{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:30:06Z","timestamp":1793133006925,"version":"4.5.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17lk0310031h0001"],"award-info":[{"award-number":["17lk0310031h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-07385-9","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:42:03Z","timestamp":1751384523000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A prospective, randomized, double-blind, placebo-controlled trial of the Kampo formula daiobotanpito combined with antibiotic therapy for acute diverticulitis"],"prefix":"10.1038","volume":"15","author":[{"given":"Keiko","family":"Ogawa-Ochiai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetsugu","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuki","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatomo","family":"Ikehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Dohmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Ojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goro","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hisabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Suenaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kagaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Ishigure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Okochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyotaka","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Takehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Munemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Esaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nishijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seisho","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Honyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Doyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihisa","family":"Uchita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kodera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"7385_CR1","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1053\/j.gastro.2015.10.003","volume":"149","author":"N Stollman","year":"2015","unstructured":"Stollman, N., Smalley, W., Hirano, I. & AGA Institute Clinical Guidelines Committee. American gastroenterological association Institute guideline on the management of acute diverticulitis. Gastroenterology 149, 1944\u20131949 (2015).","journal-title":"Gastroenterology"},{"key":"7385_CR2","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1053\/j.gastro.2020.09.059","volume":"160","author":"AF Peery","year":"2021","unstructured":"Peery, A. F., Shaukat, A. & Strate, L. L. AGA clinical practice update on medical management of colonic diverticulitis: expert review. Gastroenterology 160, 906\u2013911 (2021). e1.","journal-title":"Gastroenterology"},{"issue":"Suppl 1","key":"7385_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000495282","volume":"99","author":"N Nagata","year":"2019","unstructured":"Nagata, N. et al. Guidelines for colonic diverticular bleeding and colonic diverticulitis: Japan gastroenterological association. Digestion 99 (Suppl 1), 1\u201326 (2019).","journal-title":"Digestion"},{"key":"7385_CR4","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.2169\/internalmedicine.9361-22","volume":"61","author":"K Soma","year":"2022","unstructured":"Soma, K. et al. Efficacy and safety of a strategy for reviewing intravenous antibiotics for hospitalized Japanese patients with uncomplicated diverticulitis: a single-center observational study. Intern. Med. 61, 3475\u20133482 (2022).","journal-title":"Intern. Med."},{"key":"7385_CR5","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s00384-021-03899-6","volume":"36","author":"H Fowler","year":"2021","unstructured":"Fowler, H. et al. Failure of nonoperative management in patients with acute diverticulitis complicated by abscess: a systematic review. Int. J. Colorectal Dis. 36, 1367\u20131383 (2021).","journal-title":"Int. J. Colorectal Dis."},{"key":"7385_CR6","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s00384-017-2872-y","volume":"32","author":"HE Bolkenstein","year":"2017","unstructured":"Bolkenstein, H. E. et al. Risk factors for complicated diverticulitis: systematic review and meta-analysis. Int. J. Colorectal Dis. 32, 1375\u20131383 (2017).","journal-title":"Int. J. Colorectal Dis."},{"key":"7385_CR7","unstructured":"Scheid, V. et al. Chinese Herbal Medicine: Formulas and Strategies 2nd edn 685\u2013772 (Eastland, 2009)."},{"key":"7385_CR8","doi-asserted-by":"publisher","first-page":"19355","DOI":"10.3390\/ijms151119355","volume":"15","author":"M Xiao","year":"2014","unstructured":"Xiao, M. et al. Emodin ameliorates LPS-induced acute lung injury, involving the inactivation of NF-\u03baB in mice. Int. J. Mol. Sci. 15, 19355\u201319368 (2014).","journal-title":"Int. J. Mol. Sci."},{"key":"7385_CR9","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.phymed.2012.07.013","volume":"19","author":"PK Fu","year":"2012","unstructured":"Fu, P. K. et al. Moutan cortex radicis improves lipopolysaccharide-induced acute lung injury in rats through anti-inflammation. Phytomedicine 19, 1206\u20131215 (2012).","journal-title":"Phytomedicine"},{"key":"7385_CR10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0378-8741(02)00285-4","volume":"84","author":"GS Oh","year":"2003","unstructured":"Oh, G. S. et al. Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells. J. Ethnopharmacol. 84, 85\u201389 (2003).","journal-title":"J. Ethnopharmacol."},{"key":"7385_CR11","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1248\/bpb.30.912","volume":"30","author":"HS Chung","year":"2007","unstructured":"Chung, H. S. et al. Inhibition of nitric oxide and tumor necrosis factor-alpha by Moutan cortex in activated mouse peritoneal macrophages. Biol. Pharm. Bull. 30, 912\u2013916 (2007).","journal-title":"Biol. Pharm. Bull."},{"key":"7385_CR12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/tkm2.1358","volume":"10","author":"T Utsunomiya","year":"2023","unstructured":"Utsunomiya, T. et al. Acute appendicitis with fecaliths requiring surgery in a patient with COVID-19 successfully treated with Daiobotanpito and antibiotics. Trad Kampo Med. 10, 72\u201374 (2023).","journal-title":"Trad Kampo Med."},{"key":"7385_CR13","doi-asserted-by":"crossref","unstructured":"Ogawa, K. et al. Effectiveness of traditional Japanese herbal (kampo) medicine, daiobotanpito, in combination with antibiotic therapy in the treatment of acute diverticulitis: a preliminary study. Evid Based Complement Alternat Med. ; 2013:305414. (2013).","DOI":"10.1155\/2013\/305414"},{"key":"7385_CR14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1186\/s13063-020-04370-7","volume":"21","author":"K Ogawa-Ochiai","year":"2020","unstructured":"Ogawa-Ochiai, K. et al. Study protocol for Daiobotanpito combined with antibiotic therapy for treatment of acute diverticulitis: a study protocol for a randomized controlled trial. Trials 21, 531 (2020).","journal-title":"Trials"},{"key":"7385_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1749-7922-10-3","volume":"10","author":"M Sartelli","year":"2015","unstructured":"Sartelli, M. et al. A proposal for a CT driven classification of left colon acute diverticulitis. World J. Emerg. Surg. 10, 3 (2015).","journal-title":"World J. Emerg. Surg."},{"key":"7385_CR16","first-page":"326","volume":"96","author":"C Camilla","year":"2024","unstructured":"Camilla, C. et al. What are the differences between the three most used classifications for acute colonic diverticulitis? A comparative multicenter study. J. Trauma. Acute Care Surg. 96, 326\u2013331 (2024).","journal-title":"J. Trauma. Acute Care Surg."},{"key":"7385_CR17","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/BF02234169","volume":"42","author":"S Schechter","year":"1999","unstructured":"Schechter, S., Mulvey, J. & Eisenstat, T. E. Management of uncomplicated acute diverticulitis: results of a survey. Dis. Colon Rectum. 42, 470\u2013476 (1999).","journal-title":"Dis. Colon Rectum"},{"key":"7385_CR18","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1248\/bpb.21.360","volume":"21","author":"DH Kim","year":"1998","unstructured":"Kim, D. H. et al. Metabolism of Kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites. Biol. Pharm. Bull. 21, 360\u2013365 (1998).","journal-title":"Biol. Pharm. Bull."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07385-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07385-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07385-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:42:05Z","timestamp":1751384525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07385-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7385"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-07385-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"13 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"KO (Keiko Ogawa-Ochiai)\u00a0reports grants from Tsumura Co., Ltd.\u00a0outside the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21069"}}