{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:25:55Z","timestamp":1776788755163,"version":"3.51.2"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Misr University for Science & Technology"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>To evaluate endothelial cell density (ECD) and corneal biomechanical changes following implantation of Veriflex and Implantable Collamer Lens (ICL) phakic intraocular lenses (pIOLs) over a 12-month period. Sixty <jats:bold>patients (117 eyes)<\/jats:bold> were included in this prospective comparative study. <jats:bold>58 eyes<\/jats:bold> underwent implantation with the Veriflex lens (Group I), while <jats:bold>59 eyes<\/jats:bold> received the ICL (Group II). Preoperative and postoperative ECD and corneal biomechanical values were assessed using specular microscopy and Corvis St at baseline, 6\u00a0months, and 1\u00a0year. Endothelial cell loss percentages and corneal biomechanical changes were calculated and compared between the 2 groups. Preoperatively, the mean ECD was <jats:bold>2683.4\u2009\u00b1\u2009340.6 cells\/mm<\/jats:bold>\n            <jats:sup>\n              <jats:bold>2<\/jats:bold>\n            <\/jats:sup> in Group I and <jats:bold>2732\u2009\u00b1\u2009322.8 cells\/mm<\/jats:bold>\n            <jats:sup>\n              <jats:bold>2<\/jats:bold>\n            <\/jats:sup> in Group II (<jats:bold>\n              <jats:italic>P<\/jats:italic>\n            <\/jats:bold>\n            <jats:bold>\u2009=\u20090.718<\/jats:bold>). At 1\u00a0year, Group I exhibited a significantly greater reduction in ECD compared to Group II (<jats:italic>P<\/jats:italic>\u2009=\u20090.021), indicating higher endothelial cell loss with Veriflex. The mean endothelial cell loss at 12\u00a0months was <jats:bold>5.4% (145.7\u2009\u00b1\u200962.8 cells\/mm<\/jats:bold>\n            <jats:sup>\n              <jats:bold>2<\/jats:bold>\n            <\/jats:sup>\n            <jats:bold>) in Group I<\/jats:bold> compared to <jats:bold>1.53% (42\u2009\u00b1\u200917.3 cells\/mm<\/jats:bold>\n            <jats:sup>\n              <jats:bold>2<\/jats:bold>\n            <\/jats:sup>\n            <jats:bold>) in Group II<\/jats:bold> (<jats:bold>\n              <jats:italic>P<\/jats:italic>\n            <\/jats:bold>\n            <jats:bold>\u2009&lt;\u20090.001<\/jats:bold>). The\u00a0<jats:bold>Veriflex group<\/jats:bold>\u00a0showed greater corneal biomechanical changes, with a\u00a0<jats:bold>deformation amplitude (DA)<\/jats:bold>\u00a0increase to 1.15\u2009\u00b1\u20090.11\u00a0mm and a\u00a0<jats:bold>highest concavity time (HCT)<\/jats:bold>\u00a0of 17.2\u2009\u00b1\u20091.1\u00a0ms, while the\u00a0<jats:bold>ICL group<\/jats:bold>\u00a0demonstrated more stable biomechanics, with a DA of 1.09\u2009\u00b1\u20090.09\u00a0mm and an HCT of 16.6\u2009\u00b1\u20091.0\u00a0ms at one year postoperatively. Both Veriflex and ICL pIOLs resulted in a decrease in ECD over one year, with Veriflex showing a significantly higher rate of endothelial cell loss. These findings suggest that ICL may be a safer option for long-term endothelial preservation. Long-term studies are required to assess the continued impact of both lenses on corneal endothelial health.<\/jats:p>","DOI":"10.1038\/s41598-025-14330-3","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:28:44Z","timestamp":1756283324000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of veriflex and ICL on corneal biomechanics and endothelial cell density"],"prefix":"10.1038","volume":"15","author":[{"given":"Passant Sayed","family":"Saif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Gaber","family":"Okasha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Samir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdelmonagy Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"issue":"5","key":"14330_CR1","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","volume":"123","author":"BA Holden","year":"2016","unstructured":"Holden, B. 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