{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:09:08Z","timestamp":1791598148978,"version":"4.3.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"2021 Hebei medical science research project plan, research on the mechanism of secondary glucocorticoid resistance in patients with acute on chronic liver failure","award":["20210869"],"award-info":[{"award-number":["20210869"]}]},{"name":"2021 Hebei medical science research project plan, research on the mechanism of secondary glucocorticoid resistance in patients with acute on chronic liver failure","award":["20210869"],"award-info":[{"award-number":["20210869"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-13798-3","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T14:43:23Z","timestamp":1755096203000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["HNF4A ameliorates acute liver failure by inhibiting NCOA4-mediated ferritinophagy"],"prefix":"10.1038","volume":"15","author":[{"given":"Weiyan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"issue":"7","key":"13798_CR1","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41419-020-2732-5","volume":"11","author":"L Mao","year":"2020","unstructured":"Mao, L. et al. The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope? Cell Death Dis. 11 (7), 518 (2020).","journal-title":"Cell Death Dis."},{"issue":"3","key":"13798_CR2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","volume":"29","author":"J Chen","year":"2022","unstructured":"Chen, J., Li, X., Ge, C., Min, J. & Wang, F. The multifaceted role of ferroptosis in liver disease. Cell. Death Differ. 29 (3), 467\u2013480 (2022).","journal-title":"Cell. Death Differ."},{"key":"13798_CR3","doi-asserted-by":"crossref","unstructured":"Lemmer, P., Sowa, J. P., Bulut, Y., Strnad, P. & Canbay, A. Mechanisms and aetiology-dependent Treatment of Acute Liver Failure. Liver International (official journal of the International Association for the Study of the Liver, 2023).","DOI":"10.1111\/liv.15739"},{"key":"13798_CR4","doi-asserted-by":"publisher","first-page":"1279264","DOI":"10.3389\/fimmu.2023.1279264","volume":"14","author":"D Xie","year":"2023","unstructured":"Xie, D. & Ouyang, S. The role and mechanisms of macrophage polarization and hepatocyte pyroptosis in acute liver failure. Front. Immunol. 14, 1279264 (2023).","journal-title":"Front. Immunol."},{"issue":"10201","key":"13798_CR5","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","volume":"394","author":"RT Stravitz","year":"2019","unstructured":"Stravitz, R. T. & Lee, W. M. Acute liver failure. Lancet (London England). 394 (10201), 869\u2013881 (2019).","journal-title":"Lancet (London England)"},{"issue":"6","key":"13798_CR6","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","volume":"32","author":"J Zheng","year":"2020","unstructured":"Zheng, J. & Conrad, M. The metabolic underpinnings of ferroptosis. Cell Metabol. 32 (6), 920\u2013937 (2020).","journal-title":"Cell Metabol."},{"issue":"11","key":"13798_CR7","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/ncb3053","volume":"16","author":"WE Dowdle","year":"2014","unstructured":"Dowdle, W. E. et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 (11), 1069\u20131079 (2014).","journal-title":"Nat. Cell Biol."},{"key":"13798_CR8","doi-asserted-by":"publisher","first-page":"102413","DOI":"10.1016\/j.redox.2022.102413","volume":"55","author":"H Zhou","year":"2022","unstructured":"Zhou, H. et al. NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells. Redox Biol. 55, 102413 (2022).","journal-title":"Redox Biol."},{"issue":"6","key":"13798_CR9","first-page":"1413","volume":"11","author":"Y Wang","year":"2023","unstructured":"Wang, Y., Shi, C., Guo, J., Zhang, Y. & Gong, Z. Distinct types of cell death and implications in liver diseases: an overview of mechanisms and application. J. Clin. Translational Hepatol. 11 (6), 1413\u20131424 (2023).","journal-title":"J. Clin. Translational Hepatol."},{"issue":"4","key":"13798_CR10","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang, X., Stockwell, B. R. & Conrad, M. Ferroptosis: mechanisms, biology and role in disease. Nat. Rev. Mol. Cell Biol. 22 (4), 266\u2013282 (2021).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"13798_CR11","doi-asserted-by":"publisher","first-page":"102131","DOI":"10.1016\/j.redox.2021.102131","volume":"46","author":"A Wu","year":"2021","unstructured":"Wu, A. et al. Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis. Redox Biol. 46, 102131 (2021).","journal-title":"Redox Biol."},{"issue":"6","key":"13798_CR12","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1111\/liv.14428","volume":"40","author":"X Li","year":"2020","unstructured":"Li, X. et al. Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver International: Official J. Int. Association Study Liver. 40 (6), 1378\u20131394 (2020).","journal-title":"Liver International: Official J. Int. Association Study Liver"},{"key":"13798_CR13","doi-asserted-by":"publisher","first-page":"101470","DOI":"10.1016\/j.molmet.2022.101470","volume":"60","author":"J He","year":"2022","unstructured":"He, J. et al. Ferroptosis and ferritinophagy in diabetes complications. Mol. Metabolism. 60, 101470 (2022).","journal-title":"Mol. Metabolism"},{"issue":"7","key":"13798_CR14","doi-asserted-by":"publisher","first-page":"e13621","DOI":"10.1111\/cpr.13621","volume":"57","author":"JY Li","year":"2024","unstructured":"Li, J. Y. et al. Ferritinophagy: A novel insight into the double-edged sword in ferritinophagy-ferroptosis axis and human diseases. Cell Prolif. 57 (7), e13621 (2024).","journal-title":"Cell Prolif."},{"issue":"34","key":"13798_CR15","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.3748\/wjg.v30.i34.3856","volume":"30","author":"YW Sun","year":"2024","unstructured":"Sun, Y. W., Zhao, B. W., Li, H. F. & Zhang, G. X. Overview of ferroptosis and pyroptosis in acute liver failure. World J. Gastroenterol. 30 (34), 3856\u20133861 (2024).","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"13798_CR16","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1038\/s41467-019-10991-7","volume":"10","author":"M Yoshida","year":"2019","unstructured":"Yoshida, M. et al. Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis. Nat. Commun. 10 (1), 3145 (2019).","journal-title":"Nat. Commun."},{"key":"13798_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2023.03.008","volume":"200","author":"K Sun","year":"2023","unstructured":"Sun, K. et al. JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy. Free Radic. Biol. Med. 200, 87\u2013101 (2023).","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"13798_CR18","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1016\/j.apsb.2023.12.012","volume":"14","author":"Z Huang","year":"2024","unstructured":"Huang, Z. et al. FGF4 protects the liver from immune-mediated injury by activating CaMKK\u03b2-PINK1 signal pathway to inhibit hepatocellular apoptosis. Acta Pharm. Sinica B. 14 (4), 1605\u20131623 (2024).","journal-title":"Acta Pharm. Sinica B"},{"issue":"2","key":"13798_CR19","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1055\/a-2097-0660","volume":"43","author":"M Kotulkar","year":"2023","unstructured":"Kotulkar, M., Robarts, D. R. & Apte, U. HNF4\u03b1 in hepatocyte health and disease. Semin. Liver Dis. 43 (2), 234\u2013244 (2023).","journal-title":"Semin. Liver Dis."},{"issue":"1","key":"13798_CR20","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41467-019-09046-8","volume":"10","author":"W Yang","year":"2019","unstructured":"Yang, W. et al. Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair. Nat. Commun. 10 (1), 1076 (2019).","journal-title":"Nat. Commun."},{"issue":"1","key":"13798_CR21","doi-asserted-by":"publisher","first-page":"e22942","DOI":"10.1002\/jbt.22942","volume":"36","author":"T Liu","year":"2022","unstructured":"Liu, T., Sun, L., Zhang, Y., Wang, Y. & Zheng, J. Imbalanced GSH\/ROS and sequential cell death. J. Biochem. Mol. Toxicol. 36 (1), e22942 (2022).","journal-title":"J. Biochem. Mol. Toxicol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-13798-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-13798-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-13798-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T12:52:47Z","timestamp":1757422367000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-13798-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["13798"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-13798-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"assertion":[{"value":"22 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The research in this paper adheres to the Declaration of Helsinki","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations statement"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study protocol was approved by the Medical ethics committee of the Third Hospital of Hebei Medical University (2024-052-1).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients obtained written informed consent.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"29714"}}