{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:31:23Z","timestamp":1779924683615,"version":"3.53.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Fisher & Paykel healthcare"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-14082-0","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T18:38:46Z","timestamp":1755196726000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Visualisation and quantification of the effects of surgical humidification on intestinal perfusion and viability in a porcine model"],"prefix":"10.1038","volume":"15","author":[{"given":"Mahdi","family":"Al-Taher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Felli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariaki","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita","family":"Rodriguez-Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baiocchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Noll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Diemunsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bouvy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurents","family":"Stassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Diemunsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Diana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"14082_CR1","doi-asserted-by":"publisher","first-page":"306","DOI":"10.4103\/joacp.JOACP_334_16","volume":"33","author":"B Bindu","year":"2017","unstructured":"Bindu, B., Bindra, A. & Rath, G. Temperature management under general anesthesia: Compulsion or option. J. Anaesthesiol. Clin. Pharmacol. 33, 306\u2013316. https:\/\/doi.org\/10.4103\/joacp.JOACP_334_16 (2017).","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"key":"14082_CR2","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/bjs.10685","volume":"105","author":"S Carpinteri","year":"2018","unstructured":"Carpinteri, S. et al. Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery. Br. J. Surg. 105, 597\u2013605. https:\/\/doi.org\/10.1002\/bjs.10685 (2018).","journal-title":"Br. J. Surg."},{"key":"14082_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/bjs5.50227","volume":"4","author":"JY Cheong","year":"2020","unstructured":"Cheong, J. Y. et al. Randomized clinical trial of the effect of intraoperative humidified carbon dioxide insufflation in open laparotomy for colorectal resection. BJS Open. 4, 45\u201358. https:\/\/doi.org\/10.1002\/bjs5.50227 (2020).","journal-title":"BJS Open."},{"key":"14082_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0022-5223(19)33287-8","volume":"49","author":"NA Delin","year":"1965","unstructured":"Delin, N. A. et al. J. Thorac. Cardiovasc. Surg. 49, 511\u2013516 https:\/\/doi.org:https:\/\/doi.org\/10.1016\/S0022-5223(19)33287-8 (1965).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"14082_CR5","doi-asserted-by":"publisher","unstructured":"Marshall, J. K. et al. Intra-operative tissue oxygen tension is increased by local insufflation of humidified-warm CO2during open abdominal surgery in a rat model. PloS One 10, e0122838 https:\/\/doi.org\/10.1371\/journal.pone.0122838(2015).","DOI":"10.1371\/journal.pone.0122838"},{"key":"14082_CR6","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jss.2017.06.057","volume":"220","author":"JK Marshall","year":"2017","unstructured":"Marshall, J. K., Tait, N. & van der Linden, J. Laparotomy causes loss of peritoneal mesothelium prevented by humidified CO2 insufflation in rats. J. Surg. Res. 220, 300\u2013310. https:\/\/doi.org\/10.1016\/j.jss.2017.06.057 (2017).","journal-title":"J. Surg. Res."},{"key":"14082_CR7","doi-asserted-by":"publisher","first-page":"e0195465","DOI":"10.1371\/journal.pone.0195465","volume":"13","author":"JP Robson","year":"2018","unstructured":"Robson, J. P., Kokhanenko, P., Marshall, J. K., Phillips, A. R. & van der Linden, J. Increased visceral tissue perfusion with heated, humidified carbon dioxide insufflation during open abdominal surgery in a rodent model. PloS One. 13, e0195465\u2013e0195465. https:\/\/doi.org\/10.1371\/journal.pone.0195465 (2018).","journal-title":"PloS One"},{"key":"14082_CR8","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jamcollsurg.2008.10.015","volume":"208","author":"TPMD Kingham","year":"2009","unstructured":"Kingham, T. P. M. D. & Pachter, H. L. M. D. F. Colonic anastomotic leak: risk factors, diagnosis, and treatment. J. Am. Coll. Surg. 208, 269\u2013278. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2008.10.015 (2009).","journal-title":"J. Am. Coll. Surg."},{"key":"14082_CR9","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jamcollsurg.2014.09.015","volume":"220","author":"MDMD Jafari","year":"2015","unstructured":"Jafari, M. D. M. D. et al. Perfusion assessment in laparoscopic Left-Sided\/Anterior resection (PILLAR II): A Multi-Institutional study. J. Am. Coll. Surg. 220, 82\u201392e81. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2014.09.015 (2015).","journal-title":"J. Am. Coll. Surg."},{"key":"14082_CR10","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/BF02555426","volume":"30","author":"WG Sheridan","year":"1987","unstructured":"Sheridan, W. G., Lowndes, R. H. & Young, H. L. Tissue oxygen tension as a predictor of colonic anastomotic healing. Dis. Colon Rectum. 30, 867\u2013871. https:\/\/doi.org\/10.1007\/BF02555426 (1987).","journal-title":"Dis. Colon Rectum"},{"key":"14082_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18116","author":"A Arachchi","year":"2022","unstructured":"Arachchi, A. et al. Does intra-operative humidification with warmed CO2 reduce surgical site infection in open colorectal surgery? A randomized control trial. ANZ J. Surgery N\/a. https:\/\/doi.org\/10.1111\/ans.18116 (2022). https:\/\/doi.org:","journal-title":"ANZ J. Surgery N\/a"},{"key":"14082_CR12","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1213\/ANE.0b013e31826ac49f","volume":"115","author":"JM Frey","year":"2012","unstructured":"Frey, J. M., Janson, M., Svanfeldt, M., Svenarud, P. K. & van der Linden, J. A. Local insufflation of warm humidified co2increases open wound and core temperature during open colon surgery: A randomized clinical trial. Anesth. Analg. 115, 1204\u20131211. https:\/\/doi.org\/10.1213\/ANE.0b013e31826ac49f (2012).","journal-title":"Anesth. Analg"},{"key":"14082_CR13","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1007\/s00268-012-1735-5","volume":"36","author":"JM Frey","year":"2012","unstructured":"Frey, J. M., Janson, M., Svanfeldt, M., Svenarud, P. K. & van der Linden, J. A. Intraoperative local insufflation of warmed humidified CO2 increases open wound and core temperatures: A randomized clinical trial. World J. Surg. 36, 2567\u20132575. https:\/\/doi.org\/10.1007\/s00268-012-1735-5 (2012).","journal-title":"World J. Surg."},{"key":"14082_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12893-017-0208-z","volume":"17","author":"L Weinberg","year":"2017","unstructured":"Weinberg, L. et al. Prevention of hypothermia in patients undergoing orthotopic liver transplantation using the humigard\u00ae open surgery humidification system: A prospective randomized pilot and feasibility clinical trial. BMC Surg. 17, 1\u201310. https:\/\/doi.org\/10.1186\/s12893-017-0208-z (2017).","journal-title":"BMC Surg."},{"key":"14082_CR15","doi-asserted-by":"publisher","unstructured":"Hopf, H. W. et al. Wound tissue oxygen tension predicts the risk of wound infection in surgical patients. Arch. surgery (Chicago.) 132, 997\u20131004 https:\/\/doi.org\/10.1001\/archsurg.1997.01430330063010 (1997).","DOI":"10.1001\/archsurg.1997.01430330063010"},{"key":"14082_CR16","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1056\/nejm199605093341901","volume":"334","author":"A Kurz","year":"1996","unstructured":"Kurz, A., Sessler, D. I. & Lenhardt, R. Perioperative normothermia to reduce the incidence of Surgical-Wound infection and shorten hospitalization. N. Engl. J. Med. 334, 1209\u20131216. https:\/\/doi.org\/10.1056\/nejm199605093341901 (1996).","journal-title":"N. Engl. J. Med."},{"key":"14082_CR17","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/S0140-6736(01)06071-8","volume":"358","author":"AC Melling","year":"2001","unstructured":"Melling, A. C., Ali, B., Scott, E. M. & Leaper, D. J. Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomised controlled trial. Lancet 358, 876\u2013880. https:\/\/doi.org\/10.1016\/S0140-6736(01)06071-8 (2001).","journal-title":"Lancet"},{"key":"14082_CR18","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mehy.2007.12.016","volume":"71","author":"M Persson","year":"2008","unstructured":"Persson, M. & van der Linden, J. Intraoperative CO2 insufflation can decrease the risk of surgical site infection. Med. Hypotheses. 71, 8\u201313. https:\/\/doi.org\/10.1016\/j.mehy.2007.12.016 (2008).","journal-title":"Med. Hypotheses"},{"key":"14082_CR19","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 8, e1000412. https:\/\/doi.org\/10.1371\/journal.pbio.1000412 (2010).","journal-title":"PLoS Biol."},{"key":"14082_CR20","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1515\/bmt-2017-0155","volume":"63","author":"A Holmer","year":"2018","unstructured":"Holmer, A., Marotz, J., Wahl, P., Dau, M. & K\u00e4mmerer, P. W. Hyperspectral imaging in perfusion and wound diagnostics\u2014methods and algorithms for the determination of tissue parameters. Biomed. Tech. (Berl). 63, 547\u2013556. https:\/\/doi.org\/10.1515\/bmt-2017-0155 (2018).","journal-title":"Biomed. Tech. (Berl)"},{"key":"14082_CR21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.30476\/acrr.2020.46746","volume":"8","author":"JY Cheong","year":"2020","unstructured":"Cheong, J. Y., Keshava, A. & Young, C. J. The effect of humidified warmed CO2 during open colorectal surgery on body temperature and postoperative pain: A randomized controlled trial. Iran. J. Colorectal Res. 8, 79\u201387. https:\/\/doi.org\/10.30476\/acrr.2020.46746 (2020).","journal-title":"Iran. J. Colorectal Res."},{"key":"14082_CR22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/14737167.2017.1270759","volume":"17","author":"M Jenks","year":"2017","unstructured":"Jenks, M., Taylor, M. & Shore, J. Cost-utility analysis of the insufflation of warmed humidified carbon dioxide during open and laparoscopic colorectal surgery. Expert Rev. PharmacoEcon. Outcomes Res. 17, 99\u2013107. https:\/\/doi.org\/10.1080\/14737167.2017.1270759 (2017).","journal-title":"Expert Rev. PharmacoEcon. Outcomes Res."},{"key":"14082_CR23","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s10151-020-02293-8","volume":"24","author":"N Kulkarni","year":"2020","unstructured":"Kulkarni, N. & Arulampalam, T. Laparoscopic surgery reduces the incidence of surgical site infections compared to the open approach for colorectal procedures: A meta-analysis. Tech. Coloproctol. 24, 1017\u20131024. https:\/\/doi.org\/10.1007\/s10151-020-02293-8 (2020).","journal-title":"Tech. Coloproctol."},{"key":"14082_CR24","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1002\/bjs5.50302","volume":"4","author":"J Lawler","year":"2020","unstructured":"Lawler, J. et al. Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery. BJS Open. 4, 737\u2013747. https:\/\/doi.org\/10.1002\/bjs5.50302 (2020).","journal-title":"BJS Open."},{"key":"14082_CR25","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1097\/00000542-200410000-00020","volume":"101","author":"M Persson","year":"2004","unstructured":"Persson, M., Elmqvist, H. & Van Der Linden, J. Topical humidified carbon dioxide to keep the open surgical wound warm: the greenhouse effect revisited. Anesthesiology (Philadelphia). 101, 945\u2013949. https:\/\/doi.org\/10.1097\/00000542-200410000-00020 (2004).","journal-title":"Anesthesiology (Philadelphia)"},{"key":"14082_CR26","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1053\/j.jvca.2004.01.024","volume":"18","author":"M Persson","year":"2004","unstructured":"Persson, M., Svenarud, P. & van der Linden, J. What is the optimal device for carbon dioxide Deairing of the cardiothoracic wound and how should it be positioned? J. Cardiothorac. Vasc Anesth. 18, 180\u2013184. https:\/\/doi.org\/10.1053\/j.jvca.2004.01.024 (2004).","journal-title":"J. Cardiothorac. Vasc Anesth."},{"key":"14082_CR27","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1524-475X.2010.00602.x","volume":"18","author":"JM Frey","year":"2010","unstructured":"Frey, J. M., Svegby, H. K., Svenarud, P. K. & Van Der Linden, J. A. CO2 insufflation influences the temperature of the open surgical wound. Wound Repair. Regeneration. 18, 378\u2013382. https:\/\/doi.org\/10.1111\/j.1524-475X.2010.00602.x (2010).","journal-title":"Wound Repair. Regeneration"},{"key":"14082_CR28","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1590\/s0102-86502014001800008","volume":"29","author":"JC Oliveira","year":"2014","unstructured":"Oliveira, J. C. et al. Effects of perioperative hypothermia and reactive oxygen species in the healing of colonic anastomosis in rats. Acta Cir. Bras. 29, 742\u2013747. https:\/\/doi.org\/10.1590\/s0102-86502014001800008 (2014).","journal-title":"Acta Cir. Bras."},{"key":"14082_CR29","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00384-013-1695-8","volume":"28","author":"JC de Oliveira","year":"2013","unstructured":"de Oliveira, J. C. et al. Effects of perioperative hypothermia on healing of anastomosis of the colon in rats. Int. J. Colorectal Dis. 28, 705\u2013712. https:\/\/doi.org\/10.1007\/s00384-013-1695-8 (2013).","journal-title":"Int. J. Colorectal Dis."},{"key":"14082_CR30","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1007\/s11605-021-05119-6","volume":"26","author":"I Ozmen","year":"2022","unstructured":"Ozmen, I. et al. Risk nomogram does not predict anastomotic leakage after colon surgery accurately: Results of the multi-center lekcheck study. J. Gastrointest. Surg. 26, 900\u2013910. https:\/\/doi.org\/10.1007\/s11605-021-05119-6 (2022).","journal-title":"J. Gastrointest. Surg."},{"key":"14082_CR31","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1177\/1553350615598620","volume":"22","author":"M Diana","year":"2015","unstructured":"Diana, M. et al. Metabolism-Guided bowel resection: potential role and accuracy of instant capillary lactates to identify the optimal resection site. Surg. Innov. 22, 453\u2013461. https:\/\/doi.org\/10.1177\/1553350615598620 (2015).","journal-title":"Surg. Innov."},{"key":"14082_CR32","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ejvs.2011.12.015","volume":"43","author":"E Noll","year":"2012","unstructured":"Noll, E. et al. Local but not systemic capillary lactate is a reperfusion biomarker in experimental acute limb ischaemia. Eur. J. Vasc. Endovasc. Surg. 43, 339\u2013340. https:\/\/doi.org\/10.1016\/j.ejvs.2011.12.015 (2012). https:\/\/doi.org:.","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"14082_CR33","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1365-2885.2010.01177.x","volume":"33","author":"L Mat\u00c9","year":"2010","unstructured":"Mat\u00c9, L. et al. Phase 1 and phase 2 metabolic activities along the small intestine in adult male sheep. J. Vet. Pharmacol. Ther. 33, 537\u2013545. https:\/\/doi.org\/10.1111\/j.1365-2885.2010.01177.x (2010).","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"14082_CR34","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/jcp.25402","volume":"232","author":"R Clara","year":"2017","unstructured":"Clara, R. et al. Metabolic adaptation of the small intestine to short- and medium\u2010term high\u2010fat diet exposure. J. Cell. Physiol. 232, 167\u2013175. https:\/\/doi.org\/10.1002\/jcp.25402 (2017).","journal-title":"J. Cell. Physiol."},{"key":"14082_CR35","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1152\/jappl.1959.14.3.414","volume":"14","author":"A Diji","year":"1959","unstructured":"Diji, A. Local vasodilator action of carbon dioxide on blood vessels of the hand. J. Appl. Physiol. 14, 414\u2013416. https:\/\/doi.org\/10.1152\/jappl.1959.14.3.414 (1959).","journal-title":"J. Appl. Physiol."},{"key":"14082_CR36","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/000331979704800406","volume":"48","author":"BR Hartmann","year":"1997","unstructured":"Hartmann, B. R., Bassenge, E., Pittler, M. & Hartmann, B. R. Effect of carbon dioxide-enriched water and fresh water on the cutaneous microcirculation and oxygen tension in the skin of the foot. Angiology 48, 337\u2013343. https:\/\/doi.org\/10.1177\/000331979704800406 (1997).","journal-title":"Angiology"},{"key":"14082_CR37","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1046\/j.1524-475X.1996.40310.x","volume":"4","author":"CW Sheffield","year":"1996","unstructured":"Sheffield, C. W. et al. Centrally and locally mediated thermoregulatory responses alter subcutaneous oxygen tension. Wound Repair. Regeneration. 4, 339\u2013345. https:\/\/doi.org\/10.1046\/j.1524-475X.1996.40310.x (1996).","journal-title":"Wound Repair. Regeneration"},{"key":"14082_CR38","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1007\/s00464-020-07922-9","volume":"35","author":"A D\u2019Urso","year":"2021","unstructured":"D\u2019Urso, A. et al. Computer-assisted quantification and visualization of bowel perfusion using fluorescence-based enhanced reality in left-sided colonic resections. Surg. Endosc. 35, 4321\u20134331. https:\/\/doi.org\/10.1007\/s00464-020-07922-9 (2021).","journal-title":"Surg. Endosc"},{"key":"14082_CR39","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1002\/bjs.9725","volume":"102","author":"M Diana","year":"2015","unstructured":"Diana, M. et al. Intraoperative fluorescence-based enhanced reality laparoscopic real-time imaging to assess bowel perfusion at the anastomotic site in an experimental model. Br. J. Surg. 102, e169\u2013176. https:\/\/doi.org\/10.1002\/bjs.9725 (2015).","journal-title":"Br. J. Surg."},{"key":"14082_CR40","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s00508-021-01916-w","volume":"134","author":"E Montanari","year":"2022","unstructured":"Montanari, E., Reh, L. M., Dauser, B., Birsan, T. & Hudelist, G. Serial assessment of inflammatory parameters for prediction of septic complications following surgery for colorectal endometriosis: A descriptive, retrospective study. Wien Klin. Wochenschr. 134, 118\u2013124. https:\/\/doi.org\/10.1007\/s00508-021-01916-w (2022).","journal-title":"Wien Klin. Wochenschr"},{"key":"14082_CR41","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1186\/s12893-021-01315-y","volume":"21","author":"K Henry","year":"2021","unstructured":"Henry, K. et al. Elevated serum lactate as a predictor of outcomes in patients following major abdominal surgery at a tertiary hospital in Uganda. BMC Surg. 21, 319. https:\/\/doi.org\/10.1186\/s12893-021-01315-y (2021).","journal-title":"BMC Surg."},{"key":"14082_CR42","doi-asserted-by":"publisher","unstructured":"Jane\u017e, J., Horvat, G., Jerin, A. & Grosek, J. The significance of blood and peritoneal fluid biochemical markers in identifying early anastomotic leak following colorectal resection-findings from a single-center study. Med. (Kaunas). 58. https:\/\/doi.org\/10.3390\/medicina58091253 (2022).","DOI":"10.3390\/medicina58091253"},{"key":"14082_CR43","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1007\/s11605-023-05798-3","volume":"27","author":"JDW Choi","year":"2023","unstructured":"Choi, J. D. W. et al. C-Reactive protein as a predictive marker for anastomotic leak following restorative colorectal surgery in an enhanced recovery after surgery program. J. Gastrointest. Surg. 27, 2604\u20132607. https:\/\/doi.org\/10.1007\/s11605-023-05798-3 (2023).","journal-title":"J. Gastrointest. Surg."},{"key":"14082_CR44","doi-asserted-by":"publisher","first-page":"7911","DOI":"10.1245\/s10434-022-12057-3","volume":"29","author":"S Sampurno","year":"2022","unstructured":"Sampurno, S. et al. Effect of surgical humidification on inflammation and peritoneal trauma in colorectal cancer surgery: A randomized controlled trial. Ann. Surg. Oncol. 29, 7911\u20137920. https:\/\/doi.org\/10.1245\/s10434-022-12057-3 (2022).","journal-title":"Ann. Surg. Oncol."},{"issue":"3","key":"14082_CR45","first-page":"164","volume":"86","author":"Y Liu","year":"2006","unstructured":"Liu, Y. & Hou, Q. X. [Effect of carbon dioxide Pneumoperitoneum during laparoscopic surgery on morphology of peritoneum]. Zhonghua Yi Xue Za Zhi. 86 (3), 164\u2013166 (2006).","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"1","key":"14082_CR46","doi-asserted-by":"publisher","first-page":"20408","DOI":"10.1038\/s41598-024-71611-z","volume":"14","author":"G Mazzinari","year":"2024","unstructured":"Mazzinari, G. et al. Estimation of the difference between peritoneal microenvironment and core body temperature during laparoscopic surgery\u2013a prospective observational study. Sci. Rep. 14 (1), 20408. https:\/\/doi.org\/10.1038\/s41598-024-71611-z (2024).","journal-title":"Sci. Rep."},{"issue":"4","key":"14082_CR47","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1007\/s00464-016-5195-0","volume":"31","author":"SE Mason","year":"2017","unstructured":"Mason, S. E., Kinross, J. M., Hendricks, J. & Arulampalam, T. H. Postoperative hypothermia and surgical site infection following peritoneal insufflation with warm, humidified carbon dioxide during laparoscopic colorectal surgery: a cohort study with cost-effectiveness analysis. Surg. Endosc. 31 (4), 1923\u20131929 (2017).","journal-title":"Surg. Endosc."},{"key":"14082_CR48","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1007\/s00464-019-06959-9","volume":"34","author":"M Barberio","year":"2020","unstructured":"Barberio, M. et al. HYPerspectral enhanced reality (HYPER): A physiology-based surgical guidance tool. Surg. Endosc. 34, 1736\u20131744. https:\/\/doi.org\/10.1007\/s00464-019-06959-9 (2020).","journal-title":"Surg. Endosc."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14082-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14082-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14082-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T04:22:26Z","timestamp":1757391746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14082-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["14082"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-14082-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"assertion":[{"value":"22 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"EN has given paid lectures for Fisher & Paykel. All other authors have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29892"}}