{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:50:21Z","timestamp":1792785021015,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"NIH CFAR","award":["P30A1027763"],"award-info":[{"award-number":["P30A1027763"]}]},{"name":"CFAR Booster","award":["BO-1122"],"award-info":[{"award-number":["BO-1122"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-10686-8","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T15:58:53Z","timestamp":1752681533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["\u201cInjectable ARVs will give me peace\u201d women\u2019s acceptability of injectable antiretroviral therapy in prevention of HIV vertical transmission in Uganda"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-6185","authenticated-orcid":false,"given":"Deborah","family":"Ekusai -Sebatta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Laker","family":"Agnes Odongpiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes N.","family":"Kiragga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Byakika-Kibwika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"issue":"2","key":"10686_CR1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.2174\/1570162X11311020007","volume":"11","author":"J Aizire","year":"2013","unstructured":"Aizire, J., Fowler, G. & Coovadia, M. M. Operational issues and barriers to implementation of prevention of mother-to-child transmission of HIV (PMTCT) interventions in Sub-Saharan Africa. Curr. HIV Res. 11 (2), 144\u2013159 (2013).","journal-title":"Curr. HIV Res."},{"issue":"8","key":"10686_CR2","doi-asserted-by":"publisher","first-page":"e0238232","DOI":"10.1371\/journal.pone.0238232","volume":"15","author":"GA Kisigo","year":"2020","unstructured":"Kisigo, G. A. et al. At home, no one knows: A qualitative study of retention challenges among women living with HIV in Tanzania. Plos One. 15 (8), e0238232 (2020).","journal-title":"Plos One"},{"issue":"1","key":"10686_CR3","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1186\/s12889-018-5651-y","volume":"18","author":"O Omonaiye","year":"2018","unstructured":"Omonaiye, O., Kusljic, S., Nicholson, P. & Manias, E. Medication adherence in pregnant women with human immunodeficiency virus receiving antiretroviral therapy in sub-Saharan africa: a systematic review. BMC Public. Health. 18 (1), 805 (2018).","journal-title":"BMC Public. Health"},{"issue":"10","key":"10686_CR4","doi-asserted-by":"publisher","first-page":"e0223332","DOI":"10.1371\/journal.pone.0223332","volume":"14","author":"JO Igumbor","year":"2019","unstructured":"Igumbor, J. O. et al. Effect of a mentor mother programme on retention of mother-baby pairs in HIV care: A secondary analysis of programme data in Uganda. PloS One. 14 (10), e0223332 (2019).","journal-title":"PloS One"},{"key":"10686_CR5","doi-asserted-by":"crossref","unstructured":"Knettel, B. A. et al. Retention in HIV care during pregnancy and the postpartum period in the Option B\u2009+\u2009era: a systematic review and meta-analysis of studies in Africa. Journal of acquired immune deficiency syndromes 2018;77(5):427. (1999).","DOI":"10.1097\/QAI.0000000000001616"},{"issue":"5","key":"10686_CR6","doi-asserted-by":"publisher","first-page":"e0251413","DOI":"10.1371\/journal.pone.0251413","volume":"16","author":"AN Kiragga","year":"2021","unstructured":"Kiragga, A. N. et al. Outcomes of retained and disengaged pregnant women living with HIV in Uganda. Plos One. 16 (5), e0251413 (2021).","journal-title":"Plos One"},{"issue":"1","key":"10686_CR7","doi-asserted-by":"publisher","first-page":"e0190487","DOI":"10.1371\/journal.pone.0190487","volume":"13","author":"D Kerrigan","year":"2018","unstructured":"Kerrigan, D. et al. Experiences with long acting injectable ART: A qualitative study among PLHIV participating in a phase II study of cabotegravir\u2009+\u2009rilpivirine (LATTE-2) in the united States and Spain. PloS One. 13 (1), e0190487 (2018).","journal-title":"PloS One"},{"issue":"1","key":"10686_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1186\/s12879-018-3450-9","volume":"18","author":"G Kiwanuka","year":"2018","unstructured":"Kiwanuka, G. et al. Retention of HIV infected pregnant and breastfeeding women on option B\u2009+\u2009in Gomba district, uganda: a retrospective cohort study. BMC Infect. Dis. 18 (1), 533 (2018).","journal-title":"BMC Infect. Dis."},{"issue":"4","key":"10686_CR9","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/hiv.13260","volume":"23","author":"ELA Odongpiny","year":"2022","unstructured":"Odongpiny, E. L. A. et al. High willingness to use injectable antiretroviral therapy among women who have been lost to follow-up from HIV programmes: A nested cross\u2010sectional study. HIV Med. 23 (4), 319\u2013323 (2022).","journal-title":"HIV Med."},{"issue":"2","key":"10686_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/QAI.0000000000002549","volume":"86","author":"P Ehrenkranz","year":"2021","unstructured":"Ehrenkranz, P., Grimsrud, A., Holmes, C. B., Preko, P. & Rabkin, M. Expanding the vision for differentiated service delivery: a call for more inclusive and truly patient-centered care for people living with HIV. JAIDS J. Acquir. Immune Defic. Syndr. 86 (2), 147\u2013152 (2021).","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"issue":"1","key":"10686_CR11","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1186\/s12913-024-10833-3","volume":"24","author":"L Katirayi","year":"2024","unstructured":"Katirayi, L. et al. Evaluation of a peer-support,\u2018mentor mother\u2019program in gaza, mozambique; a qualitative study. BMC Health Serv. Res. 24 (1), 382 (2024).","journal-title":"BMC Health Serv. Res."},{"issue":"4","key":"10686_CR12","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1007\/s10461-019-02701-7","volume":"24","author":"JM Simoni","year":"2020","unstructured":"Simoni, J. M. et al. A conjoint analysis of the acceptability of targeted long-acting injectable antiretroviral therapy among persons living with HIV in the US. AIDS Behav. 24 (4), 1226\u20131236 (2020).","journal-title":"AIDS Behav."},{"issue":"1","key":"10686_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12913-017-2031-8","volume":"17","author":"M Sekhon","year":"2017","unstructured":"Sekhon, M., Cartwright, M. & Francis, J. J. Acceptability of healthcare interventions: an overview of reviews and development of a theoretical framework. BMC Health Serv. Res. 17 (1), 1\u201313 (2017).","journal-title":"BMC Health Serv. Res."},{"key":"10686_CR14","unstructured":"Broder, M. U.S. Waits on approval of Long-Acting HIV treatment cabotegravir and rilpivirine as European union gives the green light. 2020 29\/December\/2020."},{"issue":"7","key":"10686_CR15","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1016\/S2352-3018(23)00134-0","volume":"10","author":"C Norcross","year":"2023","unstructured":"Norcross, C. et al. Long-acting antiretrovirals: research and implementation considerations in Africa. Lancet HIV. 10 (7), e428\u2013e9 (2023).","journal-title":"Lancet HIV"},{"issue":"5","key":"10686_CR16","doi-asserted-by":"publisher","first-page":"e620","DOI":"10.1016\/S2214-109X(21)00025-5","volume":"9","author":"AN Phillips","year":"2021","unstructured":"Phillips, A. N. et al. The potential role of long-acting injectable cabotegravir\u2013rilpivirine in the treatment of HIV in sub-Saharan africa: a modelling analysis. Lancet Global Health. 9 (5), e620\u2013e7 (2021).","journal-title":"Lancet Global Health"},{"issue":"4","key":"10686_CR17","first-page":"394","volume":"6","author":"KM Cummings","year":"1978","unstructured":"Cummings, K. M., Jette, A. M. & Rosenstock, I. M. Construct validation of the health belief model. Health Educ. Monogr. 6 (4), 394\u2013405 (1978).","journal-title":"Health Educ. Monogr."},{"key":"10686_CR18","doi-asserted-by":"crossref","unstructured":"Green, E. C., Murphy, E. M. & Gryboski, K. The health belief model. The Wiley encyclopedia of health psychology. :211-4. (2020).","DOI":"10.1002\/9781119057840.ch68"},{"issue":"1","key":"10686_CR19","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jana.2015.10.005","volume":"27","author":"X Li","year":"2016","unstructured":"Li, X., Lei, Y., Wang, H., He, G. & Williams, A. B. The health belief model: A qualitative study to understand High-risk sexual behavior in Chinese men who have sex with men. J. Assoc. Nurses AIDS Care. 27 (1), 66\u201376 (2016).","journal-title":"J. Assoc. Nurses AIDS Care"},{"key":"10686_CR20","unstructured":"Creswell, J. W. Qualitative, Quantitative and Mixed Methods Approaches (Sage, 2014)."},{"issue":"1","key":"10686_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12936-021-03811-1","volume":"20","author":"D Ekusai-Sebatta","year":"2021","unstructured":"Ekusai-Sebatta, D. et al. Challenges and opportunities for use of long-lasting insecticidal Nets to prevent malaria during overnight travel in uganda: a qualitative study. Malar. J. 20 (1), 1\u20139 (2021).","journal-title":"Malar. J."},{"issue":"9","key":"10686_CR22","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1097\/ACM.0000000000000388","volume":"89","author":"BC O\u2019Brien","year":"2014","unstructured":"O\u2019Brien, B. C., Harris, I. B., Beckman, T. J., Reed, D. A. & Cook, D. A. Standards for reporting qualitative research: a synthesis of recommendations. Acad. Med. 89 (9), 1245\u20131251 (2014).","journal-title":"Acad. Med."},{"key":"10686_CR23","doi-asserted-by":"crossref","unstructured":"Garris, C. et al. Qualitative evaluation of survey questions to assess treatment preference for daily oral or long\u2013acting injectable antiretroviral therapy among people living with HIV. PLoS One ;19(12). (2024).","DOI":"10.1371\/journal.pone.0309588"},{"issue":"3","key":"10686_CR24","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/QAI.0000000000002337","volume":"84","author":"MM Philbin","year":"2020","unstructured":"Philbin, M. M. et al. Multisite study of women living with hiv\u2019s perceived barriers to, and interest in, long-acting injectable antiretroviral therapy. JAIDS J. Acquir. Immune Defic. Syndr. 84 (3), 263\u2013270 (2020).","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"10686_CR25","doi-asserted-by":"crossref","unstructured":"Derrick, C. B. et al. (eds) Who Wants To Switch?? Gauging Patient Interest in Novel Antiretroviral Therapies. Open Forum Infectious Diseases (Oxford University Press US, 2018).","DOI":"10.1093\/ofid\/ofy247"},{"key":"10686_CR26","doi-asserted-by":"publisher","first-page":"18640","DOI":"10.7448\/IAS.16.3.18640","volume":"16","author":"IT Katz","year":"2013","unstructured":"Katz, I. T. et al. Impact of HIV-related stigma on treatment adherence: systematic review and meta\u2010synthesis. J. Int. AIDS. Soc. 16, 18640 (2013).","journal-title":"J. Int. AIDS. Soc."},{"issue":"8","key":"10686_CR27","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1080\/09540120500330554","volume":"18","author":"NC Ware","year":"2006","unstructured":"Ware, N. C., Wyatt, M. A. & Tugenberg, T. Social relationships, stigma and adherence to antiretroviral therapy for HIV\/AIDS. AIDS Care. 18 (8), 904\u2013910 (2006).","journal-title":"AIDS Care"},{"key":"10686_CR28","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s11606-009-1068-8","volume":"24","author":"JN Sayles","year":"2009","unstructured":"Sayles, J. N., Wong, M. D., Kinsler, J. J., Martins, D. & Cunningham, W. E. The association of stigma with self-reported access to medical care and antiretroviral therapy adherence in persons living with HIV\/AIDS. J. Gen. Intern. Med. 24, 1101\u20131108 (2009).","journal-title":"J. Gen. Intern. Med."},{"key":"10686_CR29","doi-asserted-by":"crossref","unstructured":"Ekusai-Sebatta, D. et al. Ethical issues surrounding the implementation of long-acting injectable antiretroviral therapy in sub-Saharan Africa. Int. Health :ihaf016. (2025).","DOI":"10.1093\/inthealth\/ihaf016"},{"issue":"3","key":"10686_CR30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1089\/apc.2018.0198","volume":"33","author":"JM Simoni","year":"2019","unstructured":"Simoni, J. M. et al. Long-acting injectable antiretroviral treatment acceptability and preferences: a qualitative study among US providers, adults living with HIV, and parents of youth living with HIV. AIDS Patient Care STDs. 33 (3), 104\u2013111 (2019).","journal-title":"AIDS Patient Care STDs"},{"key":"10686_CR31","doi-asserted-by":"crossref","unstructured":"Rutstein, S. E. et al. Acceptability and feasibility of long-acting injectable antiretroviral therapy for HIV-infected persons who inject drugs in vietnam: A qualitative study. Lancet Reg. Health\u2013Western Pac. ;31. (2023).","DOI":"10.1016\/j.lanwpc.2022.100603"},{"key":"10686_CR32","doi-asserted-by":"crossref","unstructured":"Durham, S. H. & Chahine, E. B. Cabotegravir-Rilpivirine: the first complete Long-Acting injectable regimen for the treatment of HIV-1 infection. Ann. Pharmacother. :1060028021995586. (2021).","DOI":"10.1177\/1060028021995586"},{"issue":"4","key":"10686_CR33","doi-asserted-by":"publisher","first-page":"e0231181","DOI":"10.1371\/journal.pone.0231181","volume":"15","author":"S Willan","year":"2020","unstructured":"Willan, S., Gibbs, A., Petersen, I. & Jewkes, R. Exploring young women\u2019s reproductive decision-making, agency and social norms in South African informal settlements. PloS One. 15 (4), e0231181 (2020).","journal-title":"PloS One"},{"issue":"1","key":"10686_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12910-020-00516-z","volume":"21","author":"DE Sebatta","year":"2020","unstructured":"Sebatta, D. E. et al. You would not be in a hurry to go back home: patients\u2019 willingness to participate in HIV\/AIDS clinical trials at a clinical and research facility in kampala, Uganda. BMC Med. Ethics. 21 (1), 1\u201314 (2020).","journal-title":"BMC Med. Ethics"},{"key":"10686_CR35","unstructured":"UPHIA. Uganda population based HIV impact assessment. (2017)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10686-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10686-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10686-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T12:44:33Z","timestamp":1757249073000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10686-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10686"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-10686-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]},"assertion":[{"value":"7 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki. Ethics approval was obtained from the Infectious Diseases Institute (IDIREC) on 3 November 2021 (\n                      IDIREC 032\/2021\n                      ). Additional approvals were obtained from the Uganda National Council for Science and Technology (\n                      SS1095ES\n                      ) on 8\/12 2021. UCSF approval (\n                      Ref 327715\n                      ) in 05\/04\/2022. All participants signed an informed consent sheet either in English or Luganda and confidentiality was maintained by anonymizing participants\u2019 identifiers at all stages of data collection and reporting. All data were stored on encrypted computers. Filed notes and signed participant-informed consent forms were kept in a locked drawer at the study site. Participants\u2019 names were not recorded anywhere during data collection. Each participant was given a unique identifying number to ensure confidentiality. The research teams did not include any identifying information that could have harmful consequences for the participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors reviewed approved the final manuscript and consented to submission for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"25818"}}