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Therefore, a retrospective monocentric cohort of 91 MM patients was analyzed. The BCA algorithm, powered by a convolutional neural network, quantified tissue compartments and bone density based on routine CT scans. Correlations between BCA data and demographic\/clinical parameters were investigated. BCA-endotypes were identified and survival rates were compared between BCA-derived patient clusters. Patients with high-risk cytogenetics exhibited elevated cardiac marker index values. Across Revised-International Staging System (R-ISS) categories, BCA parameters did not show significant differences. However, both subcutaneous and total adipose tissue volumes were significantly lower in patients with progressive disease or death during follow-up compared to patients without progression. Cluster analysis revealed two distinct BCA-endotypes, with one group displaying significantly better survival. Furthermore, a combined model composed of clinical parameters and BCA data demonstrated a higher predictive capability for disease progression compared to models based solely on high-risk cytogenetics or R-ISS. These findings underscore the potential of BCA to improve patient stratification and refining prognostic models in MM.<\/jats:p>","DOI":"10.1038\/s41598-025-11560-3","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T16:39:15Z","timestamp":1753115955000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["AI-based body composition analysis of CT data has the potential to predict disease course in patients with multiple myeloma"],"prefix":"10.1038","volume":"15","author":[{"given":"Franz","family":"Wegner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte Maria","family":"Sieren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Grasshoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Berkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Rowold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Philipp","family":"R\u00f6ttgerding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soleiman","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Mogadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Nensa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Hosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Riemekasten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Franziska","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolas","family":"von Bubnoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Barkhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Kloeckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Khandanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Leitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"11560_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70270","volume":"13","author":"D Liang","year":"2024","unstructured":"Liang, D. et al. 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