{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:03:45Z","timestamp":1792026225874,"version":"4.4.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Fujian Province science and technology innovation joint fund","award":["2023Y9602"],"award-info":[{"award-number":["2023Y9602"]}]},{"name":"Fujian Province science and technology innovation joint fund","award":["2023Y9602"],"award-info":[{"award-number":["2023Y9602"]}]},{"name":"Longyan Science and Technology Innovation Joint Fund Health Project","award":["2024LYF17018"],"award-info":[{"award-number":["2024LYF17018"]}]},{"name":"Longyan Science and Technology Innovation Joint Fund Health Project","award":["2024LYF17018"],"award-info":[{"award-number":["2024LYF17018"]}]},{"name":"Longyan Science and Technology Innovation Joint Fund Health Project","award":["2024LYF17018"],"award-info":[{"award-number":["2024LYF17018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-11571-0","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T17:14:55Z","timestamp":1752945295000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ROC analysis determines optimal cutoff and doubtable interval of the Bath ankylosing spondylitis metrology index in a multicenter case control study"],"prefix":"10.1038","volume":"15","author":[{"given":"Genggeng","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenmin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diantian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zugang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"issue":"3","key":"11571_CR1","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.21037\/apm-19-409(","volume":"10","author":"S Zhang","year":"2021","unstructured":"Zhang, S. et al. Efficacy and safety of thalidomide on psychological symptoms and sleep disturbances in the patient with refractory ankylosing spondylitis. Ann. Palliat. Med. 10 (3), 2512\u20132519. https:\/\/doi.org\/10.21037\/apm-19-409( (2021).","journal-title":"Ann. Palliat. Med."},{"issue":"2","key":"11571_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3760\/cma.j.issn.0578-1426.2019.02.003","volume":"58","author":"S Zhang","year":"2019","unstructured":"Zhang, S., Lin, H. & Huang, F. [Standardize the multiple disciplinary diagnosis and treatment of ankylosing spondylitis-associated uveitis]. Zhonghua Nei Ke Za Zhi. 58 (2), 85\u201388. https:\/\/doi.org\/10.3760\/cma.j.issn.0578-1426.2019.02.003 (2019). Chinese.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"issue":"3","key":"11571_CR3","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3760\/cma.j.issn.0578-1426.2016.03.010","volume":"55","author":"X Ji","year":"2016","unstructured":"Ji, X., Du, J., Zhu, J., Huang, F. & Zhang, J. [A study on calculating the ankylosing spondylitis disease activity score according to the C-reactive protein level]. Zhonghua Nei Ke Za Zhi. 55 (3), 206\u2013210. https:\/\/doi.org\/10.3760\/cma.j.issn.0578-1426.2016.03.010 (2016). Chinese.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"11571_CR4","unstructured":"Gurpinar, B., Ilcin, N., Savci, S. & Akkoc, N. Do mobility exercises in different environments have different effects in ankylosing spondylitis? Acta Reumatol Port. 46(4):297\u2013316.PMID: 34962245 (2021)."},{"key":"11571_CR5","doi-asserted-by":"publisher","first-page":"1135748","DOI":"10.3389\/fmed.2023.1135748","volume":"10","author":"G Guo","year":"2023","unstructured":"Guo, G. et al. Correlation of finger-to-floor distance with the spinal mobility, spinal function indices and initial determination of its optimal cutoff value: a multicentre case-control study. Front. Med(Lausanne). 10, 1135748. https:\/\/doi.org\/10.3389\/fmed.2023.1135748 (2023).","journal-title":"Front. Med(Lausanne)"},{"issue":"3","key":"11571_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11030490","volume":"11","author":"M O\u2019Grady","year":"2021","unstructured":"O\u2019Grady, M. et al. Measuring spinal mobility using an inertial measurement unit system: A reliability study in axial spondyloarthritis. Diagnostics11(3), 490. https:\/\/doi.org\/10.3390\/diagnostics11030490 (2021).","journal-title":"Diagnostics"},{"key":"11571_CR7","doi-asserted-by":"publisher","first-page":"ii1","DOI":"10.1136\/ard.2008.104018","volume":"68 Suppl2","author":"J Sieper","year":"2009","unstructured":"Sieper, J. et al. The assessment of spondyloarthritis international society (ASAS) handbook: a guide to assess spondyloarthritis. Ann. Rheum. Dis. 68 Suppl2, ii1\u201344. https:\/\/doi.org\/10.1136\/ard.2008.104018 (2009).","journal-title":"Ann. Rheum. Dis."},{"key":"11571_CR8","unstructured":"Jenkinson, T. R. et al. Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS Metrology Index. J Rheumatol. 21(9):1694-8.PMID: 7799351 (1994)."},{"issue":"11","key":"11571_CR9","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1007\/s10067-012-2057-6","volume":"31","author":"JH Martindale","year":"2012","unstructured":"Martindale, J. H., Sutton, C. J. & Goodacre, L. An exploration of the inter- and intra-rater reliability of the Bath ankylosing spondylitis metrology index. Clin. Rheumatol.31(11), 1627\u20131631. https:\/\/doi.org\/10.1007\/s10067-012-2057-6 (2012).","journal-title":"Clin. Rheumatol."},{"issue":"4","key":"11571_CR10","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"S van der Linden","year":"1984","unstructured":"van der Linden, S., Valkenburg, H. A. & Cats, A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the new York criteria. Arthritis Rheum. 27 (4), 361\u2013368. https:\/\/doi.org\/10.1002\/art.1780270401 (1984).","journal-title":"Arthritis Rheum."},{"issue":"11","key":"11571_CR11","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1093\/rheumatology\/ket272","volume":"52","author":"L Chilton-Mitchell","year":"2013","unstructured":"Chilton-Mitchell, L., Martindale, J., Hart, A. & Goodacre, L. Normative values for the Bath ankylosing spondylitis metrology index in a UK population. Rheumatology52(11), 2086\u20132090. https:\/\/doi.org\/10.1093\/rheumatology\/ket272 (2013).","journal-title":"Rheumatology"},{"issue":"4","key":"11571_CR12","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/bimj.200410135","volume":"47","author":"R Fluss","year":"2005","unstructured":"Fluss, R., Faraggi, D. & Reiser, B. Estimation of the Youden index and its associated cutoff point. Biometrical J.47(4), 458\u2013472. https:\/\/doi.org\/10.1002\/bimj.200410135 (2005).","journal-title":"Biometrical J."},{"issue":"7","key":"11571_CR13","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1373\/clinchem.2004.031823","volume":"50","author":"NA Obuchowski","year":"2004","unstructured":"Obuchowski, N. A., Lieber, M. L. & Wians, F. H. ROC curves in clinical chemistry: Uses, misuses, and possible solutions. Clin. Chem.50(7), 1118\u20131125 (2004).","journal-title":"Clin. Chem."},{"issue":"1","key":"11571_CR14","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1001\/jama.294.1.66","volume":"294","author":"IM Thompson","year":"2005","unstructured":"Thompson, I. M. Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng\/ml or lower. JAMA294(1), 66\u201370. https:\/\/doi.org\/10.1001\/jama.294.1.66 (2005).","journal-title":"JAMA"},{"issue":"2","key":"11571_CR15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s100670050031","volume":"19","author":"JV Viitanen","year":"2000","unstructured":"Viitanen, J. V., Heikkil\u00e4, S., Kokko, M. L. & Kautiainen, H. Clinical assessment of spinal mobility measurements in ankylosing spondylitis: A compact set for follow-up and trials?. Clin. Rheumatol.19(2), 131\u2013137. https:\/\/doi.org\/10.1007\/s100670050031 (2000).","journal-title":"Clin. Rheumatol."},{"issue":"6","key":"11571_CR16","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s00296-020-04537-0","volume":"40","author":"J Zhao","year":"2020","unstructured":"Zhao, J. et al. Prevalence of ankylosing spondylitis in a Chinese population: A systematic review and meta-analysis. Rheumatol. Int.40(6), 859\u2013872. https:\/\/doi.org\/10.1007\/s00296-020-04537-0 (2020).","journal-title":"Rheumatol. Int."},{"key":"11571_CR17","doi-asserted-by":"crossref","unstructured":"Ramiro, S. et al. Reference intervals of spinal mobility measures in normal individuals: the mobilitystudy. Ann Rheum. Dis 74(6):1218\u20131224 (2015).","DOI":"10.1136\/annrheumdis-2013-204953"},{"issue":"12","key":"11571_CR18","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1093\/rheumatology\/39.12.1337","volume":"39","author":"G Van Herp","year":"2000","unstructured":"Van Herp, G., Rowe, P., Salter, P. & PaulJP Three-dimensional lumbar spinal kinematics: a study of range of movement in 100 healthy subjects aged 20 to 60\u2009+\u2009years. Rheumatol. (Oxford). 39 (12), 1337\u20131340. https:\/\/doi.org\/10.1093\/rheumatology\/39.12.1337 (2000).","journal-title":"Rheumatol. (Oxford)"},{"issue":"3","key":"11571_CR19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s10067-011-1854-7","volume":"31","author":"FM Pimentel-Santos","year":"2012","unstructured":"Pimentel-Santos, F. M. et al. Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts. Clin. Rheumatol.31(3), 447\u2013454. https:\/\/doi.org\/10.1007\/s10067-011-1854-7 (2012).","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"11571_CR20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10067-011-1819-x","volume":"31","author":"Y Ibn Yacoub","year":"2012","unstructured":"Ibn Yacoub, Y., Amine, B., Laatiris, A. & Hajjaj-Hassouni, N. Gender and disease features in Moroccan patients with ankylosing spondylitis. Clin. Rheumatol.31(2), 293\u2013297. https:\/\/doi.org\/10.1007\/s10067-011-1819-x (2012).","journal-title":"Clin. Rheumatol."},{"issue":"5","key":"11571_CR21","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.jbi.2005.02.008","volume":"38","author":"TA Lasko","year":"2005","unstructured":"Lasko, T. A., Bhagwat, J. G., Zou, K. H. & Ohno-Machado, L. The use of receiver operating characteristic curves in biomedical informatics. J. Biomed. Inform.38(5), 404\u2013415. https:\/\/doi.org\/10.1016\/j.jbi.2005.02.008 (2005).","journal-title":"J. Biomed. Inform."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11571-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11571-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11571-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T15:41:49Z","timestamp":1757259709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11571-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,19]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["11571"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-11571-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,19]]},"assertion":[{"value":"25 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the ethics committee of Fujian Provincial Hospital (Approval ID: K-2018-10-014) and conducted in accordance with the Declaration of Helsinki (as revised in 2013). All the subjects included in this study have been informed in detail and signed the informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations"}}],"article-number":"26290"}}