{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:15:48Z","timestamp":1790651748138,"version":"4.1.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-11099-3","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T20:39:35Z","timestamp":1752525575000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insights into TtCIPK gene family and its roles in durum wheat in response to PEG and ABA treatments"],"prefix":"10.1038","volume":"15","author":[{"given":"Hadiseh Sadat Hosseini","family":"Pouya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monireh","family":"Cheniany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"11099_CR1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/BF03543249","volume":"31","author":"KF Solomon","year":"2003","unstructured":"Solomon, K. F. & Labuschagne, M. T. Expression of drought tolerance in F1 hybrids of a diallel cross of durum wheat (Triticum turgidum var. durum L.). Cereal Res. Commun. 31, 49\u201356 (2003).","journal-title":"Cereal Res. Commun."},{"key":"11099_CR2","first-page":"9","volume":"3","author":"AA Diab","year":"2008","unstructured":"Diab, A. A. et al. Drought - inducible genes and differentially expressed sequence tags associated with components of drought tolerance in durum wheat. Sci. Res. Essay 3, 9\u201326 (2008).","journal-title":"Sci. Res. Essay"},{"key":"11099_CR3","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.3389\/fpls.2016.01029","volume":"7","author":"R Joshi","year":"2016","unstructured":"Joshi, R. et al. Transcription factors and plants response to drought stress\u202f: Current understanding and future directions. Front. Plant Sci. 7, 1029 (2016).","journal-title":"Front. Plant Sci."},{"key":"11099_CR4","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1126\/science.aaz7614","volume":"368","author":"A Gupta","year":"2020","unstructured":"Gupta, A., Rico-Medina, A. & Ca\u00f1o-Delgado, A. I. The physiology of plant responses to drought. Science (80-) 368, 266\u2013269 (2020).","journal-title":"Science (80-)"},{"key":"11099_CR5","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.plaphy.2012.04.006","volume":"56","author":"P Rampino","year":"2012","unstructured":"Rampino, P. et al. Novel durum wheat genes up-regulated in response to a combination of heat and drought stress. Plant Physiol. Biochem. 56, 72\u201378 (2012).","journal-title":"Plant Physiol. Biochem."},{"key":"11099_CR6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.17113\/ftb.52.04.14.3701","volume":"52","author":"M Melloul","year":"2014","unstructured":"Melloul, M. et al. Identification of differentially expressed genes by cDNA-AFLP technique in response to drought stress in Triticum durum. Food Technol. Biotechnol. 52, 479\u2013488 (2014).","journal-title":"Food Technol. Biotechnol."},{"key":"11099_CR7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2016.08.029","volume":"167","author":"J Zhu","year":"2016","unstructured":"Zhu, J. Review abiotic stress signaling and responses in plants. Cell 167, 313\u2013324 (2016).","journal-title":"Cell"},{"key":"11099_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-981-15-2172-0_9","volume-title":"Plant Ecophysiology and Adaptation under Climate Change: Mechanisms and Perspectives II: Mechanisms of Adaptation and Stress Amelioration","author":"M Khan","year":"2020","unstructured":"Khan, M., Jannat, A., Munir, F., Fatima, N. & Rabia, A. Biochemical and molecular mechanisms of abiotic stress tolerance. In Plant Ecophysiology and Adaptation under Climate Change: Mechanisms and Perspectives II: Mechanisms of Adaptation and Stress Amelioration 187\u2013230 (Springer, 2020)."},{"key":"11099_CR9","doi-asserted-by":"publisher","first-page":"743506","DOI":"10.3389\/fpls.2022.743506","volume":"13","author":"X Xiao","year":"2022","unstructured":"Xiao, X. et al. The calcium sensor calcineurin B-like proteins -calcineurin B-like interacting protein kinases is involved in leaf development and stress responses related to latex flow in Hevea brasiliensis. Front. Plant Sci. 13, 743506 (2022).","journal-title":"Front. Plant Sci."},{"key":"11099_CR10","doi-asserted-by":"publisher","first-page":"28225","DOI":"10.1038\/srep28225","volume":"6","author":"K Zhu","year":"2016","unstructured":"Zhu, K. et al. Evolution of an intron-poor cluster of the CIPK gene family and expression in response to drought stress in soybean. Sci. Rep. 6, 28225 (2016).","journal-title":"Sci. Rep."},{"key":"11099_CR11","doi-asserted-by":"publisher","first-page":"1041078","DOI":"10.3389\/fgene.2022.1041078","volume":"13","author":"C Yang","year":"2022","unstructured":"Yang, C. et al. Diverse roles of the CIPK gene family in transcription regulation and various biotic and abiotic stresses: A literature review and bibliometric study. Front. Genet. 13, 1041078 (2022).","journal-title":"Front. Genet."},{"key":"11099_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1105\/tpc.006858","volume":"15","author":"KN Kim","year":"2003","unstructured":"Kim, K. N., Cheong, Y. H., Grant, J. J., Pandey, G. K. & Luan, S. CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in arabidopsis. Plant Cell 15, 411\u2013423 (2003).","journal-title":"Plant Cell"},{"key":"11099_CR13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1365-313X.2007.03236.x","volume":"52","author":"YH Cheong","year":"2007","unstructured":"Cheong, Y. H. et al. Two calcineurin B-like calcium sensors, interacting with protein kinase CIPK23, regulate leaf transpiration and root potassium uptake in Arabidopsis. Plant J. 52, 223\u2013239 (2007).","journal-title":"Plant J."},{"key":"11099_CR14","doi-asserted-by":"publisher","first-page":"5886","DOI":"10.1038\/s41467-023-41657-0","volume":"14","author":"Z You","year":"2023","unstructured":"You, Z., Guo, S., Li, Q., Fang, Y. & Huang, P. The CBL1 \/ 9-CIPK1 calcium sensor negatively regulates drought stress by phosphorylating the PYLs ABA receptor. Nat. Commun. 14, 5886 (2023).","journal-title":"Nat. Commun."},{"key":"11099_CR15","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.3389\/fpls.2017.01924","volume":"8","author":"SK Sanyal","year":"2017","unstructured":"Sanyal, S. K. et al. Alternative splicing of CIPK3 results in distinct target selection to propagate ABA signaling in Arabidopsis. Front. Plant Sci. 8, 1924 (2017).","journal-title":"Front. Plant Sci."},{"key":"11099_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12870-021-02878-x","volume":"21","author":"L Lu","year":"2021","unstructured":"Lu, L. et al. CIPK11: a calcineurin B-like protein-interacting protein kinase from Nitraria tangutorum, confers tolerance to salt and drought in Arabidopsis. BMC Plant Biol. 21, 1\u201316 (2021).","journal-title":"BMC Plant Biol."},{"key":"11099_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-020-07264-9","volume":"21","author":"W Su","year":"2020","unstructured":"Su, W. et al. New insights into the evolution and functional divergence of the CIPK gene family in Saccharum. BMC Genom. 21, 1\u201320 (2020).","journal-title":"BMC Genom."},{"key":"11099_CR18","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3390\/genes13071191","volume":"13","author":"Q Wang","year":"2022","unstructured":"Wang, Q., Zhao, K., Gong, Y., Yang, Y. & Yue, Y. Genome-wide identification and functional analysis of the calcineurin B-like protein and calcineurin B-like protein-interacting protein kinase gene families in Chinese cabbage (Brassica rapa ssp. pekinensis). Genes 13, 1191 (2022).","journal-title":"Genes"},{"key":"11099_CR19","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.3390\/ijms24043613","volume":"24","author":"L Yang","year":"2023","unstructured":"Yang, L. et al. CBL-interacting protein kinases 18 (CIPK18) gene positively regulates drought resistance in potato. Int. J. Mol. Sci. 24, 3613 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"11099_CR20","doi-asserted-by":"publisher","first-page":"e0167962","DOI":"10.1371\/journal.pone.0167962","volume":"11","author":"Y Wang","year":"2016","unstructured":"Wang, Y. et al. A CBL-interacting protein kinase TaCIPK2 confers drought tolerance in transgenic tobacco plants through regulating the stomatal movement. PLoS ONE 11, e0167962 (2016).","journal-title":"PLoS ONE"},{"key":"11099_CR21","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.tplants.2020.01.009","volume":"25","author":"RJ Tang","year":"2020","unstructured":"Tang, R. J., Wang, C., Li, K. & Luan, S. The CBL\u2013CIPK calcium signaling network: Unified paradigm from 20 years of discoveries. Trends Plant Sci. 25, 604\u2013617 (2020).","journal-title":"Trends Plant Sci."},{"key":"11099_CR22","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.3390\/plants11091100","volume":"11","author":"B Paes de Melo","year":"2022","unstructured":"Paes de Melo, B. et al. Abiotic stresses in plants and their markers: A practice view of plant stress responses and programmed cell death mechanisms. Plants 11, 1100 (2022).","journal-title":"Plants"},{"key":"11099_CR23","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3389\/fpls.2017.00978","volume":"8","author":"Y Xi","year":"2017","unstructured":"Xi, Y., Liu, J., Dong, C. & Cheng, Z. M. M. The CBL and CIPK gene family in grapevine (Vitis vinifera): Genome-wide analysis and expression profiles in response to various abiotic stresses. Front. Plant Sci. 8, 978 (2017).","journal-title":"Front. Plant Sci."},{"key":"11099_CR24","doi-asserted-by":"publisher","first-page":"e3653","DOI":"10.7717\/peerj.3653","volume":"5","author":"T Lu","year":"2017","unstructured":"Lu, T., Zhang, G., Sun, L., Wang, J. & Hao, F. Genome-wide identification of CBL family and expression analysis of CBLs in response to potassium deficiency in cotton. PeerJ 5, e3653 (2017).","journal-title":"PeerJ"},{"key":"11099_CR25","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1104\/pp.16.00949","volume":"173","author":"E Guti\u00e9rrez-Beltr\u00e1n","year":"2017","unstructured":"Guti\u00e9rrez-Beltr\u00e1n, E., Personat, J. M., de la Torre, F. & del Pozo, O. A universal stress protein involved in oxidative stress1 is a phosphorylation target for protein kinase CIPK6. Plant Physiol. 173, 836\u2013852 (2017).","journal-title":"Plant Physiol."},{"key":"11099_CR26","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/1541-4337.12262","volume":"16","author":"A Arzani","year":"2017","unstructured":"Arzani, A. & Ashraf, M. Cultivated ancient wheats (Triticum spp.): A potential source of health-beneficial food products. Compr. Rev. Food Sci. Food Saf. 16, 477\u2013488 (2017).","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"11099_CR27","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s42976-022-00305-x","volume":"51","author":"P Saini","year":"2023","unstructured":"Saini, P. et al. Nutritional value and end-use quality of durum wheat. Cereal Res. Commun. 51, 283\u2013294 (2023).","journal-title":"Cereal Res. Commun."},{"key":"11099_CR28","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.3390\/plants10122599","volume":"10","author":"MA De Santis","year":"2021","unstructured":"De Santis, M. A., Soccio, M., Laus, M. N. & Flagella, Z. Influence of drought and salt stress on durum wheat grain quality and composition: A review. Plants 10, 2599 (2021).","journal-title":"Plants"},{"key":"11099_CR29","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3390\/plants12020397","volume":"12","author":"DBM Ficco","year":"2023","unstructured":"Ficco, D. B. M. et al. Durum wheat bread with a potentially high health value through the addition of durum wheat thin bran or barley flour. Plants 12, 397 (2023).","journal-title":"Plants"},{"key":"11099_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-6658-5_1","volume":"1533","author":"DM Bolser","year":"2017","unstructured":"Bolser, D. M., Staines, D. M. & Perry, E. K. P. Ensembl plants: integrating tools for visualizing, mining, and analyzing plant genomic data. Plant Genom. Databases Methods Protoc. 1533, 1\u201331 (2017).","journal-title":"Plant Genom. Databases Methods Protoc."},{"key":"11099_CR31","doi-asserted-by":"publisher","first-page":"D222","DOI":"10.1093\/nar\/gku1221","volume":"43","author":"A Marchler-Bauer","year":"2015","unstructured":"Marchler-Bauer, A. et al. CDD: NCBI\u2019s conserved domain database. Nucleic Acids Res. 43, D222\u2013D226 (2015).","journal-title":"Nucleic Acids Res."},{"key":"11099_CR32","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1093\/nar\/gkt1223","volume":"42","author":"RD Finn","year":"2014","unstructured":"Finn, R. D. et al. Pfam: The protein families database. Nucleic Acids Res. 42, 222\u2013230 (2014).","journal-title":"Nucleic Acids Res."},{"key":"11099_CR33","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1093\/nar\/gkg563","volume":"31","author":"E Gasteiger","year":"2003","unstructured":"Gasteiger, E. et al. ExPASy: The proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res. 31, 3784\u20133788 (2003).","journal-title":"Nucleic Acids Res."},{"key":"11099_CR34","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.molp.2020.06.009","volume":"13","author":"C Chen","year":"2020","unstructured":"Chen, C. et al. TBtools: An integrative toolkit developed for interactive analyses of big biological data. Mol. Plant. 13, 1194\u20131202 (2020).","journal-title":"Mol. Plant."},{"key":"11099_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/0471250953.bi0203s00","volume":"00","author":"JD Thompson","year":"2003","unstructured":"Thompson, J. D., Gibson, T. J. & Higgins, D. G. Multiple sequence alignment Using ClustalW and ClustalX. Curr. Protoc. Bioinform. 00, 1\u201322 (2003).","journal-title":"Curr. Protoc. Bioinform."},{"key":"11099_CR36","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/molbev\/msu300","volume":"32","author":"LT Nguyen","year":"2015","unstructured":"Nguyen, L. T., Schmidt, H. A., Von Haeseler, A. & Minh, B. Q. IQ-TREE: A fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol. Biol. Evol. 32, 268\u2013274 (2015).","journal-title":"Mol. Biol. Evol."},{"key":"11099_CR37","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1093\/nar\/gkz239","volume":"47","author":"I Letunic","year":"2019","unstructured":"Letunic, I. & Bork, P. Interactive Tree of Life (iTOL) v4: Recent updates and new developments. Nucleic Acids Res. 47, 256\u2013259 (2019).","journal-title":"Nucleic Acids Res."},{"key":"11099_CR38","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3390\/genes14010202","volume":"14","author":"M Yaghobi","year":"2023","unstructured":"Yaghobi, M. & Heidari, P. Genome-wide analysis of aquaporin gene family in Triticum turgidum and Its expression profile in response to salt stress. Genes 14, 202 (2023).","journal-title":"Genes"},{"key":"11099_CR39","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/S0168-9525(02)02722-1","volume":"18","author":"LD Hurst","year":"2002","unstructured":"Hurst, L. D. The Ka\/Ks ratio: Diagnosing the form of sequence evolution. Trends Genet. 18, 486\u2013487 (2002).","journal-title":"Trends Genet."},{"key":"11099_CR40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2229-4-10","volume":"4","author":"SB Cannon","year":"2004","unstructured":"Cannon, S. B., Mitra, A., Baumgarten, A., Young, N. D. & May, G. The roles of segmental and tandem gene duplication in the evolution of large gene families in Arabidopsis thaliana. BMC Plant Biol. 4, 10 (2004).","journal-title":"BMC Plant Biol."},{"key":"11099_CR41","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1093\/aob\/mcu061","volume":"113","author":"D Liu","year":"2014","unstructured":"Liu, D. et al. Phylogenetic analyses provide the first insights into the evolution of OVATE family proteins in land plants. Ann. Bot. 113, 1219\u20131233 (2014).","journal-title":"Ann. Bot."},{"key":"11099_CR42","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/nar\/30.1.325","volume":"30","author":"M Lescot","year":"2002","unstructured":"Lescot, M. et al. PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences. Nucleic Acids Res. 30, 325\u2013327 (2002).","journal-title":"Nucleic Acids Res."},{"key":"11099_CR43","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3390\/genes14020333","volume":"14","author":"F Puresmaeli","year":"2023","unstructured":"Puresmaeli, F., Heidari, P. & Lawson, S. Insights into the sulfate transporter gene family and its expression patterns in durum wheat seedlings under salinity. Genes 14, 333 (2023).","journal-title":"Genes"},{"key":"11099_CR44","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nprot.2015.053","volume":"10","author":"LA Kelley","year":"2016","unstructured":"Kelley, L. A., Mezulis, S., Yates, C. M., Wass, M. N. & Sternberg, M. J. The Phyre2 web portal for protein modeling, prediction and analysis. Nat. Protoc. 10, 845\u2013858 (2016).","journal-title":"Nat. Protoc."},{"key":"11099_CR45","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1007\/s11033-019-04704-y","volume":"46","author":"ML D\u00edaz","year":"2019","unstructured":"D\u00edaz, M. L., Soresi, D. S., Basualdo, J., Cuppari, S. J. & Carrera, A. Transcriptomic response of durum wheat to cold stress at reproductive stage. Mol. Biol. Rep. 46, 2427\u20132445 (2019).","journal-title":"Mol. Biol. Rep."},{"key":"11099_CR46","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders, S., Pyl, P. T. & Huber, W. HTSeq-A python framework to work with high-throughput sequencing data. Bioinformatics 31, 166\u2013169 (2015).","journal-title":"Bioinformatics"},{"key":"11099_CR47","doi-asserted-by":"publisher","first-page":"18","DOI":"10.14806\/ej.17.B.265","volume":"17","author":"S Tarazona","year":"2012","unstructured":"Tarazona, S., Garc\u00eda, F., Ferrer, A., Dopazo, J. & Conesa, A. NOIseq: a RNA-seq differential expression method robust for sequencing depth biases. EMBnet J. 17, 18 (2012).","journal-title":"EMBnet J."},{"key":"11099_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/genes11121464","volume":"11","author":"S Faraji","year":"2020","unstructured":"Faraji, S. et al. The AP2\/ERF gene family in Triticum durum: Genome-wide identification and expression analysis under drought and salinity stresses. Genes 11, 1\u201324 (2020).","journal-title":"Genes"},{"key":"11099_CR49","first-page":"2628","volume":"34","author":"AH Huang","year":"2021","unstructured":"Huang, A. H. et al. Response of maize seed germination characteristics to different concentrations PEG-6000. Southwest China J Agric Sci. 34, 2628\u20132633 (2021).","journal-title":"Southwest China J Agric Sci."},{"key":"11099_CR50","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.envexpbot.2010.01.009","volume":"86","author":"S Sripinyowanich","year":"2013","unstructured":"Sripinyowanich, S., Klomsakul, P. & Boonburapong, B. Exogenous ABA induces salt tolerance in indica rice ( Oryza sativa L.): The role of OsP5CS1 and OsP5CR gene expression during salt stress. Environ. Exp. Bot. 86, 94\u2013105 (2013).","journal-title":"Environ. Exp. Bot."},{"key":"11099_CR51","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.plaphy.2011.06.002","volume":"49","author":"M Ayadi","year":"2011","unstructured":"Ayadi, M., Cavez, D., Miled, N., Chaumont, F. & Masmoudi, K. Identification and characterization of two plasma membrane aquaporins in durum wheat (Triticum turgidum L. subsp. durum) and their role in abiotic stress tolerance. Plant Physiol. Biochem. 49, 1029\u20131039 (2011).","journal-title":"Plant Physiol. Biochem."},{"issue":"2","key":"11099_CR52","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/nar\/gkm306","volume":"35","author":"A Untergasser","year":"2007","unstructured":"Untergasser, A. et al. Primer3Plus, an enhanced web interface to Primer3. Nucleic Acids Res. 35(2), 71\u201374 (2007).","journal-title":"Nucleic Acids Res."},{"key":"11099_CR53","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/978-1-4939-2365-6_13","volume":"1275","author":"B Thornton","year":"2015","unstructured":"Thornton, B. & Basu, C. Rapid and simple method of qPCR primer design. Methods Mol. Biol. 1275, 173\u2013179 (2015).","journal-title":"Methods Mol. Biol."},{"key":"11099_CR54","doi-asserted-by":"publisher","first-page":"E4532","DOI":"10.1073\/pnas.1407610111","volume":"111","author":"A Chaves-sanjuan","year":"2014","unstructured":"Chaves-sanjuan, A., Sanchez-barrena, M. J., Gonzalez-rubio, J. M., Moreno, M. & Ragel, P. Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress. Proc. Natl. Acad. Sci. 111, E4532\u2013E4541 (2014).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"11099_CR55","doi-asserted-by":"publisher","first-page":"13535","DOI":"10.3390\/ijms222413535","volume":"22","author":"R Ma","year":"2021","unstructured":"Ma, R. et al. Genome-wide identification, characterization and expression analysis of the CIPK gene family in potato ( Solanum tuberosum L.) and the role of StCIPK10 in response to drought and osmotic stress. Int. J. Mol. Sci. 22, 13535 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"11099_CR56","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.3390\/ijms19072131","volume":"19","author":"L Niu","year":"2018","unstructured":"Niu, L., Dong, B., Song, Z. & Meng, D. Genome-wide identification and characterization of CIPK family and analysis responses to various stresses in apple ( Malus domestica). Int. J. Mol. Sci. 19, 2131 (2018).","journal-title":"Int. J. Mol. Sci."},{"key":"11099_CR57","doi-asserted-by":"publisher","first-page":"e6847","DOI":"10.7717\/peerj.6847","volume":"7","author":"P Li","year":"2019","unstructured":"Li, P., Zheng, T. & Li, L. Identi fi cation and comparative analysis of the CIPK gene family and characterization of the cold stress response in the woody plant Prunus mume. PeerJ 7, e6847 (2019).","journal-title":"PeerJ"},{"key":"11099_CR58","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1111\/pce.14396","volume":"46","author":"J Mao","year":"2023","unstructured":"Mao, J. et al. The CBL-CIPK network is involved in the physiological crosstalk between plant growth and stress adaptation. Plant Cell Environ. 46, 3012\u20133022 (2023).","journal-title":"Plant Cell Environ."},{"key":"11099_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/agronomy12051135","volume":"12","author":"F Mart\u00ednez-Moreno","year":"2022","unstructured":"Mart\u00ednez-Moreno, F., Ammar, K. & Sol\u00eds, I. Global changes in cultivated area and breeding activities of durum wheat from 1800 to date: A historical review. Agronomy 12, 1\u201317 (2022).","journal-title":"Agronomy"},{"key":"11099_CR60","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3390\/ijms21010110","volume":"21","author":"Y Zhang","year":"2020","unstructured":"Zhang, Y. et al. Identification and functional analysis of tomato CIPK gene family. Int. J. Mol. Sci. 21, 110 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"11099_CR61","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10725-007-9165-3","volume":"35","author":"Y Yu","year":"2007","unstructured":"Yu, Y., Xia, \u00c6. X. & Yin, \u00c6. W. Comparative genomic analysis of CIPK gene family in Arabidopsis and Populus. Plant Growth Regul. 35, 101\u2013110 (2007).","journal-title":"Plant Growth Regul."},{"key":"11099_CR62","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s12870-015-0657-4","volume":"15","author":"T Sun","year":"2015","unstructured":"Sun, T. et al. Identification and comprehensive analyses of the CBL and CIPK gene families in wheat (Triticum aestivum L.). BMC Plant Biol. 15, 269 (2015).","journal-title":"BMC Plant Biol."},{"key":"11099_CR63","doi-asserted-by":"publisher","first-page":"100417","DOI":"10.1016\/j.stress.2024.100417","volume":"11","author":"P Narwal","year":"2024","unstructured":"Narwal, P., Singh, R. K., Pathak, A. K., Kumar, D. & Negi, N. P. Genome-wide profiling of CBL interacting protein kinases (CIPKs) in banana unveils their role in abiotic stress signaling and stress tolerance enhancement. Plant Stress 11, 100417 (2024).","journal-title":"Plant Stress"},{"key":"11099_CR64","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1007\/s11270-023-06758-y","volume":"234","author":"SA Sharifi","year":"2023","unstructured":"Sharifi, S. A., Zaeimdar, M., Jozi, S. A. & Hejazi, R. Effects of soil, water and air pollution with heavy metal ions around lead and zinc mining and processing factories. Water Air Soil Pollut. 234, 760 (2023).","journal-title":"Water Air Soil Pollut."},{"key":"11099_CR65","doi-asserted-by":"publisher","first-page":"e0225091","DOI":"10.1371\/journal.pone.0225091","volume":"14","author":"J Zhao","year":"2019","unstructured":"Zhao, J. et al. Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses. PLoS ONE 14, e0225091 (2019).","journal-title":"PLoS ONE"},{"key":"11099_CR66","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3389\/fpls.2016.00571","volume":"7","author":"SK Sah","year":"2016","unstructured":"Sah, S. K., Reddy, K. R. & Li, J. Abscisic acid and abiotic stress tolerance in crop plants. Front. Plant Sci. 7, 571 (2016).","journal-title":"Front. Plant Sci."},{"key":"11099_CR67","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00299-013-1414-5","volume":"32","author":"R Aryadeep","year":"2013","unstructured":"Aryadeep, R., Saikat, P. & Basu, S. Cross-talk between abscisic acid-dependent and abscisic acid-independent pathways during abiotic stress. Plant Cell Rep. 32, 985\u20131006 (2013).","journal-title":"Plant Cell Rep."},{"key":"11099_CR68","doi-asserted-by":"publisher","first-page":"11599","DOI":"10.3390\/ijms231911599","volume":"23","author":"L Zhu","year":"2022","unstructured":"Zhu, L. et al. Genome-wide investigation and expression analysis of the Nitraria sibirica Pall. CIPK gene family. Int. J. Mol. Sci. 23, 11599 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"11099_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/plants8120592","volume":"8","author":"M Kumar","year":"2019","unstructured":"Kumar, M. et al. Integration of abscisic acid signaling with other signaling pathways in plant stress responses and development. Plants 8, 1\u201320 (2019).","journal-title":"Plants"},{"key":"11099_CR70","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/s12864-022-08683-6","volume":"23","author":"Z Xiaolin","year":"2022","unstructured":"Xiaolin, Z., Baoqiang, W., Xian, W. & Xiaohong, W. Identification of the CIPK - CBL family gene and functional characterization of CqCIPK14 gene under drought stress in quinoa. BMC Genom. 23, 447 (2022).","journal-title":"BMC Genom."},{"key":"11099_CR71","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1111\/pce.14596","volume":"46","author":"B Ravi","year":"2023","unstructured":"Ravi, B., Foyer, C. H. & Pandey, G. K. The integration of reactive oxygen species (ROS) and calcium signalling in abiotic stress responses. Plant Cell Environ. 46, 1985\u20132006 (2023).","journal-title":"Plant Cell Environ."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11099-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11099-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11099-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T10:53:11Z","timestamp":1757242391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11099-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["11099"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-11099-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"17 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25419"}}