{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T03:40:05Z","timestamp":1752205205807,"version":"3.41.2"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>This study investigates vessel density (VD) changes in the lamina cribrosa (LC) and peripapillary sclera (PPS) after glaucoma surgery and their association with visual field (VF) progression. Primary open-angle glaucoma patients undergoing surgery for uncontrolled intraocular pressure (IOP) at Seoul St. Mary\u2019s Hospital were included. Optical coherence tomography angiography (OCT-A) assessed VD changes in the LC and PPS one month post-surgery. VF progression was evaluated using mean deviation (MD) values from serial VF tests over six months. Of 80 enrolled eyes, 74 were analyzed. Laminar VD recovery occurred in 12 eyes (16.2%), with a 21.92%\u2009\u00b1\u20097.37% increase, linked to shorter axial length (P\u2009=\u20090.005), thinner corneal thickness (P\u2009=\u20090.016), and less PPS VD change (P\u2009&lt;\u20090.001). PPS VD recovery occurred in 14 eyes (18.9%), with an 18.50%\u2009\u00b1\u20097.28% increase, associated with younger age (P\u2009=\u20090.043), longer axial length (P\u2009=\u20090.010), and lower preoperative PPS VD (P\u2009&lt;\u20090.001). Multivariate analysis showed that both laminar and PPS VD recovery significantly reduced VF progression risk (P\u2009&lt;\u20090.001). VD recovery, particularly in the LC, predicts better glaucoma outcomes. The distinct responses of LC and PPS to IOP reduction highlight the need to consider individual anatomical factors in glaucoma management.<\/jats:p>","DOI":"10.1038\/s41598-025-08205-w","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T03:13:37Z","timestamp":1752203617000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microvasculature recovery in lamina cribrosa and peripapillary sclera after glaucoma surgery and its impact on visual field progression"],"prefix":"10.1038","volume":"15","author":[{"given":"Hee Jong","family":"Shin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Kyung","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Ah","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younhea","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Kee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Young Lopilly","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"8205_CR1","doi-asserted-by":"crossref","unstructured":"Strickland, R. G. et al. Remodeling of the lamina cribrosa: mechanisms and potential therapeutic approaches for glaucoma (2022).","DOI":"10.3390\/ijms23158068"},{"key":"8205_CR2","doi-asserted-by":"publisher","first-page":"100933","DOI":"10.1016\/j.preteyeres.2020.100933","volume":"83","author":"YX Wang","year":"2021","unstructured":"Wang, Y. X., Panda-Jonas, S. & Jonas, J. B. Optic nerve head anatomy in myopia and glaucoma, including parapapillary zones alpha, beta, gamma and delta: Histology and clinical features. Prog. Retinal Eye Res. 83, 100933. https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100933 (2021).","journal-title":"Prog. Retinal Eye Res."},{"issue":"5","key":"8205_CR3","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1167\/iovs.07-1429","volume":"50","author":"R Ren","year":"2009","unstructured":"Ren, R. et al. Lamina cribrosa and peripapillary sclera histomorphometry in normal and advanced glaucomatous Chinese eyes with various axial length. Investig. Ophthalmol. Vis. Sci. 50(5), 2175\u20132184. https:\/\/doi.org\/10.1167\/iovs.07-1429 (2009).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"4","key":"8205_CR4","doi-asserted-by":"publisher","first-page":"e273","DOI":"10.1111\/aos.12324","volume":"92","author":"JB Jonas","year":"2014","unstructured":"Jonas, J. B., Holbach, L. & Panda-Jonas, S. Peripapillary ring: histology and correlations. Acta Ophthalmol. 92(4), e273\u2013e279. https:\/\/doi.org\/10.1111\/aos.12324 (2014).","journal-title":"Acta Ophthalmol."},{"key":"8205_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.actbio.2018.08.020","volume":"79","author":"AP Voorhees","year":"2018","unstructured":"Voorhees, A. P. et al. Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications. Acta Biomater. 79, 113\u2013122. https:\/\/doi.org\/10.1016\/j.actbio.2018.08.020 (2018).","journal-title":"Acta Biomater."},{"issue":"9","key":"8205_CR6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1167\/iovs.15-18944","volume":"57","author":"A Yarmohammadi","year":"2016","unstructured":"Yarmohammadi, A. et al. Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes. Invest. Ophthalmol. Vis. Sci. 57(9), 451\u2013459. https:\/\/doi.org\/10.1167\/iovs.15-18944 (2016).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"8205_CR7","doi-asserted-by":"publisher","first-page":"8909714","DOI":"10.1155\/2018\/8909714","volume":"2018","author":"JH In","year":"2018","unstructured":"In, J. H. et al. Peripapillary vessel density reversal after trabeculectomy in glaucoma. J. Ophthalmol. 2018, 8909714. https:\/\/doi.org\/10.1155\/2018\/8909714 (2018).","journal-title":"J. Ophthalmol."},{"issue":"8","key":"8205_CR8","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1007\/s10792-021-01823-z","volume":"41","author":"A Miraftabi","year":"2021","unstructured":"Miraftabi, A. et al. Effect of trabeculectomy on optic nerve head and macular vessel density: an optical coherence tomography angiography study. Int. Ophthalmol. 41(8), 2677\u20132688. https:\/\/doi.org\/10.1007\/s10792-021-01823-z (2021).","journal-title":"Int. Ophthalmol."},{"issue":"8","key":"8205_CR9","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/ijg.0000000000002230","volume":"32","author":"MS Baek","year":"2023","unstructured":"Baek, M. S. et al. Change of choroidal microvasculature dropout after trabeculectomy as assessed by optical coherence tomography angiography. J. Glaucoma 32(8), 665\u2013672. https:\/\/doi.org\/10.1097\/ijg.0000000000002230 (2023).","journal-title":"J. Glaucoma"},{"issue":"1","key":"8205_CR10","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s10103-023-03907-x","volume":"38","author":"N El-Haddad","year":"2023","unstructured":"El-Haddad, N. et al. Comparison between open-angle glaucoma and angle-closure glaucoma regarding the short-term optic disc vessel density changes after trabeculectomy. Lasers Med. Sci. 38(1), 246. https:\/\/doi.org\/10.1007\/s10103-023-03907-x (2023).","journal-title":"Lasers Med. Sci."},{"issue":"13","key":"8205_CR11","doi-asserted-by":"publisher","first-page":"5993","DOI":"10.1167\/iovs.17-22787","volume":"58","author":"JW Shin","year":"2017","unstructured":"Shin, J. W. et al. Peripapillary microvascular improvement and lamina cribrosa depth reduction after trabeculectomy in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 58(13), 5993\u20135999. https:\/\/doi.org\/10.1167\/iovs.17-22787 (2017).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"11","key":"8205_CR12","doi-asserted-by":"publisher","first-page":"4614","DOI":"10.1167\/iovs.18-25038","volume":"59","author":"JA Kim","year":"2018","unstructured":"Kim, J. A. et al. Microvascular changes in peripapillary and optic nerve head tissues after trabeculectomy in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 59(11), 4614\u20134621. https:\/\/doi.org\/10.1167\/iovs.18-25038 (2018).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"15","key":"8205_CR13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/iovs.62.15.17","volume":"62","author":"HL Park","year":"2021","unstructured":"Park, H. L. et al. Microvasculature recovery detected using optical coherence tomography angiography and the rate of visual field progression after glaucoma surgery. Invest. Ophthalmol. Vis. Sci. 62(15), 17. https:\/\/doi.org\/10.1167\/iovs.62.15.17 (2021).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"8205_CR14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/ijg.0000000000002148","volume":"32","author":"JW Hong","year":"2023","unstructured":"Hong, J. W., Sung, K. R. & Shin, J. W. Optical coherence tomography angiography of the retinal circulation following trabeculectomy for glaucoma. J. Glaucoma 32(4), 293\u2013300. https:\/\/doi.org\/10.1097\/ijg.0000000000002148 (2023).","journal-title":"J. Glaucoma"},{"issue":"3","key":"8205_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10384-022-00919-y","volume":"66","author":"D G\u00fcng\u00f6r","year":"2022","unstructured":"G\u00fcng\u00f6r, D. et al. Changes in optic nerve head and macula optical coherence tomography angiography parameters before and after trabeculectomy. Jpn. J. Ophthalmol. 66(3), 305\u2013313. https:\/\/doi.org\/10.1007\/s10384-022-00919-y (2022).","journal-title":"Jpn. J. Ophthalmol."},{"issue":"5","key":"8205_CR16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1097\/ijg.0000000000000652","volume":"26","author":"P Z\u00e9boulon","year":"2017","unstructured":"Z\u00e9boulon, P. et al. Effect of surgical intraocular pressure lowering on peripapillary and macular vessel density in glaucoma patients: an optical coherence tomography angiography study. J. Glaucoma 26(5), 466\u2013472. https:\/\/doi.org\/10.1097\/ijg.0000000000000652 (2017).","journal-title":"J. Glaucoma"},{"issue":"1","key":"8205_CR17","doi-asserted-by":"publisher","first-page":"17251","DOI":"10.1038\/s41598-022-22091-6","volume":"12","author":"E Reitemeyer","year":"2022","unstructured":"Reitemeyer, E. et al. Stabilization of macular, peripapillary and papillary vascular parameters after XEN and trabeculectomy visualized by the optical coherence tomography angiography. Sci. Rep. 12(1), 17251. https:\/\/doi.org\/10.1038\/s41598-022-22091-6 (2022).","journal-title":"Sci. Rep."},{"key":"8205_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/bs.pbr.2015.04.003","volume":"220","author":"HA Quigley","year":"2015","unstructured":"Quigley, H. A. The contribution of the sclera and lamina cribrosa to the pathogenesis of glaucoma: Diagnostic and treatment implications. Prog. Brain Res. 220, 59\u201386. https:\/\/doi.org\/10.1016\/bs.pbr.2015.04.003 (2015).","journal-title":"Prog. Brain Res."},{"issue":"1","key":"8205_CR19","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40662-020-00210-6","volume":"7","author":"JB Jonas","year":"2020","unstructured":"Jonas, J. B. et al. Advances in myopia research anatomical findings in highly myopic eyes. Eye Vis. 7(1), 45. https:\/\/doi.org\/10.1186\/s40662-020-00210-6 (2020).","journal-title":"Eye Vis."},{"key":"8205_CR20","first-page":"164","volume":"36","author":"J Fran\u00e7ois","year":"1978","unstructured":"Fran\u00e7ois, J. & Fryczkowski, A. The blood supply of the optic nerve. Adv. Ophthalmol. 36, 164\u2013173 (1978).","journal-title":"Adv. Ophthalmol."},{"issue":"8","key":"8205_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1167\/iovs.65.8.47","volume":"65","author":"EJ Lee","year":"2024","unstructured":"Lee, E. J. et al. Underlying microstructure of the lamina cribrosa at the site of microvasculature dropout. Invest. Ophthalmol. Vis. Sci. 65(8), 47. https:\/\/doi.org\/10.1167\/iovs.65.8.47 (2024).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"8205_CR22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","volume":"24","author":"CF Burgoyne","year":"2005","unstructured":"Burgoyne, C. F. et al. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog. Retin. Eye Res. 24(1), 39\u201373. https:\/\/doi.org\/10.1016\/j.preteyeres.2004.06.001 (2005).","journal-title":"Prog. Retin. Eye Res."},{"key":"8205_CR23","doi-asserted-by":"publisher","first-page":"108188","DOI":"10.1016\/j.exer.2020.108188","volume":"199","author":"Y Hua","year":"2020","unstructured":"Hua, Y. et al. Role of radially aligned scleral collagen fibers in optic nerve head biomechanics. Exp. Eye Res. 199, 108188. https:\/\/doi.org\/10.1016\/j.exer.2020.108188 (2020).","journal-title":"Exp. Eye Res."},{"issue":"1","key":"8205_CR24","doi-asserted-by":"publisher","first-page":"E23","DOI":"10.1097\/OPX.0b013e3181940669","volume":"86","author":"NA McBrien","year":"2009","unstructured":"McBrien, N. A., Jobling, A. I. & Gentle, A. Biomechanics of the sclera in myopia: extracellular and cellular factors. Optom. Vis. Sci. 86(1), E23-30. https:\/\/doi.org\/10.1097\/OPX.0b013e3181940669 (2009).","journal-title":"Optom. Vis. Sci."},{"key":"8205_CR25","doi-asserted-by":"publisher","first-page":"100773","DOI":"10.1016\/j.preteyeres.2019.100773","volume":"74","author":"C Boote","year":"2020","unstructured":"Boote, C. et al. Scleral structure and biomechanics. Prog Retin Eye Res 74, 100773. https:\/\/doi.org\/10.1016\/j.preteyeres.2019.100773 (2020).","journal-title":"Prog Retin Eye Res"},{"key":"8205_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ajo.2025.02.001","volume":"273","author":"MH Suh","year":"2025","unstructured":"Suh, M. H. et al. Optic disc microvasculature reduction and visual field progression in primary open-angle glaucoma. Am. J. Ophthalmol. 273, 43\u201355. https:\/\/doi.org\/10.1016\/j.ajo.2025.02.001 (2025).","journal-title":"Am. J. Ophthalmol."},{"issue":"11","key":"8205_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078867","volume":"8","author":"JB Jonas","year":"2013","unstructured":"Jonas, J. B., Holbach, L. & Panda-Jonas, S. Peripapillary arterial circle of Zinn-Haller: location and spatial relationships with myopia. PLoS ONE 8(11), e78867. https:\/\/doi.org\/10.1371\/journal.pone.0078867 (2013).","journal-title":"PLoS ONE"},{"key":"8205_CR28","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.2147\/opth.s415654","volume":"17","author":"Y Yamagata","year":"2023","unstructured":"Yamagata, Y. et al. Influence of trabeculectomy with mitomycin c on longitudinal changes in the visual field in glaucoma patients with high myopia. Clin. Ophthalmol. 17, 2413\u20132422. https:\/\/doi.org\/10.2147\/opth.s415654 (2023).","journal-title":"Clin. Ophthalmol."},{"issue":"10","key":"8205_CR29","doi-asserted-by":"publisher","first-page":"4170","DOI":"10.1167\/iovs.16-19564","volume":"57","author":"HY Park","year":"2016","unstructured":"Park, H. Y. et al. Effect of glaucoma surgery on the progression rate and pattern in glaucoma patients with myopia. Invest. Ophthalmol. Vis. Sci. 57(10), 4170\u20134179. https:\/\/doi.org\/10.1167\/iovs.16-19564 (2016).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"8205_CR30","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1016\/s0161-6420(98)91049-1","volume":"105","author":"RS Ayyala","year":"1998","unstructured":"Ayyala, R. S. et al. A clinical study of the Ahmed glaucoma valve implant in advanced glaucoma. Ophthalmology 105(10), 1968\u20131976. https:\/\/doi.org\/10.1016\/s0161-6420(98)91049-1 (1998).","journal-title":"Ophthalmology"},{"issue":"15","key":"8205_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/iovs.62.15.17","volume":"62","author":"H-YL Park","year":"2021","unstructured":"Park, H.-Y.L. et al. Microvasculature recovery detected using optical coherence tomography angiography and the rate of visual field progression after glaucoma surgery. Investig. Ophthalmol. Visual Sci. 62(15), 17\u201317. https:\/\/doi.org\/10.1167\/iovs.62.15.17 (2021).","journal-title":"Investig. Ophthalmol. Visual Sci."},{"issue":"1","key":"8205_CR32","doi-asserted-by":"publisher","first-page":"18503","DOI":"10.1038\/s41598-019-54882-9","volume":"9","author":"DY Shin","year":"2019","unstructured":"Shin, D. Y. et al. Association between peripapillary scleral deformation and choroidal microvascular circulation in glaucoma. Sci. Rep. 9(1), 18503. https:\/\/doi.org\/10.1038\/s41598-019-54882-9 (2019).","journal-title":"Sci. Rep."},{"key":"8205_CR33","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ajo.2018.05.027","volume":"192","author":"HL Park","year":"2018","unstructured":"Park, H. L., Jeon, S. J. & Park, C. K. Features of the choroidal microvasculature in peripapillary atrophy are associated with visual field damage in myopic patients. Am. J. Ophthalmol. 192, 206\u2013216. https:\/\/doi.org\/10.1016\/j.ajo.2018.05.027 (2018).","journal-title":"Am. J. Ophthalmol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08205-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08205-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08205-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T03:13:38Z","timestamp":1752203618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08205-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8205"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-08205-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]},"assertion":[{"value":"23 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25011"}}