A. & Filardo, G. A call for standardization for secretome and extracellular vesicles in osteoarthritis: Results show disease-modifying potential, but protocols are too heterogeneous-a systematic review. Hum. Cell 37, 1243\u20131275. https:\/\/doi.org\/10.1007\/s13577-024-01084-9 (2024).","journal-title":"Hum. Cell"},{"key":"6454_CR5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00441-023-03854-7","volume":"395","author":"MT Ashoobi","year":"2024","unstructured":"Ashoobi, M. T. et al. Wharton\u2019s jelly mesenchymal stem cells transplantation for critical limb ischemia in patients with type 2 diabetes mellitus: A preliminary report of phase I clinical trial. Cell Tissue Res. 395, 211\u2013220. https:\/\/doi.org\/10.1007\/s00441-023-03854-7 (2024).","journal-title":"Cell Tissue Res."},{"key":"6454_CR6","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00018-020-03600-0","volume":"78","author":"LA Costa","year":"2021","unstructured":"Costa, L. A. et al. Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: Implications for further clinical uses. Cell Mol. Life Sci. 78, 447\u2013467. https:\/\/doi.org\/10.1007\/s00018-020-03600-0 (2021).","journal-title":"Cell Mol. Life Sci."},{"key":"6454_CR7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/s13287-023-03587-y","volume":"14","author":"J Li","year":"2023","unstructured":"Li, J. et al. The heterogeneity of mesenchymal stem cells: An important issue to be addressed in cell therapy. Stem. Cell Res. Ther. 14, 381. https:\/\/doi.org\/10.1186\/s13287-023-03587-y (2023).","journal-title":"Stem. Cell Res. Ther."},{"key":"6454_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40659-024-00502-4","volume":"57","author":"OI Badr","year":"2024","unstructured":"Badr, O. I., Kamal, M. M., El-Maraghy, S. A. & Ghaiad, H. R. The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells. Biol. Res. 57, 20. https:\/\/doi.org\/10.1186\/s40659-024-00502-4 (2024).","journal-title":"Biol. Res."},{"key":"6454_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.665412","volume":"9","author":"M Yin","year":"2021","unstructured":"Yin, M., Zhang, Y., Yu, H. & Li, X. Role of hyperglycemia in the senescence of mesenchymal stem cells. Front. Cell Dev. Biol. 9, 665412. https:\/\/doi.org\/10.3389\/fcell.2021.665412 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"6454_CR10","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1042\/CS20230657","volume":"138","author":"S Salem","year":"2024","unstructured":"Salem, S. & Leach, L. Umbilical cord mesenchymal stem cells from gestational diabetes show impaired ability to up-regulate paracellular permeability from sub-endothelial niche. Clin. Sci. (Lond.) 138, 87\u2013102. https:\/\/doi.org\/10.1042\/CS20230657 (2024).","journal-title":"Clin. Sci. (Lond.)"},{"key":"6454_CR11","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.2174\/1381612811319320005","volume":"19","author":"TV Fiorentino","year":"2013","unstructured":"Fiorentino, T. V., Prioletta, A., Zuo, P. & Folli, F. Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr. Pharm. Des. 19, 5695\u20135703. https:\/\/doi.org\/10.2174\/1381612811319320005 (2013).","journal-title":"Curr. Pharm. Des."},{"key":"6454_CR12","doi-asserted-by":"publisher","first-page":"1112363","DOI":"10.3389\/fendo.2023.1112363","volume":"14","author":"Z Zhang","year":"2023","unstructured":"Zhang, Z. et al. The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications. Front. Endocrinol. (Lausanne) 14, 1112363. https:\/\/doi.org\/10.3389\/fendo.2023.1112363 (2023).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"6454_CR13","first-page":"584","volume":"12","author":"J Wang","year":"2013","unstructured":"Wang, J. et al. High glucose inhibits osteogenic differentiation through the BMP signaling pathway in bone mesenchymal stem cells in mice. EXCLI J. 12, 584\u2013597 (2013).","journal-title":"EXCLI J."},{"key":"6454_CR14","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1590\/0103-6440202003120","volume":"31","author":"S Horsophonphong","year":"2020","unstructured":"Horsophonphong, S., Kitkumthorn, N., Sritanaudomchai, H., Nakornchai, S. & Surarit, R. High glucose affects proliferation, reactive oxygen species and mineralization of human dental pulp cells. Braz. Dent. J. 31, 298\u2013303. https:\/\/doi.org\/10.1590\/0103-6440202003120 (2020).","journal-title":"Braz. Dent. J."},{"key":"6454_CR15","doi-asserted-by":"publisher","first-page":"9674614","DOI":"10.1155\/2016\/9674614","volume":"2016","author":"W Hankamolsiri","year":"2016","unstructured":"Hankamolsiri, W. et al. The effects of high glucose on adipogenic and osteogenic differentiation of gestational tissue-derived MSCs. Stem. Cells Int. 2016, 9674614. https:\/\/doi.org\/10.1155\/2016\/9674614 (2016).","journal-title":"Stem. Cells Int."},{"key":"6454_CR16","doi-asserted-by":"publisher","first-page":"665412","DOI":"10.3389\/fcell.2021.665412","volume":"9","author":"M Yin","year":"2021","unstructured":"Yin, M., Zhang, Y., Yu, H. & Li, X. Role of hyperglycemia in the senescence of mesenchymal stem cells. Front. Cell Dev. Biol. 9, 665412. https:\/\/doi.org\/10.3389\/fcell.2021.665412 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"6454_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126537","volume":"10","author":"TC Chang","year":"2015","unstructured":"Chang, T. C., Hsu, M. F. & Wu, K. K. High glucose induces bone marrow-derived mesenchymal stem cell senescence by upregulating autophagy. PLoS ONE 10, e0126537. https:\/\/doi.org\/10.1371\/journal.pone.0126537 (2015).","journal-title":"PLoS ONE"},{"key":"6454_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12860-019-0235-y","volume":"20","author":"AMA Al-Qarakhli","year":"2019","unstructured":"Al-Qarakhli, A. M. A., Yusop, N., Waddington, R. J. & Moseley, R. Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche. BMC Mol. Cell Biol. 20, 51. https:\/\/doi.org\/10.1186\/s12860-019-0235-y (2019).","journal-title":"BMC Mol. Cell Biol."},{"key":"6454_CR19","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3389\/fendo.2019.00607","volume":"10","author":"T Rharass","year":"2019","unstructured":"Rharass, T. & Lucas, S. High glucose level impairs human mature bone marrow adipocyte function through increased ROS production. Front. Endocrinol. (Lausanne) 10, 607. https:\/\/doi.org\/10.3389\/fendo.2019.00607 (2019).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"6454_CR20","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/imj.12044","volume":"43","author":"S Manochantr","year":"2013","unstructured":"Manochantr, S. et al. Immunosuppressive properties of mesenchymal stromal cells derived from amnion, placenta, Wharton\u2019s jelly and umbilical cord. Intern. Med. J. 43, 430\u2013439. https:\/\/doi.org\/10.1111\/imj.12044 (2013).","journal-title":"Intern. Med. J."},{"key":"6454_CR21","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1089\/scd.2007.0154","volume":"17","author":"S Barlow","year":"2008","unstructured":"Barlow, S. et al. Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells. Stem. Cells Dev. 17, 1095\u20131107. https:\/\/doi.org\/10.1089\/scd.2007.0154 (2008).","journal-title":"Stem. Cells Dev."},{"key":"6454_CR22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13287-019-1175-3","volume":"10","author":"S Thaweesapphithak","year":"2019","unstructured":"Thaweesapphithak, S. et al. Human serum enhances the proliferative capacity and immunomodulatory property of MSCs derived from human placenta and umbilical cord. Stem. Cell Res. Ther. 10, 79. https:\/\/doi.org\/10.1186\/s13287-019-1175-3 (2019).","journal-title":"Stem. Cell Res. Ther."},{"key":"6454_CR23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici, M. et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315\u2013317. https:\/\/doi.org\/10.1080\/14653240600855905 (2006).","journal-title":"Cytotherapy"},{"key":"6454_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40824-018-0115-0","volume":"22","author":"J Jeon","year":"2018","unstructured":"Jeon, J., Lee, M. S. & Yang, H. S. Differentiated osteoblasts derived decellularized extracellular matrix to promote osteogenic differentiation. Biomater. Res. 22, 4. https:\/\/doi.org\/10.1186\/s40824-018-0115-0 (2018).","journal-title":"Biomater. Res."},{"key":"6454_CR25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ab.2004.02.002","volume":"329","author":"CA Gregory","year":"2004","unstructured":"Gregory, C. A., Gunn, W. G., Peister, A. & Prockop, D. J. An Alizarin red-based assay of mineralization by adherent cells in culture: Comparison with cetylpyridinium chloride extraction. Anal. Biochem. 329, 77\u201384. https:\/\/doi.org\/10.1016\/j.ab.2004.02.002 (2004).","journal-title":"Anal. Biochem."},{"key":"6454_CR26","doi-asserted-by":"publisher","first-page":"5999","DOI":"10.1002\/fsn3.1885","volume":"8","author":"GD Kim","year":"2020","unstructured":"Kim, G. D. & Park, S. Effects of Cudrania tricuspidata on anti-senescence in high glucose-treated endothelial cells via the Akt\/p53\/p21 pathway. Food Sci. Nutr. 8, 5999\u20136006. https:\/\/doi.org\/10.1002\/fsn3.1885 (2020).","journal-title":"Food Sci. Nutr."},{"key":"6454_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274814","volume":"17","author":"KDR Ramarao","year":"2022","unstructured":"Ramarao, K. D. R. et al. Antiproliferative effects of dried Moringa oleifera leaf extract on human Wharton\u2019s Jelly mesenchymal stem cells. PLoS ONE 17, e0274814. https:\/\/doi.org\/10.1371\/journal.pone.0274814 (2022).","journal-title":"PLoS ONE"},{"key":"6454_CR28","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.3892\/etm.2017.5466","volume":"15","author":"X Zeng","year":"2017","unstructured":"Zeng, X. et al. TMEM16A regulates portal vein smooth muscle cell proliferation in portal hypertension. Exp. Therapeutic Med. 15, 1062\u20131068. https:\/\/doi.org\/10.3892\/etm.2017.5466 (2017).","journal-title":"Exp. Therapeutic Med."},{"key":"6454_CR29","doi-asserted-by":"publisher","first-page":"22974","DOI":"10.1038\/s41598-023-49751-5","volume":"13","author":"G Suwanmanee","year":"2023","unstructured":"Suwanmanee, G., Tantrawatpan, C., Kheolamai, P., Paraoan, L. & Manochantr, S. Fucoxanthin diminishes oxidative stress damage in human placenta-derived mesenchymal stem cells through the PI3K\/Akt\/Nrf-2 pathway. Sci. Rep. 13, 22974. https:\/\/doi.org\/10.1038\/s41598-023-49751-5 (2023).","journal-title":"Sci. Rep."},{"key":"6454_CR30","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1186\/s13287-019-1404-9","volume":"10","author":"N Liao","year":"2019","unstructured":"Liao, N. et al. Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion. Stem. Cell Res. Ther. 10, 306. https:\/\/doi.org\/10.1186\/s13287-019-1404-9 (2019).","journal-title":"Stem. Cell Res. Ther."},{"key":"6454_CR31","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.3390\/cells9051185","volume":"9","author":"V Vivcharenko","year":"2020","unstructured":"Vivcharenko, V., Wojcik, M. & Przekora, A. Cellular response to vitamin C-enriched chitosan\/agarose film with potential application as artificial skin substitute for chronic wound treatment. Cells 9, 1185. https:\/\/doi.org\/10.3390\/cells9051185 (2020).","journal-title":"Cells"},{"key":"6454_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.28","volume":"46","author":"SM Han","year":"2014","unstructured":"Han, S. M. et al. Enhanced proliferation and differentiation of Oct4- and Sox2-overexpressing human adipose tissue mesenchymal stem cells. Exp. Mol. Med. 46, e101. https:\/\/doi.org\/10.1038\/emm.2014.28 (2014).","journal-title":"Exp. Mol. Med."},{"key":"6454_CR33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.molcel.2012.06.020","volume":"47","author":"CC Tsai","year":"2012","unstructured":"Tsai, C. C., Su, P. F., Huang, Y. F., Yew, T. L. & Hung, S. C. Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells. Mol. Cell 47, 169\u2013182. https:\/\/doi.org\/10.1016\/j.molcel.2012.06.020 (2012).","journal-title":"Mol. Cell"},{"key":"6454_CR34","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.yexcr.2007.11.021","volume":"314","author":"MJ Go","year":"2008","unstructured":"Go, M. J., Takenaka, C. & Ohgushi, H. Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. Exp. Cell Res. 314, 1147\u20131154. https:\/\/doi.org\/10.1016\/j.yexcr.2007.11.021 (2008).","journal-title":"Exp. Cell Res."},{"key":"6454_CR35","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1365-2184.2011.00770.x","volume":"44","author":"DS Yoon","year":"2011","unstructured":"Yoon, D. S., Kim, Y. H., Jung, H. S., Paik, S. & Lee, J. W. Importance of Sox2 in maintenance of cell proliferation and multipotency of mesenchymal stem cells in low-density culture. Cell Prolif. 44, 428\u2013440. https:\/\/doi.org\/10.1111\/j.1365-2184.2011.00770.x (2011).","journal-title":"Cell Prolif."},{"key":"6454_CR36","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1101\/gad.179515.111","volume":"25","author":"T Shimi","year":"2011","unstructured":"Shimi, T. et al. The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev 25, 2579\u20132593. https:\/\/doi.org\/10.1101\/gad.179515.111 (2011).","journal-title":"Genes Dev"},{"key":"6454_CR37","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s13770-020-00239-7","volume":"17","author":"Y Basmaeil","year":"2020","unstructured":"Basmaeil, Y. et al. Preconditioning of human decidua basalis mesenchymal stem\/stromal cells with glucose increased their engraftment and anti-diabetic properties. Tissue Eng. Regen. Med. 17, 209\u2013222. https:\/\/doi.org\/10.1007\/s13770-020-00239-7 (2020).","journal-title":"Tissue Eng. Regen. Med."},{"key":"6454_CR38","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41420-024-01954-z","volume":"10","author":"D Ramini","year":"2024","unstructured":"Ramini, D. et al. Replicative senescence and high glucose induce the accrual of self-derived cytosolic nucleic acids in human endothelial cells. Cell Death Discovery 10, 184. https:\/\/doi.org\/10.1038\/s41420-024-01954-z (2024).","journal-title":"Cell Death Discovery"},{"key":"6454_CR39","doi-asserted-by":"publisher","first-page":"16107","DOI":"10.3390\/ijms232416107","volume":"23","author":"T Eleftheriadis","year":"2022","unstructured":"Eleftheriadis, T. et al. Dapagliflozin prevents high-glucose-induced cellular senescence in renal tubular epithelial cells. Int. J. Mol. Sci. 23, 16107. https:\/\/doi.org\/10.3390\/ijms232416107 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"6454_CR40","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1089\/scd.2014.0349","volume":"24","author":"J Kim","year":"2015","unstructured":"Kim, J. et al. Umbilical cord mesenchymal stromal cells affected by gestational diabetes mellitus display premature aging and mitochondrial dysfunction. Stem. Cells Dev. 24, 575\u2013586. https:\/\/doi.org\/10.1089\/scd.2014.0349 (2015).","journal-title":"Stem. Cells Dev."},{"key":"6454_CR41","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00774-015-0662-6","volume":"34","author":"B Zhang","year":"2016","unstructured":"Zhang, B. et al. High glucose microenvironments inhibit the proliferation and migration of bone mesenchymal stem cells by activating GSK3beta. J. Bone Miner. Metab. 34, 140\u2013150. https:\/\/doi.org\/10.1007\/s00774-015-0662-6 (2016).","journal-title":"J. Bone Miner. Metab."},{"key":"6454_CR42","doi-asserted-by":"publisher","first-page":"5332","DOI":"10.1038\/s44318-024-00245-8","volume":"43","author":"PS Turano","year":"2024","unstructured":"Turano, P. S. & Herbig, U. Cellular senescence, p21, and the path to fibrosis. EMBO J. 43, 5332\u20135334. https:\/\/doi.org\/10.1038\/s44318-024-00245-8 (2024).","journal-title":"EMBO J."},{"key":"6454_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.645593","volume":"9","author":"R Kumari","year":"2021","unstructured":"Kumari, R. & Jat, P. Mechanisms of cellular senescence: Cell cycle arrest and senescence associated secretory phenotype. Front. Cell Dev. Biol. 9, 645593. https:\/\/doi.org\/10.3389\/fcell.2021.645593 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"6454_CR44","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.3892\/mmr.2014.2053","volume":"9","author":"J Gong","year":"2014","unstructured":"Gong, J. et al. The SDF-1\/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis. Mol. Med. Rep. 9, 1575\u20131582. https:\/\/doi.org\/10.3892\/mmr.2014.2053 (2014).","journal-title":"Mol. Med. Rep."},{"key":"6454_CR45","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jneuroim.2008.04.008","volume":"198","author":"RJ Miller","year":"2008","unstructured":"Miller, R. J., Banisadr, G. & Bhattacharyya, B. J. CXCR4 signaling in the regulation of stem cell migration and development. J. Neuroimmunol. 198, 31\u201338. https:\/\/doi.org\/10.1016\/j.jneuroim.2008.04.008 (2008).","journal-title":"J. Neuroimmunol."},{"key":"6454_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054077","volume":"8","author":"X Liu","year":"2013","unstructured":"Liu, X. et al. SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS ONE 8, e54077. https:\/\/doi.org\/10.1371\/journal.pone.0054077 (2013).","journal-title":"PLoS ONE"},{"key":"6454_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090136","volume":"9","author":"T Takatani-Nakase","year":"2014","unstructured":"Takatani-Nakase, T., Matsui, C., Maeda, S., Kawahara, S. & Takahashi, K. High glucose level promotes migration behavior of breast cancer cells through zinc and its transporters. PLoS ONE 9, e90136. https:\/\/doi.org\/10.1371\/journal.pone.0090136 (2014).","journal-title":"PLoS ONE"},{"key":"6454_CR48","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/BF00400671","volume":"39","author":"N Suzuki","year":"1996","unstructured":"Suzuki, N., Svensson, K. & Eriksson, U. J. High glucose concentration inhibits migration of rat cranial neural crest cells in vitro. Diabetologia 39, 401\u2013411. https:\/\/doi.org\/10.1007\/BF00400671 (1996).","journal-title":"Diabetologia"},{"key":"6454_CR49","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.biopha.2016.09.058","volume":"84","author":"B Cao","year":"2016","unstructured":"Cao, B., Liu, N. & Wang, W. High glucose prevents osteogenic differentiation of mesenchymal stem cells via lncRNA AK028326\/CXCL13 pathway. Biomed. Pharmacother 84, 544\u2013551. https:\/\/doi.org\/10.1016\/j.biopha.2016.09.058 (2016).","journal-title":"Biomed. Pharmacother"},{"key":"6454_CR50","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1186\/s13287-022-03204-4","volume":"13","author":"A Ahmadi","year":"2022","unstructured":"Ahmadi, A. et al. Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways. Stem. Cell Res. Ther. 13, 518. https:\/\/doi.org\/10.1186\/s13287-022-03204-4 (2022).","journal-title":"Stem. Cell Res. Ther."},{"key":"6454_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104859","volume":"118","author":"C Kichenbrand","year":"2020","unstructured":"Kichenbrand, C., Grossin, L., Menu, P. & Moby, V. Behaviour of human dental pulp stem cell in high glucose condition: Impact on proliferation and osteogenic differentiation. Arch. Oral. Biol. 118, 104859. https:\/\/doi.org\/10.1016\/j.archoralbio.2020.104859 (2020).","journal-title":"Arch. Oral. Biol."},{"key":"6454_CR52","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e276","volume":"37","author":"SJ Oh","year":"2022","unstructured":"Oh, S. J. & Lee, M. S. Role of autophagy in the pathogenesis of diabetes and therapeutic potential of autophagy modulators in the treatment of diabetes and metabolic syndrome. J. Korean Med. Sci. 37, e276. https:\/\/doi.org\/10.3346\/jkms.2022.37.e276 (2022).","journal-title":"J. Korean Med. Sci."},{"key":"6454_CR53","doi-asserted-by":"publisher","first-page":"1397954","DOI":"10.3389\/fcell.2024.1397954","volume":"12","author":"H Su","year":"2024","unstructured":"Su, H., Wang, Z., Zhou, L., Liu, D. & Zhang, N. Regulation of the Nrf2\/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: Implications for disease treatment. Front. Cell Dev. Biol. 12, 1397954. https:\/\/doi.org\/10.3389\/fcell.2024.1397954 (2024).","journal-title":"Front. Cell Dev. Biol."},{"key":"6454_CR54","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.molmed.2024.05.012","volume":"30","author":"S O'Reilly","year":"2024","unstructured":"O\u2019Reilly, S., Tsou, P. S. & Varga, J. Senescence and tissue fibrosis: Opportunities for therapeutic targeting. Trends Mol. Med. 30, 1113\u20131125. https:\/\/doi.org\/10.1016\/j.molmed.2024.05.012 (2024).","journal-title":"Trends Mol. Med."},{"key":"6454_CR55","doi-asserted-by":"publisher","first-page":"9453108","DOI":"10.1155\/2017\/9453108","volume":"2017","author":"A Youssef","year":"2017","unstructured":"Youssef, A., Aboalola, D. & Han, V. K. The roles of insulin-like growth factors in mesenchymal stem cell niche. Stem. Cells Int. 2017, 9453108. https:\/\/doi.org\/10.1155\/2017\/9453108 (2017).","journal-title":"Stem. Cells Int."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-06454-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-06454-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-06454-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T11:02:15Z","timestamp":1751799735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-06454-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6454"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-06454-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"All experimental procedures were conducted following the Declaration of Helsinki and the Belmont Report. This study was approved by the Human Research Ethics Committee of Thammasat University (Medicine) [Approval title: Effects of high glucose condition on survival capability and osteogenic differentiation potential of human mesenchymal stem cells.] [Approval number: 289\/2021] (Date of approval: November 3, 2021). All samples were obtained from donors with their written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"22512"}}