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While non-motor outcomes of PD impact daily well-being, they are rarely targeted by interventions or utilized for classification. Despite promising evidence, the contributions of perceived social support (PSS) to PD detection and well-being in real-world settings remain unclear. Using remote monitoring technologies, we investigated the relationship between PSS and three non-motor measures\u2014cognition, anxiety, and depression\u2014in 92 participants: 45 PD and 47 matched-controls. To examine the specificity of PSS to non-motor features, we also examined the associations between PSS and three motor-related measures: disease severity, duration, or stage. Moreover, we developed machine-learning classifiers (ML) based on only non-motor features to identify disease status (PD\/controls) in two cohorts: low and high PSS. PSS was significantly associated with non-motor measures in PD, with stronger correlations than in matched-controls in real-world settings. However, no significant correlations were found between PSS and the three motor-related measures, demonstrating PSS\u2019s limitations. While the ML classification models performed low in high-PSS, they classified 13% better in a low-PSS cohort (AUC\u2009=\u20090.8), demonstrating moderate-high discriminatory performance. Taken together, our findings underscore the role of PSS in PD, highlighting its distinct contributions to non-motor classification models and the daily well-being of patients.<\/jats:p>","DOI":"10.1038\/s41598-025-12787-w","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T05:12:14Z","timestamp":1753333934000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Perceived social support in the daily life of people with Parkinson\u2019s disease: a distinct role and potential classifier"],"prefix":"10.1038","volume":"15","author":[{"given":"J\u00falia","family":"Sch\u00f6nfeldov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ortal","family":"Otmazgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Saban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"12787_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.disamonth.2007.05.004","volume":"53","author":"A Kessler","year":"2007","unstructured":"Kessler, A. & Rezak, M. 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