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This study investigates the chemical composition of <jats:italic>Pelargonium graveolens<\/jats:italic> essential oil and explores its potential interaction with GBS-related molecular targets using <jats:italic>in-silico<\/jats:italic> tools. Essential oil was analyzed using GC\u2013MS. Identified components were subjected to network pharmacology analysis and molecular docking to assess binding affinities with GBS-relevant proteins, particularly TNF-\u03b1. Thirty compounds were identified, with citronellol (26.74%) and geraniol (20.28%) as major components. Comparative phytochemical analysis showed consistency with global <jats:italic>P. graveolens<\/jats:italic> chemotypes. Docking results suggest high binding affinity of citronellyl and geranyl derivatives toward TNF-\u03b1. These findings support further investigation of <jats:italic>P. graveolens<\/jats:italic> oil as a potential modulator of inflammatory pathways in GBS.<\/jats:p>","DOI":"10.1038\/s41598-025-13101-4","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T09:45:30Z","timestamp":1754387130000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phytochemical profiling and network pharmacology-based prediction of Pelargonium graveolens essential oil in the context of Guillain-Barr\u00e9 syndrome"],"prefix":"10.1038","volume":"15","author":[{"given":"Abdullah","family":"Haikal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman","family":"Hamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya M.","family":"Almatary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"issue":"8","key":"13101_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nrneurol.2014.121","volume":"10","author":"B Van den Berg","year":"2014","unstructured":"Van den Berg, B. et al. 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