{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:55:42Z","timestamp":1782849342094,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]},{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]},{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]},{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]},{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]},{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]},{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]},{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]},{"name":"German Ministry for Education and Research","award":["13GW0571A"],"award-info":[{"award-number":["13GW0571A"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-11583-w","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T18:27:02Z","timestamp":1752776822000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["2D-3D deformable image registration of histology slide and micro-CT with DISA-based initialization"],"prefix":"10.1038","volume":"15","author":[{"given":"Junan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ronchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Stehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhannad Al","family":"Kallaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh Thalwaththe","family":"Gedara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"L\u00f6lkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Seidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Wieczorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"11583_CR1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00428-020-02894-6","volume":"478","author":"M Bruno","year":"2021","unstructured":"Bruno, M., Laszl\u00f3, F., Ralf, H., Svenja, B. & Tina, S. Number of pathologists in germany: Comparison with european countries, usa, and canada. Virchows Arch.478, 335\u2013341 (2021).","journal-title":"Virchows Arch."},{"issue":"2","key":"11583_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bjoms.2022.11.005","volume":"61","author":"MM Dias","year":"2023","unstructured":"Dias, M. M. & Barrett, A. W. Comparison of histopathological turnaround times for mandibulectomies, glossectomies, and incisional biopsies of the tongue. Br. J. Oral Maxillofac. Surg.61(2), 131\u2013135 (2023).","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"11583_CR3","unstructured":"Sharma, A., Nishadham, V., Gupta, P., Gupta, G., Sharma, D., Goel, S., Pasricha, S., Kamboj, M. & Mehta, A.: Evaluation of turnaround times of diagnostic biopsies: A metric of quality in surgical pathology. International Journal of Surgical Pathology 0(0)."},{"issue":"1","key":"11583_CR4","doi-asserted-by":"publisher","first-page":"32156","DOI":"10.1038\/srep32156","volume":"6","author":"SE Hieber","year":"2016","unstructured":"Hieber, S. E. et al. Tomographic brain imaging with nucleolar detail and automatic cell counting. Sci. Rep.6(1), 32156 (2016).","journal-title":"Sci. Rep."},{"issue":"1","key":"11583_CR5","doi-asserted-by":"publisher","first-page":"9238","DOI":"10.1038\/s41598-022-13282-2","volume":"12","author":"JY Lee","year":"2022","unstructured":"Lee, J. Y. et al. Microvascular imaging of the unstained human superior colliculus using synchrotron-radiation phase-contrast microtomography. Sci. Rep.12(1), 9238 (2022).","journal-title":"Sci. Rep."},{"key":"11583_CR6","doi-asserted-by":"crossref","unstructured":"Pacil\u00e8, S. & Tromba, G. Introduction to x-ray micro-tomography In (eds Giuliani, A. & Cedola, A.) 19\u201339 (Springer, 2018).","DOI":"10.1007\/978-3-030-00368-5_2"},{"key":"11583_CR7","doi-asserted-by":"crossref","unstructured":"Funkhouser, W.K.: Chapter 11 - pathology: The clinical description of human disease. In: Coleman, W.B., Tsongalis, G.J. (eds.) Molecular Pathology, Second edition edn., pp. 217\u2013229. Academic Press, Rockville, MD, USA (2018).","DOI":"10.1016\/B978-0-12-802761-5.00011-0"},{"key":"11583_CR8","doi-asserted-by":"crossref","unstructured":"Dey, P. Tissue microtomy: Principle and procedure 41\u201350 (Springer, 2018).","DOI":"10.1007\/978-981-10-8252-8_5"},{"issue":"1","key":"11583_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jneumeth.2011.08.031","volume":"202","author":"G Schulz","year":"2011","unstructured":"Schulz, G. et al. Three-dimensional strain fields in human brain resulting from formalin fixation. J. Neurosci. Methods202(1), 17\u201327 (2011).","journal-title":"J. Neurosci. Methods"},{"issue":"7","key":"11583_CR10","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1109\/TMI.2013.2265603","volume":"32","author":"A Sotiras","year":"2013","unstructured":"Sotiras, A., Davatzikos, C. & Paragios, N. Deformable medical image registration: A survey. IEEE Trans. Med. Imaging32(7), 1153\u20131190 (2013).","journal-title":"IEEE Trans. Med. Imaging"},{"key":"11583_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6765895","author":"P Nolte","year":"2022","unstructured":"Nolte, P. et al. Current approaches for image fusion of histological data with computed tomography and magnetic resonance imaging. Radiol. Res. Pract.https:\/\/doi.org\/10.1155\/2022\/6765895 (2022).","journal-title":"Radiol. Res. Pract."},{"key":"11583_CR12","doi-asserted-by":"crossref","unstructured":"Leroy, A. et al. Structuregnet: Structure-guided multimodal 2d\u20133d registration. In Medical Image Computing and Computer Assisted Intervention - MICCAI 2023 (eds Greenspan, H. et al.) 771\u2013780 (Springer, Cham, 2023).","DOI":"10.1007\/978-3-031-43999-5_73"},{"key":"11583_CR13","doi-asserted-by":"crossref","unstructured":"Chicherova, N., Fundana, K., M\u00fcller, B., Cattin, P.C. Histology to $$\\mu$$ct data matching using landmarks and a density biased ransac. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2014 (eds Golland, P. et al.) 243\u2013250 (Springer, Cham, 2014).","DOI":"10.1007\/978-3-319-10404-1_31"},{"key":"11583_CR14","doi-asserted-by":"crossref","unstructured":"Chicherova, N. et al. Automatic deformable registration of histological slides to $$\\mu$$ct volume data. Journal of Microscopy 271(1), 49\u201361 (2018).","DOI":"10.1111\/jmi.12692"},{"issue":"2","key":"11583_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1023\/B:VISI.0000029664.99615.94","volume":"60","author":"DG Lowe","year":"2004","unstructured":"Lowe, D. G. Distinctive image features from scale-invariant keypoints. Int. J. Comput. Vis.60(2), 91\u2013110 (2004).","journal-title":"Int. J. Comput. Vis."},{"key":"11583_CR16","unstructured":"Chen, e.a.: Deformable Registration of $$\\mu$$CT and Histology Slide. In: Proceedings of the 6th International Symposium on Medical Applications of X-ray Phase-Contrast & Photon-Counting, Technical University of Munich, July 2023 (2023)."},{"key":"11583_CR17","doi-asserted-by":"crossref","unstructured":"Chen, e.a.: 2D-3D Deformable Image Registration of Histology Slide and Phase-contrast Micro-CT. In: Proceedings of The 6th International Conference on X-ray and Neutron Phase Imaging with Gratings, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, April 2024 (2024).","DOI":"10.1038\/s41598-025-11583-w"},{"key":"11583_CR18","doi-asserted-by":"crossref","unstructured":"Ronchetti, M., Wein, W., Navab, N., Zettinig, O. & Prevost, R. Disa: Differentiable similarity approximation for universal multimodal registration. In Medical Image Computing and Computer Assisted Intervention - MICCAI 2023 (eds Greenspan, H. et al.) 761\u2013770 (Springer, Cham, 2023).","DOI":"10.1007\/978-3-031-43999-5_72"},{"issue":"5","key":"11583_CR19","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.media.2008.06.006","volume":"12","author":"W Wein","year":"2008","unstructured":"Wein, W., Brunke, S., Khamene, A., Callstrom, M. R. & Navab, N. Automatic CT-ultrasound registration for diagnostic imaging and image-guided intervention. Med. Image Anal.12(5), 577\u2013585 (2008).","journal-title":"Med. Image Anal."},{"key":"11583_CR20","doi-asserted-by":"crossref","unstructured":"Wein, W., Ladikos, A., Fuerst, B., Shah, A., Sharma, K. spsampsps Navab, N.: Global registration of ultrasound to mri using the lc2 metric for enabling neurosurgical guidance 16(Pt 1), 34\u201341 (2013).","DOI":"10.1007\/978-3-642-40811-3_5"},{"issue":"8","key":"11583_CR21","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1109\/42.796284","volume":"18","author":"D Rueckert","year":"1999","unstructured":"Rueckert, D. et al. Nonrigid registration using free-form deformations: Application to breast mr images. IEEE Trans. Med. Imaging18(8), 712\u2013721 (1999).","journal-title":"IEEE Trans. Med. Imaging"},{"key":"11583_CR22","unstructured":"Maas, A.L.: Rectifier nonlinearities improve neural network acoustic models. In: Proceedings of the International Conference on Machine Learning (ICML) (2013)."},{"key":"11583_CR23","doi-asserted-by":"crossref","unstructured":"He, K., Zhang, X., Ren, S. & Sun, J.: Deep residual learning for image recognition. In: 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 770\u2013778 (2016).","DOI":"10.1109\/CVPR.2016.90"},{"key":"11583_CR24","unstructured":"Zhang, R.: Making convolutional networks shift-invariant again. In: Chaudhuri, K., Salakhutdinov, R. (eds.) Proceedings of the 36th International Conference on Machine Learning. Proceedings of Machine Learning Research, vol. 97, pp. 7324\u20137334 (2019)."},{"key":"11583_CR25","unstructured":"Exciscope. https:\/\/exciscope.com\/"},{"key":"11583_CR26","unstructured":"Fletcher, R.: Newton-like methods. In: Alex, A. (ed.) Practical Methods of Optimization, pp. 44\u201379. John Wiley & Sons, Ltd, The Atrium, Southern Gate Chichester, England PO19 8SQ (2000). Chap. 3."},{"key":"11583_CR27","unstructured":"Powell, M.J.D.: The BOBYQA algorithm for bound constrained optimization without derivatives. Technical Report NA2009\/06, Department of Applied Mathematics and Theoretical Physics, Cambridge University, Cambridge, UK (2009)."},{"key":"11583_CR28","unstructured":"Johnson, S.G.: The NLopt nonlinear-optimization package. https:\/\/github.com\/stevengj\/nlopt (2007)."},{"key":"11583_CR29","unstructured":"TOMCAT, Swiss Light Source, Paul Scherrer Institute. https:\/\/www.psi.ch\/en\/sls\/tomcat."},{"key":"11583_CR30","unstructured":"MITOS GmbH. https:\/\/www.mitos.de\/en\/services.html."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11583-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11583-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11583-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T13:33:25Z","timestamp":1757252005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-11583-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["11583"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-11583-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]},"assertion":[{"value":"28 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25972"}}