{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:32:27Z","timestamp":1790742747130,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Engineered stone silicosis is an interstitial lung disease that progresses rapidly; in many cases, it can cause respiratory insufficiency and death. The metabolic activities occurring in the lungs and adenopathies, as well as their relationships with systemic inflammation, are unknown. Patients with complicated silicosis were enrolled in this study. All of the patients had worked for at least 5 years in finishing and installing engineered stone and had not been exposed to these working conditions for at least 7 years. Clinical data measurements, positron emission tomography\/computed tomography using\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorodeoxyglucose (\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET\/CT), respiratory function tests and blood samples were performed. The mean age of the patients was 44\u2009\u00b1\u20095.4 years. Moreover, the average exposure duration was 10.94\u2009\u00b1\u20093.2 years, and the average number of years from cessation of exposure was 11.6\u2009\u00b1\u20091.6 years. The average maximum standardized uptake value (SUVmax) of large opacities was 6.32\u2009\u00b1\u20093. All of the patients demonstrated hypermetabolic mediastinal lymphadenopathies, and 88.2% of the patients also demonstrated extrathoracic lymphadenopathies. The SUVmax of the large opacities was correlated with fibrinogen (\n                    <jats:italic>\u03c1\u2009<\/jats:italic>\n                    =\u20090.717,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001), the lymphocyte-to-monocyte ratio (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    = \u2212 0.506,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.038), the systemic inflammatory response index (\n                    <jats:italic>\u03c1\u2009<\/jats:italic>\n                    =\u20090.559,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.02) and CD4\n                    <jats:sup>+<\/jats:sup>\n                    NKT cells. Large areas of lung opacity and lymphadenopathies exhibited high metabolic activities years after the cessation of silica exposure. The relationships between metabolic activity and several inflammatory factors may lead to the exploration of new therapeutic targets.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-10562-5","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T16:06:40Z","timestamp":1752509200000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High metabolic activity in positron emission tomography and systemic inflammation occurring years after exposure cessation in engineered stone silicosis"],"prefix":"10.1038","volume":"15","author":[{"given":"Antonio","family":"Le\u00f3n-Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Rodr\u00edguez-Rubio Corona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Jim\u00e9nez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Pi\u00f1ero Fern\u00e1ndez-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Hidalgo-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Pajares-Vinardel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Conde-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Campos-Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sanchez-Morillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"10562_CR1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/resp.14242","volume":"27","author":"RF Hoy","year":"2022","unstructured":"Hoy, R. F. et al. Current global perspectives on silicosis-Convergence of old and newly emergent hazards. Respirology 27, 387\u2013398. https:\/\/doi.org\/10.1111\/resp.14242 (2022).","journal-title":"Respirology"},{"key":"10562_CR2","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1001\/jamainternmed.2023.3295","volume":"183","author":"JC Fazio","year":"2023","unstructured":"Fazio, J. C. et al. Silicosis among immigrant engineered stone (Quartz) countertop fabrication workers in California. JAMA Intern. Med. 183, 991\u2013998. https:\/\/doi.org\/10.1001\/jamainternmed.2023.3295 (2023).","journal-title":"JAMA Intern. Med."},{"key":"10562_CR3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.arbres.2019.01.017","volume":"55","author":"C Martinez Gonzalez","year":"2019","unstructured":"Martinez Gonzalez, C. et al. Silicosis in artificial quartz conglomerate workers. Arch. Bronconeumol. (Engl Ed). 55, 459\u2013464. https:\/\/doi.org\/10.1016\/j.arbres.2019.01.017 (2019).","journal-title":"Arch. Bronconeumol. (Engl Ed)"},{"key":"10562_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1136\/oemed-2024-109708","volume":"81","author":"H Kromhout","year":"2024","unstructured":"Kromhout, H., van Tongeren, M. & Cherrie, J. W. Should engineered stone products be banned? Occup. Environ. Med. 81, 329\u2013330. https:\/\/doi.org\/10.1136\/oemed-2024-109708 (2024).","journal-title":"Occup. Environ. Med."},{"key":"10562_CR5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.arbres.2023.03.003","volume":"59","author":"A Leon-Jimenez","year":"2023","unstructured":"Leon-Jimenez, A. New etiological agents of silicosis. Arch. Bronconeumol. 59, 479\u2013480. https:\/\/doi.org\/10.1016\/j.arbres.2023.03.003 (2023).","journal-title":"Arch. Bronconeumol."},{"key":"10562_CR6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/resp.14625","volume":"29","author":"C Ramkissoon","year":"2024","unstructured":"Ramkissoon, C. et al. Understanding the pathogenesis of engineered stone-associated silicosis: the effect of particle chemistry on the lung cell response. Respirology 29, 217\u2013227. https:\/\/doi.org\/10.1111\/resp.14625 (2024).","journal-title":"Respirology"},{"key":"10562_CR7","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/resp.13744","volume":"25","author":"N Wu","year":"2020","unstructured":"Wu, N., Xue, C., Yu, S. & Ye, Q. Artificial stone-associated silicosis in china: A prospective comparison with natural stone-associated silicosis. Respirology 25, 518\u2013524. https:\/\/doi.org\/10.1111\/resp.13744 (2020).","journal-title":"Respirology"},{"key":"10562_CR8","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.chest.2020.03.026","volume":"158","author":"A Leon-Jimenez","year":"2020","unstructured":"Leon-Jimenez, A. et al. Artificial stone silicosis: rapid progression following exposure cessation. Chest 158, 1060\u20131068. https:\/\/doi.org\/10.1016\/j.chest.2020.03.026 (2020).","journal-title":"Chest"},{"key":"10562_CR9","doi-asserted-by":"publisher","unstructured":"Li, R., Kang, H. & Chen, S. From basic research to clinical practice: considerations for treatment drugs for silicosis. Int. J. Mol. Sci. 24 https:\/\/doi.org\/10.3390\/ijms24098333 (2023).","DOI":"10.3390\/ijms24098333"},{"key":"10562_CR10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1183\/16000617.0051-2016","volume":"25","author":"S Capitanio","year":"2016","unstructured":"Capitanio, S., Nordin, A. J., Noraini, A. R. & Rossetti, C. PET\/CT in nononcological lung diseases: current applications and future perspectives. Eur. Respir Rev. 25, 247\u2013258. https:\/\/doi.org\/10.1183\/16000617.0051-2016 (2016).","journal-title":"Eur. Respir Rev."},{"key":"10562_CR11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.15406\/jlprr.2024.11.00316","volume":"11","author":"D del Castillo-Otero","year":"2024","unstructured":"del Castillo-Otero, D., Hidalgo-Molina, R. R. J. & Conde- S\u00e1nchez, A. Pajares -Vinardell M and Le\u00f3n- Jim\u00e9nez A. Positron emission tomography in artificial stone silicosis. J. Lung Pulmonary Respiratory Res. 11, 37\u201339. https:\/\/doi.org\/10.15406\/jlprr.2024.11.00316 (2024).","journal-title":"J. Lung Pulmonary Respiratory Res."},{"key":"10562_CR12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.5694\/mja16.00257","volume":"206","author":"E Matar","year":"2017","unstructured":"Matar, E. et al. Complicated silicosis resulting from occupational exposure to engineered stone products. Med. J. Aust. 206, 385\u2013386. https:\/\/doi.org\/10.5694\/mja16.00257 (2017).","journal-title":"Med. J. Aust"},{"key":"10562_CR13","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/JTO.0b013e31819d4778","volume":"4","author":"M Reichert","year":"2009","unstructured":"Reichert, M. & Bensadoun, E. S. PET imaging in patients with coal workers pneumoconiosis and suspected malignancy. J. Thorac. Oncol. 4, 649\u2013651. https:\/\/doi.org\/10.1097\/JTO.0b013e31819d4778 (2009).","journal-title":"J. Thorac. Oncol."},{"key":"10562_CR14","unstructured":"Banjar, F. K. & Wilson, A. M. In Anatomy, Head and Neck, Supraclavicular Lymph Node (StatPearls Publishing, 2025)."},{"key":"10562_CR15","doi-asserted-by":"publisher","first-page":"e23879","DOI":"10.1096\/fj.202400160RR","volume":"38","author":"C Zhou","year":"2024","unstructured":"Zhou, C., Sun, T., Dong, Z., Lu, F. & Li, B. The interplay between lymphatic vessels and macrophages in inflammation response. FASEB J. 38, e23879. https:\/\/doi.org\/10.1096\/fj.202400160RR (2024).","journal-title":"FASEB J."},{"key":"10562_CR16","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1111\/1759-7714.14014","volume":"12","author":"W Ryu","year":"2021","unstructured":"Ryu, W. et al. Abdominal lymph node metastasis by lymphatic spread through the thoracic duct in patients with non-small-cell lung cancer. Thorac. Cancer. 12, 2078\u20132084. https:\/\/doi.org\/10.1111\/1759-7714.14014 (2021).","journal-title":"Thorac. Cancer"},{"key":"10562_CR17","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1038\/s41598-022-08378-8","volume":"12","author":"C Ramkissoon","year":"2022","unstructured":"Ramkissoon, C. et al. Characterisation of dust emissions from machined engineered stones to understand the hazard for accelerated silicosis. Sci. Rep. 12, 4351. https:\/\/doi.org\/10.1038\/s41598-022-08378-8 (2022).","journal-title":"Sci. Rep."},{"key":"10562_CR18","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.3348\/jksr.2021.0185","volume":"83","author":"SR Kang","year":"2022","unstructured":"Kang, S. R. & Rho, J. Y. Progressive massive fibrosis mimicking lung cancer: two case reports with potentially useful CT features for differential diagnosis. J. Korean Soc. Radiol. 83, 1175\u20131181. https:\/\/doi.org\/10.3348\/jksr.2021.0185 (2022).","journal-title":"J. Korean Soc. Radiol."},{"key":"10562_CR19","doi-asserted-by":"publisher","first-page":"8211","DOI":"10.1038\/s41598-022-11926-x","volume":"12","author":"A Garcia-Nunez","year":"2022","unstructured":"Garcia-Nunez, A. et al. Inflammatory indices obtained from routine blood tests show an inflammatory state associated with disease progression in engineered stone silicosis patients. Sci. Rep. 12, 8211. https:\/\/doi.org\/10.1038\/s41598-022-11926-x (2022).","journal-title":"Sci. Rep."},{"key":"10562_CR20","doi-asserted-by":"publisher","first-page":"568","DOI":"10.2119\/molmed.2010.00146","volume":"17","author":"C Jennewein","year":"2011","unstructured":"Jennewein, C. et al. Novel aspects of fibrin(ogen) fragments during inflammation. Mol. Med. 17, 568\u2013573. https:\/\/doi.org\/10.2119\/molmed.2010.00146 (2011).","journal-title":"Mol. Med."},{"key":"10562_CR21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10753-013-9706-z","volume":"37","author":"E Bargagli","year":"2014","unstructured":"Bargagli, E. et al. Serum analysis of coagulation factors in IPF and NSIP. Inflammation 37, 10\u201316. https:\/\/doi.org\/10.1007\/s10753-013-9706-z (2014).","journal-title":"Inflammation"},{"key":"10562_CR22","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.biocel.2018.02.016","volume":"97","author":"M Schuliga","year":"2018","unstructured":"Schuliga, M., Grainge, C., Westall, G. & Knight, D. The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis. Int. J. Biochem. Cell. Biol. 97, 108\u2013117. https:\/\/doi.org\/10.1016\/j.biocel.2018.02.016 (2018).","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10562_CR23","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1164\/rccm.202312-2357LE","volume":"210","author":"JK Munchel","year":"2024","unstructured":"Munchel, J. K. et al. Fibrin-Positron emission tomography imaging reveals ongoing lung injury in idiopathic pulmonary fibrosis. Am. J. Respir Crit. Care Med. 210, 514\u2013517. https:\/\/doi.org\/10.1164\/rccm.202312-2357LE (2024).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"10562_CR24","doi-asserted-by":"publisher","unstructured":"Leon-Jimenez, A. et al. Compositional and structural analysis of engineered stones and inorganic particles in silicotic nodules of exposed workers. Part. Fibre Toxicol. 18 https:\/\/doi.org\/10.1186\/s12989-021-00434-x (2021).","DOI":"10.1186\/s12989-021-00434-x"},{"key":"10562_CR25","doi-asserted-by":"publisher","unstructured":"Vanka, K. S. et al. Understanding the pathogenesis of occupational coal and silica dust-associated lung disease. Eur. Respir Rev. 31 https:\/\/doi.org\/10.1183\/16000617.0250-2021 (2022).","DOI":"10.1183\/16000617.0250-2021"},{"key":"10562_CR26","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1164\/rccm.202003-0669OC","volume":"204","author":"M Kreuter","year":"2021","unstructured":"Kreuter, M. et al. Monocyte count as a prognostic biomarker in patients with idiopathic pulmonary fibrosis. Am. J. Respir Crit. Care Med. 204, 74\u201381. https:\/\/doi.org\/10.1164\/rccm.202003-0669OC (2021).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"10562_CR27","doi-asserted-by":"publisher","unstructured":"Achaiah, A. et al. Increased monocyte level is a risk factor for radiological progression in patients with early fibrotic interstitial lung abnormality. ERJ Open. Res. 8 https:\/\/doi.org\/10.1183\/23120541.00226-2022 (2022).","DOI":"10.1183\/23120541.00226-2022"},{"key":"10562_CR28","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/ajim.23528","volume":"66","author":"EMS Lombardi","year":"2023","unstructured":"Lombardi, E. M. S., Mizutani, R. F., Terra-Filho, M., Ubiratan & de Paula Biomarkers related to silicosis and pulmonary function in individuals exposed to silica. Am. J. Ind. Med. 66, 984\u2013995. https:\/\/doi.org\/10.1002\/ajim.23528 (2023).","journal-title":"Am. J. Ind. Med."},{"issue":"Suppl 1","key":"10562_CR29","first-page":"53","volume":"20","author":"GS Davis","year":"2001","unstructured":"Davis, G. S., Holmes, C. E., Pfeiffer, L. M. & Hemenway, D. R. Lymphocytes, lymphokines, and silicosis. J. Environ. Pathol. Toxicol. Oncol. 20 (Suppl 1), 53\u201365 (2001).","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10562_CR30","doi-asserted-by":"publisher","unstructured":"Nelson, A., Lukacs, J. D. & Johnston, B. The current landscape of NKT cell immunotherapy and the hills ahead. Cancers (Basel). 13 https:\/\/doi.org\/10.3390\/cancers13205174 (2021).","DOI":"10.3390\/cancers13205174"},{"key":"10562_CR31","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.4049\/jimmunol.1601399","volume":"198","author":"MV Dhodapkar","year":"2017","unstructured":"Dhodapkar, M. V. & Kumar, V. Type II NKT cells and their emerging role in health and disease. J. Immunol. 198, 1015\u20131021. https:\/\/doi.org\/10.4049\/jimmunol.1601399 (2017).","journal-title":"J. Immunol."},{"key":"10562_CR32","doi-asserted-by":"publisher","first-page":"e489","DOI":"10.1002\/hsr2.489","volume":"5","author":"A Ahmadi","year":"2022","unstructured":"Ahmadi, A. et al. The role of NK and NKT cells in the pathogenesis and improvement of multiple sclerosis following disease-modifying therapies. Health Sci. Rep. 5, e489. https:\/\/doi.org\/10.1002\/hsr2.489 (2022).","journal-title":"Health Sci. Rep."},{"key":"10562_CR33","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1183\/09031936.06.00129505","volume":"27","author":"JM Naccache","year":"2006","unstructured":"Naccache, J. M. et al. Increasing level of CD56\u2009+\u2009T-cells in peripheral blood in sarcoidosis. Eur. Respir J. 27, 654. https:\/\/doi.org\/10.1183\/09031936.06.00129505 (2006).","journal-title":"Eur. Respir J."},{"key":"10562_CR34","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.exphem.2005.12.008","volume":"34","author":"H Lin","year":"2006","unstructured":"Lin, H., Nieda, M., Rozenkov, V. & Nicol, A. J. Analysis of the effect of different NKT cell subpopulations on the activation of CD4 and CD8 T cells, NK cells, and B cells. Exp. Hematol. 34, 289\u2013295. https:\/\/doi.org\/10.1016\/j.exphem.2005.12.008 (2006).","journal-title":"Exp. Hematol."},{"key":"10562_CR35","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.3389\/fimmu.2018.01360","volume":"9","author":"DG Doherty","year":"2018","unstructured":"Doherty, D. G., Melo, A. M., Moreno-Olivera, A. & Solomos, A. C. Activation and regulation of B cell responses by invariant natural killer T cells. Front. Immunol. 9, 1360. https:\/\/doi.org\/10.3389\/fimmu.2018.01360 (2018).","journal-title":"Front. Immunol."},{"key":"10562_CR36","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/imr.12938","volume":"299","author":"EA Leadbetter","year":"2021","unstructured":"Leadbetter, E. A. & Karlsson, M. C. I. Invariant natural killer T cells balance B cell immunity. Immunol. Rev. 299, 93\u2013107. https:\/\/doi.org\/10.1111\/imr.12938 (2021).","journal-title":"Immunol. Rev."},{"key":"10562_CR37","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3233\/WOR-213582","volume":"70","author":"A Perez-Alonso","year":"2021","unstructured":"Perez-Alonso, A., Gonzalez-Dominguez, M. E., Novalbos-Ruiz, J. P., Leon-Jimenez, A. & Cordoba-Dona, J. A. Artificial stone silicosis: accumulation of errors in the resurgence of an occupational disease: A qualitative study. Work 70, 433\u2013442. https:\/\/doi.org\/10.3233\/WOR-213582 (2021).","journal-title":"Work"},{"key":"10562_CR38","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1007\/s00330-024-10949-4","volume":"35","author":"R Donnelly","year":"2025","unstructured":"Donnelly, R. et al. Meta-analysis of [(18)F]FDG-PET\/CT in pulmonary sarcoidosis. Eur. Radiol. 35, 2222\u20132232. https:\/\/doi.org\/10.1007\/s00330-024-10949-4 (2025).","journal-title":"Eur. Radiol."},{"key":"10562_CR39","doi-asserted-by":"publisher","first-page":"PA3800","DOI":"10.1183\/13993003.congress-2023.PA3800","volume":"62","author":"A Thiruvarudchelvan","year":"2023","unstructured":"Thiruvarudchelvan, A., Hart-Brown, L., Bloch, M. & Yates, D. The nintedanib in progressive pneumoconiosis study (NiPPs): early data from Australia. Eur. Respir. J. 62, PA3800. https:\/\/doi.org\/10.1183\/13993003.congress-2023.PA3800 (2023).","journal-title":"Eur. Respir. J."},{"key":"10562_CR40","doi-asserted-by":"publisher","unstructured":"Jimenez-Gomez, G. et al. Analysis of immune cell subsets in peripheral blood from patients with engineered stone Silica-Induced lung inflammation. Int. J. Mol. Sci. 25 https:\/\/doi.org\/10.3390\/ijms25115722 (2024).","DOI":"10.3390\/ijms25115722"},{"key":"10562_CR41","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1164\/rccm.201908-1590ST","volume":"200","author":"BL Graham","year":"2019","unstructured":"Graham, B. L. et al. Standardization of spirometry 2019 update. An official American thoracic society and European respiratory society technical statement. Am. J. Respir Crit. Care Med. 200, e70\u2013e88. https:\/\/doi.org\/10.1164\/rccm.201908-1590ST (2019).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"10562_CR42","doi-asserted-by":"publisher","unstructured":"Graham, B. L. et al. 2017 ERS\/ATS standards for single-breath carbon monoxide uptake in the lung. Eur. Respir J. 49 https:\/\/doi.org\/10.1183\/13993003.00016-2016 (2017).","DOI":"10.1183\/13993003.00016-2016"},{"key":"10562_CR43","unstructured":"International Labour Office. Geneva, S. I. L. O (International Labour Office, 2011)."},{"key":"10562_CR44","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1539\/joh.l8030","volume":"51","author":"N Suganuma","year":"2009","unstructured":"Suganuma, N. et al. Reliability of the proposed international classification of high-resolution computed tomography for occupational and environmental respiratory diseases. J. Occup. Health. 51, 210\u2013222. https:\/\/doi.org\/10.1539\/joh.l8030 (2009).","journal-title":"J. Occup. Health"},{"key":"10562_CR45","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s00259-014-2961-x","volume":"42","author":"R Boellaard","year":"2015","unstructured":"Boellaard, R. et al. FDG PET\/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur. J. Nucl. Med. Mol. Imaging. 42, 328\u2013354. https:\/\/doi.org\/10.1007\/s00259-014-2961-x (2015).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10562_CR46","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. Roy. Stat. Soc.: Ser. B (Methodol.). 57, 289\u2013300. https:\/\/doi.org\/10.1111\/j.2517-6161.1995.tb02031.x (1995).","journal-title":"J. Roy. Stat. Soc.: Ser. B (Methodol.)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10562-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10562-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10562-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T16:06:41Z","timestamp":1752509201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10562-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10562"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-10562-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5879579\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"22 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"25364"}}