{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:51:08Z","timestamp":1793317868442,"version":"4.5.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"crossref","award":["22-25-00459"],"award-info":[{"award-number":["22-25-00459"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-07709-9","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T17:41:33Z","timestamp":1751391693000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary high-dose irradiation of the recipient and associated damage of bone marrow stromal compartment enables bone marrow stroma transplantation"],"prefix":"10.1038","volume":"15","author":[{"given":"Aleksei","family":"Bigildeev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Bigildeev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Bulygina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Tsygankova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariia","family":"Gusakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Illarionova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"22","key":"7709_CR1","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.1158\/0008-5472.CAN-16-1311","volume":"76","author":"AK Singh","year":"2016","unstructured":"Singh, A. K. & McGuirk, J. P. Allogeneic stem cell transplantation: A historical and scientific overview. Cancer Res. 76 (22), 6445\u20136451 (2016).","journal-title":"Cancer Res."},{"key":"7709_CR2","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3389\/fonc.2018.00587","volume":"8","author":"M Medinger","year":"2018","unstructured":"Medinger, M., Drexler, B., Lengerke, C. & Passweg, J. Pathogenesis of acquired aplastic Anemia and the role of the bone marrow microenvironment. Front. Oncol. 8, 587 (2018).","journal-title":"Front. Oncol."},{"issue":"6","key":"7709_CR3","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41409-024-02248-9","volume":"59","author":"JR Passweg","year":"2024","unstructured":"Passweg, J. R. et al. Hematopoietic cell transplantation and cellular therapies in Europe 2022. CAR-T activity continues to grow; transplant activity has slowed: a report from the EBMT. Bone Marrow Transplant. 59 (6), 803\u2013812 (2024).","journal-title":"Bone Marrow Transplant."},{"issue":"10","key":"7709_CR4","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.bbmt.2016.06.024","volume":"22","author":"L De Felice","year":"2016","unstructured":"De Felice, L. et al. Hematopoietic, mesenchymal, and immune cells are more enhanced in bone marrow than in peripheral blood from granulocyte Colony-Stimulating factor primed healthy donors. Biol. Blood Marrow Transplant. 22 (10), 1758\u20131764 (2016).","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"9","key":"7709_CR5","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/bmt.2015.80","volume":"50","author":"U Deotare","year":"2015","unstructured":"Deotare, U., Al-Dawsari, G., Couban, S. & Lipton, J. H. G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept. Bone Marrow Transplant. 50 (9), 1150\u20131156 (2015).","journal-title":"Bone Marrow Transplant."},{"issue":"10","key":"7709_CR6","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1016\/j.bbmt.2019.06.009","volume":"25","author":"Q Li","year":"2019","unstructured":"Li, Q. et al. G-CSF-Mobilized blood and bone marrow grafts as the source of stem cells for HLA-Identical sibling transplantation in patients with thalassemia major. Biology Blood Marrow Transplantation: J. Am. Soc. Blood Marrow Transplantation. 25 (10), 2040\u20132044 (2019).","journal-title":"Biology Blood Marrow Transplantation: J. Am. Soc. Blood Marrow Transplantation"},{"key":"7709_CR7","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.3389\/fimmu.2019.02516","volume":"10","author":"YJ Chang","year":"2019","unstructured":"Chang, Y. J., Zhao, X. Y. & Huang, X. J. Granulocyte Colony-Stimulating Factor-Primed unmanipulated haploidentical blood and marrow transplantation. Front. Immunol. 10, 2516 (2019).","journal-title":"Front. Immunol."},{"issue":"1","key":"7709_CR8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/s12916-023-03059-3","volume":"21","author":"J Epah","year":"2023","unstructured":"Epah, J. et al. Small volume bone marrow aspirates with high progenitor cell concentrations maximize cell therapy dose manufacture and substantially reduce donor hemoglobin loss. BMC Med. 21 (1), 360 (2023).","journal-title":"BMC Med."},{"key":"7709_CR9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.exphem.2018.09.004","volume":"68","author":"SB Hay","year":"2018","unstructured":"Hay, S. B., Ferchen, K., Chetal, K., Grimes, H. L. & Salomonis, N. The human cell atlas bone marrow single-cell interactive web portal. Exp. Hematol. 68, 51\u201361 (2018).","journal-title":"Exp. Hematol."},{"issue":"12","key":"7709_CR10","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.bbmt.2010.02.002","volume":"16","author":"S Fruehauf","year":"2010","unstructured":"Fruehauf, S. & Tricot, G. Comparison of unmobilized and mobilized graft characteristics and the implications of cell subsets on autologous and allogeneic transplantation outcomes. Biology Blood Marrow Transplantation: J. Am. Soc. Blood Marrow Transplantation. 16 (12), 1629\u20131648 (2010).","journal-title":"Biology Blood Marrow Transplantation: J. Am. Soc. Blood Marrow Transplantation"},{"issue":"5","key":"7709_CR11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.exphem.2005.02.004","volume":"33","author":"K Rieger","year":"2005","unstructured":"Rieger, K. et al. Mesenchymal stem cells remain of host origin even a long time after allogeneic peripheral blood stem cell or bone marrow transplantation. Exp. Hematol. 33 (5), 605\u2013611 (2005).","journal-title":"Exp. Hematol."},{"issue":"12","key":"7709_CR12","first-page":"1421","volume":"89","author":"EM Villaron","year":"2004","unstructured":"Villaron, E. M. et al. Mesenchymal stem cells are present in peripheral blood and can engraft after allogeneic hematopoietic stem cell transplantation. Haematologica 89 (12), 1421\u20131427 (2004).","journal-title":"Haematologica"},{"issue":"10","key":"7709_CR13","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3109\/14653249.2012.729817","volume":"14","author":"CS Lin","year":"2012","unstructured":"Lin, C. S., Ning, H., Lin, G. & Lue, T. F. Is CD34 truly a negative marker for mesenchymal stromal cells? Cytotherapy 14 (10), 1159\u20131163 (2012).","journal-title":"Cytotherapy"},{"issue":"6","key":"7709_CR14","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1002\/stem.1661","volume":"32","author":"LE Sidney","year":"2014","unstructured":"Sidney, L. E., Branch, M. J., Dunphy, S. E., Dua, H. S. & Hopkinson, A. Concise review: evidence for CD34 as a common marker for diverse progenitors. Stem Cells. 32 (6), 1380\u20131389 (2014).","journal-title":"Stem Cells"},{"issue":"26","key":"7709_CR15","doi-asserted-by":"publisher","first-page":"5401","DOI":"10.1182\/blood-2009-11-253559","volume":"115","author":"Y Shono","year":"2010","unstructured":"Shono, Y. et al. Bone marrow graft-versus-host disease: early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation. Blood 115 (26), 5401\u20135411 (2010).","journal-title":"Blood"},{"issue":"10","key":"7709_CR16","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.bbmt.2013.07.014","volume":"19","author":"Y Kong","year":"2013","unstructured":"Kong, Y. et al. Association of an impaired bone marrow microenvironment with secondary poor graft function after allogeneic hematopoietic stem cell transplantation. Biology Blood Marrow Transplantation: J. Am. Soc. Blood Marrow Transplantation. 19 (10), 1465\u20131473 (2013).","journal-title":"Biology Blood Marrow Transplantation: J. Am. Soc. Blood Marrow Transplantation"},{"issue":"2","key":"7709_CR17","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/bmt.2015.229","volume":"51","author":"Y Kong","year":"2016","unstructured":"Kong, Y. et al. The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function. Bone Marrow Transplant. 51 (2), 249\u2013255 (2016).","journal-title":"Bone Marrow Transplant."},{"issue":"8","key":"7709_CR18","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1080\/10428194.2018.1554861","volume":"60","author":"IN Shipounova","year":"2019","unstructured":"Shipounova, I. N. et al. Alterations in multipotent mesenchymal stromal cells from the bone marrow of acute myeloid leukemia patients at diagnosis and during treatment. Leuk. Lymphoma. 60 (8), 2042\u20132049 (2019).","journal-title":"Leuk. Lymphoma"},{"issue":"2","key":"7709_CR19","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1080\/10428194.2016.1187277","volume":"58","author":"IN Shipounova","year":"2017","unstructured":"Shipounova, I. N. et al. Alterations of the bone marrow stromal microenvironment in adult patients with acute myeloid and lymphoblastic leukemias before and after allogeneic hematopoietic stem cell transplantation. Leuk. Lymphoma. 58 (2), 408\u2013417 (2017).","journal-title":"Leuk. Lymphoma"},{"issue":"1","key":"7709_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12929-018-0407-7","volume":"25","author":"C Somaiah","year":"2018","unstructured":"Somaiah, C. et al. Mesenchymal stem cells show functional defect and decreased anti-cancer effect after exposure to chemotherapeutic drugs. J. Biomed. Sci. 25 (1), 5 (2018).","journal-title":"J. Biomed. Sci."},{"issue":"2","key":"7709_CR21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s12079-017-0412-8","volume":"12","author":"A Kumar","year":"2017","unstructured":"Kumar, A., Anand, T., Bhattacharyya, J., Sharma, A. & Jaganathan, B. G. K562 chronic myeloid leukemia cells modify osteogenic differentiation and gene expression of bone marrow stromal cells. J. Cell. Communication Signal. 12 (2), 441\u2013450 (2017).","journal-title":"J. Cell. Communication Signal."},{"key":"7709_CR22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fimmu.2017.00106","volume":"8","author":"AK Brenner","year":"2017","unstructured":"Brenner, A. K., Nepstad, I. & Bruserud, \u00d8. Mesenchymal stem cells support survival and proliferation of primary human acute myeloid leukemia cells through heterogeneous molecular mechanisms. Front. Immunol. 8, 106 (2017).","journal-title":"Front. Immunol."},{"issue":"11","key":"7709_CR23","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1158\/0008-5472.CAN-14-3379","volume":"75","author":"JA Kim","year":"2015","unstructured":"Kim, J. A. et al. Microenvironmental remodeling as a parameter and prognostic factor of heterogeneous leukemogenesis in acute myelogenous leukemia. Cancer Res. 75 (11), 2222\u20132231 (2015).","journal-title":"Cancer Res."},{"issue":"1","key":"7709_CR24","doi-asserted-by":"publisher","first-page":"9535","DOI":"10.1038\/s41598-017-10373-3","volume":"7","author":"A Kumar","year":"2017","unstructured":"Kumar, A., Bhattacharyya, J. & Jaganathan, B. G. Adhesion to stromal cells mediates Imatinib resistance in chronic myeloid leukemia through ERK and BMP signaling pathways. Sci. Rep. 7 (1), 9535 (2017).","journal-title":"Sci. Rep."},{"issue":"9","key":"7709_CR25","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1038\/s41417-024-00785-5","volume":"31","author":"LH Mochmann","year":"2024","unstructured":"Mochmann, L. H. et al. Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia. Cancer Gene Ther. 31 (9), 1344\u20131356 (2024).","journal-title":"Cancer Gene Ther."},{"issue":"4","key":"7709_CR26","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/MOH.0000000000000508","volume":"26","author":"IH Oh","year":"2019","unstructured":"Oh, I. H., Jeong, S. Y. & Kim, J. A. Normal and leukemic stem cell niche interactions. Curr. Opin. Hematol. 26 (4), 249\u2013257 (2019).","journal-title":"Curr. Opin. Hematol."},{"issue":"7456","key":"7709_CR27","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/nature12323","volume":"499","author":"L Orlando","year":"2013","unstructured":"Orlando, L. et al. Recalibrating Equus evolution using the genome sequence of an early middle pleistocene horse. Nature 499 (7456), 74\u201378 (2013).","journal-title":"Nature"},{"issue":"1","key":"7709_CR28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.scr.2008.07.007","volume":"2","author":"SA Kuznetsov","year":"2009","unstructured":"Kuznetsov, S. A., Mankani, M. H., Bianco, P. & Robey, P. G. Enumeration of the colony-forming units-fibroblast from mouse and human bone marrow in normal and pathological conditions. Stem Cell. Res. 2 (1), 83\u201394 (2009).","journal-title":"Stem Cell. Res."},{"issue":"4","key":"7709_CR29","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.cell.2014.09.052","volume":"159","author":"YQS Soh","year":"2014","unstructured":"Soh, Y. Q. S. et al. Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes. Cell 159 (4), 800\u2013813 (2014).","journal-title":"Cell"},{"issue":"3","key":"7709_CR30","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1093\/biolre\/ioac084","volume":"107","author":"H Holmlund","year":"2022","unstructured":"Holmlund, H., Yamauchi, Y., Durango, G., Fujii, W. & Ward, M. A. Two acquired mouse Y chromosome-linked genes, Prssly and Teyorf1, are dispensable for male fertility\u2021. Biol. Reprod. 107 (3), 752\u2013764 (2022).","journal-title":"Biol. Reprod."},{"issue":"1","key":"7709_CR31","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/sj.leu.2402763","volume":"17","author":"WJ Rombouts","year":"2003","unstructured":"Rombouts, W. J. & Ploemacher, R. E. Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia 17 (1), 160\u2013170 (2003).","journal-title":"Leukemia"},{"issue":"23","key":"7709_CR32","doi-asserted-by":"publisher","first-page":"19366","DOI":"10.18632\/oncotarget.4358","volume":"6","author":"NH Nicolay","year":"2015","unstructured":"Nicolay, N. H., Lopez Perez, R., Saffrich, R. & Huber, P. E. Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic. Oncotarget 6 (23), 19366\u201319380 (2015).","journal-title":"Oncotarget"},{"issue":"1","key":"7709_CR33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/icb.2012.61","volume":"91","author":"T Sugrue","year":"2013","unstructured":"Sugrue, T., Lowndes, N. F. & Ceredig, R. Mesenchymal stromal cells: radio-resistant members of the bone marrow. Immunol. Cell. Biol. 91 (1), 5\u201311 (2013).","journal-title":"Immunol. Cell. Biol."},{"issue":"6","key":"7709_CR34","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/mutage\/geab033","volume":"36","author":"LE Gynn","year":"2021","unstructured":"Gynn, L. E. et al. Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected. Mutagenesis 36 (6), 419\u2013428 (2021).","journal-title":"Mutagenesis"},{"issue":"3","key":"7709_CR35","first-page":"231","volume":"11","author":"JL Chertkov","year":"1983","unstructured":"Chertkov, J. L., Drize, N. J., Gurevitch, O. A. & Udalov, G. A. Hemopoietic stromal precursors in long-term culture of bone marrow: I. Precursor characteristics, kinetics in culture, and dependence on quality of donor Hemopoietic cells in chimeras. Exp. Hematol. 11 (3), 231\u2013242 (1983).","journal-title":"Exp. Hematol."},{"issue":"1","key":"7709_CR36","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2307\/3575031","volume":"79","author":"JL Chertkov","year":"1979","unstructured":"Chertkov, J. L. & Gurevitch, O. A. Radiosensitivity of progenitor cells of the hematopoietic microenvironment. Radiat. Res. 79 (1), 177\u2013186 (1979).","journal-title":"Radiat. Res."},{"issue":"7","key":"7709_CR37","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/0360-3016(81)90012-2","volume":"7","author":"LM Wathen","year":"1981","unstructured":"Wathen, L. M., Knapp, S. A. & Degowin, R. L. Suppression of marrow stromal cells and microenvironmental damage following sequential radiation and cyclophosphamide. Int. J. Radiat. Oncol. Biol. Phys. 7 (7), 935\u2013941 (1981).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"6","key":"7709_CR38","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1089\/ten.tec.2022.0048","volume":"28","author":"RCH Gresham","year":"2022","unstructured":"Gresham, R. C. H., Kumar, D., Copp, J., Lee, M. A. & Leach, J. K. Characterization of induction and targeting of senescent mesenchymal stromal cells. Tissue Eng. Part. C Methods. 28 (6), 239 (2022).","journal-title":"Tissue Eng. Part. C Methods"},{"issue":"3","key":"7709_CR39","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nprot.2009.238","volume":"5","author":"H Zhu","year":"2010","unstructured":"Zhu, H. et al. A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat. Protoc. 5 (3), 550\u2013560 (2010).","journal-title":"Nat. Protoc."},{"issue":"3","key":"7709_CR40","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/6529","volume":"5","author":"EM Horwitz","year":"1999","unstructured":"Horwitz, E. M. et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat. Med. 5 (3), 309\u2013313 (1999).","journal-title":"Nat. Med."},{"key":"7709_CR41","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3389\/fcell.2020.00592","volume":"8","author":"AD Kurenkova","year":"2020","unstructured":"Kurenkova, A. D., Medvedeva, E. V., Newton, P. T. & Chagin, A. S. Niches for skeletal stem cells of mesenchymal origin. Front. Cell. Dev. Biol. 8, 592 (2020).","journal-title":"Front. Cell. Dev. Biol."},{"issue":"3","key":"7709_CR42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41574-024-01039-y","volume":"21","author":"S Melis","year":"2025","unstructured":"Melis, S., Trompet, D., Chagin, A. S. & Maes, C. Skeletal stem and progenitor cells in bone physiology, ageing and disease. Nat. Rev. Endocrinol. 21 (3), 135\u2013153 (2025).","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"7709_CR43","doi-asserted-by":"publisher","first-page":"5380","DOI":"10.1038\/s41467-022-33134-x","volume":"13","author":"M Pitonak","year":"2022","unstructured":"Pitonak, M. et al. Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice. Nat. Commun. 13 (1), 5380 (2022).","journal-title":"Nat. Commun."},{"key":"7709_CR44","doi-asserted-by":"publisher","first-page":"110194","DOI":"10.1016\/j.radonc.2024.110194","volume":"194","author":"N Chaudary","year":"2024","unstructured":"Chaudary, N., Hill, R. P. & Milosevic, M. Targeting the CXCL12\/CXCR4 pathway to reduce radiation treatment side effects. Radiother Oncol. 194, 110194 (2024).","journal-title":"Radiother Oncol."},{"issue":"3","key":"7709_CR45","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.radonc.2017.07.018","volume":"124","author":"S Hui","year":"2017","unstructured":"Hui, S. et al. Early assessment of dosimetric and biological differences of total marrow irradiation versus total body irradiation in rodents. Radiother Oncol. 124 (3), 468\u2013474 (2017).","journal-title":"Radiother Oncol."},{"key":"7709_CR46","doi-asserted-by":"crossref","unstructured":"Cacha\u00e7o, A. S. et al. TNF-\u03b1 regulates the effects of irradiation in the mouse bone marrow microenvironment. PLoS One 5(2), e8980 .","DOI":"10.1371\/journal.pone.0008980"},{"issue":"1","key":"7709_CR47","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.intimp.2012.10.016","volume":"15","author":"Y Li","year":"2013","unstructured":"Li, Y. et al. Staphylococcus aureus infection of intestinal epithelial cells induces human umbilical cord-derived mesenchymal stem cell migration. Int. Immunopharmacol. 15 (1), 176\u2013181 (2013).","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"7709_CR48","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3390\/jcm8040497","volume":"8","author":"N Durand","year":"2019","unstructured":"Durand, N., Russell, A. & Zubair, A. C. Effect of comedications and endotoxins on mesenchymal stem cell secretomes, migratory and Immunomodulatory capacity. J. Clin. Med. 8 (4), 497 (2019).","journal-title":"J. Clin. Med."},{"issue":"2","key":"7709_CR49","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1365-2141.1983.tb02097.x","volume":"54","author":"AH Piersma","year":"1983","unstructured":"Piersma, A. H., Ploemacher, R. E. & Brockbank, K. G. Transplantation of bone marrow fibroblastoid stromal cells in mice via the intravenous route. Br. J. Haematol. 54 (2), 285\u2013290 (1983).","journal-title":"Br. J. Haematol."},{"issue":"10","key":"7709_CR50","first-page":"961","volume":"11","author":"GE Sale","year":"1983","unstructured":"Sale, G. E. & Storb, R. Bilateral diffuse pulmonary ectopic ossification after marrow allograft in a dog. Evidence for allotransplantation of Hemopoietic and mesenchymal stem cells. Exp. Hematol. 11 (10), 961\u2013966 (1983).","journal-title":"Exp. Hematol."},{"issue":"21","key":"7709_CR51","doi-asserted-by":"publisher","first-page":"7681","DOI":"10.1073\/pnas.84.21.7681","volume":"84","author":"P Anklesaria","year":"1987","unstructured":"Anklesaria, P. et al. Engraftment of a clonal bone marrow stromal cell line in vivo stimulates hematopoietic recovery from total body irradiation. Proc. Natl. Acad. Sci. U S A. 84 (21), 7681\u20137685 (1987).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"4","key":"7709_CR52","first-page":"367","volume":"10","author":"SA Bentley","year":"1982","unstructured":"Bentley, S. A., Knutsen, T. & Whang-Peng, J. The origin of the hematopoietic microenvironment in continuous bone marrow culture. Exp. Hematol. 10 (4), 367\u2013372 (1982).","journal-title":"Exp. Hematol."},{"issue":"2","key":"7709_CR53","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/00007890-197802000-00010","volume":"25","author":"FD Wilson","year":"1978","unstructured":"Wilson, F. D., Konrad, P. N., Greenberg, B. R., Klein, A. K. & Walling, P. A. Cytogenetic studies on bone marrow fibroblasts from a male-female hematopoietic chimera. Evidence that stromal elements in human transplantation recipients are of host type. Transplantation 25 (2), 87\u201388 (1978).","journal-title":"Transplantation"},{"issue":"2","key":"7709_CR54","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2141.1980.tb01200.x","volume":"44","author":"DW Golde","year":"1980","unstructured":"Golde, D. W., Hocking, W. G., Quan, S. G., Sparkes, R. S. & Gale, R. P. Origin of human bone marrow fibroblasts. Br. J. Haematol. 44 (2), 183\u2013187 (1980).","journal-title":"Br. J. Haematol."},{"issue":"22","key":"7709_CR55","doi-asserted-by":"publisher","first-page":"16040","DOI":"10.3390\/ijms242216040","volume":"24","author":"LN Zaripova","year":"2023","unstructured":"Zaripova, L. N. et al. Mesenchymal stem cells in the pathogenesis and therapy of autoimmune and autoinflammatory diseases. Int. J. Mol. Sci. 24 (22), 16040 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"7709_CR56","doi-asserted-by":"publisher","first-page":"1045168","DOI":"10.3389\/fimmu.2022.1045168","volume":"13","author":"M Doglio","year":"2022","unstructured":"Doglio, M. et al. Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease. Front. Immunol. 13, 1045168 (2022).","journal-title":"Front. Immunol."},{"issue":"3","key":"7709_CR57","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/leu.2008.25","volume":"22","author":"F Vianello","year":"2008","unstructured":"Vianello, F. & Dazzi, F. Mesenchymal stem cells for graft-versus-host disease: a double edged sword? Leukemia 22 (3), 463\u2013465 (2008).","journal-title":"Leukemia"},{"issue":"5","key":"7709_CR58","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.cmet.2020.09.001","volume":"32","author":"D Forte","year":"2020","unstructured":"Forte, D. et al. Bone marrow mesenchymal stem cells support acute myeloid leukemia bioenergetics and enhance antioxidant defense and escape from chemotherapy. Cell Metabol. 32 (5), 829\u2013843 (2020).","journal-title":"Cell Metabol."},{"issue":"49","key":"7709_CR59","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1038\/s41388-024-03183-1","volume":"43","author":"R Antoon","year":"2024","unstructured":"Antoon, R., Overdevest, N., Saleh, A. H. & Keating, A. Mesenchymal stromal cells as cancer promoters. Oncogene 43 (49), 3545\u20133555 (2024).","journal-title":"Oncogene"},{"issue":"15","key":"7709_CR60","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.3390\/cancers14153761","volume":"14","author":"T\u017d Ramuta","year":"2022","unstructured":"Ramuta, T. \u017d. & Kreft, M. E. Mesenchymal stem\/stromal cells May decrease success of Cancer treatment by inducing resistance to chemotherapy in Cancer cells. Cancers 14 (15), 3761 (2022).","journal-title":"Cancers"},{"issue":"3","key":"7709_CR61","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41375-018-0373-9","volume":"33","author":"MW Lee","year":"2019","unstructured":"Lee, M. W. et al. Mesenchymal stem cells in suppression or progression of hematologic malignancy: current status and challenges. Leukemia 33 (3), 597\u2013611 (2019).","journal-title":"Leukemia"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07709-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07709-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07709-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T19:11:53Z","timestamp":1751397113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07709-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7709"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-07709-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"14 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animals used in this study were purchased from the Nursery for Laboratory Animals, Pushchino Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences. All the animals were kept in the animal facility of the National Medical Research Center for Hematology, Moscow, Russian Federation (Russia). All the studies involving animals were conducted in accordance with the European Convention for the Protection of Vertebrate Animals Used for Experiments and Other Scientific Purposes. The study was approved by the local ethical committee, protocol \u2116 183, from 12.12.2024. The study is reported in accordance with ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22295"}}