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Two EDoF lenses, Clareon Vivity and Tecnis PureSee, were evaluated for optical quality using the OptiSpheric IOL Pro2 according to ISO 11979-2 guidelines and measured using Modulation Transfer Function (MTF) and 1951 USAF resolution test chart at 3.0- and 4.5-mm apertures. The IOLs\u2019 tolerance to 0.50\u00a0mm decentration and a 5\u00b0 tilt were tested. The unwanted visual effects were compared using their light distribution at 4.5\u00a0mm aperture beyond a polychromatic point spread function center. The two models demonstrated comparable optical qualities at intermediate and far focuses; the predicted visual acuities for the Vivity and PureSee were respectively \u2212\u20090.04 versus \u2212\u20090.05logMAR at 0 diopter and 0.05 versus 0.07logMAR at \u2212 1.50 diopters of defocus. Increasing pupil size decreased both lenses\u2019 optical quality. While decentration decreased the optical quality of both models, tilt had less of an effect. Both were similar in introducing minimal unwanted side effects through visualizing a halo pattern. The results indicate that these lenses offer a good option for patients interested in EDoF lenses and future clinical studies should contribute further insight into their performance and side effects.<\/jats:p>","DOI":"10.1038\/s41598-025-07970-y","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T13:39:52Z","timestamp":1753364392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of Clareon Vivity and PureSee intraocular lenses: optical quality, depth of focus and misalignment effects"],"prefix":"10.1038","volume":"15","author":[{"given":"Ava","family":"Niknahad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeck-Soo","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd U","family":"Auffarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Khoramnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"\u0141abuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"7970_CR1","unstructured":"Revealing Average Screen Time Statistics for 2024. 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GU Auffarth reports grants, personal fees, nonfinancial support and consulting fees from Alcon, Johnson & Johnson, Carl Zeiss Meditec, Rayner and SIFI, grants, personal fees, and nonfinancial support from Hoya, Kowa, Teleon and Santen, grants, personal fees and consulting fees from Cristalens and VSY, grants and personal fees from Bausch\u2009+\u2009Lomb, Biotech and Oculus, personal fees from Eyebright, grants from Contamac, Croma, Hanita, Ophtec and Physiol, outside the submitted work. R Khoramnia reports grants, personal fees and nonfinancial support from Alcon and Teleon; grants, personal fees and nonfinancial support from Hoya and Johnson&Johnson, grants and personal fees from Bausch\u2009+\u2009Lomb, personal fees and nonfinancial support from Carl Zeiss Meditec and Ophtec, personal fees from Heidelberg Engineering, Oculus and Rayner, outside the submitted work. G \u0141abuz reports nonfinancial support from Contamac outside the submitted work. The University of Heidelberg holds a patent application (No. EP22187235) entitled \u201cLens with extended depth of focus by inducing an excess of longitudinal chromatic aberration\u201d, with GUA and G\u0141 as inventors. A Niknahad, Z Wu and H-S Son have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26943"}}