{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:07:44Z","timestamp":1793070464311,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Beijing-Tianjin-Hebei Basic Research Cooperation Project","award":["19JCZDJC64400"],"award-info":[{"award-number":["19JCZDJC64400"]}]},{"name":"the Tianjin Northern Medicine Development Foundation","award":["TJNMDF2020ZD-01"],"award-info":[{"award-number":["TJNMDF2020ZD-01"]}]},{"name":"the Tianjin Natural Science Foundation of Key Program","award":["19JCZDJC35500"],"award-info":[{"award-number":["19JCZDJC35500"]}]},{"name":"Tianjin Medical University General Hospital Clinical Research Program","award":["22ZYYLCCG08"],"award-info":[{"award-number":["22ZYYLCCG08"]}]},{"name":"the Tianjin Natural Science Foundation of Youth Program","award":["19JCQNJC12000"],"award-info":[{"award-number":["19JCQNJC12000"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-10055-5","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T19:47:59Z","timestamp":1751658479000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of regulatory B cell\/T follicular helper cell balance in thymoma and thymoma-associated myasthenia gravis"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-0225","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZiYou","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuning","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"issue":"3","key":"10055_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/14737175.2017.1241144","volume":"17","author":"J-I Lee","year":"2017","unstructured":"Lee, J.-I. & Jander, S. Myasthenia gravis: recent advances in immunopathology and therapy. Expert Rev. Neurother. 17(3), 287\u2013299. https:\/\/doi.org\/10.1080\/14737175.2017.1241144 (2017).","journal-title":"Expert Rev. Neurother."},{"issue":"1","key":"10055_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/nyas.14195","volume":"1452","author":"X-J Cai","year":"2019","unstructured":"Cai, X.-J. et al. Myasthenia gravis and specific immunotherapy: monoclonal antibodies. Ann. N. Y. Acad. Sci. 1452(1), 18\u201333. https:\/\/doi.org\/10.1111\/nyas.14195 (2019).","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10055_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/s1474-4422(21)00297-0","volume":"21","author":"AR Punga","year":"2022","unstructured":"Punga, A. R., Maddison, P., Heckmann, J. M., Guptill, J. T. & Evoli, A. Epidemiology, diagnostics, and biomarkers of autoimmune neuromuscular junction disorders. Lancet Neurol. 21(2), 176\u2013188. https:\/\/doi.org\/10.1016\/s1474-4422(21)00297-0 (2022).","journal-title":"Lancet Neurol."},{"key":"10055_CR4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev-immunol-120419-022408","volume":"40","author":"GD Victora","year":"2022","unstructured":"Victora, G. D. & Nussenzweig, M. C. Germinal centers. Annu. Rev. Immunol. 40, 413\u2013442. https:\/\/doi.org\/10.1146\/annurev-immunol-120419-022408 (2022).","journal-title":"Annu. Rev. Immunol."},{"issue":"9","key":"10055_CR5","doi-asserted-by":"publisher","first-page":"114677","DOI":"10.1016\/j.celrep.2024.114677","volume":"43","author":"Y Yasumizu","year":"2024","unstructured":"Yasumizu, Y. et al. Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma. Cell Rep. 43(9), 114677. https:\/\/doi.org\/10.1016\/j.celrep.2024.114677 (2024).","journal-title":"Cell Rep."},{"key":"10055_CR6","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.3389\/fimmu.2019.02116","volume":"10","author":"T Arulraj","year":"2019","unstructured":"Arulraj, T., Binder, S. C., Robert, P. A. & Meyer-Hermann, M. Synchronous germinal center onset impacts the efficiency of antibody responses. Front. Immunol. 10, 2116. https:\/\/doi.org\/10.3389\/fimmu.2019.02116 (2019).","journal-title":"Front. Immunol."},{"issue":"1","key":"10055_CR7","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1038\/s41598-024-53250-6","volume":"14","author":"P Zhang","year":"2024","unstructured":"Zhang, P. et al. Distribution of multi-level B cell subsets in thymoma and thymoma-associated myasthenia gravis. Sci. Rep. 14(1), 2674. https:\/\/doi.org\/10.1038\/s41598-024-53250-6 (2024).","journal-title":"Sci. Rep."},{"key":"10055_CR8","doi-asserted-by":"publisher","DOI":"10.1212\/nxi.0000000000001087","author":"Y Yamamoto","year":"2021","unstructured":"Yamamoto, Y. et al. Intrathymic plasmablasts are affected in patients with myasthenia gravis with active disease. Neurol. Neuroimmunol. Neuroinflamm. https:\/\/doi.org\/10.1212\/nxi.0000000000001087 (2021).","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"issue":"1","key":"10055_CR9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s12035-014-8985-1","volume":"53","author":"X Zhang","year":"2016","unstructured":"Zhang, X. et al. Intrathymic Tfh\/B cells interaction leads to ectopic GCs formation and anti-AChR antibody production: central role in triggering MG occurrence. Mol. Neurobiol. 53(1), 120\u2013131. https:\/\/doi.org\/10.1007\/s12035-014-8985-1 (2016).","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10055_CR10","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.immuni.2019.04.011","volume":"50","author":"S Crotty","year":"2019","unstructured":"Crotty, S. T follicular helper cell biology: a decade of discovery and diseases. Immunity 50(5), 1132\u20131148. https:\/\/doi.org\/10.1016\/j.immuni.2019.04.011 (2019).","journal-title":"Immunity"},{"issue":"6","key":"10055_CR11","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nri3447","volume":"13","author":"SG Tangye","year":"2013","unstructured":"Tangye, S. G., Ma, C. S., Brink, R. & Deenick, E. K. The good, the bad and the ugly\u2014TFH cells in human health and disease. Nat. Rev. Immunol. 13(6), 412\u2013426. https:\/\/doi.org\/10.1038\/nri3447 (2013).","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10055_CR12","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/imr.12747","volume":"288","author":"Z Wan","year":"2019","unstructured":"Wan, Z., Lin, Y., Zhao, Y. & Qi, H. T cells in bystander and cognate interactions with B cells. Immunol. Rev. 288(1), 28\u201336. https:\/\/doi.org\/10.1111\/imr.12747 (2019).","journal-title":"Immunol. Rev."},{"key":"10055_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.08.003","author":"D Liu","year":"2021","unstructured":"Liu, D. et al. BCL6 controls contact-dependent help delivery during follicular T-B cell interactions. Immunity https:\/\/doi.org\/10.1016\/j.immuni.2021.08.003 (2021).","journal-title":"Immunity"},{"key":"10055_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.808322","volume":"13","author":"Y Lin","year":"2022","unstructured":"Lin, Y. et al. Regulatory B cells are decreased and functionally impaired in myasthenia gravis patients. Front. Neurol. 13, 808322. https:\/\/doi.org\/10.3389\/fneur.2022.808322 (2022).","journal-title":"Front. Neurol."},{"key":"10055_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.611795","volume":"12","author":"D Catal\u00e1n","year":"2021","unstructured":"Catal\u00e1n, D. et al. Immunosuppressive mechanisms of regulatory B cells. Front. Immunol. 12, 611795. https:\/\/doi.org\/10.3389\/fimmu.2021.611795 (2021).","journal-title":"Front. Immunol."},{"issue":"12","key":"10055_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101189","volume":"6","author":"N Petriv","year":"2024","unstructured":"Petriv, N. et al. Essential roles of B cell subsets in the progression of MASLD and HCC. JHEP Rep. 6(12), 101189. https:\/\/doi.org\/10.1016\/j.jhepr.2024.101189 (2024).","journal-title":"JHEP Rep."},{"key":"10055_CR17","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jneuroim.2015.10.023","volume":"289","author":"JR Sheng","year":"2015","unstructured":"Sheng, J. R., Quan, S. & Soliven, B. IL-10 derived from CD1dhiCD5\u207a B cells regulates experimental autoimmune myasthenia gravis. J. Neuroimmunol. 289, 130\u2013138. https:\/\/doi.org\/10.1016\/j.jneuroim.2015.10.023 (2015).","journal-title":"J. Neuroimmunol."},{"key":"10055_CR18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/fneur.2017.00034","volume":"8","author":"JS Yi","year":"2017","unstructured":"Yi, J. S. et al. B10 cell frequencies and suppressive capacity in myasthenia gravis are associated with disease severity. Front. Neurol. 8, 34. https:\/\/doi.org\/10.3389\/fneur.2017.00034 (2017).","journal-title":"Front. Neurol."},{"issue":"12","key":"10055_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109286","volume":"35","author":"NR Mathew","year":"2021","unstructured":"Mathew, N. R. et al. Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells. Cell Rep. 35(12), 109286. https:\/\/doi.org\/10.1016\/j.celrep.2021.109286 (2021).","journal-title":"Cell Rep."},{"issue":"2","key":"10055_CR20","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jtho.2021.10.010","volume":"17","author":"A Marx","year":"2022","unstructured":"Marx, A. et al. The 2021 WHO classification of tumors of the thymus and mediastinum: what is new in thymic epithelial, germ cell, and mesenchymal tumors?. J. Thorac. Oncol. 17(2), 200\u2013213. https:\/\/doi.org\/10.1016\/j.jtho.2021.10.010 (2022).","journal-title":"J. Thorac. Oncol."},{"issue":"2","key":"10055_CR21","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.ccell.2018.01.003","volume":"33","author":"M Radovich","year":"2018","unstructured":"Radovich, M. et al. The integrated genomic landscape of thymic epithelial tumors. Cancer Cell 33(2), 244-258.e10. https:\/\/doi.org\/10.1016\/j.ccell.2018.01.003 (2018).","journal-title":"Cancer Cell"},{"key":"10055_CR22","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba2429","author":"JFAP Miller","year":"2020","unstructured":"Miller, J. F. A. P. The function of the thymus and its impact on modern medicine. Science https:\/\/doi.org\/10.1126\/science.aba2429 (2020).","journal-title":"Science"},{"issue":"1","key":"10055_CR23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41467-017-00452-4","volume":"8","author":"R Somasundaram","year":"2017","unstructured":"Somasundaram, R. et al. Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Nat. Commun. 8(1), 607. https:\/\/doi.org\/10.1038\/s41467-017-00452-4 (2017).","journal-title":"Nat. Commun."},{"issue":"8","key":"10055_CR24","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.4049\/jimmunol.1003050","volume":"186","author":"S Garaud","year":"2011","unstructured":"Garaud, S. et al. CD5 promotes IL-10 production in chronic lymphocytic leukemia B cells through STAT3 and NFAT2 activation. J. Immunol. 186(8), 4835\u20134844. https:\/\/doi.org\/10.4049\/jimmunol.1003050 (2011).","journal-title":"J. Immunol."},{"issue":"11","key":"10055_CR25","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.autrev.2012.02.007","volume":"11","author":"RA Mageed","year":"2012","unstructured":"Mageed, R. A. et al. CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte. Autoimmun. Rev. 11(11), 795\u2013798. https:\/\/doi.org\/10.1016\/j.autrev.2012.02.007 (2012).","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"10055_CR26","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.4049\/jimmunol.1401805","volume":"193","author":"MS Chaudhry","year":"2014","unstructured":"Chaudhry, M. S. & Karadimitris, A. Role and regulation of CD1d in normal and pathological B cells. J. Immunol. 193(10), 4761\u20134768. https:\/\/doi.org\/10.4049\/jimmunol.1401805 (2014).","journal-title":"J. Immunol."},{"key":"10055_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.oraloncology.2015.11.003","volume":"53","author":"X Zhou","year":"2016","unstructured":"Zhou, X., Su, Y.-X., Lao, X.-M., Liang, Y.-J. & Liao, G.-Q. CD19(+)IL-10(+) regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4(+) T cells to CD4(+)Foxp3(+) regulatory T cells. Oral Oncol. 53, 27\u201335. https:\/\/doi.org\/10.1016\/j.oraloncology.2015.11.003 (2016).","journal-title":"Oral Oncol."},{"key":"10055_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.biocel.2014.10.005","volume":"57","author":"S Han","year":"2014","unstructured":"Han, S. et al. Glioma cell-derived placental growth factor induces regulatory B cells. Int. J. Biochem. Cell Biol. 57, 63\u201368. https:\/\/doi.org\/10.1016\/j.biocel.2014.10.005 (2014).","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"5","key":"10055_CR29","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1158\/2159-8290.CD-15-1408","volume":"6","author":"X Xiao","year":"2016","unstructured":"Xiao, X. et al. PD-1hi identifies a novel regulatory B-cell population in human hepatoma that promotes disease progression. Cancer Discov. 6(5), 546\u2013559. https:\/\/doi.org\/10.1158\/2159-8290.CD-15-1408 (2016).","journal-title":"Cancer Discov."},{"key":"10055_CR30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1146\/annurev-immunol-101220-015603","volume":"40","author":"SM Downs-Canner","year":"2022","unstructured":"Downs-Canner, S. M., Meier, J., Vincent, B. G. & Serody, J. S. B cell function in the tumor microenvironment. Annu. Rev. Immunol. 40, 169\u2013193. https:\/\/doi.org\/10.1146\/annurev-immunol-101220-015603 (2022).","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10055_CR31","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.immuni.2009.11.009","volume":"32","author":"PA Blair","year":"2010","unstructured":"Blair, P. A. et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 32(1), 129\u2013140. https:\/\/doi.org\/10.1016\/j.immuni.2009.11.009 (2010).","journal-title":"Immunity"},{"issue":"10","key":"10055_CR32","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1172\/JCI36030","volume":"118","author":"T Matsushita","year":"2008","unstructured":"Matsushita, T., Yanaba, K., Bouaziz, J.-D., Fujimoto, M. & Tedder, T. F. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J. Clin. Investig. 118(10), 3420\u20133430. https:\/\/doi.org\/10.1172\/JCI36030 (2008).","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10055_CR33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00281-021-00842-3","volume":"43","author":"A Marx","year":"2021","unstructured":"Marx, A. et al. Thymus and autoimmunity. Semin. Immunopathol. 43(1), 45\u201364. https:\/\/doi.org\/10.1007\/s00281-021-00842-3 (2021).","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10055_CR34","doi-asserted-by":"publisher","first-page":"5004","DOI":"10.1080\/21655979.2021.1958634","volume":"12","author":"Z Tao","year":"2021","unstructured":"Tao, Z. et al. Two types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma. Bioengineered 12(1), 5004\u20135016. https:\/\/doi.org\/10.1080\/21655979.2021.1958634 (2021).","journal-title":"Bioengineered"},{"issue":"7423","key":"10055_CR35","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nature11501","volume":"491","author":"A Yoshizaki","year":"2012","unstructured":"Yoshizaki, A. et al. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 491(7423), 264\u2013268. https:\/\/doi.org\/10.1038\/nature11501 (2012).","journal-title":"Nature"},{"issue":"6","key":"10055_CR36","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.immuni.2015.05.013","volume":"42","author":"T Yamano","year":"2015","unstructured":"Yamano, T. et al. Thymic B cells are licensed to present self antigens for central T cell tolerance induction. Immunity 42(6), 1048\u20131061. https:\/\/doi.org\/10.1016\/j.immuni.2015.05.013 (2015).","journal-title":"Immunity"},{"issue":"2","key":"10055_CR37","doi-asserted-by":"publisher","first-page":"516","DOI":"10.4049\/jimmunol.1800348","volume":"201","author":"EJ Cosway","year":"2018","unstructured":"Cosway, E. J. et al. Formation of the intrathymic dendritic cell pool requires CCL21-mediated recruitment of CCR7 progenitors to the thymus. J. Immunol. 201(2), 516\u2013523. https:\/\/doi.org\/10.4049\/jimmunol.1800348 (2018).","journal-title":"J. Immunol."},{"issue":"2","key":"10055_CR38","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41582-023-00916-w","volume":"20","author":"R Iorio","year":"2024","unstructured":"Iorio, R. Myasthenia gravis: the changing treatment landscape in the era of molecular therapies. Nat. Rev. Neurol. 20(2), 84\u201398. https:\/\/doi.org\/10.1038\/s41582-023-00916-w (2024).","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10055_CR39","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3988\/jcn.2015.11.4.372","volume":"11","author":"SH Kim","year":"2015","unstructured":"Kim, S. H., Koh, I. S. & Minn, Y. K. Pathologic finding of thymic carcinoma accompanied by myasthenia gravis. J. Clin. Neurol. 11(4), 372\u2013375. https:\/\/doi.org\/10.3988\/jcn.2015.11.4.372 (2015).","journal-title":"J. Clin. Neurol."},{"issue":"1","key":"10055_CR40","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1089\/thy.2020.0312","volume":"31","author":"J Ahn","year":"2021","unstructured":"Ahn, J. et al. Immune profiling of advanced thyroid cancers using fluorescent multiplex immunohistochemistry. Thyroid 31(1), 61\u201367. https:\/\/doi.org\/10.1089\/thy.2020.0312 (2021).","journal-title":"Thyroid"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10055-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10055-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10055-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T19:47:59Z","timestamp":1751658479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10055-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10055"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-10055-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"28 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Medical Ethics Committee of Tianjin Medical University General Hospital, IRB2019-KY-179. Informed consent was obtained from all subjects for this study. (1) All methods were carried out in accordance with relevant guidelines and regulations. (2) All methods were carried out in accordance with relevant institutional guidelines and regulations. (3) All methods were carried out in accordance with declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23978"}}