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To address this issue, this work aims to identify a stable subset of radiomics features in prostate MRI for radiomics modelling. A prospective study was conducted in 43 patients who received a clinical MRI examination and a research exam with repetition of T2-weighted and two different diffusion-weighted imaging (DWI) sequences with repositioning in between. Radiomics feature (RF) extraction was performed from MRI segmentations accounting for intra-rater and inter-rater effects, and three different image normalization methods were compared. Stability of RFs was assessed using the concordance correlation coefficient (CCC) for different comparisons: rater effects, inter-scan (before and after repositioning) and inter-sequence (between the two diffusion-weighted sequences) variability. In total, only 64 out of 321 (~\u200920%) extracted features demonstrated stability, defined as CCC\u2009\u2265\u20090.75 in all settings (5 high-b value, 7 ADC- and 52 T2-derived features). For DWI, primarily intensity-based features proved stable with no shape feature passing the CCC threshold. T2-weighted images possessed the largest number of stable features with multiple shape (7), intensity-based (7) and texture features (28). Z-score normalization for high-b value images and muscle-normalization for T2-weighted images were identified as suitable.<\/jats:p>","DOI":"10.1038\/s41598-025-09989-7","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T13:54:00Z","timestamp":1755093240000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In vivo variability of MRI radiomics features in prostate lesions assessed by a test-retest study with repositioning"],"prefix":"10.1038","volume":"15","author":[{"given":"Kevin Sun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Jan Oliver","family":"Neelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Wennmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hielscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balint","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip Alexander","family":"Glemser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"G\u00f6rtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Stenzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus H.","family":"Maier-Hein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz-Peter","family":"Schlemmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bonekamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"9989_CR1","doi-asserted-by":"publisher","first-page":"4006","DOI":"10.1038\/ncomms5006","volume":"5","author":"HJ Aerts","year":"2014","unstructured":"Aerts, H. 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