{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:53:46Z","timestamp":1787064826183,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-10034-w","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T05:06:40Z","timestamp":1751951200000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In-vitro antimicrobial activity of Jatropha variegata Vahl. (Euphorbiaceae) against some pathogenic microbes isolated from clinical samples in Ibb City, Yemen"],"prefix":"10.1038","volume":"15","author":[{"given":"Abeer","family":"Esmail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Alakhshar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esam","family":"Aqlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashar","family":"Atef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turki","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othman","family":"Al-parah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakil","family":"Alashmali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radwan","family":"Almshrqyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montaser","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouath","family":"Qasim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmaldyn","family":"Alnsyry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"issue":"21","key":"10034_CR1","doi-asserted-by":"publisher","first-page":"7532","DOI":"10.3390\/molecules27217532","volume":"27","author":"AS Nugraha","year":"2022","unstructured":"Nugraha, A. S. et al. Phytochemistry and pharmacology of medicinal plants used by the Tenggerese society in Java Island of Indonesia. Molecules 27 (21), 7532 (2022).","journal-title":"Molecules"},{"issue":"4","key":"10034_CR2","first-page":"107","volume":"6","author":"S Hussein","year":"2018","unstructured":"Hussein, S. Ethnobotanical of Euphorbiaceae used in Hajjah district-Republic of Yemen. J. Med. Plants Stud. 6 (4), 107\u2013109 (2018).","journal-title":"J. Med. Plants Stud."},{"key":"10034_CR3","doi-asserted-by":"publisher","first-page":"108976","DOI":"10.1016\/j.cbi.2020.108976","volume":"318","author":"NB Cavalcante","year":"2020","unstructured":"Cavalcante, N. B., da Concei\u00e7\u00e3o Santos, A. D. & da Silva Almeida, J. R. G. The genus Jatropha (Euphorbiaceae): A review on secondary chemical metabolites and biological aspects. Chemico-Biol. Interact. 318, 108976 (2020).","journal-title":"Chemico-Biol. Interact."},{"key":"10034_CR4","volume-title":"Jatropha Challenges for a New Energy Crop","author":"B Bahadur","year":"2012","unstructured":"Bahadur, B., Sujatha, M., &  Carels, N. Jatropha Challenges for a New Energy Crop (Springer, Cham, 2012)."},{"key":"10034_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-1-4614-4915-7_11","volume-title":"Jatropha, Challenges for a New Energy Crop: Volume 2: Genetic Improvement and Biotechnology","author":"T Pullaiah","year":"2013","unstructured":"Pullaiah, T. & Bahadur, B. Economic and medicinal importance of Jatrophas. In Jatropha, Challenges for a New Energy Crop: Volume 2: Genetic Improvement and Biotechnology. 187\u2013217 (Springer, Cham, 2013)."},{"issue":"2","key":"10034_CR6","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3390\/plants11020218","volume":"11","author":"EA Mahrous","year":"2022","unstructured":"Mahrous, E. A., Elosaily, A. H., Salama, A. A., Salama, A. M. & El-Zalabani, S. M. Oral and topical anti-Inflammatory activity of Jatropha integerrima leaves extract in relation to its metabolite profile. Plants 11 (2), 218 (2022).","journal-title":"Plants"},{"key":"10034_CR7","first-page":"48","volume":"4","author":"S Jonathan","year":"2012","unstructured":"Jonathan, S., Udoh, E., Ojomo, E., Olawuyi, O. & Babalola, B. Efficacy of Jatropha curcas linn. As fungicides in the control of ceratocystis paradoxa (Chalara anamorph) IMI 501775 associated with bole rot of Cocos nucifera linn. Seedlings.  Rep. Opin. Nat. Sci. 4, 48\u201360 (2012).","journal-title":"Nat. Sci."},{"key":"10034_CR8","first-page":"287","volume":"6","author":"AK Alzomor","year":"2020","unstructured":"Alzomor, A. K., Sallam, N. M., Al-Fotaihy, S. A., Al-Moliki, B. & Al-Zohairy, B. A. Antibacterial and wound healing activities of topical gel of Jatropha variegata Vahl extract in rats. Pharm. Biom. Res. 6, 287 (2020).","journal-title":"Pharm. Biom. Res."},{"key":"10034_CR9","unstructured":"Al-Khulaidi, A. Flora of Yemen. The Sustainable Natural Resource Management Project (SNRMP II) EPA and UNDP. Republic of Yemen; Environ; 2013. (2013)."},{"issue":"12","key":"10034_CR10","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.3923\/pjbs.2020.1581.1590","volume":"23","author":"T Al-Maqtari","year":"2020","unstructured":"Al-Maqtari, T., Al-Doaiss, A. Antioxidant antimicrobial and wound healing potential of Jatropha variegata\u2013an interesting plant endemic to Yemen. Pak. J. Biol. Sci. PJBS. 23 (12), 1581\u20131590 (2020).","journal-title":"Pakistan J. Biol. Sciences: PJBS"},{"key":"10034_CR11","doi-asserted-by":"publisher","first-page":"1365526","DOI":"10.1155\/2022\/1365526","volume":"2022","author":"WT Alhaj","year":"2022","unstructured":"Alhaj, W. T., Moharram, B. A., Al-Maqtari, T., Al-Mahbashi, H. M. & Al-Doaiss, A. A. The potential of jatropha variegata fruits as a natural contraceptive: Antifertility activity and phytochemical analysis. Evidence-Based Complement. Altern. Med. 2022, 1365526 (2022).","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"1","key":"10034_CR12","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/prac.19953370109","volume":"337","author":"M Masaoud","year":"1995","unstructured":"Masaoud, M., Ripperger, H., Porzel, A. & Adam, G. Flavonol glycosides from Jatropha variegata. J. F\u00fcr Praktische Chemie\/Chemiker-Zeitung 337 (1), 43\u201345 (1995).","journal-title":"J. F\u00fcr Praktische Chemie\/Chemiker-Zeitung"},{"issue":"3","key":"10034_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1093\/ecam\/nen004","volume":"7","author":"RA Mothana","year":"2010","unstructured":"Mothana, R. A. et al. Antimicrobial, antioxidant and cytotoxic activities and phytochemical screening of some Yemeni medicinal plants. Evidence-based Complement. Altern. Med. 7 (3), 323\u2013330 (2010).","journal-title":"Evidence-based Complement. Altern. Med."},{"issue":"2","key":"10034_CR14","first-page":"1","volume":"4","author":"RH Alasbahi","year":"2012","unstructured":"Alasbahi, R. H. Evaluation of the antibacterial activity of some Yemeni Euphorbiaceae species. Sana\u2019a Univ. J. Med. Sci. 4 (2), 1\u20139 (2012).","journal-title":"Sana\u2019a Univ. J. Med. Sci."},{"key":"10034_CR15","doi-asserted-by":"publisher","first-page":"6225","DOI":"10.2147\/IDR.S366063","volume":"15","author":"T Dilbato Dinbiso","year":"2022","unstructured":"Dilbato Dinbiso, T. et al. Antimicrobial activity of selected ethnoveterinary medicinal plants of Southern region, Ethiopia. Infect. Drug Resist. 15, 6225\u20136235 (2022).","journal-title":"Infect. Drug Resist."},{"issue":"7","key":"10034_CR16","first-page":"2770","volume":"4","author":"G Visweswari","year":"2013","unstructured":"Visweswari, G., Christopher, R. & Rajendra, W. Phytochemical screening of active secondary metabolites present in Withania somnifera root: Role in traditional medicine. Int. J. Pharm. Sci. Res. 4 (7), 2770 (2013).","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10034_CR17","first-page":"5","volume":"2","author":"J Herborne","year":"1973","unstructured":"Herborne, J. Phytochemical methods. Guide Mod. Tech. Plant. Anal. 2, 5\u201311 (1973).","journal-title":"Guide Mod. Techniques Plant. Anal."},{"key":"10034_CR18","first-page":"1","volume-title":"Trease and Evans\u2019 Pharmacognosy","author":"WC Evans","year":"2009","unstructured":"Evans, W. C. Trease and Evans\u2019 Pharmacognosy 16th edn 1\u2013603 (Elsevier,  Amsterdam, 2009).","edition":"16"},{"key":"10034_CR19","doi-asserted-by":"publisher","DOI":"10.59317\/9789390083404","volume-title":"Phytochemical Techniques","author":"N Raaman","year":"2006","unstructured":"Raaman, N. Phytochemical Techniques (New India Publishing Agency, New Delhi, 2006)."},{"key":"10034_CR20","volume-title":"Bergey\u2019s Manual of Determinative Bacteriology","author":"D Bergey","year":"2000","unstructured":"Bergey, D. & Holt, J. Bergey\u2019s Manual of Determinative Bacteriology 9th edn (Lippincott Williams & Wilkins, Philadelphia, PA, 2000).","edition":"9"},{"key":"10034_CR21","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199581368.001.0001","volume-title":"Antibacterial Chemotherapy Theory, Problems and Practice","author":"SGB Amyes","year":"2010","unstructured":"Amyes, S. G. B. Antibacterial Chemotherapy Theory, Problems and Practice Vol. 93 (Oxford University Press, Oxford, 2010)."},{"key":"10034_CR22","doi-asserted-by":"publisher","first-page":"07","DOI":"10.1590\/S0102-695X2010000100003","volume":"20","author":"P Kumar","year":"2010","unstructured":"Kumar, P. & Bilakanti, L. Pharmacognostical studies on tubers of Momordica tuberosa cogn., Cucurbitaceae. Revi. Bras. Farmacogn. 20, 07\u201311 (2010).","journal-title":"Revista Brasileira De Farmacognosia"},{"key":"10034_CR23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.phytochem.2012.10.009","volume":"85","author":"CW Sabandar","year":"2013","unstructured":"Sabandar, C. W., Ahmat, N., Jaafar, F. M. & Sahidin, I. Medicinal property, phytochemistry and Pharmacology of several Jatropha species (Euphorbiaceae): A review. Phytochemistry 85, 7\u201329 (2013).","journal-title":"Phytochemistry"},{"key":"10034_CR24","doi-asserted-by":"publisher","first-page":"351","DOI":"10.52756\/ijerr.2024.v42.031","volume":"42","author":"S Chakrabarty","year":"2024","unstructured":"Chakrabarty, S., Swain, S. S., & Mishra, M. P. Quantitative phytochemical investigation, antibacterial potency, and drug-ability assessment of three Indian medicinal plants leaf extracts using bioinformatics tools. Int. J. Exp. Res. Rev. 42, 351\u2013364 (2024).","journal-title":"Int. J. Experimental Res. Rev."},{"key":"10034_CR25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jksus.2015.05.007","volume":"29","author":"MP Mishra","year":"2017","unstructured":"Mishra, M. P. et al. In vitro antibacterial activity of crude extracts of 9 selected medicinal plants against UTI causing MDR bacteria. J. King Saud Univ. Sci. 29, 84\u201395 (2017).","journal-title":"J. King Saud Univ. Sci."},{"key":"10034_CR26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1155\/2020\/8509650","volume":"2020","author":"ME Prastiyanto","year":"2020","unstructured":"Prastiyanto, M. E., Tama, P. D., Ananda, N., Wilson, W. & Mukaromah, A. H. Antibacterial potential of Jatropha sp. Latex against multidrug-resistant bacteria. Int. J. Microbiol., 2020, 6 (2020).","journal-title":"Int. J. Microbiol."},{"issue":"4","key":"10034_CR27","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1056\/NEJMp1215093","volume":"368","author":"B Spellberg","year":"2013","unstructured":"Spellberg, B., Bartlett, J. G. & Gilbert, D. N. The future of antibiotics and resistance. N. Engl. J. Med. 368 (4), 299\u2013302 (2013).","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10034_CR28","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.cmi.2015.06.007","volume":"21","author":"A Muller","year":"2015","unstructured":"Muller, A., Theuretzbacher, U. & Mouton, J. Use of old antibiotics now and in the future from a pharmacokinetic\/pharmacodynamic perspective. Clin. Microbiol. Infect. 21 (10), 881\u2013885 (2015).","journal-title":"Clin. Microbiol. Infect."}],"updated-by":[{"DOI":"10.1038\/s41598-025-22879-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10034-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10034-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10034-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T13:17:52Z","timestamp":1759843072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10034-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10034"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-10034-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]},"assertion":[{"value":"30 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-025-22879-2","URL":"https:\/\/doi.org\/10.1038\/s41598-025-22879-2","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All authors have reviewed and approved the final manuscript and consented to its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"24409"}}