{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:09:11Z","timestamp":1791925751818,"version":"4.3.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Special Project for Clinical and Basic Sci&Tech Innovation of Guangdong Medical University","award":["GDMULCJC2024112"],"award-info":[{"award-number":["GDMULCJC2024112"]}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023AFB409"],"award-info":[{"award-number":["2023AFB409"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Protein lactylation, a novel post-translational modification (PTM), has emerged as a critical factor in disease processes related to glycolysis and immune responses. However, its role in aortic dissection (AD) has yet to be thoroughly investigated. This study aimed to investigate the involvement of protein lactylation in AD and identify key lactylation-related genes as potential diagnostic biomarkers. Transcriptomic data from public databases were analyzed to identify differentially expressed lactylation-related genes in AD. Functional enrichment analyses were performed, and Weighted Gene Co-expression Network Analysis (WGCNA) was utilized to identify gene modules associated with AD. Machine learning methods, including LASSO and Random Forest, were employed to identify key diagnostic genes. Experimental validation was performed using human aortic tissues and an AD model. Bioinformatics analysis identified 11 lactylation-related differentially expressed genes (LR-DEGs) in AD. WGCNA and machine learning revealed two optimal feature genes, PGK1 and HMGA1, which were validated in an independent dataset and demonstrated high diagnostic accuracy (AUC: PGK1\u2009=\u20091, HMGA1\u2009=\u20090.94). Immune infiltration analysis indicated significant correlations between these genes and specific immune cell types, suggesting a role in immune regulation. Experimental validation in human and murine AD tissues confirmed the upregulation of PGK1 and HMGA1. This study underscores the importance of lactylation in the pathogenesis of AD and identifies PGK1 and HMGA1 as key biomarkers related to lactylation. These findings enhance our understanding of the metabolic and immune mechanisms involved in AD, thereby presenting new molecular targets for diagnosis and therapeutic intervention.<\/jats:p>","DOI":"10.1038\/s41598-025-08613-y","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T18:00:35Z","timestamp":1751392835000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lactylation associated biomarkers and immune infiltration in aortic dissection"],"prefix":"10.1038","volume":"15","author":[{"given":"Jianfeng","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjia","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sini","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"41","key":"8613_CR1","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"R Erbel","year":"2014","unstructured":"Erbel, R. et al. 2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The task force for the diagnosis and treatment of aortic diseases of the European society of cardiology (ESC). Eur. Heart J. 35 (41), 2873\u20132926. https:\/\/doi.org\/10.1093\/eurheartj\/ehu281 (2014).","journal-title":"Eur. Heart J."},{"key":"8613_CR2","doi-asserted-by":"publisher","first-page":"w14489","DOI":"10.4414\/smw.2017.14489","volume":"147","author":"J Gawinecka","year":"2017","unstructured":"Gawinecka, J., Schonrath, F. & von Eckardstein, A. Acute aortic dissection: pathogenesis, risk factors and diagnosis. Swiss Med. Wkly. 147, w14489. https:\/\/doi.org\/10.4414\/smw.2017.14489 (2017).","journal-title":"Swiss Med. Wkly."},{"key":"8613_CR3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.amjcard.2024.09.020","volume":"233","author":"CS Roberts","year":"2024","unstructured":"Roberts, C. S. & McCullough, K. A. Pros and cons of classification systems in aortic dissection. Am. J. Cardiol. 233, 62\u201364. https:\/\/doi.org\/10.1016\/j.amjcard.2024.09.020 (2024).","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"8613_CR4","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/1742-6723.14024","volume":"34","author":"J Slaven","year":"2022","unstructured":"Slaven, J., Evans, M., Partyka, C., Aneman, A. & Middleton, P. M. Characteristics, clinical findings and outcomes of acute aortic dissection: A comparison between an Australian emergency department and the international registry of acute aortic dissection. Emerg. Med. Australas. 34 (6), 927\u2013935. https:\/\/doi.org\/10.1111\/1742-6723.14024 (2022).","journal-title":"Emerg. Med. Australas"},{"issue":"4","key":"8613_CR5","doi-asserted-by":"publisher","first-page":"e13225","DOI":"10.1002\/emp2.13225","volume":"5","author":"B Briggs","year":"2024","unstructured":"Briggs, B. & Cline, D. Diagnosing aortic dissection: A review of this elusive, lethal diagnosis. J. Am. Coll. Emerg. Physicians Open. 5 (4), e13225. https:\/\/doi.org\/10.1002\/emp2.13225 (2024).","journal-title":"J. Am. Coll. Emerg. Physicians Open."},{"key":"8613_CR6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.avsg.2024.11.099","volume":"112","author":"O Borghese","year":"2024","unstructured":"Borghese, O., Vincenzoni, C., Nocerino, M., Mangiacotti, L. P. & Tshomba, Y. Conservative treatment of retrograde aortic dissection after endovascular or hybrid repair of descending aorta pathologies. Ann. Vasc Surg. 112, 63\u201370. https:\/\/doi.org\/10.1016\/j.avsg.2024.11.099 (2024).","journal-title":"Ann. Vasc Surg."},{"key":"8613_CR7","doi-asserted-by":"publisher","first-page":"104889","DOI":"10.1016\/j.jprot.2023.104889","volume":"280","author":"H Zhang","year":"2023","unstructured":"Zhang, H. et al. Global proteomic analysis reveals lysine succinylation contributes to the pathogenesis of aortic aneurysm and dissection. J. Proteom. 280, 104889. https:\/\/doi.org\/10.1016\/j.jprot.2023.104889 (2023).","journal-title":"J. Proteom."},{"issue":"1","key":"8613_CR8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41420-023-01560-5","volume":"9","author":"X Cheng","year":"2023","unstructured":"Cheng, X., Wang, K., Zhao, Y. & Wang, K. Research progress on post-translational modification of proteins and cardiovascular diseases. Cell. Death Discov. 9 (1), 275. https:\/\/doi.org\/10.1038\/s41420-023-01560-5 (2023).","journal-title":"Cell. Death Discov"},{"key":"8613_CR9","doi-asserted-by":"publisher","first-page":"113742","DOI":"10.1016\/j.intimp.2024.113742","volume":"145","author":"Y Wang","year":"2025","unstructured":"Wang, Y. et al. Ubiquitin-like modifier-activating enzyme 1 as a potential therapeutic target for aortic dissection. Int. Immunopharmacol. 145, 113742. https:\/\/doi.org\/10.1016\/j.intimp.2024.113742 (2025).","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"8613_CR10","doi-asserted-by":"publisher","first-page":"H999","DOI":"10.1152\/ajpheart.00488.2020","volume":"320","author":"V Dhagia","year":"2021","unstructured":"Dhagia, V. et al. G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases. Am. J. Physiol. Heart Circ. Physiol. 320 (3), H999\u2013H1016. https:\/\/doi.org\/10.1152\/ajpheart.00488.2020 (2021).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"39","key":"8613_CR11","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1093\/eurheartj\/ehae379","volume":"45","author":"X Li","year":"2024","unstructured":"Li, X. et al. TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation. Eur. Heart J. 45 (39), 4219\u20134235. https:\/\/doi.org\/10.1093\/eurheartj\/ehae379 (2024).","journal-title":"Eur. Heart J."},{"issue":"1","key":"8613_CR12","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41392-023-01605-2","volume":"8","author":"ZW Huang","year":"2023","unstructured":"Huang, Z. W. et al. STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia. Signal. Transduct. Target. Ther. 8 (1), 391. https:\/\/doi.org\/10.1038\/s41392-023-01605-2 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"8613_CR13","doi-asserted-by":"publisher","first-page":"1489438","DOI":"10.3389\/fcvm.2024.1489438","volume":"11","author":"H Zhang","year":"2024","unstructured":"Zhang, H. et al. Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets. Front. Cardiovasc. Med. 11, 1489438. https:\/\/doi.org\/10.3389\/fcvm.2024.1489438 (2024).","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"8613_CR14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41467-024-55165-2","volume":"16","author":"C Shao","year":"2025","unstructured":"Shao, C. et al. Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions. Nat. Commun. 16 (1), 227. https:\/\/doi.org\/10.1038\/s41467-024-55165-2 (2025).","journal-title":"Nat. Commun."},{"issue":"11","key":"8613_CR15","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1161\/CIRCRESAHA.123.323699","volume":"134","author":"W Ma","year":"2024","unstructured":"Ma, W. et al. Orphan nuclear receptor NR4A3 promotes vascular calcification via histone lactylation. Circul. Res. 134 (11), 1427\u20131447. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.323699 (2024).","journal-title":"Circul. Res."},{"issue":"47","key":"8613_CR16","doi-asserted-by":"publisher","first-page":"e2406184","DOI":"10.1002\/advs.202406184","volume":"11","author":"Y Xu","year":"2024","unstructured":"Xu, Y. et al. PKM2-Driven lactate overproduction triggers Endothelial-To-Mesenchymal transition in ischemic flap via mediating TWIST1 lactylation. Adv. Sci. (Weinh). 11 (47), e2406184. https:\/\/doi.org\/10.1002\/advs.202406184 (2024).","journal-title":"Adv. Sci. (Weinh)"},{"issue":"8","key":"8613_CR17","doi-asserted-by":"publisher","first-page":"e73","DOI":"10.1161\/CIRCRESAHA.124.325049","volume":"136","author":"YE Li","year":"2025","unstructured":"Li, Y. E. et al. March2 alleviates aortic aneurysm\/dissection by regulating PKM2 polymerization. Circ. Res. 136 (8), e73\u2013e93. https:\/\/doi.org\/10.1161\/CIRCRESAHA.124.325049 (2025).","journal-title":"Circ. Res."},{"key":"8613_CR18","doi-asserted-by":"publisher","unstructured":"Wang, J. et al. GMRSP encoded by LncRNA H19 regulates metabolic reprogramming and alleviates aortic dissection. Nat. Commun. 2025, 16(1):1719. https:\/\/doi.org\/10.1038\/s41467-025-57011-5","DOI":"10.1038\/s41467-025-57011-5"},{"issue":"21","key":"8613_CR19","doi-asserted-by":"publisher","first-page":"15908","DOI":"10.3390\/ijms242115908","volume":"24","author":"S Li","year":"2023","unstructured":"Li, S., Li, J., Cheng, W., He, W. & Dai, S. S. Independent and interactive roles of immunity and metabolism in aortic dissection. Int. J. Mol. Sci. 24 (21), 15908. https:\/\/doi.org\/10.3390\/ijms242115908 (2023).","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt 1","key":"8613_CR20","doi-asserted-by":"publisher","first-page":"128270","DOI":"10.1016\/j.ijbiomac.2023.128270","volume":"256","author":"CQ Xu","year":"2024","unstructured":"Xu, C. Q. et al. Sirtuins in macrophage immune metabolism: A novel target for cardiovascular disorders. Int. J. Biol. Macromol. 256 (Pt 1), 128270. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.128270 (2024).","journal-title":"Int. J. Biol. Macromol."},{"key":"8613_CR21","doi-asserted-by":"publisher","first-page":"989933","DOI":"10.3389\/fimmu.2022.989933","volume":"13","author":"AC Marquez-Sanchez","year":"2022","unstructured":"Marquez-Sanchez, A. C. & Koltsova, E. K. Immune and inflammatory mechanisms of abdominal aortic aneurysm. Front. Immunol. 13, 989933. https:\/\/doi.org\/10.3389\/fimmu.2022.989933 (2022).","journal-title":"Front. Immunol."},{"issue":"10","key":"8613_CR22","doi-asserted-by":"publisher","first-page":"114884","DOI":"10.1016\/j.celrep.2024.114884","volume":"43","author":"Y Zhang","year":"2024","unstructured":"Zhang, Y. et al. Macrophage MCT4 Inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation. Cell. Rep. 43 (10), 114884. https:\/\/doi.org\/10.1016\/j.celrep.2024.114884 (2024).","journal-title":"Cell. Rep."},{"key":"8613_CR23","doi-asserted-by":"publisher","first-page":"1395786","DOI":"10.3389\/fimmu.2024.1395786","volume":"15","author":"B Xu","year":"2024","unstructured":"Xu, B., Liu, Y., Li, N. & Geng, Q. Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues. Front. Immunol. 15, 1395786. https:\/\/doi.org\/10.3389\/fimmu.2024.1395786 (2024).","journal-title":"Front. Immunol."},{"issue":"2","key":"8613_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/biotech12020038","volume":"12","author":"Z Kozlakidis","year":"2023","unstructured":"Kozlakidis, Z., Shi, P., Abarbanel, G., Klein, C. & Sfera, A. Recent developments in protein lactylation in PTSD and CVD: novel strategies and targets. Biotech. (Basel (Switzerland)). 12 (2), 38. https:\/\/doi.org\/10.3390\/biotech12020038 (2023).","journal-title":"Biotech. (Basel (Switzerland))"},{"key":"8613_CR25","doi-asserted-by":"publisher","unstructured":"Cheng, Z. et al. Lactylation-Related gene signature effectively predicts prognosis and treatment responsiveness in hepatocellular carcinoma. Pharmaceuticals (Basel). 16 (5). https:\/\/doi.org\/10.3390\/ph16050644 (2023).","DOI":"10.3390\/ph16050644"},{"issue":"D1","key":"8613_CR26","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. & Ishiguro-Watanabe, M. KEGG: biological systems database as a model of the real world. Nucleic Acids Res. 53 (D1), D672\u2013D677. https:\/\/doi.org\/10.1093\/nar\/gkae909 (2025).","journal-title":"Nucleic Acids Res."},{"key":"8613_CR27","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward Understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"issue":"1","key":"8613_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28 (1), 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"issue":"13","key":"8613_CR29","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.7150\/ijbs.34888","volume":"15","author":"W Liu","year":"2019","unstructured":"Liu, W. et al. Obstructive sleep apnea syndrome promotes the progression of aortic dissection via a ROS-HIF-1alpha-MMPs associated pathway. Int. J. Biol. Sci. 15 (13), 2774\u20132782. https:\/\/doi.org\/10.7150\/ijbs.34888 (2019).","journal-title":"Int. J. Biol. Sci."},{"issue":"12","key":"8613_CR30","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.7150\/ijbs.85467","volume":"19","author":"Q Wang","year":"2023","unstructured":"Wang, Q. et al. Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications. Int. J. Biol. Sci. 19 (12), 3869\u20133891. https:\/\/doi.org\/10.7150\/ijbs.85467 (2023).","journal-title":"Int. J. Biol. Sci."},{"key":"8613_CR31","doi-asserted-by":"publisher","first-page":"102631","DOI":"10.1016\/j.arr.2024.102631","volume":"104","author":"Z Liao","year":"2024","unstructured":"Liao, Z., Chen, B., Yang, T., Zhang, W. & Mei, Z. Lactylation modification in cardio-cerebral diseases: A state-of-the-art review. Ageing Res. Rev. 104, 102631. https:\/\/doi.org\/10.1016\/j.arr.2024.102631 (2024).","journal-title":"Ageing Res. Rev."},{"key":"8613_CR32","doi-asserted-by":"publisher","unstructured":"Chen, A. N. et al. Lactylation, a novel metabolic reprogramming code: current status and prospects. Front. Immunol. 2021, 12:688910. https:\/\/doi.org\/10.3389\/fimmu.2021.688910","DOI":"10.3389\/fimmu.2021.688910"},{"key":"8613_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-024-01408-0","author":"W Weng","year":"2024","unstructured":"Weng, W. et al. Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury. Cell. Death Differ. https:\/\/doi.org\/10.1038\/s41418-024-01408-0 (2024).","journal-title":"Cell. Death Differ."},{"issue":"1","key":"8613_CR34","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/s41467-023-44121-1","volume":"15","author":"F Merkuri","year":"2024","unstructured":"Merkuri, F., Rothstein, M. & Simoes-Costa, M. Histone lactylation couples cellular metabolism with developmental gene regulatory networks. Nat. Commun. 15 (1), 90. https:\/\/doi.org\/10.1038\/s41467-023-44121-1 (2024).","journal-title":"Nat. Commun."},{"key":"8613_CR35","doi-asserted-by":"publisher","unstructured":"Feng, X. et al. Lactate dehydrogenase A is a novel positive regulator of vascular smooth muscle cell ferroptosis during aortic dissection. Antioxid Redox Signal 2024. https:\/\/doi.org\/10.1089\/ars.2024.0585","DOI":"10.1089\/ars.2024.0585"},{"issue":"10","key":"8613_CR36","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.7150\/ijms.97185","volume":"21","author":"M Tang","year":"2024","unstructured":"Tang, M., Wang, M., Wang, Z. & Jiang, B. RBM15 activates Glycolysis in M1-type macrophages to promote the progression of aortic aneurysm and dissection. Int. J. Med. Sci. 21 (10), 1976\u20131989. https:\/\/doi.org\/10.7150\/ijms.97185 (2024).","journal-title":"Int. J. Med. Sci."},{"key":"8613_CR37","doi-asserted-by":"publisher","first-page":"117863","DOI":"10.1016\/j.lfs.2020.117863","volume":"256","author":"Q Fu","year":"2020","unstructured":"Fu, Q. & Yu, Z. Phosphoglycerate kinase 1 (PGK1) in cancer: A promising target for diagnosis and therapy. Life Sci. 256, 117863. https:\/\/doi.org\/10.1016\/j.lfs.2020.117863 (2020).","journal-title":"Life Sci."},{"issue":"1","key":"8613_CR38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41420-024-01898-4","volume":"10","author":"S Wei","year":"2024","unstructured":"Wei, S. et al. Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K\/AKT\/HIF-1alpha signal pathway in endometrial carcinoma. Cell. Death Discov. 10 (1), 121. https:\/\/doi.org\/10.1038\/s41420-024-01898-4 (2024).","journal-title":"Cell. Death Discov"},{"key":"8613_CR39","doi-asserted-by":"publisher","unstructured":"Pan, C. H. et al. Pathological role of phosphoglycerate kinase 1 in balloon Angioplasty-Induced Neointima formation. Int. J. Mol. Sci. 22 (16). https:\/\/doi.org\/10.3390\/ijms22168822 (2021).","DOI":"10.3390\/ijms22168822"},{"issue":"11","key":"8613_CR40","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.7150\/ijbs.72952","volume":"18","author":"L Wang","year":"2022","unstructured":"Wang, L. et al. High mobility group A1 (HMGA1): structure, biological function, and therapeutic potential. Int. J. Biol. Sci. 18 (11), 4414\u20134431. https:\/\/doi.org\/10.7150\/ijbs.72952 (2022).","journal-title":"Int. J. Biol. Sci."},{"issue":"10","key":"8613_CR41","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.7150\/jca.89056","volume":"15","author":"Y Ma","year":"2024","unstructured":"Ma, Y., Ma, X., Du, B., Li, X. & Li, Y. HMGA1 is a prognostic biomarker and correlated with Glycolysis in lung adenocarcinoma. J. Cancer. 15 (10), 2913\u20132927. https:\/\/doi.org\/10.7150\/jca.89056 (2024).","journal-title":"J. Cancer"},{"key":"8613_CR42","doi-asserted-by":"publisher","first-page":"4727198","DOI":"10.1155\/2022\/4727198","volume":"2022","author":"J Chen","year":"2022","unstructured":"Chen, J. et al. HMGA1 promotes macrophage recruitment via activation of NF-kappaB-CCL2 signaling in hepatocellular carcinoma. J. Immunol. Res. 2022, 4727198. https:\/\/doi.org\/10.1155\/2022\/4727198 (2022).","journal-title":"J. Immunol. Res."},{"issue":"20","key":"8613_CR43","doi-asserted-by":"publisher","first-page":"11268","DOI":"10.18632\/aging.205126","volume":"15","author":"K Feng","year":"2023","unstructured":"Feng, K. et al. Integrated bulk and ScRNA sequence identified anoikis-related diagnostic biomarkers and potential association with immune infiltration in type A aortic dissection. Aging (Albany NY). 15 (20), 11268\u201311285. https:\/\/doi.org\/10.18632\/aging.205126 (2023).","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"8613_CR44","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.devcel.2023.11.018","volume":"59","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development. Dev. Cell. 59 (1), 108\u2013124e7. https:\/\/doi.org\/10.1016\/j.devcel.2023.11.018 (2024).","journal-title":"Dev. Cell."},{"key":"8613_CR45","doi-asserted-by":"publisher","unstructured":"Li, T. et al. Cancer-Associated fibroblasts foster a High-Lactate microenvironment to drive perineural invasion in pancreatic Cancer. Cancer Res. 26 https:\/\/doi.org\/10.1158\/0008-5472.CAN-24-3173 (2025).","DOI":"10.1158\/0008-5472.CAN-24-3173"},{"key":"8613_CR46","doi-asserted-by":"publisher","first-page":"1513806","DOI":"10.3389\/fimmu.2025.1513806","volume":"16","author":"F Ren","year":"2025","unstructured":"Ren, F. et al. Integration of scRNA-seq and bulk RNA-seq to reveal the association and potential molecular mechanisms of metabolic reprogramming regulated by lactylation and chemotherapy resistance in ovarian cancer. Front. Immunol. 16, 1513806. https:\/\/doi.org\/10.3389\/fimmu.2025.1513806 (2025).","journal-title":"Front. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08613-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08613-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08613-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T18:00:36Z","timestamp":1751392836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-08613-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8613"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-08613-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"18 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21536"}}