{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:14:58Z","timestamp":1783606498330,"version":"3.55.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"NIH","award":["AI140132"],"award-info":[{"award-number":["AI140132"]}]},{"name":"NIH","award":["AI140132"],"award-info":[{"award-number":["AI140132"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-11209-1","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T12:47:05Z","timestamp":1753188425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["IgM+IgD\u2212 B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells"],"prefix":"10.1038","volume":"15","author":[{"given":"Ameera M.","family":"Bukhari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline T. Luning","family":"Prak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"11209_CR1","first-page":"73","volume-title":"Richard Polin","author":"WAW Erika Claud","year":"2008","unstructured":"Erika Claud, W. A. W. Chap. 5 - The intestinal microbiota and the microbiome. Gastroenterology and nutrition: neonatology questions and controversies, 73\u201392, ed. J.N. Richard Polin. W.B. Saunders: Elsevier Inc. (2008)."},{"issue":"4","key":"11209_CR2","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41385-021-00389-4","volume":"14","author":"UM Morbe","year":"2021","unstructured":"Morbe, U. M. et al. Human gut-associated lymphoid tissues (GALT); diversity, structure, and function. Mucosal Immunol. 14(4), 793\u2013802 (2021).","journal-title":"Mucosal Immunol."},{"issue":"5","key":"11209_CR3","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/0016-5085(93)90128-Y","volume":"105","author":"MF Kagnoff","year":"1993","unstructured":"Kagnoff, M. F. Immunology of the intestinal tract. Gastroenterology 105(5), 1275\u20131280 (1993).","journal-title":"Gastroenterology"},{"issue":"5","key":"11209_CR4","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/mi.2016.59","volume":"9","author":"J Spencer","year":"2016","unstructured":"Spencer, J. & Sollid, L. M. The human intestinal B-cell response. Mucosal Immunol. 9(5), 1113\u20131124 (2016).","journal-title":"Mucosal Immunol."},{"issue":"2","key":"11209_CR5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.it.2019.12.005","volume":"41","author":"E Michaud","year":"2020","unstructured":"Michaud, E. et al. Human secretory IgM: an elusive player in mucosal immunity. Trends Immunol. 41(2), 141\u2013156 (2020).","journal-title":"Trends Immunol."},{"issue":"1","key":"11209_CR6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.immuni.2017.06.013","volume":"47","author":"G Magri","year":"2017","unstructured":"Magri, G. et al. Human secretory IgM emerges from plasma cells clonally related to gut memory B cells and targets highly diverse commensals. Immunity 47(1), 118\u2013134e8 (2017).","journal-title":"Immunity"},{"issue":"31","key":"11209_CR7","doi-asserted-by":"publisher","first-page":"21617","DOI":"10.1074\/jbc.M114.549139","volume":"289","author":"S Longet","year":"2014","unstructured":"Longet, S. et al. Reconstituted human polyclonal plasma-derived secretory-like IgM and IgA maintain the barrier function of epithelial cells infected with an enteropathogen. J. Biol. Chem. 289(31), 21617\u201321626 (2014).","journal-title":"J. Biol. Chem."},{"key":"11209_CR8","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.3389\/fimmu.2017.01043","volume":"8","author":"G Bioley","year":"2017","unstructured":"Bioley, G. et al. Plasma-derived polyreactive secretory-like IgA and IgM opsonizing Salmonella enterica typhimurium reduces invasion and gut tissue inflammation through agglutination. Front. Immunol. 8, 1043 (2017).","journal-title":"Front. Immunol."},{"issue":"1","key":"11209_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/sji.12499","volume":"85","author":"R Yazdani","year":"2017","unstructured":"Yazdani, R. et al. Selective IgA deficiency: epidemiology, pathogenesis, clinical phenotype, diagnosis, prognosis and management. Scand. J. Immunol. 85(1), 3\u201312 (2017).","journal-title":"Scand. J. Immunol."},{"issue":"4","key":"11209_CR10","doi-asserted-by":"publisher","first-page":"170","DOI":"10.4049\/immunohorizons.2100014","volume":"5","author":"MA Mella","year":"2021","unstructured":"Mella, M. A. et al. Compensatory IgM to the rescue: patients with selective IgA deficiency have increased natural IgM antibodies to MAA-LDL and no changes in oral microbiota. Immunohorizons 5(4), 170\u2013181 (2021).","journal-title":"Immunohorizons"},{"issue":"1","key":"11209_CR11","doi-asserted-by":"publisher","first-page":"13574","DOI":"10.1038\/s41598-019-49923-2","volume":"9","author":"JR Catanzaro","year":"2019","unstructured":"Catanzaro, J. R. et al. IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM. Sci. Rep. 9(1), 13574 (2019).","journal-title":"Sci. Rep."},{"issue":"4","key":"11209_CR12","doi-asserted-by":"publisher","first-page":"p332","DOI":"10.1007\/s10875-017-0392-8","volume":"37","author":"JP Hodkinson","year":"2017","unstructured":"Hodkinson, J. P. et al. Low IgA and IgM is associated with a higher prevalence of bronchiectasis in primary antibody deficiency (37, Pg 329, 2017). J. Clin. Immunol. 37(4), p332\u2013p332 (2017).","journal-title":"J. Clin. Immunol."},{"issue":"1","key":"11209_CR13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s10875-008-9229-9","volume":"29","author":"A Aghamohammadi","year":"2009","unstructured":"Aghamohammadi, A. et al. IgA deficiency: correlation between clinical and immunological phenotypes. J. Clin. Immunol. 29(1), 130\u2013136 (2009).","journal-title":"J. Clin. Immunol."},{"key":"11209_CR14","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.3389\/fimmu.2017.01056","volume":"8","author":"S Gupta","year":"2017","unstructured":"Gupta, S. & Gupta, A. Selective IgM deficiency-An underestimated primary immunodeficiency. Front. Immunol. 8, 1056 (2017).","journal-title":"Front. Immunol."},{"issue":"1","key":"11209_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1084\/jem.20101499","volume":"208","author":"DO Griffin","year":"2011","unstructured":"Griffin, D. O., Holodick, N. E. & Rothstein, T. L. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20\u2009+\u2009CD27\u2009+\u2009CD43\u2009+\u2009CD70. J. Exp. Med. 208(1), 67\u201380 (2011).","journal-title":"J. Exp. Med."},{"key":"11209_CR16","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.3389\/fimmu.2018.02242","volume":"9","author":"D Appelgren","year":"2018","unstructured":"Appelgren, D. et al. Marginal-zone B-cells are main producers of IgM in humans, and are reduced in patients with autoimmune vasculitis. Front. Immunol. 9, 2242 (2018).","journal-title":"Front. Immunol."},{"key":"11209_CR17","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3389\/fimmu.2020.00736","volume":"11","author":"D Bautista","year":"2020","unstructured":"Bautista, D. et al. Differential expression of IgM and IgD discriminates two subpopulations of human circulating IgM(+)IgD(+)CD27(+) B cells that differ phenotypically, functionally, and genetically. Front. Immunol. 11, 736 (2020).","journal-title":"Front. Immunol."},{"issue":"12","key":"11209_CR18","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1182\/blood-2004-01-0346","volume":"104","author":"S Weller","year":"2004","unstructured":"Weller, S. et al. Human blood IgM memory B cells are circulating splenic marginal zone B cells harboring a prediversified Immunoglobulin repertoire. Blood 104(12), 3647\u20133654 (2004).","journal-title":"Blood"},{"issue":"3","key":"11209_CR19","first-page":"607","volume":"62","author":"J Spencer","year":"1985","unstructured":"Spencer, J. et al. The human gut contains a novel population of B lymphocytes which resemble marginal zone cells. Clin. Exp. Immunol. 62(3), 607\u2013612 (1985).","journal-title":"Clin. Exp. Immunol."},{"issue":"8","key":"11209_CR20","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.4049\/jimmunol.1500753","volume":"195","author":"D Bagnara","year":"2015","unstructured":"Bagnara, D. et al. A reassessment of IgM memory subsets in humans. J. Immunol. 195(8), 3716\u20133724 (2015).","journal-title":"J. Immunol."},{"issue":"1","key":"11209_CR21","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1038\/s41467-018-06089-1","volume":"9","author":"Y Zhao","year":"2018","unstructured":"Zhao, Y. et al. Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue. Nat. Commun. 9(1), 3857 (2018).","journal-title":"Nat. Commun."},{"issue":"9","key":"11209_CR22","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nbt.3942","volume":"35","author":"W Meng","year":"2017","unstructured":"Meng, W. et al. An atlas of B-cell clonal distribution in the human body. Nat. Biotechnol. 35(9), 879\u2013884 (2017).","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"11209_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/imr.12736","volume":"288","author":"JJ Knox","year":"2019","unstructured":"Knox, J. J., Myles, A. & Cancro, M. P. T-bet(+) memory B cells: generation, function, and fate. Immunol. Rev. 288(1), 149\u2013160 (2019).","journal-title":"Immunol. Rev."},{"issue":"4","key":"11209_CR24","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.immuni.2018.08.015","volume":"49","author":"SA Jenks","year":"2018","unstructured":"Jenks, S. A. et al. Distinct effector B cells induced by unregulated Toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus. Immunity 49(4), 725\u2013739e6 (2018).","journal-title":"Immunity"},{"key":"11209_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.cellimm.2017.05.008","volume":"321","author":"JL Karnell","year":"2017","unstructured":"Karnell, J. L. et al. Role of CD11c(+) T-bet(+) B cells in human health and disease. Cell. Immunol. 321, 40\u201345 (2017).","journal-title":"Cell. Immunol."},{"key":"11209_CR26","doi-asserted-by":"crossref","unstructured":"Ghraichy, M. et al. Different B cell subpopulations show distinct patterns in their IgH repertoire metrics. Elife. 10 (2021).","DOI":"10.7554\/eLife.73111"},{"issue":"7","key":"11209_CR27","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1172\/JCI200112462","volume":"108","author":"AE Pugh-Bernard","year":"2001","unstructured":"Pugh-Bernard, A. E. et al. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J. Clin. Invest. 108(7), 1061\u20131070 (2001).","journal-title":"J. Clin. Invest."},{"key":"11209_CR28","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3389\/fimmu.2016.00546","volume":"7","author":"VG Martin","year":"2016","unstructured":"Martin, V. G. et al. Transitional B cells in early human B cell development - Time to revisit the paradigm? Front. Immunol. 7, 546 (2016).","journal-title":"Front. Immunol."},{"issue":"1","key":"11209_CR29","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/cei.12149","volume":"174","author":"S Agrawal","year":"2013","unstructured":"Agrawal, S. et al. Transitional B cell subsets in human bone marrow. Clin. Exp. Immunol. 174(1), 53\u201359 (2013).","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"11209_CR30","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1084\/jem.188.9.1679","volume":"188","author":"U Klein","year":"1998","unstructured":"Klein, U., Rajewsky, K. & Kuppers, R. Human immunoglobulin (Ig)M\u2009+\u2009IgD\u2009+\u2009peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188(9), 1679\u20131689 (1998).","journal-title":"J. Exp. Med."},{"issue":"38","key":"11209_CR31","doi-asserted-by":"publisher","first-page":"E5281","DOI":"10.1073\/pnas.1511270112","volume":"112","author":"B Budeus","year":"2015","unstructured":"Budeus, B. et al. Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers. Proc. Natl. Acad. Sci. U S A. 112(38), E5281\u2013E5289 (2015).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"11209_CR32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fimmu.2011.00081","volume":"2","author":"YC Wu","year":"2011","unstructured":"Wu, Y. C., Kipling, D. & Dunn-Walters, D. K. The relationship between CD27 negative and positive B cell populations in human peripheral blood. Front. Immunol. 2, 81 (2011).","journal-title":"Front. Immunol."},{"issue":"9","key":"11209_CR33","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1016\/j.celrep.2020.02.022","volume":"30","author":"O Grimsholm","year":"2020","unstructured":"Grimsholm, O. et al. The interplay between CD27(dull) and CD27(bright) B cells ensures the flexibility, stability, and resilience of human B cell memory. Cell. Rep. 30(9), 2963\u20132977e6 (2020).","journal-title":"Cell. Rep."},{"issue":"6","key":"11209_CR34","doi-asserted-by":"publisher","first-page":"E546","DOI":"10.1073\/pnas.1416276112","volume":"112","author":"M Seifert","year":"2015","unstructured":"Seifert, M. et al. Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions. Proc. Natl. Acad. Sci. U S A. 112(6), E546\u2013E555 (2015).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"11209_CR35","doi-asserted-by":"crossref","unstructured":"Noviski, M. et al. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. 7 (2018).","DOI":"10.7554\/eLife.35074"},{"issue":"10","key":"11209_CR36","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/gtc.12635","volume":"23","author":"S Yasuda","year":"2018","unstructured":"Yasuda, S. et al. Opposing roles of IgM and IgD in BCR-induced B-cell survival. Genes Cells. 23(10), 868\u2013879 (2018).","journal-title":"Genes Cells"},{"issue":"7","key":"11209_CR37","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/eji.201646547","volume":"48","author":"C Gutzeit","year":"2018","unstructured":"Gutzeit, C., Chen, K. & Cerutti, A. The enigmatic function of IgD: some answers at last. Eur. J. Immunol. 48(7), 1101\u20131113 (2018).","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"11209_CR38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/cyto.a.24507","volume":"101","author":"R Carsetti","year":"2022","unstructured":"Carsetti, R. et al. Comprehensive phenotyping of human peripheral blood B lymphocytes in healthy conditions. Cytometry A. 101(2), 131\u2013139 (2022).","journal-title":"Cytometry A"},{"key":"11209_CR39","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.3389\/fimmu.2019.02458","volume":"10","author":"I Sanz","year":"2019","unstructured":"Sanz, I. et al. Challenges and opportunities for consistent classification of human B cell and plasma cell populations. Front. Immunol. 10, 2458 (2019).","journal-title":"Front. Immunol."},{"issue":"24","key":"11209_CR40","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.1182\/blood.2019002782","volume":"136","author":"NM Weisel","year":"2020","unstructured":"Weisel, N. M. et al. Comprehensive analyses of B-cell compartments across the human body reveal novel subsets and a gut-resident memory phenotype. Blood 136(24), 2774\u20132785 (2020).","journal-title":"Blood"},{"key":"11209_CR41","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3389\/fimmu.2019.00483","volume":"10","author":"N Rodriguez-Zhurbenko","year":"2019","unstructured":"Rodriguez-Zhurbenko, N. et al. Human B-1 cells and B-1 cell antibodies change with advancing age. Front. Immunol. 10, 483 (2019).","journal-title":"Front. Immunol."},{"issue":"3","key":"11209_CR42","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/s41590-023-01721-9","volume":"25","author":"D Callahan","year":"2024","unstructured":"Callahan, D. et al. Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states. Nat. Immunol. 25(3), 562\u2013575 (2024).","journal-title":"Nat. Immunol."},{"key":"11209_CR43","doi-asserted-by":"publisher","first-page":"1380386","DOI":"10.3389\/fimmu.2024.1380386","volume":"15","author":"JI Pernes","year":"2024","unstructured":"Pernes, J. I. et al. Unravelling B cell heterogeneity: insights into flow cytometry-gated B cells from single-cell multi-omics data. Front. Immunol. 15, 1380386 (2024).","journal-title":"Front. Immunol."},{"issue":"1","key":"11209_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/imr.12731","volume":"288","author":"AM Haberman","year":"2019","unstructured":"Haberman, A. M. et al. Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches. Immunol. Rev. 288(1), 10\u201327 (2019).","journal-title":"Immunol. Rev."},{"key":"11209_CR45","doi-asserted-by":"crossref","unstructured":"Smith, F. L. et al. B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM. J. Exp. Med., 220(4). (2023).","DOI":"10.1084\/jem.20220195"},{"issue":"3","key":"11209_CR46","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.cell.2020.11.035","volume":"184","author":"AS Japp","year":"2021","unstructured":"Japp, A. S. et al. TCR(+)\/BCR(+) dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes. Cell 184(3), 827\u2013839e14 (2021).","journal-title":"Cell"},{"issue":"8","key":"11209_CR47","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/s41590-023-01557-3","volume":"24","author":"R Matsumoto","year":"2023","unstructured":"Matsumoto, R. et al. Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity. Nat. Immunol. 24(8), 1370\u20131381 (2023).","journal-title":"Nat. Immunol."},{"key":"11209_CR48","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/B978-012053641-2\/50029-0","volume-title":"Molecular Biology of B Cells","author":"D Lanning","year":"2004","unstructured":"Lanning, D., Knight, K. L. & Wilson, R. A. A key role for GALT in B cell development, in Molecular Biology of B Cells, F.W. Alt, T. Honjo, and N.S. Neuberger, Editors. Elsevier: London. 433\u2013448. (2004)."},{"issue":"3","key":"11209_CR49","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0145-305X(98)00014-7","volume":"22","author":"JC Weill","year":"1998","unstructured":"Weill, J. C. & Reynaud, C. A. GALT versus bone marrow models of B cell ontogeny. Dev. Comp. Immunol. 22(3), 379\u2013385 (1998).","journal-title":"Dev. Comp. Immunol."},{"key":"11209_CR50","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/978-1-0716-2115-8_18","volume":"2453","author":"AM Rosenfeld","year":"2022","unstructured":"Rosenfeld, A. M. et al. Bulk gDNA sequencing of antibody heavy-chain gene rearrangements for detection and analysis of B-cell clone distribution: A method by the AIRR community. Methods Mol. Biol. 2453, 317\u2013343 (2022).","journal-title":"Methods Mol. Biol."},{"issue":"13","key":"11209_CR51","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1093\/bioinformatics\/btu138","volume":"30","author":"JA Vander Heiden","year":"2014","unstructured":"Vander Heiden, J. A. et al. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics 30(13), 1930\u20131932 (2014).","journal-title":"Bioinformatics"},{"issue":"Web Server issu","key":"11209_CR52","doi-asserted-by":"publisher","first-page":"W34","DOI":"10.1093\/nar\/gkt382","volume":"41","author":"J Ye","year":"2013","unstructured":"Ye, J. et al. IgBLAST: an immunoglobulin variable domain sequence analysis tool. Nucleic Acids Res. 41(Web Server issue), W34\u201340 (2013).","journal-title":"Nucleic Acids Res."},{"key":"11209_CR53","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.3389\/fimmu.2018.02107","volume":"9","author":"AM Rosenfeld","year":"2018","unstructured":"Rosenfeld, A. M. et al. ImmuneDB, a novel tool for the analysis, storage, and dissemination of immune repertoire sequencing data. Front. Immunol. 9, 2107 (2018).","journal-title":"Front. Immunol."},{"issue":"6","key":"11209_CR54","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1093\/molbev\/msw046","volume":"33","author":"J Huerta-Cepas","year":"2016","unstructured":"Huerta-Cepas, J., Serra, F. & Bork, P. ETE 3: reconstruction, analysis, and visualization of phylogenomic data. Mol. Biol. Evol. 33(6), 1635\u20131638 (2016).","journal-title":"Mol. Biol. Evol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11209-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11209-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11209-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T18:48:47Z","timestamp":1757270927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11209-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["11209"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-11209-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"7 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26613"}}