{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:51:06Z","timestamp":1792525866436,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260193"],"award-info":[{"award-number":["82260193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260193"],"award-info":[{"award-number":["82260193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260193"],"award-info":[{"award-number":["82260193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260193"],"award-info":[{"award-number":["82260193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260193"],"award-info":[{"award-number":["82260193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260193"],"award-info":[{"award-number":["82260193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260193"],"award-info":[{"award-number":["82260193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260193"],"award-info":[{"award-number":["82260193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu - ZK[2024] General 251"],"award-info":[{"award-number":["Qiankehejichu - ZK[2024] General 251"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu - ZK[2024] General 251"],"award-info":[{"award-number":["Qiankehejichu - ZK[2024] General 251"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu - ZK[2024] General 251"],"award-info":[{"award-number":["Qiankehejichu - ZK[2024] General 251"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu - ZK[2024] General 251"],"award-info":[{"award-number":["Qiankehejichu - ZK[2024] General 251"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu - ZK[2024] General 251"],"award-info":[{"award-number":["Qiankehejichu - ZK[2024] General 251"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu - ZK[2024] General 251"],"award-info":[{"award-number":["Qiankehejichu - ZK[2024] General 251"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu - ZK[2024] General 251"],"award-info":[{"award-number":["Qiankehejichu - ZK[2024] General 251"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu - ZK[2024] General 251"],"award-info":[{"award-number":["Qiankehejichu - ZK[2024] General 251"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-13153-6","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:45:28Z","timestamp":1753710328000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CSF1R inhibitor (PLX3397) alleviates experimental periodontitis by reducing macrophage senescence through the PI3K\/AKT\/FOXO1 signaling pathway"],"prefix":"10.1038","volume":"15","author":[{"given":"Jiabing","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"issue":"7","key":"13153_CR1","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1111\/jcpe.13462","volume":"48","author":"GB Ortigara","year":"2021","unstructured":"Ortigara, G. B. et al. The 2018 EFP\/AAP periodontitis case classification demonstrates high agreement with the 2012 CDC\/AAP criteria. J. Clin. Periodontol.48(7), 886\u2013895 (2021).","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"13153_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12344","volume":"83","author":"RJ Genco","year":"2020","unstructured":"Genco, R. J. & Sanz, M. Clinical and public health implications of periodontal and systemic diseases: An overview. Periodontol. 200083(1), 7\u201313 (2020).","journal-title":"Periodontol. 2000"},{"issue":"12","key":"13153_CR3","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/S2213-8587(18)30038-X","volume":"6","author":"F D\u2032Aiuto","year":"2018","unstructured":"D\u2032Aiuto, F. et al. Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, singlecentre, investigatormasked, randomised trial. Lancet Diabetes Endocrinol. 6 (12), 954\u2013965 (2018).","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"10","key":"13153_CR4","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","volume":"13","author":"J Potempa","year":"2017","unstructured":"Potempa, J., Mydel, P. & Koziel, J. The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat. Rev. Rheumatol. 13 (10), 606\u2013620 (2017). (2017).","journal-title":"Nat. Rev. Rheumatol."},{"key":"13153_CR5","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3389\/fimmu.2020.00511","volume":"11","author":"TE Van Dyke","year":"2020","unstructured":"Van Dyke, T. E., Bartold, P. M. & Reynolds, E. C. The nexus between periodontal inflammation and dysbiosis. Front. Immunol. 11, 511 (2020).","journal-title":"Front. Immunol."},{"key":"13153_CR6","doi-asserted-by":"crossref","unstructured":"Bartold, P. M. & Van Dyke, T. E. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts[J]. Periodontol. 203\u2013217 (2013). (2000) 62(1).","DOI":"10.1111\/j.1600-0757.2012.00450.x"},{"key":"13153_CR7","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1590\/1678-775720140259","volume":"23","author":"N Silva","year":"2015","unstructured":"Silva, N. et al. Host response mechanisms in periodontal diseases. J. Appl. Oral Sci.23, 329\u2013355 (2015).","journal-title":"J. Appl. Oral Sci."},{"issue":"8","key":"13153_CR8","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1177\/00220345231154567","volume":"102","author":"R Aquino-Martinez","year":"2023","unstructured":"Aquino-Martinez, R. The emerging role of accelerated cellular senescence in periodontitis. J. Dent. Res.102(8), 854\u2013862 (2023).","journal-title":"J. Dent. Res."},{"issue":"10","key":"13153_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/biology11101419","volume":"11","author":"S Chen","year":"2022","unstructured":"Chen, S. et al. Cellular senescence and periodontitis: Mechanisms and therapeutics. Biology11(10), 1419 (2022).","journal-title":"Biology"},{"key":"13153_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115220","volume":"132","author":"R Aquino-Martinez","year":"2020","unstructured":"Aquino-Martinez, R. et al. LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis. Bone132, 115220 (2020).","journal-title":"Bone"},{"issue":"5","key":"13153_CR11","first-page":"1279","volume":"15","author":"K Ikegami","year":"2023","unstructured":"Ikegami, K. et al. Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue. Aging (Albany NY). 15 (5), 1279 (2023).","journal-title":"Aging (Albany NY)"},{"issue":"10","key":"13153_CR12","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1002\/JPER.20-0529","volume":"92","author":"R Aquino-Martinez","year":"2021","unstructured":"Aquino-Martinez, R. et al. Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice. J. Periodontol. 92 (10), 1483\u20131495 (2021).","journal-title":"J. Periodontol"},{"key":"13153_CR13","doi-asserted-by":"crossref","unstructured":"Nie, L. et al. lncRNA-triggered macrophage inflammaging deteriorates age-related diseases. Mediators Inflamm. 4260309 (2019). (2019)(1).","DOI":"10.1155\/2019\/4260309"},{"key":"13153_CR14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.redox.2017.12.001","volume":"15","author":"F Prattichizzo","year":"2018","unstructured":"Prattichizzo, F. et al. Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages. Redox Biol. 15, 170\u2013181 (2018).","journal-title":"Redox Biol."},{"issue":"49","key":"13153_CR15","doi-asserted-by":"publisher","first-page":"18807","DOI":"10.1074\/jbc.RA119.010648","volume":"294","author":"P Zhang","year":"2019","unstructured":"Zhang, P. et al. Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation. J. Biol. Chem.294(49), 18807\u201318819 (2019).","journal-title":"J. Biol. Chem."},{"issue":"1","key":"13153_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41368-021-00116-6","volume":"13","author":"Q Wang","year":"2021","unstructured":"Wang, Q. et al. Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging. Int. J. Oral Sci. 13 (1), 1\u201310 (2021).","journal-title":"Int. J. Oral Sci."},{"issue":"15","key":"13153_CR17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158450","volume":"132","author":"L Zhang","year":"2022","unstructured":"Zhang, L. et al. Cellular senescence: A key therapeutic target in aging and diseases. J. Clin. Invest.132(15), e158450 (2022).","journal-title":"J. Clin. Invest."},{"issue":"23","key":"13153_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222313173","volume":"22","author":"L Roger","year":"2021","unstructured":"Roger, L., Tomas, F. & Gire, V. Mechanisms and regulation of cellular senescence. Int. J. Mol. Sci.22(23), 13173 (2021).","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"13153_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112974","volume":"10","author":"I Mart\u00ednez de Toda","year":"2021","unstructured":"Mart\u00ednez de Toda, I. et al. The role of immune cells in oxi-inflamm-aging. Cells10(11), 2974 (2021).","journal-title":"Cells"},{"issue":"2","key":"13153_CR20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3390\/antiox10020271","volume":"10","author":"CY Ok","year":"2021","unstructured":"Ok, C. Y. et al. FK866 protects human dental pulp cells against oxidative stress-induced cellular senescence. Antioxidants 10 (2), 271 (2021).","journal-title":"Antioxidants"},{"key":"13153_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1081977","volume":"10","author":"X Li","year":"2022","unstructured":"Li, X. et al. Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway. Front. Bioeng. Biotechnol.10, 1081977 (2022).","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"13153_CR22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/bab.2104","volume":"69","author":"L Kma","year":"2022","unstructured":"Kma, L. & Baruah, T. J. The interplay of ROS and the PI3K\/Akt pathway in autophagy regulation. Biotechnol. Appl. Biochem. 69 (1), 248\u2013264 (2022).","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"7629","key":"13153_CR23","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nature19834","volume":"539","author":"MM Kaneda","year":"2016","unstructured":"Kaneda, M. M. et al. PI3K\u03b3 is a molecular switch that controls immune suppression. Nature539(7629), 437\u2013442 (2016).","journal-title":"Nature"},{"issue":"1","key":"13153_CR24","doi-asserted-by":"publisher","first-page":"1068962","DOI":"10.1155\/2022\/1068962","volume":"2022","author":"SJ Rong","year":"2022","unstructured":"Rong, S. J. et al. The essential role of FoxO1 in the regulation of macrophage function. Biomed. Res. Int. 2022 (1), 1068962 (2022).","journal-title":"Biomed. Res. Int."},{"issue":"4","key":"13153_CR25","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.7150\/thno.50683","volume":"11","author":"J Mu\u00f1oz-Garcia","year":"2021","unstructured":"Mu\u00f1oz-Garcia, J. et al. The twin cytokines interleukin-34 and CSF-1: Masterful conductors of macrophage homeostasis. Theranostics11(4), 1568 (2021).","journal-title":"Theranostics"},{"issue":"8","key":"13153_CR26","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1158\/1535-7163.MCT-20-0591","volume":"20","author":"T Fujiwara","year":"2021","unstructured":"Fujiwara, T. et al. CSF1\/CSF1R signaling inhibitor pexidartinib (plx3397) reprograms tumorassociated macrophages and stimulates tcell infiltration in the sarcoma microenvironment. Mol. Cancer Ther.20(8), 1388\u20131399 (2021).","journal-title":"Mol. Cancer Ther."},{"issue":"4","key":"13153_CR27","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1093\/neuonc\/nov245","volume":"18","author":"N Butowski","year":"2015","unstructured":"Butowski, N. et al. Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: An Ivy foundation early phase clinical trials consortium phase II study. Neuro Oncol.18(4), 557\u2013564 (2015).","journal-title":"Neuro Oncol."},{"key":"13153_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115353","volume":"136","author":"BA Smeester","year":"2020","unstructured":"Smeester, B. A. et al. PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma. Bone136, 115353 (2020).","journal-title":"Bone"},{"key":"13153_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13569-018-0101-2","volume":"8","author":"N Giustini","year":"2018","unstructured":"Giustini, N. et al. Tenosynovial giant cell tumor: case report of a patient effectively treated with pexidartinib (PLX3397) and review of the literature. Clin. Sarcoma Res. 8, 1\u20135 (2018).","journal-title":"Clin. Sarcoma Res."},{"issue":"12","key":"13153_CR30","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1177\/00220345211009463","volume":"100","author":"D Clark","year":"2021","unstructured":"Clark, D. et al. The contribution of macrophages in old mice to periodontal disease. J. Dent. Res.100(12), 1397\u20131404 (2021).","journal-title":"J. Dent. Res."},{"issue":"6","key":"13153_CR31","first-page":"575","volume":"58","author":"TJ Xiao","year":"2023","unstructured":"Xiao, T. J. et al. Regulation of colony-stimulating factor 1 receptor inhibitor pexidartinib on the senescence of mouse bone marrow-derived macrophages stimulated by lipopolysaccharide. Zhonghua Kou Qiang Yi Xue Za Zhi. 58 (6), 575\u2013583 (2023).","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"13153_CR32","doi-asserted-by":"publisher","first-page":"117836","DOI":"10.1016\/j.biopha.2025.117836","volume":"183","author":"R Ashfaq","year":"2025","unstructured":"Ashfaq, R. et al. Smart biomaterial gels for periodontal therapy: A novel approach. Biomed. Pharmacother. 183, 117836 (2025).","journal-title":"Biomed. Pharmacother"},{"key":"13153_CR33","doi-asserted-by":"crossref","unstructured":"Xu, M. et al. Bupleurum chinense polysaccharide improves lps-induced senescence of RAW264.7 cells by regulating the NF-\u03baB signaling pathway. Evid. Based Complement. Alternat. Med. 7060812 (2020). (2020).","DOI":"10.1155\/2020\/7060812"},{"issue":"10","key":"13153_CR34","doi-asserted-by":"publisher","first-page":"9240","DOI":"10.18632\/aging.103200","volume":"12","author":"H Wang","year":"2020","unstructured":"Wang, H. et al. BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake. Aging (Albany NY)12(10), 9240\u20139259 (2020).","journal-title":"Aging (Albany NY)"},{"issue":"20","key":"13153_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207441","volume":"21","author":"R Aquino-Martinez","year":"2020","unstructured":"Aquino-Martinez, R. et al. Periodontal disease and senescent cells: New players for an old oral health problem?. Int. J. Mol. Sci.21(20), 7441 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"7861","key":"13153_CR36","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-021-03547-7","volume":"594","author":"MJ Yousefzadeh","year":"2021","unstructured":"Yousefzadeh, M. J. et al. An aged immune system drives senescence and ageing of solid organs. Nature594(7861), 100\u2013105 (2021).","journal-title":"Nature"},{"issue":"12","key":"13153_CR37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081665","volume":"8","author":"EA Bostr\u00f6m","year":"2013","unstructured":"Bostr\u00f6m, E. A. & Lundberg, P. The newly discovered cytokine IL-34 is expressed in gingival fibroblasts, shows enhanced expression by pro-inflammatory cytokines, and stimulates osteoclast differentiation. PLoS One8(12), e81665 (2013).","journal-title":"PLoS One"},{"key":"13153_CR38","doi-asserted-by":"publisher","first-page":"763334","DOI":"10.3389\/fimmu.2021.763334","volume":"12","author":"X Sun","year":"2021","unstructured":"Sun, X. et al. Polarized macrophages in periodontitis: characteristics, function, and molecular signaling. Front. Immunol. 12, 763334 (2021).","journal-title":"Front. Immunol."},{"key":"13153_CR39","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.biopha.2018.04.046","volume":"103","author":"A Kumari","year":"2018","unstructured":"Kumari, A., Silakari, O. & Singh, R. K. Recent advances in colony stimulating factor-1 receptor\/cfms as an emerging target for various therapeutic implications. Biomed. Pharmacother.103, 662\u2013679 (2018).","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"13153_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061665","volume":"19","author":"AD Truong","year":"2018","unstructured":"Truong, A. D. et al. Interleukin-34 regulates Th1 and Th17 cytokine production by activating multiple signaling pathways through CSF-1R in chicken cell lines. Int. J. Mol. Sci.19(6), 1665 (2018).","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"13153_CR41","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1111\/jre.12926","volume":"56","author":"R Clark","year":"2021","unstructured":"Clark, R. et al. Colony-stimulating factor\u20101 receptor blockade attenuates inflammation in inflamed gingival tissue explants. J. Periodontal Res.56(6), 1141\u20131153 (2021).","journal-title":"J. Periodontal Res."},{"issue":"6","key":"13153_CR42","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1002\/JPER.19-0296","volume":"91","author":"R Clark","year":"2020","unstructured":"Clark, R. et al. Expression of colonystimulating factor 1 and interleukin-34 in gingival tissue and gingival fibroblasts from periodontitis patients and controls. J. Periodontol.91(6), 828\u2013835 (2020).","journal-title":"J. Periodontol."},{"key":"13153_CR43","doi-asserted-by":"publisher","first-page":"108916","DOI":"10.1016\/j.biopha.2019.108916","volume":"115","author":"XF Wang","year":"2019","unstructured":"Wang, X. F. et al. Colonystimulating factor 1 receptor Inhibition prevents against lipopolysaccharideinduced osteoporosis by inhibiting osteoclast formation. Biomed. Pharmacother. 115, 108916 (2019).","journal-title":"Biomed. Pharmacother"},{"key":"13153_CR44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.freeradbiomed.2021.05.031","volume":"172","author":"L Shi","year":"2021","unstructured":"Shi, L. et al. Crosstalk between reactive oxygen species and dynamin-related protein 1 in periodontitis. Free Radic. Biol. Med.172, 19\u201332 (2021).","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"13153_CR45","doi-asserted-by":"publisher","first-page":"e00297","DOI":"10.1128\/IAI.00297-17","volume":"85","author":"J Hirschfeld","year":"2017","unstructured":"Hirschfeld, J. et al. Modulation of neutrophil extracellular trap and reactive oxygen species release by periodontal bacteria. Infect. Immun. 85 (12), e00297\u2013e00217 (2017).","journal-title":"Infect. Immun."},{"key":"13153_CR46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ijbiomac.2015.02.037","volume":"77","author":"J Wang","year":"2015","unstructured":"Wang, J. et al. Molecular mechanism on cadmium-induced activity changes of catalase and superoxide dismutase. Int. J. Biol. Macromol. 77, 59\u201367 (2015).","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"13153_CR47","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1111\/andr.13027","volume":"9","author":"B Feng","year":"2021","unstructured":"Feng, B. et al. Li-ESWT treatment reduces inflammation, oxidative stress, and pain via the PI3K\/AKT\/FOXO1 pathway in autoimmune prostatitis rat models. Andrology9(5), 1593\u20131602 (2021).","journal-title":"Andrology"},{"issue":"1","key":"13153_CR48","doi-asserted-by":"publisher","first-page":"e269","DOI":"10.1002\/ctm2.269","volume":"11","author":"S Xu","year":"2021","unstructured":"Xu, S. et al. CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K\/AKT\/Foxo1 signaling. Clin. Transl Med. 11 (1), e269 (2021).","journal-title":"Clin. Transl Med."},{"key":"13153_CR49","doi-asserted-by":"publisher","first-page":"114164","DOI":"10.1016\/j.intimp.2025.114164","volume":"149","author":"J Chen","year":"2025","unstructured":"Chen, J. et al. Senescent macrophages trigger a pro-inflammatory program and promote the progression of rheumatoid arthritis. Int. Immunopharmacol. 149, 114164 (2025).","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"13153_CR50","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/s42255-020-00305-3","volume":"2","author":"AJ Covarrubias","year":"2020","unstructured":"Covarrubias, A. J. et al. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat. Metab.2(11), 1265\u20131283 (2020).","journal-title":"Nat. Metab."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-13153-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-13153-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-13153-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T07:08:41Z","timestamp":1757315321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-13153-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["13153"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-13153-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"14 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27446"}}