{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:10:12Z","timestamp":1786482612982,"version":"build-2736575974"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-07183-3","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T18:40:42Z","timestamp":1751395242000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between adherence to Mediterranean-DASH intervention for neurodegenerative delay diet and disease severity in patients with ulcerative colitis"],"prefix":"10.1038","volume":"15","author":[{"given":"Zeinab","family":"Nikniaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Mahdavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Bakhtiari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Maddahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Masnadi Shirazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"10","key":"7183_CR1","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1001\/jama.2023.15389","volume":"330","author":"B Gros","year":"2023","unstructured":"Gros, B. & Kaplan, G. G. Ulcerative colitis in adults: A review. Jama 330 (10), 951\u2013965 (2023).","journal-title":"Jama"},{"issue":"33","key":"7183_CR2","doi-asserted-by":"publisher","first-page":"6137","DOI":"10.3748\/wjg.v23.i33.6137","volume":"23","author":"ML Halling","year":"2017","unstructured":"Halling, M. L., Kjeldsen, J., Knudsen, T., Nielsen, J. & Hansen, L. K. Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases. World J. Gastroenterol. 23 (33), 6137\u20136146 (2017).","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"7183_CR3","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/01.MIB.0000160809.38611.f7","volume":"11","author":"KH Janke","year":"2005","unstructured":"Janke, K. H., Klump, B., Gregor, M., Meisner, C. & Haeuser, W. Determinants of life satisfaction in inflammatory bowel disease. Inflamm. Bowel Dis. 11 (3), 272\u2013286 (2005).","journal-title":"Inflamm. Bowel Dis."},{"issue":"7","key":"7183_CR4","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.dld.2021.03.002","volume":"53","author":"A Armuzzi","year":"2021","unstructured":"Armuzzi, A. & Liguori, G. Quality of life in patients with moderate to severe ulcerative colitis and the impact of treatment: A narrative review. Dig. Liver Disease. 53 (7), 803\u2013808 (2021).","journal-title":"Dig. Liver Disease"},{"issue":"9","key":"7183_CR5","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/ajg.2015.233","volume":"110","author":"L Peyrin-Biroulet","year":"2015","unstructured":"Peyrin-Biroulet, L. et al. Selecting therapeutic targets in inflammatory bowel disease (STRIDE): determining therapeutic goals for treat-to-target. Official J. Am. Coll. Gastroenterology| ACG. 110 (9), 1324\u20131338 (2015).","journal-title":"Official J. Am. Coll. Gastroenterology| ACG"},{"issue":"1","key":"7183_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/ecco-jcc\/jjab178","volume":"16","author":"T Raine","year":"2022","unstructured":"Raine, T. et al. ECCO guidelines on therapeutics in ulcerative colitis: medical treatment. J. Crohn\u2019s Colitis. 16 (1), 2\u201317 (2022).","journal-title":"J. Crohn\u2019s Colitis"},{"issue":"2","key":"7183_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.fshw.2021.02.016","volume":"10","author":"W Zeng","year":"2021","unstructured":"Zeng, W. et al. Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review. Food Sci. Hum. Wellness. 10 (2), 119\u2013130 (2021).","journal-title":"Food Sci. Hum. Wellness"},{"issue":"4","key":"7183_CR8","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.cgh.2019.07.022","volume":"18","author":"GR Lichtenstein","year":"2020","unstructured":"Lichtenstein, G. R. et al. Lifetime economic burden of crohn\u2019s disease and ulcerative colitis by age at diagnosis. Clin. Gastroenterol. Hepatol. 18 (4), 889\u2013897 (2020). e810.","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"7183_CR9","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/ajg.2011.44","volume":"106","author":"JK Hou","year":"2011","unstructured":"Hou, J. K., Abraham, B. & El-Serag, H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Official J. Am. Coll. Gastroenterology| ACG. 106 (4), 563\u2013573 (2011).","journal-title":"Official J. Am. Coll. Gastroenterology| ACG"},{"issue":"10","key":"7183_CR10","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1111\/apt.12501","volume":"38","author":"C Spooren","year":"2013","unstructured":"Spooren, C. et al. The association of diet with onset and relapse in patients with inflammatory bowel disease. Aliment. Pharmacol. Ther. 38 (10), 1172\u20131187 (2013).","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"6","key":"7183_CR11","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1093\/advances\/nmab069","volume":"12","author":"Z Tian","year":"2021","unstructured":"Tian, Z. et al. Index-based dietary patterns and inflammatory bowel disease: a systematic review of observational studies. Adv. Nutr. 12 (6), 2288\u20132300 (2021).","journal-title":"Adv. Nutr."},{"issue":"3","key":"7183_CR12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1258\/acb.2010.010093","volume":"48","author":"Z Faghfoori","year":"2011","unstructured":"Faghfoori, Z. et al. Effects of an oral supplementation of germinated barley foodstuff on serum tumour necrosis factor-\u03b1, interleukin-6 and-8 in patients with ulcerative colitis. Ann. Clin. Biochem. 48 (3), 233\u2013237 (2011).","journal-title":"Ann. Clin. Biochem."},{"issue":"1","key":"7183_CR13","first-page":"116","volume":"4","author":"Z Faghfoori","year":"2014","unstructured":"Faghfoori, Z. et al. Effects of an oral supplementation of germinated barley foodstuff on serum CRP level and clinical signs in patients with ulcerative colitis. Health Promotion Perspect. 4 (1), 116 (2014).","journal-title":"Health Promotion Perspect."},{"issue":"2","key":"7183_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5152\/tjg.2020.181028","volume":"31","author":"A Sharifi","year":"2020","unstructured":"Sharifi, A. et al. Vitamin D decreases CD40L gene expression in ulcerative colitis patients: A randomized, double-blinded, placebo-controlled trial. Turkish J. Gastroenterol. 31 (2), 99 (2020).","journal-title":"Turkish J. Gastroenterol."},{"key":"7183_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ctim.2018.09.026","volume":"41","author":"KM Shirazi","year":"2018","unstructured":"Shirazi, K. M., Nikniaz, Z., Shirazi, A. M. & Rohani, M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement. Ther. Med. 41, 215\u2013219 (2018).","journal-title":"Complement. Ther. Med."},{"issue":"4","key":"7183_CR16","doi-asserted-by":"publisher","first-page":"101532","DOI":"10.1016\/j.clinre.2020.08.010","volume":"45","author":"KM Shirazi","year":"2021","unstructured":"Shirazi, K. M. et al. Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: A randomized, double-blind controlled clinical trial. Clin. Res. Hepatol. Gastroenterol. 45 (4), 101532 (2021).","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"7183_CR17","doi-asserted-by":"publisher","first-page":"112502","DOI":"10.1016\/j.nut.2024.112502","volume":"126","author":"Z Bakhtiari","year":"2024","unstructured":"Bakhtiari, Z., Mahdavi, R., Masnadi Shirazi, K. & Nikniaz, Z. Association not found between dietary fermentable oligosaccharides, disaccharides, monosaccharides, and polyols score and disease severity in patients with ulcerative colitis. Nutrition 126, 112502 (2024).","journal-title":"Nutrition"},{"key":"7183_CR18","doi-asserted-by":"crossref","unstructured":"Chiba, M. et al. Relapse prevention by plant-based diet incorporated into induction therapy for ulcerative colitis: a single-group trial. The Permanente Journal 23, 18-220 (2019).","DOI":"10.7812\/TPP\/18-220"},{"key":"7183_CR19","doi-asserted-by":"crossref","unstructured":"Phase, Q. High remission rate with Infliximab and plant-based diet as first-line (IPF) therapy for severe ulcerative colitis: single-group trial. The Permanente Journal 24, 1-10 (2020).","DOI":"10.7812\/TPP\/19.166"},{"key":"7183_CR20","doi-asserted-by":"crossref","unstructured":"Vrdoljak, J. et al. Mediterranean diet adherence and dietary attitudes in patients with inflammatory bowel disease. Nutrients 12, 1-14 (2020).","DOI":"10.3390\/nu12113429"},{"issue":"9","key":"7183_CR21","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jalz.2014.11.009","volume":"11","author":"MC Morris","year":"2015","unstructured":"Morris, M. C. et al. MIND diet associated with reduced incidence of alzheimer\u2019s disease. Alzheimer\u2019s Dement. 11 (9), 1007\u20131014 (2015).","journal-title":"Alzheimer\u2019s Dement."},{"issue":"9753","key":"7183_CR22","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","volume":"376","author":"C Baigent","year":"2010","unstructured":"Baigent, C. et al. Efficacy and safety of more intensive Lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomized trials. Lancet 376 (9753), 1670\u20131681 (2010).","journal-title":"Lancet"},{"issue":"2","key":"7183_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.tifs.2011.11.005","volume":"25","author":"I Bj\u00f6rck","year":"2012","unstructured":"Bj\u00f6rck, I. et al. Cereal grains for nutrition and health benefits: overview of results from in vitro, animal and human studies in the HEALTHGRAIN project. Trends Food Sci. Technol. 25 (2), 87\u2013100 (2012).","journal-title":"Trends Food Sci. Technol."},{"issue":"2","key":"7183_CR24","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jcs.2008.01.002","volume":"48","author":"A Fardet","year":"2008","unstructured":"Fardet, A., Rock, E. & R\u00e9m\u00e9sy, C. Is the in vitro antioxidant potential of whole-grain cereals and cereal products well reflected in vivo? J. Cereal Sci. 48 (2), 258\u2013276 (2008).","journal-title":"J. Cereal Sci."},{"issue":"20","key":"7183_CR25","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1161\/CIRCULATIONAHA.109.907360","volume":"121","author":"M He","year":"2010","unstructured":"He, M., van Dam, R. M., Rimm, E., Hu, F. B. & Qi, L. Whole-grain, cereal fiber, bran, and germ intake and the risks of all-cause and cardiovascular disease\u2013specific mortality among women with type 2 diabetes mellitus. Circulation 121 (20), 2162\u20132168 (2010).","journal-title":"Circulation"},{"key":"7183_CR26","doi-asserted-by":"crossref","unstructured":"Pateiro, M. et al. Bioactive compounds from leaf vegetables as preservatives. Foods 12, 1-20 (2023).","DOI":"10.3390\/foods12030637"},{"key":"7183_CR27","doi-asserted-by":"publisher","first-page":"100521","DOI":"10.1016\/j.crfs.2023.100521","volume":"6","author":"PE Jamieson","year":"2023","unstructured":"Jamieson, P. E., Carbonero, F. & Stevens, J. F. Dietary (poly)phenols mitigate inflammatory bowel disease: therapeutic targets, mechanisms of action, and clinical observations. Curr. Res. Food Sci. 6, 100521 (2023).","journal-title":"Curr. Res. Food Sci."},{"key":"7183_CR28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ctim.2018.09.026","volume":"41","author":"K Masnadi Shirazi","year":"2018","unstructured":"Masnadi Shirazi, K., Nikniaz, Z., Masnadi Shirazi, A. & Rohani, M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement. Ther. Med. 41, 215\u2013219 (2018).","journal-title":"Complement. Ther. Med."},{"key":"7183_CR29","doi-asserted-by":"publisher","first-page":"866059","DOI":"10.3389\/fimmu.2022.866059","volume":"13","author":"PA Gill","year":"2022","unstructured":"Gill, P. A., Inniss, S., Kumagai, T., Rahman, F. Z. & Smith, A. M. The role of diet and gut microbiota in regulating Gastrointestinal and inflammatory disease. Front. Immunol. 13, 866059 (2022).","journal-title":"Front. Immunol."},{"issue":"12 Suppl","key":"7183_CR30","doi-asserted-by":"publisher","first-page":"3479s","DOI":"10.1093\/jn\/134.12.3479S","volume":"134","author":"RH Liu","year":"2004","unstructured":"Liu, R. H. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J. Nutr. 134 (12 Suppl), 3479s\u20133485s (2004).","journal-title":"J. Nutr."},{"issue":"10","key":"7183_CR31","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1136\/gut.2003.024828","volume":"53","author":"SL Jowett","year":"2004","unstructured":"Jowett, S. L. et al. Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study. Gut 53 (10), 1479\u20131484 (2004).","journal-title":"Gut"},{"issue":"5","key":"7183_CR32","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1017\/S1368980009991698","volume":"13","author":"P Mirmiran","year":"2010","unstructured":"Mirmiran, P., Esfahani, F. H., Mehrabi, Y., Hedayati, M. & Azizi, F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public. Health Nutr. 13 (5), 654\u2013662 (2010).","journal-title":"Public. Health Nutr."},{"issue":"5","key":"7183_CR33","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/dar.13093","volume":"39","author":"M Chegeni","year":"2020","unstructured":"Chegeni, M. et al. Alcohol consumption in iran: A systematic review and meta-analysis of the literature. Drug Alcohol Rev. 39 (5), 525\u2013538 (2020).","journal-title":"Drug Alcohol Rev."},{"issue":"1","key":"7183_CR34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12902-023-01284-8","volume":"23","author":"AM Ardekani","year":"2023","unstructured":"Ardekani, A. M. et al. Evaluating the association between the Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet, mental health, and cardio-metabolic risk factors among individuals with obesity. BMC Endocr. Disord. 23 (1), 29 (2023).","journal-title":"BMC Endocr. Disord"},{"issue":"2","key":"7183_CR35","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3748\/wjg.v16.i2.232","volume":"16","author":"LS Roth","year":"2010","unstructured":"Roth, L. S., Chande, N., Ponich, T., Roth, M. L. & Gregor, J. Predictors of disease severity in ulcerative colitis patients from Southwestern Ontario. World J. Gastroenterology: WJG. 16 (2), 232 (2010).","journal-title":"World J. Gastroenterology: WJG"},{"issue":"3","key":"7183_CR36","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.alcohol.2009.10.019","volume":"44","author":"GR Swanson","year":"2010","unstructured":"Swanson, G. R., Sedghi, S., Farhadi, A. & Keshavarzian, A. Pattern of alcohol consumption and its effect on Gastrointestinal symptoms in inflammatory bowel disease. Alcohol 44 (3), 223\u2013228 (2010).","journal-title":"Alcohol"},{"issue":"12","key":"7183_CR37","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1097\/MEG.0000000000000728","volume":"28","author":"RE Rossi","year":"2016","unstructured":"Rossi, R. E. et al. The role of dietary supplements in inflammatory bowel disease: a systematic review. Eur. J. Gastroenterol. Hepatol. 28 (12), 1357\u20131364 (2016).","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"29","key":"7183_CR38","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.3748\/wjg.v18.i29.3814","volume":"18","author":"E Cabr\u00e9","year":"2012","unstructured":"Cabr\u00e9, E. & Dom\u00e8nech, E. Impact of environmental and dietary factors on the course of inflammatory bowel disease. World J. Gastroenterology: WJG. 18 (29), 3814 (2012).","journal-title":"World J. Gastroenterology: WJG"},{"key":"7183_CR39","doi-asserted-by":"crossref","unstructured":"Ye, S. et al. Greater adherence to the mediterranean dietary approaches to stop hypertension intervention for neurodegenerative delay (MIND) diet is associated with lower risk of inflammatory bowel disease: a prospective cohort study. Food Funct 15, 7631-7340 (2024).","DOI":"10.1039\/D4FO00641K"},{"issue":"2","key":"7183_CR40","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1159\/000517015","volume":"40","author":"S Nouri-Majd","year":"2022","unstructured":"Nouri-Majd, S., Salari-Moghaddam, A., Keshteli, A. H., Esmaillzadeh, A. & Adibi, P. The association between adherence to the MIND diet and irritable bowel syndrome. Dig. Dis. 40 (2), 198\u2013205 (2022).","journal-title":"Dig. Dis."},{"issue":"4","key":"7183_CR41","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3390\/gidisord4040021","volume":"4","author":"M Chiba","year":"2022","unstructured":"Chiba, M., Komatsu, M., Hosoba, M., Hatano, K. & Takeda, M. Onset of ulcerative colitis in a patient with type 2 diabetes: efficacy of a Plant-Based diet for both diseases. Gastrointest. Disorders. 4 (4), 223\u2013229 (2022).","journal-title":"Gastrointest. Disorders"},{"issue":"7","key":"7183_CR42","doi-asserted-by":"publisher","first-page":"714","DOI":"10.5152\/tjg.2023.22193","volume":"34","author":"K \u00c7elik","year":"2023","unstructured":"\u00c7elik, K., G\u00fcveli, H., Erzin, Y., Kenge, E. B. & \u00d6zl\u00fc, T. The effect of adherence to mediterranean diet on disease activity in patients with inflammatory bowel disease. Turk. J. Gastroenterol. 34 (7), 714\u2013719 (2023).","journal-title":"Turk. J. Gastroenterol."},{"issue":"9","key":"7183_CR43","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.jalz.2015.04.011","volume":"11","author":"MC Morris","year":"2015","unstructured":"Morris, M. C. et al. MIND diet slows cognitive decline with aging. Alzheimer\u2019s Dement. 11 (9), 1015\u20131022 (2015).","journal-title":"Alzheimer\u2019s Dement."},{"key":"7183_CR44","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00394-015-0852-y","volume":"54","author":"A Duda-Chodak","year":"2015","unstructured":"Duda-Chodak, A., Tarko, T., Satora, P. & Sroka, P. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. Eur. J. Nutr. 54, 325\u2013341 (2015).","journal-title":"Eur. J. Nutr."},{"key":"7183_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-021-01115-9","volume":"9","author":"Z Wu","year":"2021","unstructured":"Wu, Z. et al. Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis. Microbiome 9, 1\u201322 (2021).","journal-title":"Microbiome"},{"issue":"2","key":"7183_CR46","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1093\/advances\/nmaa104","volume":"12","author":"Y Zhao","year":"2021","unstructured":"Zhao, Y. & Jiang, Q. Roles of the polyphenol\u2013gut microbiota interaction in alleviating colitis and preventing colitis-associated colorectal cancer. Adv. Nutr. 12 (2), 546\u2013565 (2021).","journal-title":"Adv. Nutr."},{"issue":"10","key":"7183_CR47","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/s41419-023-06190-4","volume":"14","author":"D Han","year":"2023","unstructured":"Han, D. et al. Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation. Cell Death Dis. 14 (10), 656 (2023).","journal-title":"Cell Death Dis."},{"issue":"2","key":"7183_CR48","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1572-0241.1999.872_a.x","volume":"94","author":"F Fernandez-Banares","year":"1999","unstructured":"Fernandez-Banares, F. et al. Randomized clinical trial OfPlantago ovataseeds (Dietary Fiber) as compared with Mesalamine in maintaining remission in ulcerative colitis. Official J. Am. Coll. Gastroenterology| ACG. 94 (2), 427\u2013433 (1999).","journal-title":"Official J. Am. Coll. Gastroenterology| ACG"},{"issue":"3","key":"7183_CR49","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1097\/01.MIB.0000437984.92565.31","volume":"20","author":"L Wedlake","year":"2014","unstructured":"Wedlake, L., Slack, N., Andreyev, H. J. N. & Whelan, K. Fiber in the treatment and maintenance of inflammatory bowel disease: a systematic review of randomized controlled trials. Inflamm. Bowel Dis. 20 (3), 576\u2013586 (2014).","journal-title":"Inflamm. Bowel Dis."},{"key":"7183_CR50","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1007\/s10620-019-05648-w","volume":"64","author":"M Zhao","year":"2019","unstructured":"Zhao, M. & Burisch, J. Impact of genes and the environment on the pathogenesis and disease course of inflammatory bowel disease. Dig. Dis. Sci. 64, 1759\u20131769 (2019).","journal-title":"Dig. Dis. Sci."},{"issue":"5","key":"7183_CR51","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/ajg.2016.53","volume":"111","author":"TA Kabbani","year":"2016","unstructured":"Kabbani, T. A. et al. Association of vitamin D level with clinical status in inflammatory bowel disease: a 5-year longitudinal study. Official J. Am. Coll. Gastroenterology| ACG. 111 (5), 712\u2013719 (2016).","journal-title":"Official J. Am. Coll. Gastroenterology| ACG"},{"issue":"2","key":"7183_CR52","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3390\/nu13020323","volume":"13","author":"M Valvano","year":"2021","unstructured":"Valvano, M. et al. The usefulness of serum vitamin D levels in the assessment of IBD activity and response to biologics. Nutrients 13 (2), 323 (2021).","journal-title":"Nutrients"},{"issue":"5","key":"7183_CR53","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1097\/MIB.0000000000000333","volume":"21","author":"PD Jones","year":"2015","unstructured":"Jones, P. D. et al. Exercise decreases risk of future active disease in patients with inflammatory bowel disease in remission. Inflamm. Bowel Dis. 21 (5), 1063\u20131071 (2015).","journal-title":"Inflamm. Bowel Dis."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07183-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07183-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07183-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T20:04:37Z","timestamp":1751400277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07183-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7183"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-07183-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"27 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All participants provided informed written consent. The ethics committee of Tabriz University of Medical Sciences approved the study protocol (Ethics code: IR.TBZMED.REC.1401.694).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"21810"}}