{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:24:06Z","timestamp":1792103046823,"version":"4.4.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Mesenteric ischemia (Me-Is) is a severe complication with high mortality after cardiac surgery. We examined whether intestinal fatty acid binding protein (I-FABP) might serve as a biomarker for early detection of Me-Is following cardiac surgery. Between March 2022 and December 2023, we conducted a prospective observational study of 500 consecutive patients undergoing cardiac surgery with cardiopulmonary bypass. Blood samples were obtained at five time points perioperatively. An immunoassay was used to determine I-FABP levels in 48 individuals at high risk of Me-Is due to lactic acidosis\u2009&gt;\u20094\u00a0mmol\/L and interleukin (IL)-6\u2009&gt;\u2009600\u00a0pg\/mL: 6 patients with confirmed Me-Is (cMe-Is), 18 patients with suspected Me-Is (sMe-Is), and 24 patients a in propensity score-matched control group. Of the 48 patients, 62.5% initially had mild gastrointestinal dysfunction (AGI\u2009\u2264\u2009II), but 80% of them progressed to AGI III or higher, with 25% reaching AGI IV. Baseline serum I-FABP values were similar between the three groups. The six patients with cMe-Is showed significantly elevated serum I-FABP levels from ICU admission to 36\u00a0h post-admission, peaking at 207,411.46\u00a0pg\/mL. ROC analysis identified serum I-FABP as the most accurate predictor of Me-Is, with an AUC of 0.973 at 36\u00a0h post-ICU admission (95% CI [0.764\u20130.997], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and an optimal cut-off of\u2009&gt;\u20091421\u00a0pg\/mL, with 100% sensitivity. In contrast, IL-6 and lactate levels showed no significant differences between groups. Serum I-FABP showed high accuracy in predicting Me-Is after cardiac surgery, outperforming IL-6 and lactate. Our data suggest that I-FABP may have value as a biomarker for early detection of Me-Is after cardiac surgery and help to improve patient management.<\/jats:p>","DOI":"10.1038\/s41598-025-10534-9","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:27:19Z","timestamp":1752139639000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early detection of mesenteric ischemia in critically ill patients following cardiac surgery"],"prefix":"10.1038","volume":"15","author":[{"given":"Zulfugar T.","family":"Taghiyev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Gunkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili-Marie","family":"Beier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Leweling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Sadowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borros M.","family":"Arneth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthi","family":"Skevaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula R.","family":"Keschenau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"B\u00f6ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"10534_CR1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00595-005-3124-2","volume":"36","author":"CS Ng","year":"2006","unstructured":"CS Ng S Wan AA Arifi  2006 Inflammatory response to pulmonary ischemia-reperfusion injury Surg. 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