{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:56:34Z","timestamp":1787504194440,"version":"build-2736575974"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["Grant-in-Aid for Scientific Research (C) 24K12727"],"award-info":[{"award-number":["Grant-in-Aid for Scientific Research (C) 24K12727"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-12239-5","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T14:54:24Z","timestamp":1753282464000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cell-specific \u03b1 and \u03b2 subunit expression patterns of Na+\/K+-ATPases in the common marmoset cochlea"],"prefix":"10.1038","volume":"15","author":[{"given":"Makoto","family":"Hosoya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie N.","family":"Shimanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"12239_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0378-5955(02)00279-4","volume":"165","author":"P Wangemann","year":"2002","unstructured":"Wangemann, P. K+ cycling and the endocochlear potential. Hear Res. 165, 1\u20139. https:\/\/doi.org\/10.1016\/s0378-5955(02)00279-4 (2002).","journal-title":"Hear Res."},{"key":"12239_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1113\/jphysiol.2006.112888","volume":"576","author":"P Wangemann","year":"2006","unstructured":"Wangemann, P. Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential. J. Physiol. 576, 11\u201321. https:\/\/doi.org\/10.1113\/jphysiol.2006.112888 (2006).","journal-title":"J. Physiol."},{"key":"12239_CR3","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1097\/00005537-200107000-00006","volume":"111","author":"PC Weber","year":"2001","unstructured":"Weber, P. C., Cunningham, C. D. 3rd. & Schulte, B. A. Potassium recycling pathways in the human cochlea. Laryngoscope 111, 1156\u20131165. https:\/\/doi.org\/10.1097\/00005537-200107000-00006 (2001).","journal-title":"Laryngoscope"},{"key":"12239_CR4","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0378-5955(96)00105-0","volume":"100","author":"S Erichsen","year":"1996","unstructured":"Erichsen, S., Zuo, J., Curtis, L., Rarey, K. & Hultcrantz, M. Na,K-ATPase alpha- and beta-isoforms in the developing cochlea of the mouse. Hear Res. 100, 143\u2013149. https:\/\/doi.org\/10.1016\/0378-5955(96)00105-0 (1996).","journal-title":"Hear Res."},{"key":"12239_CR5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s004050000304","volume":"258","author":"TA Peters","year":"2001","unstructured":"Peters, T. A., Kuijpers, W. & Curfs, J. H. Occurrence of NaK-ATPase isoforms during rat inner ear development and functional implications. Eur. Arch. Otorhinolaryngol. 258, 67\u201373. https:\/\/doi.org\/10.1007\/s004050000304 (2001).","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"12239_CR6","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3109\/00016489509139355","volume":"115","author":"J Zuo","year":"1995","unstructured":"Zuo, J., Curtis, L. M., Yao, X., Ten Cate, W. J. & Rarey, K. E. Expression of Na, K-ATPase alpha and beta isoforms in the neonatal rat cochlea. Acta Otolaryngol. 115, 497\u2013503. https:\/\/doi.org\/10.3109\/00016489509139355 (1995).","journal-title":"Acta Otolaryngol."},{"key":"12239_CR7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s10162-004-5046-x","volume":"6","author":"KA Morris","year":"2005","unstructured":"Morris, K. A. et al. Differential expression of genes within the cochlea as defined by a custom mouse inner ear microarray. J. Assoc. Res. Otolaryngol. 6, 75\u201389 (2005).","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"12239_CR8","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1002\/cphy.c200018","volume":"12","author":"NU Fedosova","year":"2022","unstructured":"Fedosova, N. U., Habeck, M. & Nissen, P. Structure and Function of Na,K-ATPase-The Sodium-Potassium Pump. Compr. Physiol. 12, 2659\u20132679. https:\/\/doi.org\/10.1002\/cphy.c200018 (2022).","journal-title":"Compr. Physiol."},{"key":"12239_CR9","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/ejhg.2014.154","volume":"23","author":"SK Oh","year":"2015","unstructured":"Oh, S. K. et al. A missense variant of the gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine. Eur. J. Hum. Genet. 23, 639\u2013645. https:\/\/doi.org\/10.1038\/ejhg.2014.154 (2015).","journal-title":"Eur. J. Hum. Genet."},{"key":"12239_CR10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1136\/jmg.33.5.419","volume":"33","author":"P Nicolaides","year":"1996","unstructured":"Nicolaides, P., Appleton, R. E. & Fryer, A. Cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS): a new syndrome. J. Med. Genet. 33, 419\u2013421. https:\/\/doi.org\/10.1136\/jmg.33.5.419 (1996).","journal-title":"J. Med. Genet."},{"key":"12239_CR11","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.anl.2024.04.004","volume":"51","author":"S Kaneshiro","year":"2024","unstructured":"Kaneshiro, S. et al. Childhood fever and hearing loss associated with CAPOS syndrome. Auris Nasus Larynx 51, 724\u2013727. https:\/\/doi.org\/10.1016\/j.anl.2024.04.004 (2024).","journal-title":"Auris Nasus Larynx"},{"key":"12239_CR12","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1007\/s00415-023-11581-w","volume":"270","author":"FC Yuksel","year":"2023","unstructured":"Yuksel, F. C. et al. The phenotypic spectrum of pathogenic ATP1A1 variants expands: the novel p. P600R substitution causes demyelinating Charcot\u2013Marie\u2013Tooth disease. J. Neurol. 270, 2576 (2023).","journal-title":"J. Neurol."},{"key":"12239_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/s0378-5955(99)00170-7","volume":"139","author":"I Ichimiya","year":"2000","unstructured":"Ichimiya, I., Suzuki, M. & Mogi, G. Age-related changes in the murine cochlear lateral wall. Hear Res. 139, 116\u2013122. https:\/\/doi.org\/10.1016\/s0378-5955(99)00170-7 (2000).","journal-title":"Hear Res."},{"key":"12239_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.heares.2018.07.006","volume":"367","author":"B Ding","year":"2018","unstructured":"Ding, B., Walton, J. P., Zhu, X. & Frisina, R. D. Age-related changes in Na, K-ATPase expression, subunit isoform selection and assembly in the stria vascularis lateral wall of mouse cochlea. Hear Res. 367, 59\u201373. https:\/\/doi.org\/10.1016\/j.heares.2018.07.006 (2018).","journal-title":"Hear Res."},{"key":"12239_CR15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0378-5955(92)90034-k","volume":"61","author":"BA Schulte","year":"1992","unstructured":"Schulte, B. A. & Schmiedt, R. A. Lateral wall Na,K-ATPase and endocochlear potentials decline with age in quiet-reared gerbils. Hear Res. 61, 35\u201346. https:\/\/doi.org\/10.1016\/0378-5955(92)90034-k (1992).","journal-title":"Hear Res."},{"key":"12239_CR16","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/BF02439970","volume":"254","author":"L Lippincott","year":"1997","unstructured":"Lippincott, L. & Rarey, K. E. Status of cochlear Na,K-ATPase in the aged SHR rat and its possible role in hearing loss. Eur. Arch. Otorhinolaryngol. 254, 413\u2013416. https:\/\/doi.org\/10.1007\/BF02439970 (1997).","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"12239_CR17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0378-5955(94)90045-0","volume":"78","author":"BA Schulte","year":"1994","unstructured":"Schulte, B. A. & Steel, K. P. Expression of alpha and beta subunit isoforms of Na,K-ATPase in the mouse inner ear and changes with mutations at the Wv or Sld loci. Hear Res. 78, 65\u201376. https:\/\/doi.org\/10.1016\/0378-5955(94)90045-0 (1994).","journal-title":"Hear Res."},{"key":"12239_CR18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1749-8104-8-20","volume":"8","author":"H Locher","year":"2013","unstructured":"Locher, H. et al. Neurosensory development and cell fate determination in the human cochlea. Neural. Dev. 8, 20. https:\/\/doi.org\/10.1186\/1749-8104-8-20 (2013).","journal-title":"Neural. Dev."},{"key":"12239_CR19","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1002\/dneu.22279","volume":"75","author":"H Locher","year":"2015","unstructured":"Locher, H. et al. Development of the stria vascularis and potassium regulation in the human fetal cochlea: Insights into hereditary sensorineural hearing loss. Dev. Neurobiol. 75, 1219\u20131240. https:\/\/doi.org\/10.1002\/dneu.22279 (2015).","journal-title":"Dev. Neurobiol."},{"key":"12239_CR20","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0378-5955(92)90166-k","volume":"64","author":"M Lavigne-Rebillard","year":"1992","unstructured":"Lavigne-Rebillard, M. & Bagger-Sjoback, D. Development of the human stria vascularis. Hear Res. 64, 39\u201351. https:\/\/doi.org\/10.1016\/0378-5955(92)90166-k (1992).","journal-title":"Hear Res."},{"key":"12239_CR21","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/febs.15341","volume":"288","author":"M Hosoya","year":"2021","unstructured":"Hosoya, M., Fujioka, M., Murayama, A. Y., Okano, H. & Ogawa, K. The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development. FEBS J. 288, 325\u2013353. https:\/\/doi.org\/10.1111\/febs.15341 (2021).","journal-title":"FEBS J."},{"key":"12239_CR22","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/dneu.22850","volume":"81","author":"M Hosoya","year":"2021","unstructured":"Hosoya, M. et al. Neuronal development in the cochlea of a nonhuman primate model, the common marmoset. Dev. Neurobiol. 81, 905\u2013938. https:\/\/doi.org\/10.1002\/dneu.22850 (2021).","journal-title":"Dev. Neurobiol."},{"key":"12239_CR23","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13064-022-00162-8","volume":"17","author":"M Hosoya","year":"2022","unstructured":"Hosoya, M. et al. Early development of the cochlea of the common marmoset, a non-human primate model. Neur. Dev. 17, 6. https:\/\/doi.org\/10.1186\/s13064-022-00162-8 (2022).","journal-title":"Neur. Dev."},{"key":"12239_CR24","doi-asserted-by":"publisher","first-page":"1781894","DOI":"10.1155\/2016\/1781894","volume":"2016","author":"M Hosoya","year":"2016","unstructured":"Hosoya, M., Fujioka, M., Okano, H. & Ogawa, K. Distinct Expression Pattern of a Deafness Gene, KIAA1199, in a Primate Cochlea. Biomed. Res. Int. 2016, 1781894. https:\/\/doi.org\/10.1155\/2016\/1781894 (2016).","journal-title":"Biomed. Res. Int."},{"key":"12239_CR25","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.neulet.2017.10.030","volume":"662","author":"S Matsuzaki","year":"2018","unstructured":"Matsuzaki, S., Hosoya, M., Okano, H., Fujioka, M. & Ogawa, K. Expression pattern of EYA4 in the common marmoset (Callithrix jacchus) cochlea. Neurosci. Lett. 662, 185\u2013188. https:\/\/doi.org\/10.1016\/j.neulet.2017.10.030 (2018).","journal-title":"Neurosci. Lett."},{"key":"12239_CR26","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1097\/WNR.0000000000000624","volume":"27","author":"N Suzuki","year":"2016","unstructured":"Suzuki, N. et al. Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea. Neuro Rep. 27, 833\u2013836. https:\/\/doi.org\/10.1097\/WNR.0000000000000624 (2016).","journal-title":"Neuro Rep."},{"key":"12239_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/genes12071082","author":"M Hosoya","year":"2021","unstructured":"Hosoya, M. et al. Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate\u2019s Cochlea. Genes (Basel) https:\/\/doi.org\/10.3390\/genes12071082 (2021).","journal-title":"Genes (Basel)"},{"key":"12239_CR28","doi-asserted-by":"publisher","first-page":"22250","DOI":"10.1038\/srep22250","volume":"6","author":"M Hosoya","year":"2016","unstructured":"Hosoya, M., Fujioka, M., Ogawa, K. & Okano, H. Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea. Sci. Rep. 6, 22250. https:\/\/doi.org\/10.1038\/srep22250 (2016).","journal-title":"Sci. Rep."},{"key":"12239_CR29","doi-asserted-by":"publisher","first-page":"12587","DOI":"10.18632\/aging.202936","volume":"13","author":"Z Sun","year":"2021","unstructured":"Sun, Z. et al. Neural presbycusis at ultra-high frequency in aged common marmosets and rhesus monkeys. Aging (Albany NY) 13, 12587\u201312606. https:\/\/doi.org\/10.18632\/aging.202936 (2021).","journal-title":"Aging (Albany NY)"},{"key":"12239_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1146\/annurev-neuro-030520-101844","volume":"44","author":"H Okano","year":"2021","unstructured":"Okano, H. Current Status of and Perspectives on the Application of Marmosets in Neurobiology. Annu. Rev. Neurosci. 44, 27\u201348. https:\/\/doi.org\/10.1146\/annurev-neuro-030520-101844 (2021).","journal-title":"Annu. Rev. Neurosci."},{"key":"12239_CR31","doi-asserted-by":"publisher","first-page":"25166","DOI":"10.1038\/s41598-024-76892-y","volume":"14","author":"M Hosoya","year":"2024","unstructured":"Hosoya, M. et al. A primate model animal revealed the inter-species differences and similarities in the subtype specifications of the spiral ganglion neurons. Sci. Rep. 14, 25166. https:\/\/doi.org\/10.1038\/s41598-024-76892-y (2024).","journal-title":"Sci. Rep."},{"key":"12239_CR32","doi-asserted-by":"publisher","first-page":"11789","DOI":"10.1038\/s41598-023-39003-x","volume":"13","author":"M Hosoya","year":"2023","unstructured":"Hosoya, M. et al. Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal. Sci. Rep. 13, 11789. https:\/\/doi.org\/10.1038\/s41598-023-39003-x (2023).","journal-title":"Sci. Rep."},{"key":"12239_CR33","doi-asserted-by":"publisher","first-page":"19811","DOI":"10.1038\/s41598-022-24380-6","volume":"12","author":"M Hosoya","year":"2022","unstructured":"Hosoya, M. et al. Development of the stria vascularis in the common marmoset, a primate model. Sci. Rep. 12, 19811. https:\/\/doi.org\/10.1038\/s41598-022-24380-6 (2022).","journal-title":"Sci. Rep."},{"key":"12239_CR34","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1080\/03009734.2019.1653408","volume":"124","author":"W Liu","year":"2019","unstructured":"Liu, W. et al. Expression of Na\/K-ATPase subunits in the human cochlea: a confocal and super-resolution microscopy study with special reference to auditory nerve excitation and cochlear implantation. Ups J. Med. Sci. 124, 168\u2013179. https:\/\/doi.org\/10.1080\/03009734.2019.1653408 (2019).","journal-title":"Ups J. Med. Sci."},{"key":"12239_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108113","author":"R Stephenson","year":"2021","unstructured":"Stephenson, R. et al. Immunohistochemical location of Na(+), K(+)-ATPase alpha1 subunit in the human inner ear. Hear Res. https:\/\/doi.org\/10.1016\/j.heares.2020.108113 (2021).","journal-title":"Hear Res."},{"key":"12239_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.857216","author":"W Liu","year":"2022","unstructured":"Liu, W. & Rask-Andersen, H. Na\/K-ATPase Gene Expression in the Human Cochlea: A Study Using mRNA in situ Hybridization and Super-Resolution Structured Illumination Microscopy. Front. Mol. Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2022.857216 (2022).","journal-title":"Front. Mol. Neurosci."},{"key":"12239_CR37","doi-asserted-by":"crossref","unstructured":"de Lores Arnaiz, G. R. & Ordieres, M. G. Brain Na(+), K(+)-ATPase Activity In Aging and Disease. Int. J. Biomed. Sci. 10, 85\u2013102 (2014).","DOI":"10.59566\/IJBS.2014.10085"},{"key":"12239_CR38","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abm4107","author":"CN Mann","year":"2022","unstructured":"Mann, C. N. et al. Astrocytic alpha2-Na(+)\/K(+) ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model. Sci. Transl. Med. https:\/\/doi.org\/10.1126\/scitranslmed.abm4107 (2022).","journal-title":"Sci. Transl. Med."},{"key":"12239_CR39","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5062","author":"L Cao","year":"2021","unstructured":"Cao, L. et al. Anti-Na(+)\/K(+)-ATPase immunotherapy ameliorates alpha-synuclein pathology through activation of Na(+)\/K(+)-ATPase alpha1-dependent autophagy. Sci. Adv. https:\/\/doi.org\/10.1126\/sciadv.abc5062 (2021).","journal-title":"Sci. Adv."},{"key":"12239_CR40","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.3390\/cells11244075","volume":"11","author":"X Zhang","year":"2022","unstructured":"Zhang, X., Lee, W. & Bian, J. S. Recent Advances in the Study of Na(+)\/K(+)-ATPase in Neurodegenerative Diseases. Cells 11, 4075. https:\/\/doi.org\/10.3390\/cells11244075 (2022).","journal-title":"Cells"},{"key":"12239_CR41","first-page":"273","volume":"15","author":"N Fischer","year":"2019","unstructured":"Fischer, N. et al. Changes in Na, K-ATPase\u03b13 in aging mouse spiral ganglion and organ of corti. B-ENT 15, 273\u2013279 (2019).","journal-title":"B-ENT"},{"key":"12239_CR42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/ilar.52.1.54","volume":"52","author":"SD Tardif","year":"2011","unstructured":"Tardif, S. D., Mansfield, K. G., Ratnam, R., Ross, C. N. & Ziegler, T. E. The marmoset as a model of aging and age-related diseases. ILAR J. 52, 54\u201365. https:\/\/doi.org\/10.1093\/ilar.52.1.54 (2011).","journal-title":"ILAR J."},{"key":"12239_CR43","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10162-008-0152-9","volume":"10","author":"WJ McLean","year":"2009","unstructured":"McLean, W. J., Smith, K. A., Glowatzki, E. & Pyott, S. J. Distribution of the Na,K-ATPase alpha subunit in the rat spiral ganglion and organ of corti. J. Assoc. Res. Otolaryngol. 10, 37\u201349. https:\/\/doi.org\/10.1007\/s10162-008-0152-9 (2009).","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"12239_CR44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.neuint.2019.04.009","volume":"128","author":"SM Sundaram","year":"2019","unstructured":"Sundaram, S. M. et al. Differential expression patterns of sodium potassium ATPase alpha and beta subunit isoforms in mouse brain during postnatal development. Neurochem. Int. 128, 163\u2013174. https:\/\/doi.org\/10.1016\/j.neuint.2019.04.009 (2019).","journal-title":"Neurochem. Int."},{"key":"12239_CR45","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1073\/pnas.85.1.284","volume":"85","author":"JW Schneider","year":"1988","unstructured":"Schneider, J. W. et al. Tissue specificity, localization in brain, and cell-free translation of mRNA encoding the A3 isoform of Na+, K+-ATPase. Proc. Natl. Acad. Sci. U S A 85, 284\u2013288. https:\/\/doi.org\/10.1073\/pnas.85.1.284 (1988).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"12239_CR46","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/38.2.2153727","volume":"38","author":"T Iwano","year":"1990","unstructured":"Iwano, T. et al. Quantitative immunogold localization of Na+, K(+)-ATPase alpha-subunit in the tympanic wall of rat cochlear duct. J. Histochem. Cytochem. 38, 225\u2013232. https:\/\/doi.org\/10.1177\/38.2.2153727 (1990).","journal-title":"J. Histochem. Cytochem."},{"key":"12239_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.720902","author":"K Ma","year":"2021","unstructured":"Ma, K. et al. Disruption of Glutamate Release and Uptake-Related Protein Expression After Noise-Induced Synaptopathy in the Cochlea. Front Cell Dev. Biol. https:\/\/doi.org\/10.3389\/fcell.2021.720902 (2021).","journal-title":"Front Cell Dev. Biol."},{"key":"12239_CR48","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1002\/glia.24229","volume":"70","author":"MW Jang","year":"2022","unstructured":"Jang, M. W., Lim, J., Park, M. G., Lee, J. H. & Lee, C. J. Active role of glia-like supporting cells in the organ of Corti: Membrane proteins and their roles in hearing. Glia 70, 1799\u20131825. https:\/\/doi.org\/10.1002\/glia.24229 (2022).","journal-title":"Glia"},{"key":"12239_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.973646","author":"W Liu","year":"2022","unstructured":"Liu, W. & Rask-Andersen, H. GJB2 and GJB6 gene transcripts in the human cochlea: A study using RNAscope, confocal, and super-resolution structured illumination microscopy. Front. Mol. Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2022.973646 (2022).","journal-title":"Front. Mol. Neurosci."},{"key":"12239_CR50","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12920-023-01549-0","volume":"16","author":"J-Y Koh","year":"2023","unstructured":"Koh, J.-Y. et al. Single-cell RNA-sequencing of stria vascularis cells in the adult Slc26a4-\/-mouse. BMC Med. Genomics 16, 133 (2023).","journal-title":"BMC Med. Genomics"},{"key":"12239_CR51","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1369\/0022155411421801","volume":"59","author":"S Mahendrasingam","year":"2011","unstructured":"Mahendrasingam, S., Bebb, C., Shepard, E. & Furness, D. N. Subcellular distribution and relative expression of fibrocyte markers in the CD\/1 mouse cochlea assessed by semiquantitative immunogold electron microscopy. J. Histochem. Cytochem. 59, 984\u20131000. https:\/\/doi.org\/10.1369\/0022155411421801 (2011).","journal-title":"J. Histochem. Cytochem."},{"key":"12239_CR52","doi-asserted-by":"publisher","first-page":"1229414","DOI":"10.3389\/fimmu.2023.1229414","volume":"14","author":"M Hosoya","year":"2023","unstructured":"Hosoya, M. et al. Distribution of macrophages in the developing cochlea of the common marmoset, a primate model animal. Front. Immunol. 14, 1229414. https:\/\/doi.org\/10.3389\/fimmu.2023.1229414 (2023).","journal-title":"Front. Immunol."},{"key":"12239_CR53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294731","author":"AK Iyer","year":"2023","unstructured":"Iyer, A. K. et al. Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice. PLoS ONE https:\/\/doi.org\/10.1371\/journal.pone.0294731 (2023).","journal-title":"PLoS ONE"},{"key":"12239_CR54","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1091\/mbc.e17-01-0064","volume":"28","author":"K Pl\u00f6ssl","year":"2017","unstructured":"Pl\u00f6ssl, K. et al. Retinoschisin is linked to retinal Na\/K-ATPase signaling and localization. Mol. Biol. Cell 28, 2178\u20132189 (2017).","journal-title":"Mol. Biol. Cell"},{"key":"12239_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111911","author":"F Chen","year":"2023","unstructured":"Chen, F., Zhu, S., Kang, R., Tang, D. & Liu, J. ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2022.111911 (2023).","journal-title":"Cell Rep."},{"key":"12239_CR56","doi-asserted-by":"publisher","unstructured":"Su, H. et al. Endothelin-1 potentiated constriction in preeclampsia placental veins: Role of ETAR\/ETBR\/CaV1.2\/CALD1. Placenta 158, 165\u2013174, https:\/\/doi.org\/10.1016\/j.placenta.2024.10.011 (2024).","DOI":"10.1016\/j.placenta.2024.10.011"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-12239-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-12239-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-12239-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T20:04:33Z","timestamp":1757275473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-12239-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["12239"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-12239-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"6 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MH was founding scientist of Otolink Inc. Other authors have no conflicts of interest directly relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The animal experiments were approved by the Animal Experiment Committee of Keio University (approval numbers: 11006, 08020) and followed the guidelines of the National Institutes of Health and the Ministry of Education, Culture, Sports, Science, and Technology of Japan.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval statement"}}],"article-number":"26814"}}