{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:06:26Z","timestamp":1792411586715,"version":"4.4.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-10982-3","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T10:30:10Z","timestamp":1752921010000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of nitrosative stress and endothelial damage on angioinvasive papillary thyroid cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"Angelika","family":"Buczy\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ko\u015bciuszko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Adamska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Siewko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Dzi\u0119cio\u0142","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Szelachowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pop\u0142awska-Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam Jacek","family":"Kr\u0119towski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"10982_CR1","unstructured":"Limaiem, F., Rehman, A., Mazzoni, T., Anastasopoulou, C. & Mazzoni, T. Papillary thyroid carcinoma. StatPearls."},{"issue":"1","key":"10982_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12022-007-0002-z","volume":"18","author":"J Albores-Saavedra","year":"2007","unstructured":"Albores-Saavedra, J., Henson, D. E., Glazer, E. & Schwartz, A. M. Changing patterns in the incidence and survival of thyroid cancer with follicular phenotype\u2014papillary, follicular, and anaplastic: A morphological and epidemiological study. Endocrine Pathol. 18(1), 1\u20137. https:\/\/doi.org\/10.1007\/s12022-007-0002-z (2007).","journal-title":"Endocrine Pathol."},{"key":"10982_CR3","doi-asserted-by":"publisher","first-page":"13711","DOI":"10.1038\/s41598-023-40898-9","volume":"13","author":"A Buczy\u0144ska","year":"2023","unstructured":"Buczy\u0144ska, A. et al. Clinical significance of oxidative stress markers as angioinvasion and metastasis indicators in papillary thyroid cancer. Sci. Rep. 13, 13711. https:\/\/doi.org\/10.1038\/s41598-023-40898-9 (2023).","journal-title":"Sci. Rep."},{"key":"10982_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jamcollsurg.2003.11.012","volume":"198","author":"JC Furlan","year":"2004","unstructured":"Furlan, J. C., Bedard, Y. C. & Rosen, I. B. Clinicopathologic significance of histologic vascular invasion in papillary and follicular thyroid carcinomas. J. Am. Coll. Surg. 198, 341\u2013348. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2003.11.012 (2004).","journal-title":"J. Am. Coll. Surg."},{"key":"10982_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12935-018-0504-4","volume":"18","author":"A Metere","year":"2018","unstructured":"Metere, A. et al. A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer: Our experience in thyroid surgery. Cancer Cell Int. 18, 7. https:\/\/doi.org\/10.1186\/s12935-018-0504-4 (2018).","journal-title":"Cancer Cell Int."},{"key":"10982_CR6","doi-asserted-by":"publisher","first-page":"17126","DOI":"10.1038\/s41598-021-96637-5","volume":"11","author":"A Buczy\u0144ska","year":"2021","unstructured":"Buczy\u0144ska, A. et al. Oxidative stress and radioiodine treatment of differentiated thyroid cancer. Sci. Rep. 11, 17126 (2021).","journal-title":"Sci. Rep."},{"key":"10982_CR7","doi-asserted-by":"publisher","first-page":"1261860","DOI":"10.3389\/fendo.2023.1261860","volume":"14","author":"A Buczy\u0144ska","year":"2023","unstructured":"Buczy\u0144ska, A., Ko\u015bciuszko, M., Kr\u0119towski, A. J. & Pop\u0142awska-Kita, A. Exploring the clinical utility of angioinvasion markers in papillary thyroid cancer: A literature review. Front. Endocrinol. 14, 1261860. https:\/\/doi.org\/10.3389\/fendo.2023.1261860 (2023).","journal-title":"Front. Endocrinol."},{"issue":"7","key":"10982_CR8","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1210\/CLINEM\/DGAE007","volume":"109","author":"A Buczy\u0144ska","year":"2024","unstructured":"Buczy\u0144ska, A. et al. Enhancing angioinvasion assessment in papillary thyroid cancer via a biomarker panel involving TAC, 8-OHdG and Sortilin. J. Clin. Endocrinol. Metabol. 109(7), 1866\u20131872. https:\/\/doi.org\/10.1210\/CLINEM\/DGAE007 (2024).","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10982_CR9","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.3390\/CANCERS15123182","volume":"15","author":"M Ko\u015bciuszko","year":"2023","unstructured":"Ko\u015bciuszko, M., Buczy\u0144ska, A., Kr\u0119towski, A. J. & Pop\u0142awska-Kita, A. Could oxidative stress play a role in the development and clinical management of differentiated thyroid cancer?. Cancers 15, 3182. https:\/\/doi.org\/10.3390\/CANCERS15123182 (2023).","journal-title":"Cancers"},{"key":"10982_CR10","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/BF03345100\/METRICS","volume":"25","author":"A Patel","year":"2002","unstructured":"Patel, A. et al. Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents. J. Endocrinol. Invest. 25, 675\u2013683. https:\/\/doi.org\/10.1007\/BF03345100\/METRICS (2002).","journal-title":"J. Endocrinol. Invest."},{"key":"10982_CR11","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/J.HUMIMM.2013.06.009","volume":"74","author":"H Ahsan","year":"2013","unstructured":"Ahsan, H. 3-Nitrotyrosine: A biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions. Hum. Immunol. 74, 1392\u20131399. https:\/\/doi.org\/10.1016\/J.HUMIMM.2013.06.009 (2013).","journal-title":"Hum. Immunol."},{"key":"10982_CR12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/METABO9020023","volume":"9","author":"L Tronci","year":"2019","unstructured":"Tronci, L. et al. Crosstalk between metabolic alterations and altered redox balance in PTC-derived cell lines. Metabolites 9, 23. https:\/\/doi.org\/10.3390\/METABO9020023 (2019).","journal-title":"Metabolites"},{"key":"10982_CR13","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.3390\/CANCERS14235857","volume":"14","author":"M Muzza","year":"2022","unstructured":"Muzza, M. et al. Oxidative stress correlates with more aggressive features in thyroid cancer. Cancers 14, 5857. https:\/\/doi.org\/10.3390\/CANCERS14235857 (2022).","journal-title":"Cancers"},{"key":"10982_CR14","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/J.1365-2265.2006.02535.X;PAGE:STRING:ARTICLE\/CHAPTER","volume":"64","author":"JE Donckier","year":"2006","unstructured":"Donckier, J. E., Michel, L., Delos, M., Havaux, X. & Van, B. R. Interrelated overexpression of endothelial and inducible nitric oxide synthases, endothelin-1 and angiogenic factors in human papillary thyroid carcinoma. Clin. Endocrinol. 64, 703\u2013710. https:\/\/doi.org\/10.1111\/J.1365-2265.2006.02535.X;PAGE:STRING:ARTICLE\/CHAPTER (2006).","journal-title":"Clin. Endocrinol."},{"key":"10982_CR15","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1210\/JC.2005-1790","volume":"91","author":"Y Nakamura","year":"2006","unstructured":"Nakamura, Y. et al. Nitric oxide in papillary thyroid carcinoma: induction of vascular endothelial growth factor d and correlation with lymph node metastasis. J. Clin. Endocrinol. Metab. 91, 1582\u20131585. https:\/\/doi.org\/10.1210\/JC.2005-1790 (2006).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10982_CR16","doi-asserted-by":"publisher","first-page":"1213802","DOI":"10.3389\/FONC.2023.1213802\/BIBTEX","volume":"13","author":"J Dorf","year":"2023","unstructured":"Dorf, J. et al. Could circulating biomarkers of nitrosative stress and protein glycoxidation be useful in patients with gastric cancer?. Front. Oncol. 13, 1213802. https:\/\/doi.org\/10.3389\/FONC.2023.1213802\/BIBTEX (2023).","journal-title":"Front. Oncol."},{"key":"10982_CR17","doi-asserted-by":"publisher","first-page":"8601","DOI":"10.1007\/S13277-015-3548-2\/METRICS","volume":"36","author":"J He","year":"2015","unstructured":"He, J., Shen, N. & Huang, X. Thyroid carcinoma cells produce PLGF to enhance metastasis. Tumor Biol. 36, 8601\u20138607. https:\/\/doi.org\/10.1007\/S13277-015-3548-2\/METRICS (2015).","journal-title":"Tumor Biol."},{"key":"10982_CR18","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.3390\/CANCERS13122937\/S1","volume":"13","author":"L Mautone","year":"2021","unstructured":"Mautone, L. et al. Higher integrin alpha 3 beta1 expression in papillary thyroid cancer is associated with worst outcome. Cancers 13, 2937. https:\/\/doi.org\/10.3390\/CANCERS13122937\/S1 (2021).","journal-title":"Cancers"},{"issue":"73","key":"10982_CR19","doi-asserted-by":"publisher","first-page":"173","DOI":"10.5603\/EP.a2022.0028","volume":"2022","author":"B Jarz\u0105b","year":"2022","unstructured":"Jarz\u0105b, B. et al. Diagnosis and treatment of thyroid cancer in adult patients - Recommendations of Polish Scientific Societies and the National Oncological Strategy. 2022 Update. Endokrynol. Pol. 2022(73), 173\u2013300. https:\/\/doi.org\/10.5603\/EP.a2022.0028 (2022).","journal-title":"Endokrynol. Pol."},{"issue":"1","key":"10982_CR20","first-page":"30","volume":"8","author":"QT Nguyen","year":"2015","unstructured":"Nguyen, Q. T. et al. Diagnosis and treatment of patients with thyroid cancer. Am. Health Drug Benefits 8(1), 30 (2015).","journal-title":"Am. Health Drug Benefits"},{"key":"10982_CR21","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/S40617-021-00664-7","volume":"15","author":"DR Mitteer","year":"2022","unstructured":"Mitteer, D. R. & Greer, B. D. Using GraphPad Prism\u2019s heat maps for efficient, fine-grained analyses of single-case data. Behav. Anal. Pract. 15, 505\u2013514. https:\/\/doi.org\/10.1007\/S40617-021-00664-7 (2022).","journal-title":"Behav. Anal. Pract."},{"key":"10982_CR22","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/S12105-015-0619-Z","volume":"9","author":"S Papp","year":"2015","unstructured":"Papp, S. & Asa, S. L. When thyroid carcinoma goes bad: A morphological and molecular analysis. Head Neck Pathol. 9, 16\u201323. https:\/\/doi.org\/10.1007\/S12105-015-0619-Z (2015).","journal-title":"Head Neck Pathol."},{"issue":"5","key":"10982_CR23","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/ANTIOX8050126","volume":"8","author":"I Szanto","year":"2019","unstructured":"Szanto, I., Pusztaszeri, M. & Mavromati, M. H2O2 metabolism in normal thyroid cells and in thyroid tumorigenesis: Focus on NADPH oxidases. Antioxidants 8(5), 126. https:\/\/doi.org\/10.3390\/ANTIOX8050126 (2019).","journal-title":"Antioxidants"},{"key":"10982_CR24","doi-asserted-by":"publisher","first-page":"218145","DOI":"10.1155\/2013\/218145","volume":"2013","author":"I Villanueva","year":"2013","unstructured":"Villanueva, I., Alva-S\u00e1nchez, C. & Pacheco-Rosado, J. The role of thyroid hormones as inductors of oxidative stress and neurodegeneration. Oxidative Med. Cell. Longevity 2013, 218145. https:\/\/doi.org\/10.1155\/2013\/218145 (2013).","journal-title":"Oxidative Med. Cell. Longevity"},{"issue":"1","key":"10982_CR25","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/HIS.15173","volume":"85","author":"M Ragazzi","year":"2024","unstructured":"Ragazzi, M. et al. Accuracy of world health organisation-grade parameters (necrosis and mitotic activity) and foci of vascular invasion in predicting prognosis of papillary thyroid carcinoma. A case-control validation study. Histopathology 85(1), 62\u201374. https:\/\/doi.org\/10.1111\/HIS.15173 (2024).","journal-title":"Histopathology"},{"key":"10982_CR26","doi-asserted-by":"publisher","first-page":"151737","DOI":"10.1016\/J.ANNDIAGPATH.2021.151737","volume":"52","author":"\u00c7 Vural","year":"2021","unstructured":"Vural, \u00c7. et al. Solid variant of papillary thyroid carcinoma: An analysis of 28 cases with current literature. Ann. Diagn. Pathol. 52, 151737. https:\/\/doi.org\/10.1016\/J.ANNDIAGPATH.2021.151737 (2021).","journal-title":"Ann. Diagn. Pathol."},{"key":"10982_CR27","first-page":"26","volume":"2016","author":"BR Haugen","year":"2015","unstructured":"Haugen, B. R. et al. American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 2016, 26 (2015).","journal-title":"Thyroid"},{"key":"10982_CR28","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/S10238-024-01320-4","volume":"24","author":"J Huang","year":"2024","unstructured":"Huang, J. et al. Genetic alterations and allele frequency of BRAF V600E and TERT mutation in papillary thyroid carcinoma with intermediate-to-high recurrence risk: A retrospective study. Clin. Exp. Med. 24, 76. https:\/\/doi.org\/10.1007\/S10238-024-01320-4 (2024).","journal-title":"Clin. Exp. Med."},{"key":"10982_CR29","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1007\/S12094-022-02891-Y","volume":"24","author":"NMD Lopes","year":"2022","unstructured":"Lopes, N. M. D. et al. Role of papillary thyroid carcinoma patients with Hashimoto thyroiditis: Evaluation of oxidative stress and inflammatory markers. Clin. Transl. Oncol.: Off. Public. Federation Span. Oncol. Soc. Natl. Cancer Instit. Mexico 24, 2366\u20132378. https:\/\/doi.org\/10.1007\/S12094-022-02891-Y (2022).","journal-title":"Clin. Transl. Oncol.: Off. Public. Federation Span. Oncol. Soc. Natl. Cancer Instit. Mexico"},{"key":"10982_CR30","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/j.1365-2265.2006.02535.x","volume":"64","author":"JE Donckier","year":"2006","unstructured":"Donckier, J. E., Michel, L., Delos, M., Havaux, X. & Van, B. R. Interrelated overexpression of endothelial and inducible nitric oxide synthases, endothelin-1 and angiogenic factors in human papillary thyroid carcinoma. Clin. Endocrinol. 64, 703\u2013710. https:\/\/doi.org\/10.1111\/j.1365-2265.2006.02535.x (2006).","journal-title":"Clin. Endocrinol."},{"key":"10982_CR31","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/BF03345100","volume":"25","author":"A Patel","year":"2002","unstructured":"Patel, A. et al. Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents. J. Endocrinol. Invest. 25, 675\u2013683. https:\/\/doi.org\/10.1007\/BF03345100 (2002).","journal-title":"J. Endocrinol. Invest."},{"key":"10982_CR32","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.3390\/CANCERS15153995","volume":"15","author":"S Galiniak","year":"2023","unstructured":"Galiniak, S., Biesiadecki, M., Mo\u0142o\u0144, M., Olech, P. & Balawender, K. Serum oxidative and nitrosative stress markers in clear cell renal cell carcinoma. Cancers 15, 3995. https:\/\/doi.org\/10.3390\/CANCERS15153995 (2023).","journal-title":"Cancers"},{"key":"10982_CR33","doi-asserted-by":"publisher","first-page":"1213802","DOI":"10.3389\/FONC.2023.1213802","volume":"13","author":"J Dorf","year":"2023","unstructured":"Dorf, J. et al. Could circulating biomarkers of nitrosative stress and protein glycoxidation be useful in patients with gastric cancer?. Front. Oncol. 13, 1213802. https:\/\/doi.org\/10.3389\/FONC.2023.1213802 (2023).","journal-title":"Front. Oncol."},{"key":"10982_CR34","doi-asserted-by":"publisher","first-page":"8601","DOI":"10.1007\/S13277-015-3548-2","volume":"36","author":"J He","year":"2015","unstructured":"He, J., Shen, N. & Huang, X. Thyroid carcinoma cells produce PLGF to enhance metastasis. Tumour Biol. J. Int. Soc. Oncodev. Biol. Med. 36, 8601\u20138607. https:\/\/doi.org\/10.1007\/S13277-015-3548-2 (2015).","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"key":"10982_CR35","first-page":"211","volume":"10","author":"IWY Cheuk","year":"2020","unstructured":"Cheuk, I. W. Y. et al. ITGAV targeting as a therapeutic approach for treatment of metastatic breast cancer. Am. J. Cancer Res. 10, 211 (2020).","journal-title":"Am. J. Cancer Res."},{"key":"10982_CR36","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1089\/THY.2021.0209","volume":"31","author":"S Xu","year":"2021","unstructured":"Xu, S. et al. Predictive value of serum thyroglobulin for structural recurrence following lobectomy for papillary thyroid carcinoma. Thyroid Off. J. Am. Thyroid Associat. 31, 1391\u20131399. https:\/\/doi.org\/10.1089\/THY.2021.0209 (2021).","journal-title":"Thyroid Off. J. Am. Thyroid Associat."},{"key":"10982_CR37","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1089\/THY.2013.0698","volume":"24","author":"C Durante","year":"2014","unstructured":"Durante, C. et al. Clinical aggressiveness and long-term outcome in patients with papillary thyroid cancer and circulating anti-thyroglobulin autoantibodies. Thyroid 24, 1139. https:\/\/doi.org\/10.1089\/THY.2013.0698 (2014).","journal-title":"Thyroid"},{"key":"10982_CR38","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4161\/CAM.23840","volume":"7","author":"KK Ganguly","year":"2013","unstructured":"Ganguly, K. K., Pal, S., Moulik, S. & Chatterjee, A. Integrins and metastasis. Cell Adhesion Migrat. 7, 251. https:\/\/doi.org\/10.4161\/CAM.23840 (2013).","journal-title":"Cell Adhesion Migrat."},{"key":"10982_CR39","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.3390\/NU14132593","volume":"14","author":"A Palanca","year":"2022","unstructured":"Palanca, A., Ampudia-Blasco, F. J. & Real, J. T. The controversial role of vitamin D in thyroid cancer prevention. Nutrients 14, 2593. https:\/\/doi.org\/10.3390\/NU14132593 (2022).","journal-title":"Nutrients"},{"key":"10982_CR40","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.3390\/CANCERS15092436","volume":"15","author":"A Buczy\u0144ska","year":"2023","unstructured":"Buczy\u0144ska, A. et al. The relationship between oxidative status and radioiodine treatment qualification among papillary thyroid cancer patients. Cancers 15, 2436. https:\/\/doi.org\/10.3390\/CANCERS15092436 (2023).","journal-title":"Cancers"},{"key":"10982_CR41","doi-asserted-by":"publisher","first-page":"682269","DOI":"10.3389\/FCELL.2021.682269\/BIBTEX","volume":"9","author":"N Jiang","year":"2021","unstructured":"Jiang, N. et al. Plasma lipidomics profiling reveals biomarkers for papillary thyroid cancer diagnosis. Front. Cell Dev. Biol. 9, 682269. https:\/\/doi.org\/10.3389\/FCELL.2021.682269\/BIBTEX (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"10982_CR42","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/S0140-6736(17)31833-0","volume":"390","author":"H Wang","year":"2017","unstructured":"Wang, H. et al. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet 390, 1084\u20131150. https:\/\/doi.org\/10.1016\/S0140-6736(17)31833-0 (2017).","journal-title":"The Lancet"},{"key":"10982_CR43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/S10434-004-1165-1","volume":"12","author":"PI Haigh","year":"2005","unstructured":"Haigh, P. I., Urbach, D. R. & Rotstein, L. E. Extent of thyroidectomy is not a major determinant of survival in low- or high-risk papillary thyroid cancer. Ann. Surg. Oncol. 12, 81\u201389. https:\/\/doi.org\/10.1007\/S10434-004-1165-1 (2005).","journal-title":"Ann. Surg. Oncol."},{"key":"10982_CR44","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1530\/ERC-19-0074","volume":"26","author":"K Bergdorf","year":"2019","unstructured":"Bergdorf, K. et al. Papillary thyroid carcinoma behavior: Clues in the tumor microenvironment. Endocr. Relat. Cancer 26, 601\u2013614. https:\/\/doi.org\/10.1530\/ERC-19-0074 (2019).","journal-title":"Endocr. Relat. Cancer"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10982-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10982-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10982-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T14:40:52Z","timestamp":1757256052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-10982-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,19]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["10982"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-10982-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,19]]},"assertion":[{"value":"29 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the Medical University of Bialystok, Poland (APK.002.7.2024).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent has been obtained from the patients to publish this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"26245"}}