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The interplay between the p63 isoform (\u0394Np63), microRNA-141-3p (miR-141-3p), and Yes-associated protein 1 (YAP1) has emerged as a potential area of interest in cancer progression. This study aimed to investigate the functional relationship between the between the p63 isoform (\u0394Np63), miR-141-3p and YAP1 in modulating migration, invasion, and epithelial\u2013mesenchymal transition (EMT) in two CC cell lines, CaSki, and HeLa, which are human cervical squamous cell carcinoma (SCC) and adenocarcinoma (ADC) cells, respectively. The Gene Expression Omnibus (GEO) datasets, were utilized to assess the expression profiles of TP63 and YAP1 in the cervical SCC and ADC samples by using the GEO2R tool. The prediction software (miRDIP, miRmap, and TargetScan), and RT-qPCR were used to determine the relationship between genes. Different assays were performed for proliferative, migratory and invasive abilities of cells. The results were confirmed by western blot analysis. The \u0394Np63-miR-141-3p-YAP1 axis exhibited distinct, cell-line-specific functions. In HeLa cells, this axis promoted a prometastatic phenotype by upregulating YAP1, leading to increased proliferation, migration, invasion, and EMT. Conversely, in CaSki cells, the same axis demonstrated an antimetastatic function by downregulating YAP1. YAP1 expression was significantly higher in HeLa cells compared to CaSki cells. In HeLa cells, YAP1 expression appeared to be regulated not solely by the upstream \u0394Np63-miR-141-3p axis, suggesting its role as a key oncogene in HeLa cell progression. MiR-141-3p demonstrated context-dependent effects, exhibiting both pro- and anti-metastatic activities depending on the specific cell line. These findings highlight the complex and subtype-specific functions of the \u0394Np63-miR-141-3p-YAP1 regulatory network in cervical cancer progression. In summary, our data highlights the different functions of \u0394Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration and invasion as well as EMT of different cervical cancer cells.<\/jats:p>","DOI":"10.1038\/s41598-025-07237-6","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T03:08:59Z","timestamp":1751425739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual functions of the \u0394Np63-miR-141-3p-YAP1 regulatory axis in cervical cancer progression are dependent on histological subtype"],"prefix":"10.1038","volume":"15","author":[{"given":"Somayeh","family":"Panahi-Moghadam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Sadeghizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirin","family":"Farivar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faezeh","family":"Vakhshiteh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"issue":"1","key":"7237_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel, RL, Miller, KD & Jemal, A. 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