{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:33:23Z","timestamp":1794047603645,"version":"4.8.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Changzhi Medical College 1+1 Research Collaboration Project","award":["HZZD202403"],"award-info":[{"award-number":["HZZD202403"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-07168-2","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:52:16Z","timestamp":1751431936000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between hepatitis A B vaccination and hearing loss across frequencies based on NHANES"],"prefix":"10.1038","volume":"15","author":[{"given":"Rong-Jing","family":"Qie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Bo","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Hao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"7168_CR1","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"GBD Disease","year":"2018","unstructured":"Disease, G. B. D., Injury, I. & Prevalence, C. Global, regional, and National incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the global burden of disease study 2017. Lancet 392, 1789\u20131858. https:\/\/doi.org\/10.1016\/S0140-6736(18)32279-7 (2018).","journal-title":"Lancet"},{"key":"7168_CR2","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s00127-017-1397-6","volume":"52","author":"J Dammeyer","year":"2017","unstructured":"Dammeyer, J. & Chapman, M. Prevalence and characteristics of self-reported physical and mental disorders among adults with hearing loss in denmark: A National survey. Soc. Psychiatry Psychiatr Epidemiol. 52, 807\u2013813. https:\/\/doi.org\/10.1007\/s00127-017-1397-6 (2017).","journal-title":"Soc. Psychiatry Psychiatr Epidemiol."},{"key":"7168_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.otc.2018.11.002","volume":"52","author":"S Lerner","year":"2019","unstructured":"Lerner, S. Limitations of conventional hearing aids: Examining common complaints and issues that can and cannot be remedied. Otolaryngol. Clin. North. Am. 52, 211\u2013220. https:\/\/doi.org\/10.1016\/j.otc.2018.11.002 (2019).","journal-title":"Otolaryngol. Clin. North. Am."},{"key":"7168_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-211977","author":"S Okhovat","year":"2015","unstructured":"Okhovat, S., Fox, R., Magill, J. & Narula, A. Sudden onset unilateral sensorineural hearing loss after rabies vaccination. BMJ Case Rep. https:\/\/doi.org\/10.1136\/bcr-2015-211977 (2015).","journal-title":"BMJ Case Rep."},{"key":"7168_CR5","doi-asserted-by":"publisher","first-page":"126525","DOI":"10.1016\/j.vaccine.2024.126525","volume":"43","author":"NS Reed","year":"2025","unstructured":"Reed, N. S. et al. Report of a SPEAC webinar 22 September 2023: Sensorineural hearing loss, Lassa virus disease and vaccines. Vaccine 43, 126525. https:\/\/doi.org\/10.1016\/j.vaccine.2024.126525 (2025).","journal-title":"Vaccine"},{"key":"7168_CR6","doi-asserted-by":"publisher","first-page":"100384","DOI":"10.1016\/j.xocr.2021.100384","volume":"21","author":"D Pisani","year":"2021","unstructured":"Pisani, D. et al. Sudden sensorineural hearing loss after covid-19 vaccine; A possible adverse reaction? Otolaryngol. Case Rep. 21, 100384. https:\/\/doi.org\/10.1016\/j.xocr.2021.100384 (2021).","journal-title":"Otolaryngol. Case Rep."},{"key":"7168_CR7","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1080\/09273948.2018.1483520","volume":"27","author":"AB Sood","year":"2019","unstructured":"Sood, A. B., O\u2019Keefe, G., Bui, D. & Jain, N. Vogt-Koyanagi-Harada disease associated with hepatitis B vaccination. Ocul Immunol. Inflamm. 27, 524\u2013527. https:\/\/doi.org\/10.1080\/09273948.2018.1483520 (2019).","journal-title":"Ocul Immunol. Inflamm."},{"key":"7168_CR8","first-page":"359","volume":"113","author":"P Bonfils","year":"1996","unstructured":"Bonfils, P., Biacabe, B., Potard, G. & Aidan, D. [Fluctuant perception hearing loss after hepatitis B vaccine]. Ann. Otolaryngol. Chir. Cervicofac. 113, 359\u2013361 (1996).","journal-title":"Ann. Otolaryngol. Chir. Cervicofac."},{"key":"7168_CR9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/s0385-8146(97)10013-x","volume":"24","author":"B Biacabe","year":"1997","unstructured":"Biacabe, B., Erminy, M. & Bonfils, P. A case report of fluctuant sensorineural hearing loss after hepatitis B vaccination. Auris Nasus Larynx. 24, 357\u2013360. https:\/\/doi.org\/10.1016\/s0385-8146(97)10013-x (1997).","journal-title":"Auris Nasus Larynx"},{"key":"7168_CR10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1749-6632.1997.tb51903.x","volume":"830","author":"MP Orlando","year":"1997","unstructured":"Orlando, M. P., Masieri, S., Pascarella, M. A., Ciofalo, A. & Filiaci, F. Sudden hearing loss in childhood consequent to hepatitis B vaccination: A case report. Ann. N Y Acad. Sci. 830, 319\u2013321. https:\/\/doi.org\/10.1111\/j.1749-6632.1997.tb51903.x (1997).","journal-title":"Ann. N Y Acad. Sci."},{"key":"7168_CR11","doi-asserted-by":"publisher","first-page":"1458484","DOI":"10.3389\/fnut.2024.1458484","volume":"11","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. Inflammatory diet, gut microbiota and sensorineural hearing loss: A cross-sectional and Mendelian randomization study. Front. Nutr. 11, 1458484. https:\/\/doi.org\/10.3389\/fnut.2024.1458484 (2024).","journal-title":"Front. Nutr."},{"key":"7168_CR12","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.2147\/JMDH.S454678","volume":"17","author":"JY Pan","year":"2024","unstructured":"Pan, J. Y. et al. Association between Triglyceride-Glucose index and hearing threshold shifts of adults in the United States: National health and nutrition examination survey, 2015\u20132016. J. Multidiscip Healthc. 17, 1791\u20131801. https:\/\/doi.org\/10.2147\/JMDH.S454678 (2024).","journal-title":"J. Multidiscip Healthc."},{"key":"7168_CR13","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41598-024-84341-z","volume":"15","author":"Y Wang","year":"2025","unstructured":"Wang, Y., Yang, H. & Huang, C. Association of serum lycopene with low-frequency hearing loss in adults in their 70s based on NHANES database. Sci. Rep. 15, 600. https:\/\/doi.org\/10.1038\/s41598-024-84341-z (2025).","journal-title":"Sci. Rep."},{"key":"7168_CR14","doi-asserted-by":"publisher","first-page":"242","DOI":"10.2471\/BLT.21.285643","volume":"99","author":"S Chadha","year":"2021","unstructured":"Chadha, S., Kamenov, K. & Cieza, A. The world report on hearing, 2021. Bull. World Health Organ. 99, 242\u2013242A. https:\/\/doi.org\/10.2471\/BLT.21.285643 (2021).","journal-title":"Bull. World Health Organ."},{"key":"7168_CR15","doi-asserted-by":"publisher","first-page":"1390953","DOI":"10.3389\/fnut.2024.1390953","volume":"11","author":"F Chen","year":"2024","unstructured":"Chen, F. et al. Association of serum 25-hydroxyvitamins D(2) and D(3) with hearing loss in US adults: Analysis from National health and nutrition examination survey, 2015\u20132016. Front. Nutr. 11, 1390953. https:\/\/doi.org\/10.3389\/fnut.2024.1390953 (2024).","journal-title":"Front. Nutr."},{"key":"7168_CR16","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1186\/s12889-023-17204-3","volume":"23","author":"L Long","year":"2023","unstructured":"Long, L. & Tang, Y. Association between sleep duration and hearing threshold shifts of adults in the United States: National health and nutrition examination survey, 2015\u20132016. BMC Public. Health. 23, 2305. https:\/\/doi.org\/10.1186\/s12889-023-17204-3 (2023).","journal-title":"BMC Public. Health"},{"key":"7168_CR17","first-page":"1","volume":"2","author":"CL Johnson","year":"2013","unstructured":"Johnson, C. L. et al. National health and nutrition examination survey: Analytic guidelines, 1999\u20132010. Vital Health Stat. 2, 1\u201324 (2013).","journal-title":"Vital Health Stat."},{"key":"7168_CR18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1542\/peds.2007-1088","volume":"120","author":"American Academy of Pediatrics Committee on Infectious","year":"2007","unstructured":"American Academy of Pediatrics Committee on Infectious. Hepatitis A vaccine recommendations. Pediatrics 120, 189\u2013199. https:\/\/doi.org\/10.1542\/peds.2007-1088 (2007).","journal-title":"Pediatrics"},{"key":"7168_CR19","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1002\/jmv.25197","volume":"90","author":"E Mosites","year":"2018","unstructured":"Mosites, E. et al. Hepatitis A vaccine immune response 22 years after vaccination. J. Med. Virol. 90, 1418\u20131422. https:\/\/doi.org\/10.1002\/jmv.25197 (2018).","journal-title":"J. Med. Virol."},{"key":"7168_CR20","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1002\/jmv.26327","volume":"93","author":"M Ramaswamy","year":"2021","unstructured":"Ramaswamy, M. et al. Hepatitis A vaccine immunogenicity 25 years after vaccination in Alaska. J. Med. Virol. 93, 3991\u20133994. https:\/\/doi.org\/10.1002\/jmv.26327 (2021).","journal-title":"J. Med. Virol."},{"key":"7168_CR21","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.gtc.2020.01.002","volume":"49","author":"A Abutaleb","year":"2020","unstructured":"Abutaleb, A., Kottilil, S. & Hepatitis, A. Epidemiology, natural history, unusual clinical manifestations, and prevention. Gastroenterol. Clin. North. Am. 49, 191\u2013199. https:\/\/doi.org\/10.1016\/j.gtc.2020.01.002 (2020).","journal-title":"Gastroenterol. Clin. North. Am."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07168-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07168-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07168-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:52:18Z","timestamp":1751431938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07168-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7168"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-07168-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"22 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study employed demographic and health data from NHANES. The NHANES program adheres to the Declaration of Helsinki and has been fully approved by the Research Ethics Review Board at the U.S. National Center for Health Statistics (NCHS). Prior to their involvement, all eligible participants gave informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"23360"}}