{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:33:58Z","timestamp":1757619238868,"version":"3.44.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-12206-0","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:18:59Z","timestamp":1753226339000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PNMA1 mediates melphalam chemoresistance in retinoblastoma via promoting DNA repair"],"prefix":"10.1038","volume":"15","author":[{"given":"Longge","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaokang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"issue":"8","key":"12206_CR1","doi-asserted-by":"publisher","first-page":"e1128","DOI":"10.1016\/S2214-109X(22)00250-9","volume":"10","author":"The Global Retinoblastoma","year":"2022","unstructured":"The Global Retinoblastoma. Outcome study: a prospective, cluster-based analysis of 4064 patients from 149 countries. Lancet Glob Health. 10 (8), e1128\u2013e1140 (2022).","journal-title":"Lancet Glob Health"},{"issue":"2","key":"12206_CR2","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1136\/bjophthalmol-2015-306672","volume":"100","author":"B Chawla","year":"2016","unstructured":"Chawla, B. et al. Clinical presentation and survival of retinoblastoma in Indian children. Br. J. Ophthalmol. 100 (2), 172\u2013178 (2016).","journal-title":"Br. J. Ophthalmol."},{"issue":"8","key":"12206_CR3","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/s41433-019-0409-z","volume":"33","author":"S Kaliki","year":"2019","unstructured":"Kaliki, S. et al. Bilateral advanced (group D or E) intraocular retinoblastoma: outcomes in 72 Asian Indian patients. Eye (Lond). 33 (8), 1297\u20131304 (2019).","journal-title":"Eye (Lond)"},{"issue":"4","key":"12206_CR4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1001\/archopht.120.4.460","volume":"120","author":"CL Shields","year":"2002","unstructured":"Shields, C. L. et al. Factors predictive of recurrence of retinal tumors, vitreous seeds, and subretinal seeds following chemoreduction for retinoblastoma. Arch. Ophthalmol. 120 (4), 460\u2013464 (2002).","journal-title":"Arch. Ophthalmol."},{"issue":"9","key":"12206_CR5","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/abbs\/gmy080","volume":"50","author":"X Zhu","year":"2018","unstructured":"Zhu, X. et al. The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells. Acta Biochim. Biophys. Sin (Shanghai). 50 (9), 914\u2013920 (2018).","journal-title":"Acta Biochim. Biophys. Sin (Shanghai)"},{"issue":"12","key":"12206_CR6","first-page":"2325","volume":"57","author":"HS Chan","year":"1997","unstructured":"Chan, H. S. et al. Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein. Cancer Res. 57 (12), 2325\u20132330 (1997).","journal-title":"Cancer Res."},{"issue":"4","key":"12206_CR7","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1167\/iovs.08-2356","volume":"50","author":"MM Balla","year":"2009","unstructured":"Balla, M. M., Vemuganti, G. K., Kannabiran, C., Honavar, S. G. & Murthy, R. Phenotypic characterization of retinoblastoma for the presence of putative cancer stem-like cell markers by flow cytometry. Invest. Ophthalmol. Vis. Sci. 50 (4), 1506\u20131514 (2009).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"12206_CR8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cellsig.2018.01.022","volume":"45","author":"SW Pang","year":"2018","unstructured":"Pang, S. W., Lahiri, C., Poh, C. L. & Tan, K. O. PNMA family: protein interaction network and cell signalling pathways implicated in cancer and apoptosis. Cell. Signal. 45, 54\u201362 (2018).","journal-title":"Cell. Signal."},{"issue":"1\u20132","key":"12206_CR9","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jneuroim.2005.08.019","volume":"169","author":"M Sch\u00fcller","year":"2005","unstructured":"Sch\u00fcller, M., Jenne, D. & Voltz, R. The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease. J. Neuroimmunol. 169 (1\u20132), 172\u2013176 (2005).","journal-title":"J. Neuroimmunol."},{"issue":"16","key":"12206_CR10","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1002\/jnr.22506","volume":"88","author":"HL Chen","year":"2010","unstructured":"Chen, H. L. & D\u2019Mello, S. R. Induction of neuronal cell death by paraneoplastic Ma1 antigen. J. Neurosci. Res. 88 (16), 3508\u20133519 (2010).","journal-title":"J. Neurosci. Res."},{"issue":"7","key":"12206_CR11","first-page":"3827","volume":"7","author":"SH Jiang","year":"2014","unstructured":"Jiang, S. H. et al. PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma. Int. J. Clin. Exp. Pathol. 7 (7), 3827\u20133835 (2014).","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"12206_CR12","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.biopha.2018.09.059","volume":"108","author":"P Liu","year":"2018","unstructured":"Liu, P., Chen, B., Gu, Y. & Liu, Q. PNMA1, regulated by miR-33a-5p, promotesproliferation and EMT in hepatocellular carcinoma by activating the Wnt\/\u03b2-catenin pathway. Biomed. Pharmacother. 108, 492\u2013499 (2018).","journal-title":"Biomed. Pharmacother"},{"key":"12206_CR13","first-page":"882","volume":"28","author":"J Leek","year":"2012","unstructured":"Leek, J., Johnson, W., Parker, H., Jaffe, A. & Storey, J. The Sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinf. (Oxford England). 28, 882\u2013883 (2012).","journal-title":"Bioinf. (Oxford England)"},{"key":"12206_CR14","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"M Ritchie","year":"2015","unstructured":"Ritchie, M. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).","journal-title":"Nucleic Acids Res."},{"issue":"Pt 1","key":"12206_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/brain\/122.1.27","volume":"122","author":"J Dalmau","year":"1999","unstructured":"Dalmau, J. et al. Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain 122 (Pt 1), 27\u201339 (1999).","journal-title":"Brain"},{"key":"12206_CR16","doi-asserted-by":"publisher","first-page":"101504","DOI":"10.1016\/j.tranon.2022.101504","volume":"25","author":"X Wei","year":"2022","unstructured":"Wei, X., Dan, L., Xi, C., Leiting, L. & Weihong, X. LncRNA JPX modulates malignant progress of osteosarcoma through targeting miR-33a-5p and PNMA1 regulatory loop. Transl Oncol. 25, 101504 (2022).","journal-title":"Transl Oncol."},{"issue":"12","key":"12206_CR17","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/s41388-017-0050-x","volume":"37","author":"ID Fabian","year":"2018","unstructured":"Fabian, I. D. et al. The management of retinoblastoma. Oncogene 37 (12), 1551\u20131560 (2018).","journal-title":"Oncogene"},{"key":"12206_CR18","first-page":"Doc03","volume":"12","author":"M Redondo-Villanueva","year":"2022","unstructured":"Redondo-Villanueva, M. & Mercado, G. Intravitreal Melphalan for persistent retinoblastoma vitreous seeds. GMS Ophthalmol. Cases. 12, Doc03 (2022).","journal-title":"GMS Ophthalmol. Cases"},{"key":"12206_CR19","doi-asserted-by":"publisher","first-page":"121493","DOI":"10.1016\/j.biomaterials.2022.121493","volume":"284","author":"K Jiang","year":"2022","unstructured":"Jiang, K. et al. Topical instillation of cell-penetrating peptide-conjugated Melphalan blocks metastases of retinoblastoma. Biomaterials 284, 121493 (2022).","journal-title":"Biomaterials"},{"issue":"6","key":"12206_CR20","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1159\/000492690","volume":"48","author":"D Lu","year":"2018","unstructured":"Lu, D., Yang, C., Zhang, Z., Cong, Y. & Xiao, M. Knockdown of Linc00515 inhibits multiple myeloma autophagy and chemoresistance by upregulating miR-140-5p and downregulating ATG14. Cell. Physiol. Biochem. 48 (6), 2517\u20132527 (2018).","journal-title":"Cell. Physiol. Biochem."},{"issue":"8","key":"12206_CR21","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s40265-021-01522-0","volume":"81","author":"S Dhillon","year":"2021","unstructured":"Dhillon, S. Melphalan flufenamide (Melflufen): first approval. Drugs 81 (8), 963\u2013969 (2021).","journal-title":"Drugs"},{"issue":"3","key":"12206_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.tcb.2022.07.006","volume":"33","author":"SK Das","year":"2023","unstructured":"Das, S. K., Lewis, B. A. & Levens, D. MYC: a complex problem. Trends Cell. Biol. 33 (3), 235\u2013246 (2023).","journal-title":"Trends Cell. Biol."},{"issue":"6","key":"12206_CR23","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1177\/1947601910378024","volume":"1","author":"AR Wasylishen","year":"2010","unstructured":"Wasylishen, A. R. & Penn, L. Z. Myc: the beauty and the Beast. Genes Cancer. 1 (6), 532\u2013541 (2010).","journal-title":"Genes Cancer"},{"key":"12206_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-230X(08)60476-5","volume":"56","author":"CA Spencer","year":"1991","unstructured":"Spencer, C. A. & Groudine, M. Control of c-myc regulation in normal and neoplastic cells. Adv. Cancer Res. 56, 1\u201348 (1991).","journal-title":"Adv. Cancer Res."},{"issue":"7784","key":"12206_CR25","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41586-019-1763-5","volume":"575","author":"S Wu","year":"2019","unstructured":"Wu, S. et al. Circular EcDNA promotes accessible chromatin and high oncogene expression. Nature 575 (7784), 699\u2013703 (2019).","journal-title":"Nature"},{"key":"12206_CR26","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev-pathmechdis-051821-114223","volume":"17","author":"S Wu","year":"2022","unstructured":"Wu, S., Bafna, V., Chang, H. Y. & Mischel, P. S. Extrachromosomal DNA: an emerging hallmark in human Cancer. Annu. Rev. Pathol. 17, 367\u2013386 (2022).","journal-title":"Annu. Rev. Pathol."},{"issue":"7461","key":"12206_CR27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature12064","volume":"500","author":"A Adey","year":"2013","unstructured":"Adey, A. et al. The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line. Nature 500 (7461), 207\u2013211 (2013).","journal-title":"Nature"},{"issue":"7152","key":"12206_CR28","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature05953","volume":"448","author":"D Dominguez-Sola","year":"2007","unstructured":"Dominguez-Sola, D. et al. Non-transcriptional control of DNA replication by c-Myc. Nature 448 (7152), 445\u2013451 (2007).","journal-title":"Nature"},{"issue":"6","key":"12206_CR29","doi-asserted-by":"publisher","first-page":"a014423","DOI":"10.1101\/cshperspect.a014423","volume":"4","author":"D Dominguez-Sola","year":"2014","unstructured":"Dominguez-Sola, D. & Gautier, J. MYC and the control of DNA replication. Cold Spring Harb Perspect. Med. 4 (6), a014423 (2014).","journal-title":"Cold Spring Harb Perspect. Med."},{"issue":"6","key":"12206_CR30","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1128\/MCB.01828-06","volume":"27","author":"VH Cowling","year":"2007","unstructured":"Cowling, V. H. & Cole, M. D. The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding. Mol. Cell. Biol. 27 (6), 2059\u20132073 (2007).","journal-title":"Mol. Cell. Biol."},{"issue":"10","key":"12206_CR31","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/nrm2467","volume":"9","author":"MD Cole","year":"2008","unstructured":"Cole, M. D. & Cowling, V. H. Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat. Rev. Mol. Cell. Biol. 9 (10), 810\u2013815 (2008).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"5","key":"12206_CR32","doi-asserted-by":"publisher","first-page":"a018408","DOI":"10.1101\/cshperspect.a018408","volume":"4","author":"KJ Campbell","year":"2014","unstructured":"Campbell, K. J. & White, R. J. MYC regulation of cell growth through control of transcription by RNA polymerases I and III. Cold Spring Harb Perspect. Med. 4 (5), a018408 (2014).","journal-title":"Cold Spring Harb Perspect. Med."},{"issue":"2","key":"12206_CR33","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.cell.2020.12.031","volume":"184","author":"EA Bowling","year":"2021","unstructured":"Bowling, E. A. et al. Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer. Cell 184 (2), 384\u2013403e21 (2021).","journal-title":"Cell"},{"issue":"5","key":"12206_CR34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41580-020-0215-2","volume":"21","author":"A Baluapuri","year":"2020","unstructured":"Baluapuri, A., Wolf, E. & Eilers, M. Target gene-independent functions of MYC oncoproteins. Nat. Rev. Mol. Cell. Biol. 21 (5), 255\u2013267 (2020).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"6","key":"12206_CR35","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/j.cell.2016.09.053","volume":"167","author":"S Hamperl","year":"2016","unstructured":"Hamperl, S. & Cimprich, K. A. Conflict resolution in the genome: how transcription and replication make it work. Cell 167 (6), 1455\u20131467 (2016).","journal-title":"Cell"},{"issue":"7938","key":"12206_CR36","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41586-022-05469-4","volume":"612","author":"D Solvie","year":"2022","unstructured":"Solvie, D. et al. MYC multimers shield stalled replication forks from RNA polymerase. Nature 612 (7938), 148\u2013155 (2022).","journal-title":"Nature"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-12206-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-12206-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-12206-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T18:41:11Z","timestamp":1757270471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-12206-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["12206"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-12206-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"6 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study did not involve human or animal subjects; therefore, ethics committee approval is not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"26690"}}