{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:14:48Z","timestamp":1792818888316,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-11246-w","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T16:13:49Z","timestamp":1752336829000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The triglyceride glucose-waist circumference index is a predictor of obstructive sleep apnea risk and all-cause and cardiovascular mortality"],"prefix":"10.1038","volume":"15","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"11246_CR1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41569-023-00846-6","volume":"20","author":"S Redline","year":"2023","unstructured":"Redline, S., Azarbarzin, A. & Peker, Y. Obstructive sleep Apnoea heterogeneity and cardiovascular disease. Nat. Rev. Cardiol. 20, 560\u2013573 (2023).","journal-title":"Nat. Rev. Cardiol."},{"key":"11246_CR2","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000988","volume":"144","author":"Y Yeghiazarians","year":"2021","unstructured":"Yeghiazarians, Y. et al. Obstructive sleep apnea and cardiovascular disease: A scientific statement from the American heart association. Circulation 144, e56\u2013e67 (2021).","journal-title":"Circulation"},{"key":"11246_CR3","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1001\/jama.2020.3514","volume":"323","author":"DJ Gottlieb","year":"2020","unstructured":"Gottlieb, D. J. & Punjabi, N. M. Diagnosis and management of obstructive sleep apnea: A review. JAMA 323, 1389\u20131400 (2020).","journal-title":"JAMA"},{"key":"11246_CR4","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.5664\/jcsm.10600","volume":"19","author":"A Sanchez-Azofra","year":"2023","unstructured":"Sanchez-Azofra, A. et al. Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease\/osa overlap syndrome. J. Clin. Sleep. Med. 19, 1447\u20131456 (2023).","journal-title":"J. Clin. Sleep. Med."},{"key":"11246_CR5","doi-asserted-by":"publisher","first-page":"101309","DOI":"10.1016\/j.smrv.2020.101309","volume":"52","author":"V Bironneau","year":"2020","unstructured":"Bironneau, V. et al. Sleep Apnoea and endothelial dysfunction: an individual patient data meta-analysis. Sleep. Med. Rev. 52, 101309 (2020).","journal-title":"Sleep. Med. Rev."},{"key":"11246_CR6","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1001\/jamacardio.2018.0095","volume":"3","author":"D Linz","year":"2018","unstructured":"Linz, D. et al. Associations of obstructive sleep apnea with atrial fibrillation and continuous positive airway pressure treatment: A review. JAMA Cardiol. 3, 532\u2013540 (2018).","journal-title":"JAMA Cardiol."},{"key":"11246_CR7","doi-asserted-by":"publisher","first-page":"915","DOI":"10.5664\/jcsm.4946","volume":"11","author":"B Abuyassin","year":"2015","unstructured":"Abuyassin, B., Sharma, K., Ayas, N. T. & Laher, I. Obstructive sleep apnea and kidney disease: A potential bidirectional relationship? J. Clin. Sleep. Med. 11, 915\u2013924 (2015).","journal-title":"J. Clin. Sleep. Med."},{"key":"11246_CR8","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1513\/AnnalsATS.202111-1260OC","volume":"19","author":"T Huang","year":"2022","unstructured":"Huang, T. et al. Insulin resistance, hyperglycemia, and risk of developing obstructive sleep apnea in men and women in the united States. Ann. Am. Thorac. Soc. 19, 1740\u20131749 (2022).","journal-title":"Ann. Am. Thorac. Soc."},{"key":"11246_CR9","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1183\/13993003.00918-2015","volume":"47","author":"OL Llanos","year":"2016","unstructured":"Llanos, O. L. et al. Pharyngeal collapsibility during sleep is elevated in insulin-resistant females with morbid obesity. Eur. Respir J. 47, 1718\u20131726 (2016).","journal-title":"Eur. Respir J."},{"key":"11246_CR10","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1210\/er.2017-00173","volume":"38","author":"A Lecube","year":"2017","unstructured":"Lecube, A. et al. Pulmonary function and sleep breathing: two new targets for type 2 diabetes care. Endocr. Rev. 38, 550\u2013573 (2017).","journal-title":"Endocr. Rev."},{"key":"11246_CR11","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12933-018-0762-4","volume":"17","author":"V Ormazabal","year":"2018","unstructured":"Ormazabal, V. et al. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc. Diabetol. 17, 122 (2018).","journal-title":"Cardiovasc. Diabetol."},{"key":"11246_CR12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/met.2008.0034","volume":"6","author":"LE Simental-Mend\u00eda","year":"2008","unstructured":"Simental-Mend\u00eda, L. E., Rodr\u00edguez-Mor\u00e1n, M. & Guerrero-Romero, F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab. Syndr. Relat. Disord. 6, 299\u2013304 (2008).","journal-title":"Metab. Syndr. Relat. Disord"},{"key":"11246_CR13","doi-asserted-by":"publisher","first-page":"9807","DOI":"10.2147\/IJGM.S339863","volume":"14","author":"L Li","year":"2021","unstructured":"Li, L., Li, L., Zhou, Y., Chen, X. & Xu, Y. Association between triglyceride-glucose index and risk of periodontitis: A cross-sectional study. Int. J. Gen. Med. 14, 9807\u20139816 (2021).","journal-title":"Int. J. Gen. Med."},{"key":"11246_CR14","first-page":"876","volume":"58","author":"P Luo","year":"2022","unstructured":"Luo, P. et al. TyG index performs better than HOMA-IR in Chinese type 2 diabetes mellitus with a BMI\u2009<\u200935 kg\/m2: A hyperglycemic clamp validated study. Med. (Kaunas). 58, 876 (2022).","journal-title":"Med. (Kaunas)"},{"key":"11246_CR15","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.numecd.2021.11.017","volume":"32","author":"DH Son","year":"2022","unstructured":"Son, D. H., Lee, H. S., Lee, Y. J., Lee, J. H. & Han, J. H. Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome. Nutr. Metab. Cardiovasc. Dis. 32, 596\u2013604 (2022).","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"11246_CR16","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.amepre.2023.07.011","volume":"65","author":"J Sun","year":"2023","unstructured":"Sun, J. et al. Association of the triglyceride-glucose index with risk of alzheimer\u2019s disease: A prospective cohort study. Am. J. Prev. Med. 65, 1042\u20131049 (2023).","journal-title":"Am. J. Prev. Med."},{"key":"11246_CR17","doi-asserted-by":"publisher","first-page":"e12426","DOI":"10.1002\/dad2.12426","volume":"15","author":"N Tian","year":"2023","unstructured":"Tian, N. et al. Triglyceride-glucose index, alzheimer\u2019s disease plasma biomarkers, and dementia in older adults: the MIND-China study. Alzheimers Dement. (Amst). 15, e12426 (2023).","journal-title":"Alzheimers Dement. (Amst)"},{"key":"11246_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12933-022-01548-y","volume":"21","author":"J Zhao","year":"2022","unstructured":"Zhao, J. et al. TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients. Cardiovasc. Diabetol. 21, 123 (2022).","journal-title":"Cardiovasc. Diabetol."},{"key":"11246_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s12933-023-02087-w","volume":"22","author":"F Xin","year":"2023","unstructured":"Xin, F. et al. The triglyceride glucose index trajectory is associated with hypertension: A retrospective longitudinal cohort study. Cardiovasc. Diabetol. 22, 347 (2023).","journal-title":"Cardiovasc. Diabetol."},{"key":"11246_CR20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12933-024-02269-0","volume":"23","author":"C Liu","year":"2024","unstructured":"Liu, C., Liang, D., Xiao, K. & Xie, L. Association between the triglyceride-glucose index and all-cause and CVD mortality in the young population with diabetes. Cardiovasc. Diabetol. 23, 171 (2024).","journal-title":"Cardiovasc. Diabetol."},{"key":"11246_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/jcm11010041","volume":"11","author":"HS Kim","year":"2021","unstructured":"Kim, H. S. et al. Triglyceride glucose-waist circumference is superior to the homeostasis model assessment of insulin resistance in identifying nonalcoholic fatty liver disease in healthy subjects. J. Clin. Med. 11, 41 (2021).","journal-title":"J. Clin. Med."},{"key":"11246_CR22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1089\/met.2020.0109","volume":"19","author":"ME Khamseh","year":"2021","unstructured":"Khamseh, M. E. et al. Triglyceride glucose index and related parameters (triglyceride glucose-body mass index and triglyceride glucose-waist circumference) identify nonalcoholic fatty liver and liver fibrosis in individuals with overweight\/obesity. Metab. Syndr. Relat. Disord. 19, 167\u2013173 (2021).","journal-title":"Metab. Syndr. Relat. Disord"},{"key":"11246_CR23","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s12933-024-02392-y","volume":"23","author":"SS Nayak","year":"2024","unstructured":"Nayak, S. S. et al. Diagnostic and prognostic value of triglyceride glucose index: A comprehensive evaluation of meta-analysis. Cardiovasc. Diabetol. 23, 310 (2024).","journal-title":"Cardiovasc. Diabetol."},{"key":"11246_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12944-024-02005-3","volume":"23","author":"AH Behnoush","year":"2024","unstructured":"Behnoush, A. H. et al. Triglyceride-glucose index and obstructive sleep apnea: A systematic review and meta-analysis. Lipids Health Dis. 23, 4 (2024).","journal-title":"Lipids Health Dis."},{"key":"11246_CR25","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12944-020-01358-9","volume":"19","author":"HH Kang","year":"2020","unstructured":"Kang, H. H., Kim, S. W. & Lee, S. H. Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: A cross-sectional cohort study. Lipids Health Dis. 19, 182 (2020).","journal-title":"Lipids Health Dis."},{"key":"11246_CR26","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/s12967-016-1020-8","volume":"14","author":"S Zheng","year":"2016","unstructured":"Zheng, S. et al. Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: Cross-sectional and prospective cohort study. J. Transl Med. 14, 260 (2016).","journal-title":"J. Transl Med."},{"key":"11246_CR27","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13098-018-0376-8","volume":"10","author":"SH Khan","year":"2018","unstructured":"Khan, S. H. et al. Metabolic clustering of risk factors: evaluation of Triglyceride-glucose index (TyG index) for evaluation of insulin resistance. Diabetol. Metab. Syndr. 10, 74 (2018).","journal-title":"Diabetol. Metab. Syndr."},{"key":"11246_CR28","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.sleh.2022.05.005","volume":"8","author":"V Cavallino","year":"2022","unstructured":"Cavallino, V. et al. Antimony and sleep health outcomes: NHANES 2009\u20132016. Sleep. Health. 8, 373\u2013379 (2022).","journal-title":"Sleep. Health"},{"key":"11246_CR29","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.3390\/biomedicines10092251","volume":"10","author":"S Song","year":"2022","unstructured":"Song, S., Son, D. H., Baik, S. J., Cho, W. J. & Lee, Y. J. Triglyceride glucose-waist circumference (TyG-WC) is a reliable marker to predict non-alcoholic fatty liver disease. Biomedicines 10, 2251 (2022).","journal-title":"Biomedicines"},{"key":"11246_CR30","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1002\/cncr.30057","volume":"122","author":"Q Qi","year":"2016","unstructured":"Qi, Q. et al. A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy. Cancer 122, 2158\u20132167 (2016).","journal-title":"Cancer"},{"key":"11246_CR31","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1001\/jama.1995.03520290054029","volume":"273","author":"RR Pate","year":"1995","unstructured":"Pate, R. R. et al. Physical activity and public health. A recommendation from the centers for disease control and prevention and the American college of sports medicine. JAMA 273, 402\u2013407 (1995).","journal-title":"JAMA"},{"key":"11246_CR32","doi-asserted-by":"crossref","unstructured":"Whelton, P. K. et al. ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: Executive summary: A report of the american college of cardiology\/american heart association task force on clinical practice guidelines. J. Am. Coll. Cardiol. 71, 2199\u20132269 (2018). (2017).","DOI":"10.1161\/HYP.0000000000000075"},{"key":"11246_CR33","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.2147\/DMSO.S469376","volume":"17","author":"J Zhao","year":"2024","unstructured":"Zhao, J. et al. J-shaped relationship between weight-adjusted-waist index and cardiovascular disease risk in hypertensive patients with obstructive sleep apnea: A cohort study. Diabetes Metab. Syndr. Obes. 17, 2671\u20132681 (2024).","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"11246_CR34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.sleep.2024.06.012","volume":"121","author":"A Ramezani","year":"2024","unstructured":"Ramezani, A. et al. Age modifies the association between severe sleep apnea and all-cause mortality. Sleep. Med. 121, 18\u201324 (2024).","journal-title":"Sleep. Med."},{"key":"11246_CR35","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1513\/AnnalsATS.202407-755OC","volume":"22","author":"M Azarian","year":"2025","unstructured":"Azarian, M. et al. The association between all-cause mortality and obstructive sleep apnea in adults: A U-shaped curve. Ann. Am. Thorac. Soc. 22, 581\u2013590 (2025).","journal-title":"Ann. Am. Thorac. Soc."},{"key":"11246_CR36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4103\/ijpvm.ijpvm_356_21","volume":"14","author":"M Mehrdad","year":"2023","unstructured":"Mehrdad, M. et al. The association between OSA and glycemic control in diabetes. Int. J. Prev. Med. 14, 26 (2023).","journal-title":"Int. J. Prev. Med."},{"key":"11246_CR37","doi-asserted-by":"publisher","first-page":"1083179","DOI":"10.3389\/fendo.2023.1083179","volume":"14","author":"Q Luo","year":"2023","unstructured":"Luo, Q. et al. Non-dipping blood pressure pattern is associated with higher risk of new-onset diabetes in hypertensive patients with obstructive sleep apnea: UROSAH data. Front. Endocrinol. (Lausanne). 14, 1083179 (2023).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"11246_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.metabol.2018.04.001","volume":"84","author":"D Koren","year":"2018","unstructured":"Koren, D. & Taveras, E. M. Association of sleep disturbances with obesity, insulin resistance and the metabolic syndrome. Metabolism 84, 67\u201375 (2018).","journal-title":"Metabolism"},{"key":"11246_CR39","doi-asserted-by":"publisher","first-page":"280","DOI":"10.31083\/j.rcm2410280","volume":"24","author":"W Wen","year":"2023","unstructured":"Wen, W. et al. Linear relationship between hepatic steatosis index and major adverse cardiovascular events in hypertensive patients with obstructive sleep apnea: A real-world cohort study from China. Rev. Cardiovasc. Med. 24, 280 (2023).","journal-title":"Rev. Cardiovasc. Med."},{"key":"11246_CR40","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12933-023-02054-5","volume":"22","author":"J Chen","year":"2023","unstructured":"Chen, J., Wu, K., Lin, Y., Huang, M. & Xie, S. Association of triglyceride glucose index with all-cause and cardiovascular mortality in the general population. Cardiovasc. Diabetol. 22, 320 (2023).","journal-title":"Cardiovasc. Diabetol."},{"key":"11246_CR41","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12944-022-01738-3","volume":"21","author":"L Wang","year":"2022","unstructured":"Wang, L. et al. Influence of age on the association between the triglyceride-glucose index and all-cause mortality in patients with cardiovascular diseases. Lipids Health Dis. 21, 135 (2022).","journal-title":"Lipids Health Dis."},{"key":"11246_CR42","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12933-023-02030-z","volume":"22","author":"Q Zhang","year":"2023","unstructured":"Zhang, Q., Xiao, S., Jiao, X. & Shen, Y. The triglyceride-glucose index is a predictor for cardiovascular and all-cause mortality in CVD patients with diabetes or pre-diabetes: evidence from NHANES 2001\u20132018. Cardiovasc. Diabetol. 22, 279 (2023).","journal-title":"Cardiovasc. Diabetol."},{"key":"11246_CR43","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12877-023-03788-3","volume":"23","author":"J Shen","year":"2023","unstructured":"Shen, J. et al. Triglyceride glucose index predicts all-cause mortality in oldest-old patients with acute coronary syndrome and diabetes mellitus. BMC Geriatr. 23, 78 (2023).","journal-title":"BMC Geriatr."},{"key":"11246_CR44","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2337\/db21-0490","volume":"71","author":"NA Yousri","year":"2022","unstructured":"Yousri, N. A. et al. Metabolic and metabo-clinical signatures of type 2 diabetes, obesity, retinopathy, and dyslipidemia. Diabetes 71, 184\u2013205 (2022).","journal-title":"Diabetes"},{"key":"11246_CR45","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","volume":"55","author":"TV Rohm","year":"2022","unstructured":"Rohm, T. V., Meier, D. T., Olefsky, J. M. & Donath, M. Y. Inflammation in obesity, diabetes, and related disorders. Immunity 55, 31\u201355 (2022).","journal-title":"Immunity"},{"key":"11246_CR46","first-page":"923","volume":"8","author":"GS Hotamisligil","year":"2008","unstructured":"Hotamisligil, G. S. & Erbay, E. Nutrient sensing and inflammation in metabolic diseases. Immunology 8, 923\u2013934 (2008).","journal-title":"Immunology"},{"issue":"Suppl 2","key":"11246_CR47","doi-asserted-by":"publisher","first-page":"S161","DOI":"10.2337\/dc08-s243","volume":"31","author":"MY Donath","year":"2008","unstructured":"Donath, M. Y. et al. Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care. 31 (Suppl 2), S161\u2013164 (2008).","journal-title":"Diabetes Care"},{"key":"11246_CR48","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jacc.2021.12.017","volume":"79","author":"L Liberale","year":"2022","unstructured":"Liberale, L. et al. Inflammation, aging, and cardiovascular disease: JACC review topic of the week. J. Am. Coll. Cardiol. 79, 837\u2013847 (2022).","journal-title":"J. Am. Coll. Cardiol."},{"key":"11246_CR49","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/cvr\/cvaa211","volume":"117","author":"L Liberale","year":"2021","unstructured":"Liberale, L., Montecucco, F., Schwarz, L., L\u00fcscher, T. F. & Camici, G. G. Inflammation and cardiovascular diseases: lessons from seminal clinical trials. Cardiovasc. Res. 117, 411\u2013422 (2021).","journal-title":"Cardiovasc. Res."},{"key":"11246_CR50","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1093\/cvr\/cvz084","volume":"115","author":"A Bonaventura","year":"2019","unstructured":"Bonaventura, A. et al. Novel findings in neutrophil biology and their impact on cardiovascular disease. Cardiovasc. Res. 115, 1266\u20131285 (2019).","journal-title":"Cardiovasc. Res."},{"key":"11246_CR51","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1161\/CIRCRESAHA.115.306427","volume":"118","author":"DF Ketelhuth","year":"2016","unstructured":"Ketelhuth, D. F. & Hansson, G. K. Adaptive response of T and B cells in atherosclerosis. Circ. Res. 118, 668\u2013678 (2016).","journal-title":"Circ. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11246-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11246-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11246-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T08:07:45Z","timestamp":1757232465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11246-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,12]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["11246"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-11246-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,12]]},"assertion":[{"value":"5 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25269"}}