{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:09:47Z","timestamp":1793740187235,"version":"4.6.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government","award":["No. 2021R1G1A1095262"],"award-info":[{"award-number":["No. 2021R1G1A1095262"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government","award":["No. 2021R1G1A1095262"],"award-info":[{"award-number":["No. 2021R1G1A1095262"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government","award":["No. 2021R1G1A1095262"],"award-info":[{"award-number":["No. 2021R1G1A1095262"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-06751-x","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T21:06:46Z","timestamp":1751404006000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of peptides derived from active sites of visfatin on wound healing"],"prefix":"10.1038","volume":"15","author":[{"given":"Bo Sun","family":"Joo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Hwa","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunseok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Myung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"6751_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15562\/gnc.61","volume":"4","author":"M Irfan-Maqsood","year":"2018","unstructured":"Irfan-Maqsood, M. Classification of wounds: know before research and clinical practice. Genes Cells. 4, 1\u20134 (2018).","journal-title":"Genes Cells"},{"key":"6751_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41038-017-0069-9","volume":"5","author":"M Rahimnejad","year":"2017","unstructured":"Rahimnejad, M., Derakhshanfar, S. & Zhongm, W. Biomaterials and tissue engineering for Scar management in wound care. Burns Trauma. 5, 1\u20139 (2017).","journal-title":"Burns Trauma."},{"key":"6751_CR3","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3390\/ebj3020028","volume":"3","author":"R Spiwak","year":"2022","unstructured":"Spiwak, R., Sareen, S. & Logsetty, S. Techniques to assess long-term outcomes after burn injuries. Eur. Burn J. 3, 328\u2013339 (2022).","journal-title":"Eur. Burn J."},{"key":"6751_CR4","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","volume":"91","author":"ACO Gonalez","year":"2016","unstructured":"Gonalez, A. C. O., Andrade, Z. A., Costa, T. F. & Medrado, A. R. A.P. Wound healing - A literature review. Bras. Dermatol. 91, 614\u2013620 (2016).","journal-title":"Bras. Dermatol."},{"key":"6751_CR5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1097\/01.ASW.0000725220.92976.a7","volume":"34","author":"S Fu","year":"2021","unstructured":"Fu, S. et al. Mechanotransduction in wound healing: from the cellular molecular levels to the clinic. Adv. Skin. Wound Care. 34, 67\u201374 (2021).","journal-title":"Adv. Skin. Wound Care"},{"key":"6751_CR6","doi-asserted-by":"crossref","unstructured":"Canedo-Dorantes, L. & Canedo-Ayala, M. Skin acute wound healing: acomprehensive review. Int. J.Inflam. 3706315 (2019).","DOI":"10.1155\/2019\/3706315"},{"key":"6751_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.trsl.2021.06.003","volume":"236","author":"AI Toma","year":"2021","unstructured":"Toma, A. I., Fuller, J. M., Willett, N. J. & Goudy, S. L. Oral wound healing models and emerging regenerative therapies. Transl Res. 236, 17\u201334 (2021).","journal-title":"Transl Res."},{"key":"6751_CR8","doi-asserted-by":"crossref","unstructured":"Hade, M. D., Suire, C. N. & Suo, Z. Mesenchymal stem cell-derived exosomes: applications in regenerative medicine. Cells 10, 1959 (2021).","DOI":"10.3390\/cells10081959"},{"key":"6751_CR9","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1021\/acsabm.2c00035","volume":"5","author":"G Kaur","year":"2022","unstructured":"Kaur, G., Narayanan, G., Garg, D., Sachdev, A. & Matai, I. Biomaterials-based regenerative strategies for skin tissue wound healing. ACS Appl. Bio Mater. 5, 2069\u20132106 (2022).","journal-title":"ACS Appl. Bio Mater."},{"key":"6751_CR10","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/03602532.2021.2025387","volume":"54","author":"I Safina","year":"2022","unstructured":"Safina, I., Childress, L. T., Myneni, S. R., Vang, K. B. & Biris, A. S. Cell-biomaterial constructs for wound healing and skin regeneration. Drug Metab. Rev. 54, 63\u201394 (2022).","journal-title":"Drug Metab. Rev."},{"key":"6751_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2174\/1574888X14666191104151928","volume":"15","author":"LVK Reddy","year":"2020","unstructured":"Reddy, L. V. K., Murugan, D., Mullick, M., Begum Moghal, E. T. & Sen, D. Recent approaches for angiogenesis in search of successful tissue engineering and regeneration. Curr. Stem Cell. Res. Ther. 15, 111\u2013134 (2020).","journal-title":"Curr. Stem Cell. Res. Ther."},{"key":"6751_CR12","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3892\/etm.2021.10254","volume":"22","author":"CC Lu","year":"2021","unstructured":"Lu, C. C. et al. Dracorhodin perchlorate enhances wound healing via \u03b2-catenin, ERK\/p38, and AKT signaling in human HaCaT keratinocytes. Exp. Ther. Med. 22, 822 (2021).","journal-title":"Exp. Ther. Med."},{"key":"6751_CR13","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jss.2008.04.023","volume":"153","author":"P Bao","year":"2009","unstructured":"Bao, P. et al. The role of vascular endothelial growth factor in wound healing. J. Surg. Res. 153, 347\u2013358 (2009).","journal-title":"J. Surg. Res."},{"key":"6751_CR14","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.3390\/ijms22105387","volume":"22","author":"THV Le","year":"2021","unstructured":"Le, T. H. V. & &Kwon, S. M. Vascular endothelial growth factor biology and its potential as a therapeutic target in rheumatic disease. Int. J. Mol. Sci. 22, 5387 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"6751_CR15","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/cvr\/cvm111","volume":"78","author":"R Adya","year":"2008","unstructured":"Adya, R., Tan, B. K., Punn, A., Chen, J. & &Randeva, H. S. .Visfatin induces human endothelial VEGF and MMP-2\/9 production via MAPK and PI3K\/Akt signaling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc. Res. 78, 356\u2013365 (2008).","journal-title":"Cardiovasc. Res."},{"key":"6751_CR16","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3892\/etm.2021.9820","volume":"21","author":"D Chen","year":"2021","unstructured":"Chen, D. et al. Visfatin promotes angiogenesis of RF\/6A cells through upregulation of VEGF\/VEGFR-2 under high-glucose conditions. Exp. Ther. Med. 21, 389 (2021).","journal-title":"Exp. Ther. Med."},{"key":"6751_CR17","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.3390\/ijms19113642","volume":"19","author":"BC Lee","year":"2018","unstructured":"Lee, B. C., Song, J., Lee, A., Cho, D. & Kim, T. S. Visfatin promotes wound healing through the activation of ERK1\/2 and JNK1\/2 pathway. Int. J. Mol. Sci. 19, 3642 (2018).","journal-title":"Int. J. Mol. Sci."},{"key":"6751_CR18","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.2147\/DDDT.S159767","volume":"12","author":"T Farhadi","year":"2018","unstructured":"Farhadi, T. & Hashemian, S. M. Computer-aided design of amino acid-based therapeutics: a review. Drug Des. Devel Ther. 12, 1239\u20131254 (2018).","journal-title":"Drug Des. Devel Ther."},{"key":"6751_CR19","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/j.drudis.2021.03.003","volume":"26","author":"AK Pandya","year":"2021","unstructured":"Pandya, A. K. & &Patravale, V. B. Computational avenues in oral protein and peptide therapeutics. Drug Discov Today. 26, 1510\u20131520 (2021).","journal-title":"Drug Discov Today"},{"key":"6751_CR20","doi-asserted-by":"publisher","first-page":"e0287577","DOI":"10.1371\/journal.pone.0287577","volume":"18","author":"JM Choi","year":"2023","unstructured":"Choi, J. M. et al. Computer simulation approach to the identification of visfatin-derived angiogenic peptides. Plus One. 18, e0287577 (2023).","journal-title":"Plus One"},{"key":"6751_CR21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1098\/rsif.2010.0223","volume":"8","author":"K Lee","year":"2011","unstructured":"Lee, K., Silva, E. A. & Mooney, D. J. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J. R Soc. Interface. 8, 153\u2013170 (2011).","journal-title":"J. R Soc. Interface"},{"key":"6751_CR22","doi-asserted-by":"publisher","first-page":"110468","DOI":"10.1016\/j.foodres.2021.110468","volume":"147","author":"K Sridhar","year":"2021","unstructured":"Sridhar, K., Inbaraj, B. S. & Chen, B. H. Recent developments on production, purification and biological activity of marine peptides. Food Res. Int. 147, 110468 (2021).","journal-title":"Food Res. Int."},{"key":"6751_CR23","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41573-020-00135-8","volume":"20","author":"M Muttenthaler","year":"2021","unstructured":"Muttenthaler, M., King, G. F., Adams, D. J. & Alewood, P. F. Trends in peptide drug discovery. Nat. Rev. Drug Discov. 20, 309\u2013325 (2021).","journal-title":"Nat. Rev. Drug Discov"},{"key":"6751_CR24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3390\/md21030169","volume":"21","author":"Y Sheng","year":"2023","unstructured":"Sheng, Y. et al. Eighteen novel bioactive peptides from Monkfish (Lophius litulon) swim bladders: production, identification, antioxidant activity, and stability. Mar. Drugs. 21, 169 (2023).","journal-title":"Mar. Drugs"},{"key":"6751_CR25","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1080\/17460441.2024.2365969","volume":"19","author":"L Otvos","year":"2024","unstructured":"Otvos, L. The latest trends in peptide drug discovery and future challenges. Expert Opin. Drug Discov. 19, 869\u2013872 (2024).","journal-title":"Expert Opin. Drug Discov"},{"key":"6751_CR26","doi-asserted-by":"crossref","unstructured":"Gomes, A., Teixeira, C., Ferraz, R. & Prudencio, C. & Gomes. P. Wound-healing peptides for treatment of chronic diabetic foot ulcers and other infected skin injuries. Molecules 22, 1743 (2017).","DOI":"10.3390\/molecules22101743"},{"key":"6751_CR27","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.3389\/fimmu.2019.02421","volume":"10","author":"X He","year":"2019","unstructured":"He, X. et al. A frog-derived Immunomodulatory peptide promotes cutaneous wound healing by regulating cellular response. Front. Immunol. 10, 2421 (2019).","journal-title":"Front. Immunol."},{"key":"6751_CR28","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.1080\/14786419.2019.1710702","volume":"35","author":"S Wang","year":"2021","unstructured":"Wang, S. et al. A novel peptide from the skin of amphibian Ranalimnocharis with potency to promote skin wound repair. Nat. Prod. Res. 35, 3514\u20133518 (2021).","journal-title":"Nat. Prod. Res."},{"key":"6751_CR29","doi-asserted-by":"crossref","unstructured":"Fu, S. et al. A novel peptide from Polypedatesmegacephalus promotes wound healing in mice. Toxins14, 753 (2022).","DOI":"10.3390\/toxins14110753"},{"key":"6751_CR30","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/sj.jid.5700786","volume":"127","author":"S Werner","year":"2007","unstructured":"Werner, S., Krieg, T. & Smola, H. Keratinocyte-fibroblast interactions in wound healing. J. Invest. Dermatol. 127, 998\u20131008 (2007).","journal-title":"J. Invest. Dermatol."},{"key":"6751_CR31","doi-asserted-by":"publisher","first-page":"8790","DOI":"10.3390\/ijms21228790","volume":"21","author":"M Piipponen","year":"2020","unstructured":"Piipponen, M., Li, D. & Land\u00e9n, N. X. The immune functions of keratinocytes in skin wound healing. Int. J. Mol. Sci. 21, 8790 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"6751_CR32","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2174\/0929866526666190124144027","volume":"26","author":"M Liu","year":"2019","unstructured":"Liu, M. et al. Accelerated wound healing induced by a novel amphibian peptide (OA-FF10). Protein Pept. Lett. 26, 261\u2013270 (2019).","journal-title":"Protein Pept. Lett."},{"key":"6751_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2020.566607","volume":"11","author":"P Henrot","year":"2020","unstructured":"Henrot, P. et al. A method for isolating and culturing skin cells: application to endothelial cells, fibroblasts, keratinocytes, and melanocytes from punch biopsies in systemic sclerosis skin. Front. Immunol. 11, 1\u201312 (2020).","journal-title":"Front. Immunol."},{"key":"6751_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.xpro.2022.101172","volume":"3","author":"DM Supp","year":"2022","unstructured":"Supp, D. M. et al. Isolation and feeder-free primary culture of four cell types from a single human skin sample. STAR. Protocols. 3, 1\u201333 (2022).","journal-title":"STAR. Protocols"},{"key":"6751_CR35","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1600-0625.2008.00775.x","volume":"18","author":"L Micallef","year":"2008","unstructured":"Micallef, L. et al. Effects of extracellular calcium on the growth-differentiation switch in immortalized keratinocyte HaCaT cells compared with normal human keratinocytes. Exp. Dermat. 18, 143\u2013151 (2008).","journal-title":"Exp. Dermat."},{"key":"6751_CR36","doi-asserted-by":"crossref","unstructured":"Colombo, I. et al. HaCaTcells as a reliable in vitro differentiation model to dissect the inflammatory\/repair responses of human keratinocytes.Mediat. Inflamm. 1\u201312 (2017).","DOI":"10.1155\/2017\/7435621"},{"key":"6751_CR37","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1042\/BCJ20180286","volume":"475","author":"J Wu","year":"2018","unstructured":"Wu, J. et al. A frog Cathelicidin peptide effectively promotes cutaneous wound healing in mice. Biochem. J. 475, 2785\u20132799 (2018).","journal-title":"Biochem. J."},{"key":"6751_CR38","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/s41598-018-19486-9","volume":"8","author":"X Cao","year":"2018","unstructured":"Cao, X. et al. Cathelicidin-OA1, a novel antioxidant peptide identified from an amphibian, accelerates skin wound healing. Sci. Rep. 8, 943 (2018).","journal-title":"Sci. Rep."},{"key":"6751_CR39","doi-asserted-by":"publisher","first-page":"324","DOI":"10.5115\/acb.19.009","volume":"52","author":"SR Kotian","year":"2019","unstructured":"Kotian, S. R. et al. Influence of traditional medicines on the activity of keratinocytes in wound healing: an in vitro study. Anat. Cell. Biol. 52, 324\u2013332 (2019).","journal-title":"Anat. Cell. Biol."},{"key":"6751_CR40","doi-asserted-by":"publisher","first-page":"173649","DOI":"10.1016\/j.ejphar.2020.173649","volume":"890","author":"S Cai","year":"2021","unstructured":"Cai, S. et al. Derivatives of gecko cathelicidin-related antioxidant peptide facilitate skin wound healing. Eur. J. Pharm. 890, 173649 (2021).","journal-title":"Eur. J. Pharm."},{"key":"6751_CR41","doi-asserted-by":"publisher","first-page":"1030851","DOI":"10.3389\/fphys.2022.1030851","volume":"13","author":"O Krizanova","year":"2022","unstructured":"Krizanova, O. et al. Signaling pathways in cutaneous wound healing. Front. Physiol. 13, 1030851 (2022).","journal-title":"Front. Physiol."},{"key":"6751_CR42","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s12964-024-01623-9","volume":"22","author":"DB Gumede","year":"2024","unstructured":"Gumede, D. B., Abrahamse, H. & &Houreld, N. N. Targeting Wnt\/\u03b2-catenin signaling and its interplay with TGF-\u03b2 and Notch signaling pathways for the treatment of chronic wounds. Cell. Commun. Signal. 22, 244 (2024).","journal-title":"Cell. Commun. Signal."},{"key":"6751_CR43","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1097\/PRS.0000000000002682","volume":"138","author":"LE Lindley","year":"2016","unstructured":"Lindley, L. E., Stojadinovic, O. & Pastar, I. Tomic\u2013Canic, M. Biology and biomarkers for wound healing. Plast. Reconstr. Surg. 138, S18\u2013S28 (2016).","journal-title":"Plast. Reconstr. Surg."},{"key":"6751_CR44","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1089\/wound.2020.1284","volume":"11","author":"S Choi","year":"2022","unstructured":"Choi, S., Yoon, M. & Choi, K. Y. Approaches for regenerative healing of cutaneous wound with an emphasis on strategies activating the Wnt\/\u03b2-Catenin pathway. Adv. Wound Care. 11, 70\u201386 (2022).","journal-title":"Adv. Wound Care"},{"key":"6751_CR45","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/jid.2009.209","volume":"130","author":"T Thuraisingam","year":"2010","unstructured":"Thuraisingam, T. et al. MAPKAPK-2 signaling is critical for cutaneous wound healing. J. Invest. Dermatol. 130, 278\u2013286 (2010).","journal-title":"J. Invest. Dermatol."},{"key":"6751_CR46","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.3390\/molecules23112819","volume":"23","author":"F Pereira Beserra","year":"2018","unstructured":"Pereira Beserra, F. et al. Lupeol, a pentacyclic triterpene, promotes migration, wound closure, and contractile effect in vitro: Pssible involvement of PI3K\/Akt and p38\/ERK\/MAPK Pthways. Molecules 23, 2819 (2018).","journal-title":"Molecules"},{"key":"6751_CR47","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.taap.2013.03.007","volume":"269","author":"JG Chung","year":"2013","unstructured":"Chung, J. G. Newly synthesized Quinazolinone HMJ\u201338 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53\u2013modulated fas\/death receptor signaling. Toxicol. Appl. Pharmacol. 269, 150\u2013162 (2013).","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"6751_CR48","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.3892\/mmr.2016.5442","volume":"14","author":"F Li","year":"2016","unstructured":"Li, F., Jiang, T., Liu, W., Hu, Q. & Yin, H. The angiogenic effect of Dracorhodin perchlorate on human umbilical vein endothelial cells and its potential mechanism of action. Mol. Med. Rep. 14, 1667\u20131672 (2016).","journal-title":"Mol. Med. Rep."},{"key":"6751_CR49","doi-asserted-by":"crossref","unstructured":"Lu, Y. et al. Autocrine and Paracrine Effects of vascular endothelial cells promote cutaneous wound healing. Biomed. Res. Int. 6695663 (2021).","DOI":"10.1155\/2021\/6695663"},{"key":"6751_CR50","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/ijms21020407","volume":"21","author":"F Cialdai","year":"2020","unstructured":"Cialdai, F., Colciago, A., Pantalone, D., Rizzo, A. M. & &Zava, S. Effect ofunloading condition on the healing process and effectiveness ofplatelet rich plasma as a countermeasure: study on in vivo and invitro wound healing models. Int. J. Mol. Sci. 21, 407 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"6751_CR51","doi-asserted-by":"publisher","first-page":"236","DOI":"10.55730\/1300-0152.2659","volume":"47","author":"MN Sarian","year":"2023","unstructured":"Sarian, M. N., Zulkefli, N., Zain, C. & Maniam, M. S. Fakurazi. S. A review with updated perspectives on in vitro and in vivo wound healing models. Turk. J. Biol. 47, 236\u2013246 (2023).","journal-title":"Turk. J. Biol."},{"key":"6751_CR52","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1515\/bnm-2016-0002","volume":"17","author":"A Stamm","year":"2016","unstructured":"Stamm, A. et al. In vitro wound healing assays\u2013state of the Art. BioNanoMat 17, 79\u201387 (2016).","journal-title":"BioNanoMat"},{"key":"6751_CR53","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1016\/j.jid.2016.11.020","volume":"137","author":"A Grada","year":"2017","unstructured":"Grada, A., Otero-Vinas, M., Prieto-Castrillo, F. & Obagi, Z. &Falanga v.research techniques made simple: analysis of collective cell migration using the wound healing assay. J. Invest. Dermatol. 137, e11\u2013e16 (2017).","journal-title":"J. Invest. Dermatol."},{"key":"6751_CR54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.phymed.2017.02.005","volume":"28","author":"HM Wahedi","year":"2017","unstructured":"Wahedi, H. M. et al. Aloesin from Aloe vera accelerated skin wound healing by modulating mapk\/rho and Smad signaling pathways in vitro and in vivo. Phytomedicine 28, 19\u201326 (2017).","journal-title":"Phytomedicine"},{"key":"6751_CR55","doi-asserted-by":"crossref","unstructured":"Jian, K. et al. PDGF-BB-derived supramolecular hydrogel for promoting skin wound healing. Nanobiotechnology20, 201 (2022).","DOI":"10.1186\/s12951-022-01390-0"},{"key":"6751_CR56","doi-asserted-by":"crossref","unstructured":"Ahmad N.In vitro and in vivo characterization methodsfor evaluation of modern wound dressings.Pharmaceutics15, 42 (2022).","DOI":"10.3390\/pharmaceutics15010042"},{"key":"6751_CR57","doi-asserted-by":"publisher","first-page":"313","DOI":"10.2119\/molmed.2014.00191","volume":"21","author":"MC Madigan","year":"2015","unstructured":"Madigan, M. C. et al. Xanthine oxidoreductase function contributes to normal wound healing. Mol. Med. 21, 313\u2013322 (2015).","journal-title":"Mol. Med."},{"key":"6751_CR58","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/iep.12346","volume":"101","author":"DS Masson-Meyers","year":"2020","unstructured":"Masson-Meyers, D. S. et al. Experimental models and methods for cutaneous wound healing assessment. Int. J. Exp. Pathol. 101, 21\u201337 (2020).","journal-title":"Int. J. Exp. Pathol."},{"key":"6751_CR59","doi-asserted-by":"publisher","first-page":"712781","DOI":"10.3389\/fimmu.2021.712781","volume":"12","author":"M Takahashi","year":"2021","unstructured":"Takahashi, M. et al. The antimicrobial peptide human \u03b2-Defensin-3 accelerates wound healing by promoting angiogenesis, cell migration, and proliferation through the FGFR\/JAK2\/STAT3 signaling pathway. Front. Immunol. 12, 712781 (2021).","journal-title":"Front. Immunol."},{"key":"6751_CR60","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/71527","volume":"6","author":"J Li","year":"2000","unstructured":"Li, J. et al. PR39, a peptide regulator of angiogenesis. Nat. Med. 6, 49\u201355 (2000).","journal-title":"Nat. Med."},{"key":"6751_CR61","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1042\/bj3540233","volume":"354","author":"AW Griffioen","year":"2001","unstructured":"Griffioen, A. W. et al. Anginex, a designed peptide that inhibits angiogenesis. Biochem. J. 354, 233\u2013242 (2001).","journal-title":"Biochem. J."},{"key":"6751_CR62","doi-asserted-by":"crossref","unstructured":"Khanna, D., Khanna, S., Khanna, P., Kahar, P. & Patel, B. M. Obesity: A Chronic Low-Grade Inflammation and Its Markers. Cureus 14, e2271 (2022).","DOI":"10.7759\/cureus.22711"},{"key":"6751_CR63","doi-asserted-by":"publisher","first-page":"10840","DOI":"10.12998\/wjcc.v10.i30.10840","volume":"10","author":"MMI Abdalla","year":"2023","unstructured":"Abdalla, M. M. I. Role of visfatin in obesity-induced insulin resistance. World J. Clin. Cases. 10, 10840\u201310851 (2023).","journal-title":"World J. Clin. Cases"},{"key":"6751_CR64","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3389\/fbioe.2019.00469","volume":"7","author":"X Ren","year":"2020","unstructured":"Ren, X., Zhao, M., Lash, B., Martino, M. M. & Julier, Z. Growth factor engineering strategies for regenerative medicine applications. Front. Bioeng. Biotechnol. 7, 469 (2020).","journal-title":"Front. Bioeng. Biotechnol."},{"key":"6751_CR65","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.dsx.2012.08.011","volume":"6","author":"J Stastny","year":"2012","unstructured":"Stastny, J. et al. Visfatin and its role in obesity development. Diabetes Metabolic Syndrome: Clin. Res. Rei. 6, 120\u2013124 (2012).","journal-title":"Diabetes Metabolic Syndrome: Clin. Res. Rei"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-06751-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-06751-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-06751-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T22:02:40Z","timestamp":1751407360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-06751-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6751"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-06751-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"24 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22169"}}