{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:54:27Z","timestamp":1787003667316,"version":"build-2736575974"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-07745-5","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T17:12:03Z","timestamp":1751389923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endoplasmic reticulum stress involved in age-related nuclear cataract induced by sodium selenite"],"prefix":"10.1038","volume":"15","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-tong","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-zhi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-fang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"24","key":"7745_CR1","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1056\/NEJM200006153422404","volume":"342","author":"J Christopher","year":"2000","unstructured":"Christopher, J. et al. Genetic and environmental factors in age-related nuclearcataracts in monozygotic and dizygotic twins. N. Engl. J. Med. 342 (24), 1786\u20131790 (2000).","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"7745_CR2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12886-017-0443-1","volume":"17","author":"Y Maddirala","year":"2017","unstructured":"Maddirala, Y. et al. Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats. BMC Ophthalmol. 17 (1), 54 (2017).","journal-title":"BMC Ophthalmol."},{"issue":"2","key":"7745_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/ceo.13892","volume":"49","author":"MJ Ang","year":"2021","unstructured":"Ang, M. J. & Afshari, N. A. Cataract and systemic disease: a review. Clin. Exp. Ophthalmol. 49 (2), 118\u2013127 (2021).","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"10","key":"7745_CR4","doi-asserted-by":"publisher","first-page":"e14356","DOI":"10.1111\/jfbc.14356","volume":"46","author":"AR Asl","year":"2022","unstructured":"Asl, A. R. et al. The protective effect of pomegranate Peel aqueous extract on selenite-induced cataract in rats. J. Food Biochem. 46 (10), e14356 (2022).","journal-title":"J. Food Biochem."},{"key":"7745_CR5","doi-asserted-by":"crossref","unstructured":"Lim, J. C. et al. Vitamin C and the lens: new insights into delaying the onset of cataract. Nutrients 12, 10  (2020).","DOI":"10.3390\/nu12103142"},{"issue":"4","key":"7745_CR6","doi-asserted-by":"publisher","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","volume":"9","author":"MJ Burton","year":"2021","unstructured":"Burton, M. J. et al. The lancet global health commission on global eye health: vision beyond 2020. Lancet Glob Health. 9 (4), e489\u2013e551 (2021).","journal-title":"Lancet Glob Health"},{"key":"7745_CR7","doi-asserted-by":"crossref","unstructured":"Genchi, G. et al. Biological activity of selenium and its impact on human health. Int. J. Mol. Sci. 24, 3  (2023).","DOI":"10.3390\/ijms24032633"},{"issue":"2","key":"7745_CR8","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/BF01944690","volume":"34","author":"AB Ivana O\u0161t\u00e1dalov\u00e1","year":"1978","unstructured":"Ivana O\u0161t\u00e1dalov\u00e1, A. B. & Obenberger, J. Cataract induced by administration of a single dose of sodium selenite to suckling rats. Experientia 34 (2), 222\u2013223 (1978).","journal-title":"Experientia"},{"issue":"3","key":"7745_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.joco.2016.05.001","volume":"28","author":"SA Khan","year":"2016","unstructured":"Khan, S. A. et al. Hypertension potentiates cataractogenesis in rat eye through modulation of oxidative stress and electrolyte homeostasis. J. Curr. Ophthalmol. 28 (3), 123\u2013130 (2016).","journal-title":"J. Curr. Ophthalmol."},{"issue":"2","key":"7745_CR10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s12011-019-02000-1","volume":"197","author":"H Chen","year":"2020","unstructured":"Chen, H. & Zhou, J. Effects of sodium selenite on oxidative damage in the liver, kidney and brain in a selenite cataract rat model. Biol. Trace Elem. Res. 197 (2), 533\u2013543 (2020).","journal-title":"Biol. Trace Elem. Res."},{"key":"7745_CR11","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.fct.2012.12.061","volume":"55","author":"S Doganay","year":"2013","unstructured":"Doganay, S. et al. The effect of apricots on the experimental cataract model formed by sodium selenite. Food Chem. Toxicol. 55, 371\u2013377 (2013).","journal-title":"Food Chem. Toxicol."},{"key":"7745_CR12","unstructured":"Shearer, T. R. et al. Selenite nuclear cataract: review of the model. Mol. Vis. 3, 8 (1997)."},{"issue":"6","key":"7745_CR13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41580-020-0231-2","volume":"21","author":"I Bludau","year":"2020","unstructured":"Bludau, I. & Aebersold, R. Proteomic and interactomic insights into the molecular basis of cell functional diversity. Nat. Rev. Mol. Cell. Biol. 21 (6), 327\u2013340 (2020).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"7745_CR14","doi-asserted-by":"crossref","unstructured":"Duong, V. A. & Lee, H. Bottom-up proteomics: advancements in sample Preparation. Int. J. Mol. Sci.  24, 6 (2023).","DOI":"10.3390\/ijms24065350"},{"issue":"6928","key":"7745_CR15","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature01514","volume":"422","author":"S Hanash","year":"2003","unstructured":"Hanash, S. Disease proteomics. Nature 422 (6928), 226\u2013232 (2003).","journal-title":"Nature"},{"key":"7745_CR16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jtos.2022.03.001","volume":"24","author":"CJ Jackson","year":"2022","unstructured":"Jackson, C. J. et al. Dry eye disease and proteomics. Ocul Surf. 24, 119\u2013128 (2022).","journal-title":"Ocul Surf."},{"key":"7745_CR17","doi-asserted-by":"publisher","first-page":"133090","DOI":"10.1016\/j.jhazmat.2023.133090","volume":"465","author":"FF Yu","year":"2024","unstructured":"Yu, F. F. et al. T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway. J. Hazard. Mater. 465, 133090 (2024).","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"7745_CR18","doi-asserted-by":"publisher","first-page":"4884","DOI":"10.1038\/s41467-021-25221-2","volume":"12","author":"K de Haan","year":"2021","unstructured":"de Haan, K. et al. Deep learning-based transformation of H&E stained tissues into special stains. Nat. Commun. 12 (1), 4884 (2021).","journal-title":"Nat. Commun."},{"issue":"1","key":"7745_CR19","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1038\/s41467-025-57364-x","volume":"16","author":"H Su","year":"2025","unstructured":"Su, H. et al. Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules. Nat. Commun. 16 (1), 2414 (2025).","journal-title":"Nat. Commun."},{"key":"7745_CR20","doi-asserted-by":"crossref","unstructured":"Yu, F. F. et al. Proteomics sequencing reveals the role of TGF-\u03b2 signaling pathway in the peripheral blood of offspring rats exposed to fluoride. Biol. Trace Elem. Res.  (2023).","DOI":"10.1007\/s12011-023-03805-x"},{"issue":"D1","key":"7745_CR21","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M. et al. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53 (D1), D672\u2013D677 (2025).","journal-title":"Nucleic Acids Res."},{"key":"7745_CR22","doi-asserted-by":"crossref","unstructured":"Zhu, Z. & Jiang, H. Identification of oxidative stress-related biomarkers associated with the development of acute-on-chronic liver failure using bioinformatics. Sci. Rep. 13, 1 (2023).","DOI":"10.1038\/s41598-023-44343-9"},{"issue":"1","key":"7745_CR23","doi-asserted-by":"publisher","first-page":"18460","DOI":"10.1038\/s41598-025-03526-2","volume":"15","author":"F Chen","year":"2025","unstructured":"Chen, F. et al. MOTS-c mimics exercise to combat diabetic liver fibrosis by targeting Keap1-Nrf2-Smad2\/3. Sci. Rep. 15 (1), 18460 (2025).","journal-title":"Sci. Rep."},{"key":"7745_CR24","doi-asserted-by":"publisher","first-page":"117569","DOI":"10.1016\/j.ecoenv.2024.117569","volume":"290","author":"FF Yu","year":"2025","unstructured":"Yu, F. F. et al. Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc(-)\/GSH\/GPX4 axis. Ecotoxicol. Environ. Saf. 290, 117569 (2025).","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"7745_CR25","doi-asserted-by":"publisher","first-page":"100008","DOI":"10.1016\/j.aopr.2021.100008","volume":"1","author":"X Chen","year":"2021","unstructured":"Chen, X. et al. Cataract: advances in surgery and whether surgery remains the only treatment in future. Adv. Ophthalmol. Pract. Res. 1 (1), 100008 (2021).","journal-title":"Adv. Ophthalmol. Pract. Res."},{"issue":"7586","key":"7745_CR26","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nature17041","volume":"529","author":"M Wang","year":"2016","unstructured":"Wang, M. & Kaufman, R. J. Protein misfolding in the Endoplasmic reticulum as a conduit to human disease. Nature 529 (7586), 326\u2013335 (2016).","journal-title":"Nature"},{"issue":"1","key":"7745_CR27","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","volume":"8","author":"X Chen","year":"2023","unstructured":"Chen, X. et al. Endoplasmic reticulum stress: molecular mechanism and therapeutic targets. Signal. Transduct. Target. Ther. 8 (1), 352 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"7745_CR28","doi-asserted-by":"crossref","unstructured":"Robert, P. C. et al. Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. Proc. Natl. Acad. Sci. USA  74 (9),  3840\u20133844 (1977).","DOI":"10.1073\/pnas.74.9.3840"},{"key":"7745_CR29","doi-asserted-by":"publisher","first-page":"1166680","DOI":"10.3389\/fimmu.2023.1166680","volume":"14","author":"T Li","year":"2023","unstructured":"Li, T. et al. New progresses on cell surface protein HSPA5\/BiP\/GRP78 in cancers and COVID-19. Front. Immunol. 14, 1166680 (2023).","journal-title":"Front. Immunol."},{"key":"7745_CR30","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.gene.2017.03.005","volume":"618","author":"J Wang","year":"2017","unstructured":"Wang, J. et al. HSPA5 gene encoding Hsp70 chaperone bip in the Endoplasmic reticulum. Gene 618, 14\u201323 (2017).","journal-title":"Gene"},{"issue":"1","key":"7745_CR31","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12967-021-02786-6","volume":"19","author":"S Xia","year":"2021","unstructured":"Xia, S. et al. GRP78 in lung cancer. J. Transl Med. 19 (1), 118 (2021).","journal-title":"J. Transl Med."},{"issue":"2","key":"7745_CR32","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.autrev.2005.08.006","volume":"5","author":"GS Panayi","year":"2006","unstructured":"Panayi, G. S. & Corrigall, V. M. BiP regulates autoimmune inflammation and tissue damage. Autoimmun. Rev. 5 (2), 140\u2013142 (2006).","journal-title":"Autoimmun. Rev."},{"issue":"4","key":"7745_CR33","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.tem.2022.01.001","volume":"33","author":"Q Tang","year":"2022","unstructured":"Tang, Q., Li, Y. & He, J. MANF: an emerging therapeutic target for metabolic diseases. Trends Endocrinol. Metabolism. 33 (4), 236\u2013246 (2022).","journal-title":"Trends Endocrinol. Metabolism"},{"issue":"1","key":"7745_CR34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41422-020-0383-9","volume":"31","author":"J Fucikova","year":"2021","unstructured":"Fucikova, J. et al. Calreticulin and cancer. Cell. Res. 31 (1), 5\u201316 (2021).","journal-title":"Cell. Res."},{"issue":"6","key":"7745_CR35","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.biocel.2012.02.009","volume":"44","author":"WA Wang","year":"2012","unstructured":"Wang, W. A., Groenendyk, J. & Michalak, M. Calreticulin signaling in health and disease. Int. J. Biochem. Cell. Biol. 44 (6), 842\u2013846 (2012).","journal-title":"Int. J. Biochem. Cell. Biol."},{"issue":"9","key":"7745_CR36","doi-asserted-by":"publisher","first-page":"668","DOI":"10.2174\/1871527317666180619162649","volume":"18","author":"Y Shi","year":"2019","unstructured":"Shi, Y., Wang, Y. & Wei, H. Dantrolene: from malignant hyperthermia to alzheimer\u2019s disease. CNS Neurol. Disord Drug Targets. 18 (9), 668\u2013676 (2019).","journal-title":"CNS Neurol. Disord Drug Targets"},{"issue":"4","key":"7745_CR37","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1365-2044.2004.03658.x","volume":"59","author":"T Krause","year":"2004","unstructured":"Krause, T. et al. Dantrolene\u2013a review of its pharmacology, therapeutic use and new developments. Anaesthesia 59 (4), 364\u2013373 (2004).","journal-title":"Anaesthesia"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07745-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07745-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07745-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T17:12:09Z","timestamp":1751389929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-07745-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7745"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-07745-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"15 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study follows the international and national biomedical ethical principles related to experimental animals, follows the \u201c3R\u201d principle, and fully considers animal welfare. All methods of this study are reported in accordance with ARRIVE guidelines. Approval was granted by the Life Science Ethics Review Committee of Zhengzhou University (ZZUIRB2024-40).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"22227"}}