{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:38:07Z","timestamp":1791945487425,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FORT23\/00013"],"award-info":[{"award-number":["FORT23\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01833"],"award-info":[{"award-number":["PI22\/01833"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FORT23\/00013"],"award-info":[{"award-number":["FORT23\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01833"],"award-info":[{"award-number":["PI22\/01833"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01833"],"award-info":[{"award-number":["PI22\/01833"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0009\/0003"],"award-info":[{"award-number":["RD21\/0009\/0003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01833"],"award-info":[{"award-number":["PI22\/01833"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/01833"],"award-info":[{"award-number":["PI22\/01833"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FORT23\/00013"],"award-info":[{"award-number":["FORT23\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009664","name":"Sociedad Espa\u00f1ola de Cardiolog\u00eda","doi-asserted-by":"publisher","award":["SEC\/FEC-INV-BAS23\/18"],"award-info":[{"award-number":["SEC\/FEC-INV-BAS23\/18"]}],"id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009664","name":"Sociedad Espa\u00f1ola de Cardiolog\u00eda","doi-asserted-by":"publisher","award":["SEC\/FEC-INV-BAS23\/18"],"award-info":[{"award-number":["SEC\/FEC-INV-BAS23\/18"]}],"id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016658","name":"Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["PNSD 2022\/020"],"award-info":[{"award-number":["PNSD 2022\/020"]}],"id":[{"id":"10.13039\/100016658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-08041-y","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:17:18Z","timestamp":1751383038000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Distinct cardiac troponin alterations in patients with cocaine and alcohol use disorders during abstinence for cardiovascular risk assessment"],"prefix":"10.1038","volume":"15","author":[{"given":"\u00d3scar","family":"Porras-Perales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Segovia-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Crespo-Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Ruiz-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Flores-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Medina-Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"S\u00e1nchez-Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mart\u00edn-Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Requena-Oca\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Molina-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jes\u00fas","family":"Ruiz-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Jim\u00e9nez-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Rodr\u00edguez-Capit\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Pav\u00f3n-Mor\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"8041_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/wps.21073","volume":"22","author":"ND Volkow","year":"2023","unstructured":"Volkow, N. D. & Blanco, C. Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention. World Psychiatry. 22, 203\u2013229 (2023).","journal-title":"World Psychiatry"},{"key":"8041_CR2","unstructured":"Deaths attributed to tobacco, alcohol and drugs. Our World in Data. https:\/\/ourworldindata.org\/grapher\/substances-risk-factor-vs-direct-deaths?time=latest."},{"key":"8041_CR3","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.medcli.2023.11.016","volume":"162","author":"D Fuster","year":"2024","unstructured":"Fuster, D., Zuluaga, P. & Muga, R. Substance use disorder: epidemiology, medical consequences and treatment. Med. Clin. (Barc). 162, 431\u2013438 (2024).","journal-title":"Med. Clin. (Barc)"},{"key":"8041_CR4","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.chc.2015.11.007","volume":"25","author":"SR LeNoue","year":"2016","unstructured":"LeNoue, S. R. & Riggs, P. D. Substance abuse prevention. Child. Adolesc. Psychiatr. Clin. N. Am. 25, 297\u2013305 (2016).","journal-title":"Child. Adolesc. Psychiatr. Clin. N. Am."},{"key":"8041_CR5","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.drugalcdep.2017.08.031","volume":"180","author":"WS John","year":"2017","unstructured":"John, W. S. & Wu, L. T. Trends and correlates of cocaine use and cocaine use disorder in the United States from 2011 to 2015. Drug Alcohol Depend. 180, 376\u2013384 (2017).","journal-title":"Drug Alcohol Depend."},{"key":"8041_CR6","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/j.1360-0443.2012.04075.x","volume":"108","author":"PK Staiger","year":"2013","unstructured":"Staiger, P. K., Richardson, B., Long, C. M., Carr, V. & Marlatt, G. A. Overlooked and underestimated? Problematic alcohol use in clients recovering from drug dependence. Addict. Abingdon Engl. 108, 1188\u20131193 (2013).","journal-title":"Addict. Abingdon Engl."},{"key":"8041_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/ADM.0000000000000016","volume":"8","author":"Y Delchev","year":"2014","unstructured":"Delchev, Y. et al. Transient cocaine-Induced chest pain: A case series. J. Addict. Med. 8, 111 (2014).","journal-title":"J. Addict. Med."},{"key":"8041_CR8","doi-asserted-by":"publisher","first-page":"704276","DOI":"10.3389\/fpsyt.2021.704276","volume":"12","author":"V Clergue-Duval","year":"2021","unstructured":"Clergue-Duval, V. et al. Risk and protective factors of lifetime cocaine-associated chest pain. Front. Psychiatry. 12, 704276 (2021).","journal-title":"Front. Psychiatry"},{"key":"8041_CR9","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.drugalcdep.2018.07.025","volume":"192","author":"Y Liu","year":"2018","unstructured":"Liu, Y., Williamson, G., Setlow, V., Cottler, B., Knackstedt, L. A. & L. B. & The importance of considering polysubstance use: lessons from cocaine research. Drug Alcohol Depend. 192, 16\u201328 (2018).","journal-title":"Drug Alcohol Depend."},{"key":"8041_CR10","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3389\/fnins.2020.00569","volume":"14","author":"EA Crummy","year":"2020","unstructured":"Crummy, E. A., O\u2019Neal, T. J., Baskin, B. M. & Ferguson, S. M. One is not enough: Understanding and modeling polysubstance use. Front. Neurosci. 14, 569 (2020).","journal-title":"Front. Neurosci."},{"key":"8041_CR11","doi-asserted-by":"publisher","first-page":"19795","DOI":"10.1038\/s41598-020-76273-1","volume":"10","author":"DJ Arenas","year":"2020","unstructured":"Arenas, D. J., Beltran, S., Zhou, S. & Goldberg, L. R. Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis. Sci. Rep. 10, 19795 (2020).","journal-title":"Sci. Rep."},{"key":"8041_CR12","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1046\/j.1360-0443.2002.00158.x","volume":"97","author":"EJM Pennings","year":"2002","unstructured":"Pennings, E. J. M., Leccese, A. P. & de Wolff, F. A. Effects of concurrent use of alcohol and cocaine. Addict. Abingdon Engl. 97, 773\u2013783 (2002).","journal-title":"Addict. Abingdon Engl."},{"key":"8041_CR13","first-page":"134","volume":"5","author":"MU Farooq","year":"2009","unstructured":"Farooq, M. U., Bhatt, A. & Patel, M. Neurotoxic and cardiotoxic effects of cocaine and ethanol. J. Med. Toxicol. Off. J. Am. Coll. Med. Toxicol. 5, 134\u2013138 (2009).","journal-title":"J. Med. Toxicol. Off. J. Am. Coll. Med. Toxicol."},{"key":"8041_CR14","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3390\/jcm13051475","volume":"13","author":"J van Amsterdam","year":"2024","unstructured":"van Amsterdam, J., Gresnigt, F. & van den Brink, W. Cardiovascular risks of simultaneous use of alcohol and cocaine\u2014A systematic review. J. Clin. Med. 13, 1475 (2024).","journal-title":"J. Clin. Med."},{"key":"8041_CR15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.alcohol.2020.11.003","volume":"90","author":"V Clergue-Duval","year":"2021","unstructured":"Clergue-Duval, V. et al. BNP worsens 12 days after alcohol cessation while other cardiovascular risk biomarkers improve: an observational study. Alcohol Fayettev. N. 90, 39\u201343 (2021).","journal-title":"Alcohol Fayettev. N"},{"key":"8041_CR16","doi-asserted-by":"publisher","first-page":"572","DOI":"10.3390\/nu12020572","volume":"12","author":"J Fern\u00e1ndez-Sol\u00e0","year":"2020","unstructured":"Fern\u00e1ndez-Sol\u00e0, J. The effects of ethanol on the heart: alcoholic cardiomyopathy. Nutrients. 12, 572 (2020).","journal-title":"Nutrients"},{"key":"8041_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s11906-019-0984-1","volume":"21","author":"IB Puddey","year":"2019","unstructured":"Puddey, I. B., Mori, T. A., Barden, A. E. & Beilin, L. J. Alcohol and hypertension-new insights and lingering controversies. Curr. Hypertens. Rep. 21, 79 (2019).","journal-title":"Curr. Hypertens. Rep."},{"key":"8041_CR18","doi-asserted-by":"publisher","first-page":"108136","DOI":"10.1016\/j.drugalcdep.2020.108136","volume":"214","author":"T Winhusen","year":"2020","unstructured":"Winhusen, T., Theobald, J., Kaelber, D. C. & Lewis, D. The association between regular cocaine use, with and without tobacco co-use, and adverse cardiovascular and respiratory outcomes. Drug Alcohol Depend. 214, 108136 (2020).","journal-title":"Drug Alcohol Depend."},{"key":"8041_CR19","doi-asserted-by":"publisher","first-page":"108252","DOI":"10.1016\/j.drugalcdep.2020.108252","volume":"217","author":"ED Riley","year":"2020","unstructured":"Riley, E. D. et al. Impact of polysubstance use on high-sensitivity cardiac troponin I over time in homeless and unstably housed women. Drug Alcohol Depend. 217, 108252 (2020).","journal-title":"Drug Alcohol Depend."},{"key":"8041_CR20","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/adb.12156","volume":"20","author":"P Araos","year":"2015","unstructured":"Araos, P. et al. Plasma profile of pro-inflammatory cytokines and chemokines in cocaine users under outpatient treatment: influence of cocaine symptom severity and psychiatric co-morbidity. Addict. Biol. 20, 756\u2013772 (2015).","journal-title":"Addict. Biol."},{"key":"8041_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/7854_2016_28","volume":"31","author":"A Halaris","year":"2017","unstructured":"Halaris, A. Inflammation-associated co-morbidity between depression and cardiovascular disease. Curr. Top. Behav. Neurosci. 31, 45\u201370 (2017).","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"8041_CR22","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/joim.13391","volume":"291","author":"MN Lyngbakken","year":"2022","unstructured":"Lyngbakken, M. N., de Lemos, J. A., Hveem, K., R\u00f8sj\u00f8, H. & Omland, T. Lifetime obesity trends are associated with subclinical myocardial injury: the Tr\u00f8ndelag health study. J. Intern. Med. 291, 317\u2013326 (2022).","journal-title":"J. Intern. Med."},{"key":"8041_CR23","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12933-022-01616-3","volume":"21","author":"J Sabbatinelli","year":"2022","unstructured":"Sabbatinelli, J. et al. Prognostic value of soluble ST2, high-sensitivity cardiac troponin, and NT-proBNP in type 2 diabetes: a 15-year retrospective study. Cardiovasc. Diabetol. 21, 180 (2022).","journal-title":"Cardiovasc. Diabetol."},{"key":"8041_CR24","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1016\/j.jacc.2016.10.020","volume":"68","author":"I Ford","year":"2016","unstructured":"Ford, I. et al. High-Sensitivity cardiac troponin, Statin therapy, and risk of coronary heart disease. J. Am. Coll. Cardiol. 68, 2719\u20132728 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"key":"8041_CR25","doi-asserted-by":"publisher","first-page":"e017239","DOI":"10.1161\/JAHA.120.017239","volume":"10","author":"E Kadesj\u00f6","year":"2021","unstructured":"Kadesj\u00f6, E., Roos, A., Siddiqui, A. J., Sartipy, U. & Holzmann, M. J. Treatment with cardiovascular medications: prognosis in patients with myocardial injury. J. Am. Heart Assoc. 10, e017239 (2021).","journal-title":"J. Am. Heart Assoc."},{"key":"8041_CR26","doi-asserted-by":"crossref","unstructured":"Sinha, R. Stress and substance use disorders: risk, relapse, and treatment outcomes. J Clin. Investig. 134, (2024).","DOI":"10.1172\/JCI172883"},{"key":"8041_CR27","doi-asserted-by":"publisher","first-page":"e0213791","DOI":"10.1371\/journal.pone.0213791","volume":"14","author":"N Garc\u00eda-Marchena","year":"2019","unstructured":"Garc\u00eda-Marchena, N. et al. Inflammatory mediators and dual depression: potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders. PLoS One. 14, e0213791 (2019).","journal-title":"PLoS One"},{"key":"8041_CR28","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.flm.2017.09.003","volume":"1","author":"AHB Wu","year":"2017","unstructured":"Wu, A. H. B. Release of cardiac troponin from healthy and damaged myocardium. Front. Lab. Med. 1, 144\u2013150 (2017).","journal-title":"Front. Lab. Med."},{"key":"8041_CR29","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1093\/cvr\/cvx183","volume":"113","author":"KC Park","year":"2017","unstructured":"Park, K. C., Gaze, D. C., Collinson, P. O. & Marber, M. S. Cardiac troponins: from myocardial infarction to chronic disease. Cardiovasc. Res. 113, 1708\u20131718 (2017).","journal-title":"Cardiovasc. Res."},{"key":"8041_CR30","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/j.jacc.2014.01.040","volume":"63","author":"LJJ Klinkenberg","year":"2014","unstructured":"Klinkenberg, L. J. J. et al. Circulating cardiac troponin T exhibits a diurnal rhythm. J. Am. Coll. Cardiol. 63, 1788\u20131795 (2014).","journal-title":"J. Am. Coll. Cardiol."},{"key":"8041_CR31","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1093\/eurheartj\/ehu188","volume":"35","author":"M Rubini Gimenez","year":"2014","unstructured":"Rubini Gimenez, M. et al. Direct comparison of high-sensitivity-cardiac troponin I vs. T for the early diagnosis of acute myocardial infarction. Eur. Heart J. 35, 2303\u20132311 (2014).","journal-title":"Eur. Heart J."},{"key":"8041_CR32","doi-asserted-by":"publisher","first-page":"1054959","DOI":"10.3389\/fcvm.2022.1054959","volume":"9","author":"L Leite","year":"2022","unstructured":"Leite, L. et al. High sensitivity troponins: A potential biomarkers of cardiovascular risk for primary prevention. Front. Cardiovasc. Med. 9, 1054959 (2022).","journal-title":"Front. Cardiovasc. Med."},{"key":"8041_CR33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1023\/A:1006939307715","volume":"190","author":"SV Perry","year":"1999","unstructured":"Perry, S. V. Troponin I: inhibitor or facilitator. Mol. Cell. Biochem. 190, 9\u201332 (1999).","journal-title":"Mol. Cell. Biochem."},{"key":"8041_CR34","doi-asserted-by":"publisher","first-page":"101263","DOI":"10.1016\/j.gendis.2024.101263","volume":"11","author":"R Ragusa","year":"2024","unstructured":"Ragusa, R. & Caselli, C. Focus on cardiac troponin complex: from gene expression to cardiomyopathy. Genes Dis. 11, 101263 (2024).","journal-title":"Genes Dis."},{"key":"8041_CR35","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1161\/CIRCULATIONAHA.118.038529","volume":"139","author":"P Welsh","year":"2019","unstructured":"Welsh, P. et al. Cardiac troponin T and troponin I in the general population. Circulation. 139, 2754\u20132764 (2019).","journal-title":"Circulation"},{"key":"8041_CR36","doi-asserted-by":"publisher","first-page":"10011","DOI":"10.3389\/adar.2021.10011","volume":"1","author":"J Alleyne","year":"2021","unstructured":"Alleyne, J. & Dopico, A. M. Alcohol use disorders and their harmful effects on the contractility of skeletal, cardiac and smooth muscles. Adv. Drug Alcohol Res. 1, 10011 (2021).","journal-title":"Adv. Drug Alcohol Res."},{"key":"8041_CR37","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.drugalcdep.2016.11.039","volume":"172","author":"ED Riley","year":"2017","unstructured":"Riley, E. D. et al. Higher prevalence of detectable troponin I among cocaine-users without known cardiovascular disease. Drug Alcohol Depend. 172, 88\u201393 (2017).","journal-title":"Drug Alcohol Depend."},{"key":"8041_CR38","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/hep.510290332","volume":"29","author":"D Pateron","year":"1999","unstructured":"Pateron, D. et al. Elevated circulating cardiac troponin I in patients with cirrhosis. Hepatol. Baltim. Md. 29, 640\u2013643 (1999).","journal-title":"Hepatol. Baltim. Md."},{"key":"8041_CR39","doi-asserted-by":"publisher","first-page":"545","DOI":"10.14740\/jmc1895w","volume":"5","author":"H Luo","year":"2014","unstructured":"Luo, H. et al. Troponin I elevation due to alcoholism in absence of acute coronary syndrome: A case report. J. Med. Cases. 5, 545\u2013548 (2014).","journal-title":"J. Med. Cases"},{"key":"8041_CR40","first-page":"701","volume":"81","author":"UK Radunski","year":"2017","unstructured":"Radunski, U. K. et al. Asymptomatic cocaine abuse\u2014myocardial tissue characterization using cardiac biomarkers and cardiovascular magnetic resonance imaging. Circ. J. Off. J. Jpn. Circ. Soc. 81, 701\u2013708 (2017).","journal-title":"Circ. J. Off J. Jpn. Circ. Soc."},{"key":"8041_CR41","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1093\/eurjhf\/hfp037","volume":"11","author":"I Laonigro","year":"2009","unstructured":"Laonigro, I., Correale, M., Di Biase, M. & Altomare, E. Alcohol abuse and heart failure. Eur. J. Heart Fail. 11, 453\u2013462 (2009).","journal-title":"Eur. J. Heart Fail."},{"key":"8041_CR42","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1016\/S0735-1097(21)04384-9","volume":"77","author":"B Klinkhammer","year":"2021","unstructured":"Klinkhammer, B. et al. Troponin correlates with inflammatory markers in COVID-19. J. Am. Coll. Cardiol. 77, 3029 (2021).","journal-title":"J. Am. Coll. Cardiol."},{"key":"8041_CR43","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1176\/appi.ajp.161.7.1231","volume":"161","author":"M Torrens","year":"2004","unstructured":"Torrens, M., Serrano, D., Astals, M., P\u00e9rez-Dom\u00ednguez, G. & Mart\u00edn-Santos, R. Diagnosing comorbid psychiatric disorders in substance abusers: validity of the Spanish versions of the psychiatric research interview for substance and mental disorders and the structured clinical interview for DSM-IV. Am. J. Psychiatry. 161, 1231\u20131237 (2004).","journal-title":"Am. J. Psychiatry"},{"key":"8041_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9780470479216.corpsy0271","volume-title":"The Corsini Encyclopedia of Psychology","author":"DL Segal","year":"2010","unstructured":"Segal, D. L. Diagnostic and statistical manual of mental disorders (DSM-IV-TR). In The Corsini Encyclopedia of Psychology, 1\u20133. https:\/\/doi.org\/10.1002\/9780470479216.corpsy0271 (Wiley, Ltd, 2010)."},{"key":"8041_CR45","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.drugalcdep.2014.12.006","volume":"148","author":"D Hasin","year":"2015","unstructured":"Hasin, D. DSM-5 SUD diagnoses: changes, reactions, remaining open questions. Drug Alcohol Depend. 148, 226\u2013229 (2015).","journal-title":"Drug Alcohol Depend."},{"key":"8041_CR46","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1001\/archpsyc.1988.01800360017003","volume":"45","author":"LN Robins","year":"1988","unstructured":"Robins, L. N. et al. The composite international diagnostic interview. An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch. Gen. Psychiatry. 45, 1069\u20131077 (1988).","journal-title":"Arch. Gen. Psychiatry"},{"key":"8041_CR47","doi-asserted-by":"publisher","first-page":"4906","DOI":"10.3390\/jcm13164906","volume":"13","author":"R Jim\u00e9nez-L\u00f3pez","year":"2024","unstructured":"Jim\u00e9nez-L\u00f3pez, R. et al. Differential ophthalmological profile in patients with coronary artery disease coexisting with type 2 diabetes mellitus: elevated tear cytokine concentrations. J. Clin. Med. 13, 4906 (2024).","journal-title":"J. Clin. Med."},{"key":"8041_CR48","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.1365-3016.2008.00969.x","volume":"22","author":"BW Whitcomb","year":"2008","unstructured":"Whitcomb, B. W. & Schisterman, E. F. Assays with lower detection limits: implications for epidemiological investigations. Paediatr. Perinat. Epidemiol. 22, 597\u2013602 (2008).","journal-title":"Paediatr. Perinat. Epidemiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08041-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08041-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08041-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:17:24Z","timestamp":1757204244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08041-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8041"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-08041-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this Article was revised: The Funding section in the original version of this Article was omitted. The Funding section now reads: \u201cThis research was supported by the following grants: Projects funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union and ERDF-EU (PI19\/00886, PI20\/01399, PI22\/00427, and PI22\/01833); Project funded by Delegaci\u00f3n de Gobierno para el Plan Nacional sobre Drogas, Ministerio de Sanidad y Consumo (PNSD 2022\/020); Project funded by Sociedad Espa\u00f1ola de Cardiolog\u00eda (SEC\/FEC-INV-BAS23\/18); Programa RICORS RIAPAD (RD21\/0009\/0003) funded by ISCIII and co-funded by the European Union; Programa Fortalece funded by ISCIII, Ministerio de Ciencia, Innovaci\u00f3n y Universidades (FORT23\/00013).\u201d The original Article has been corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21887"}}