{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:00:04Z","timestamp":1791518404415,"version":"4.3.4"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Wannan Medical College Young and Middle-aged Research Fund","award":["YR202440"],"award-info":[{"award-number":["YR202440"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-14595-8","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:17:55Z","timestamp":1754486275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mitochondrial subtypes in renal ischemia reperfusion injury guide delayed graft function and Long-Term graft prediction"],"prefix":"10.1038","volume":"15","author":[{"given":"Danni","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"14595_CR1","first-page":"d7300","volume":"343","author":"PT Thiruchelvam","year":"2011","unstructured":"Thiruchelvam, P. T. et al. Renal Transplantation BMJ, 343: d7300. (2011).","journal-title":"Renal Transplantation BMJ"},{"issue":"6","key":"14595_CR2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1056\/NEJM199408113310606","volume":"331","author":"M Suthanthiran","year":"1994","unstructured":"Suthanthiran, M. & Strom, T. B. Renal transplantation. N Engl. J. Med. 331 (6), 365\u2013376 (1994).","journal-title":"N Engl. J. Med."},{"issue":"1","key":"14595_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.kint.2018.10.009","volume":"95","author":"SF Smith","year":"2019","unstructured":"Smith, S. F., Hosgood, S. A. & Nicholson, M. L. Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells. Kidney Int. 95 (1), 50\u201356 (2019).","journal-title":"Kidney Int."},{"key":"14595_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12967-016-0767-2","volume":"14","author":"TC Saat","year":"2016","unstructured":"Saat, T. C. et al. Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation? J. Transl Med. 14, 20 (2016).","journal-title":"J. Transl Med."},{"issue":"6","key":"14595_CR5","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1093\/ndt\/gft488","volume":"29","author":"C Ponticelli","year":"2014","unstructured":"Ponticelli, C. Ischaemia-reperfusion injury: a major protagonist in kidney transplantation. Nephrol. Dial Transpl. 29 (6), 1134\u20131140 (2014).","journal-title":"Nephrol. Dial Transpl."},{"key":"14595_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ebiom.2018.01.025","volume":"28","author":"H Zhao","year":"2018","unstructured":"Zhao, H. et al. Ischemia-Reperfusion injury reduces long term renal graft survival: mechanism and beyond. EBioMedicine 28, 31\u201342 (2018).","journal-title":"EBioMedicine"},{"issue":"1","key":"14595_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/MOT.0000000000000604","volume":"24","author":"D Bahl","year":"2019","unstructured":"Bahl, D. et al. Delayed graft function in kidney transplantation. Curr. Opin. Organ. Transpl. 24 (1), 82\u201386 (2019).","journal-title":"Curr. Opin. Organ. Transpl."},{"issue":"2","key":"14595_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/ki.2014.18","volume":"86","author":"B Schroppel","year":"2014","unstructured":"Schroppel, B. & Legendre, C. Delayed kidney graft function: from mechanism to translation. Kidney Int. 86 (2), 251\u2013258 (2014).","journal-title":"Kidney Int."},{"issue":"9447","key":"14595_CR9","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1016\/S0140-6736(04)17406-0","volume":"364","author":"N Perico","year":"2004","unstructured":"Perico, N. et al. Delayed graft function in kidney transplantation. Lancet 364 (9447), 1814\u20131827 (2004).","journal-title":"Lancet"},{"issue":"8","key":"14595_CR10","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1097\/TP.0000000000001409","volume":"101","author":"IE Hall","year":"2017","unstructured":"Hall, I. E. et al. Delayed graft function phenotypes and 12-Month kidney transplant outcomes. Transplantation 101 (8), 1913\u20131923 (2017).","journal-title":"Transplantation"},{"issue":"4","key":"14595_CR11","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1093\/ndt\/gfv391","volume":"31","author":"JP Perasaari","year":"2016","unstructured":"Perasaari, J. P. et al. Pre-transplant donor-specific anti-human leukocyte antigen antibodies are associated with high risk of delayed graft function after renal transplantation. Nephrol. Dial Transpl. 31 (4), 672\u2013678 (2016).","journal-title":"Nephrol. Dial Transpl."},{"issue":"10","key":"14595_CR12","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1111\/j.1600-6143.2010.03179.x","volume":"10","author":"WD Irish","year":"2010","unstructured":"Irish, W. D. et al. A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation. Am. J. Transpl. 10 (10), 2279\u20132286 (2010).","journal-title":"Am. J. Transpl."},{"issue":"3","key":"14595_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/ars.2016.6665","volume":"25","author":"BB Ratliff","year":"2016","unstructured":"Ratliff, B. B. et al. Oxidant mechanisms in renal injury and disease. Antioxid. Redox Signal. 25 (3), 119\u2013146 (2016).","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"14595_CR14","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","volume":"148","author":"J Nunnari","year":"2012","unstructured":"Nunnari, J. & Suomalainen, A. Mitochondria: in sickness and in health. Cell 148 (6), 1145\u20131159 (2012).","journal-title":"Cell"},{"issue":"7","key":"14595_CR15","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41556-018-0124-1","volume":"20","author":"JB Spinelli","year":"2018","unstructured":"Spinelli, J. B. & Haigis, M. C. The multifaceted contributions of mitochondria to cellular metabolism. Nat. Cell. Biol. 20 (7), 745\u2013754 (2018).","journal-title":"Nat. Cell. Biol."},{"issue":"4","key":"14595_CR16","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.cmet.2019.02.011","volume":"29","author":"IY Benador","year":"2019","unstructured":"Benador, I. Y. et al. Mitochondria bound to lipid droplets: where mitochondrial dynamics regulate lipid storage and utilization. Cell. Metab. 29 (4), 827\u2013835 (2019).","journal-title":"Cell. Metab."},{"issue":"4","key":"14595_CR17","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1083\/jcb.201511036","volume":"212","author":"P Mishra","year":"2016","unstructured":"Mishra, P. & Chan, D. C. Metabolic regulation of mitochondrial dynamics. J. Cell. Biol. 212 (4), 379\u2013387 (2016).","journal-title":"J. Cell. Biol."},{"issue":"2","key":"14595_CR18","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s41418-022-01094-w","volume":"30","author":"E Vringer","year":"2023","unstructured":"Vringer, E. & Tait, S. W. G. Mitochondria and cell death-associated inflammation. Cell. Death Differ. 30 (2), 304\u2013312 (2023).","journal-title":"Cell. Death Differ."},{"issue":"16","key":"14595_CR19","doi-asserted-by":"publisher","first-page":"R891","DOI":"10.1016\/j.cub.2022.07.025","volume":"32","author":"A Poltorak","year":"2022","unstructured":"Poltorak, A. Cell death: all roads lead to mitochondria. Curr. Biol. 32 (16), R891\u2013R894 (2022).","journal-title":"Curr. Biol."},{"issue":"9","key":"14595_CR20","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41580-022-00523-5","volume":"23","author":"L Heinke","year":"2022","unstructured":"Heinke, L. Mitochondrial ROS drive cell cycle progression. Nat. Rev. Mol. Cell. Biol. 23 (9), 581 (2022).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"11","key":"14595_CR21","first-page":"1620","volume":"34","author":"M Picard","year":"2022","unstructured":"Picard, M. & Shirihai, O. S. Mitochondrial Signal. Transduct. Cell. Metab., 34(11): 1620\u20131653. (2022).","journal-title":"Mitochondrial Signal. Transduct. Cell. Metab."},{"key":"14595_CR22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/164_2016_6","volume":"240","author":"A Eirin","year":"2017","unstructured":"Eirin, A., Lerman, A. & Lerman, L. O. The emerging role of mitochondrial targeting in kidney disease. Handb. Exp. Pharmacol. 240, 229\u2013250 (2017).","journal-title":"Handb. Exp. Pharmacol."},{"issue":"5","key":"14595_CR23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41581-020-00369-0","volume":"17","author":"C Tang","year":"2021","unstructured":"Tang, C. et al. Mitochondrial quality control in kidney injury and repair. Nat. Rev. Nephrol. 17 (5), 299\u2013318 (2021).","journal-title":"Nat. Rev. Nephrol."},{"key":"14595_CR24","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/978-3-319-55330-6_27","volume":"982","author":"P Duann","year":"2017","unstructured":"Duann, P. & Lin, P. H. Mitochondria damage and kidney disease. Adv. Exp. Med. Biol. 982, 529\u2013551 (2017).","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"14595_CR25","doi-asserted-by":"publisher","first-page":"F1105","DOI":"10.1152\/ajprenal.00285.2020","volume":"319","author":"M Jiang","year":"2020","unstructured":"Jiang, M. et al. Mitochondrial dysfunction and the AKI-to-CKD transition. Am. J. Physiol. Ren. Physiol. 319 (6), F1105\u2013F1116 (2020).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"8","key":"14595_CR26","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1158\/2159-8290.CD-18-1354","volume":"9","author":"WM Linehan","year":"2019","unstructured":"Linehan, W. M. et al. The metabolic basis of kidney cancer. Cancer Discov. 9 (8), 1006\u20131021 (2019).","journal-title":"Cancer Discov"},{"issue":"6","key":"14595_CR27","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/j.transproceed.2015.04.086","volume":"47","author":"D Zepeda-Orozco","year":"2015","unstructured":"Zepeda-Orozco, D., Kong, M. & Scheuermann, R. H. Molecular profile of mitochondrial dysfunction in kidney transplant biopsies is associated with poor allograft outcome. Transpl. Proc. 47 (6), 1675\u20131682 (2015).","journal-title":"Transpl. Proc."},{"issue":"D1","key":"14595_CR28","doi-asserted-by":"publisher","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","volume":"49","author":"S Rath","year":"2021","unstructured":"Rath, S. et al. MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 49 (D1), D1541\u2013D1547 (2021).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"14595_CR29","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12967-023-04033-6","volume":"21","author":"J Chang","year":"2023","unstructured":"Chang, J. et al. Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma. J. Transl Med. 21 (1), 191 (2023).","journal-title":"J. Transl Med."},{"issue":"1","key":"14595_CR30","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","volume":"18","author":"P Charoentong","year":"2017","unstructured":"Charoentong, P. et al. Pan-cancer Immunogenomic analyses reveal Genotype-Immunophenotype relationships and predictors of response to checkpoint Blockade. Cell. Rep. 18 (1), 248\u2013262 (2017).","journal-title":"Cell. Rep."},{"issue":"3","key":"14595_CR31","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1080\/15548627.2022.2100105","volume":"19","author":"V Abbonante","year":"2023","unstructured":"Abbonante, V. et al. Lack of COL6\/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis. Autophagy 19 (3), 984\u2013999 (2023).","journal-title":"Autophagy"},{"issue":"11","key":"14595_CR32","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward Understanding the origin and evolution of cellular organisms. Protein Sci. 28 (11), 1947\u20131951 (2019).","journal-title":"Protein Sci."},{"issue":"1","key":"14595_CR33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28 (1), 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"14595_CR34","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1681\/ASN.2018020125","volume":"29","author":"H Wu","year":"2018","unstructured":"Wu, H. et al. Single-Cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response. J. Am. Soc. Nephrol. 29 (8), 2069\u20132080 (2018).","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"14595_CR35","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using cellchat. Nat. Commun. 12 (1), 1088 (2021).","journal-title":"Nat. Commun."},{"issue":"10","key":"14595_CR36","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrneph.2017.107","volume":"13","author":"P Bhargava","year":"2017","unstructured":"Bhargava, P. & Schnellmann, R. G. Mitochondrial energetics in the kidney. Nat. Rev. Nephrol. 13 (10), 629\u2013646 (2017).","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"14595_CR37","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.kint.2017.05.034","volume":"92","author":"DL Galvan","year":"2017","unstructured":"Galvan, D. L., Green, N. H. & Danesh, F. R. The hallmarks of mitochondrial dysfunction in chronic kidney disease. Kidney Int. 92 (5), 1051\u20131057 (2017).","journal-title":"Kidney Int."},{"issue":"11","key":"14595_CR38","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1681\/ASN.2015020177","volume":"27","author":"R Lan","year":"2016","unstructured":"Lan, R. et al. Mitochondrial pathology and glycolytic shift during proximal tubule atrophy after ischemic AKI. J. Am. Soc. Nephrol. 27 (11), 3356\u20133367 (2016).","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"14595_CR39","doi-asserted-by":"publisher","first-page":"e16581","DOI":"10.15252\/emmm.202216581","volume":"15","author":"M Bai","year":"2023","unstructured":"Bai, M. et al. LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease. EMBO Mol. Med. 15 (2), e16581 (2023).","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"14595_CR40","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1124\/pharmrev.122.000560","volume":"75","author":"KH Cleveland","year":"2023","unstructured":"Cleveland, K. H. & Schnellmann, R. G. Pharmacological targeting of mitochondria in diabetic kidney disease. Pharmacol. Rev. 75 (2), 250\u2013262 (2023).","journal-title":"Pharmacol. Rev."},{"key":"14595_CR41","doi-asserted-by":"crossref","unstructured":"Yu, X. et al. Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI. Sci. Transl Med., 12(543). (2020).","DOI":"10.1126\/scitranslmed.aay7591"},{"issue":"4","key":"14595_CR42","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.cmet.2019.08.003","volume":"30","author":"KW Chung","year":"2019","unstructured":"Chung, K. W. et al. Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis. Cell. Metab. 30 (4), 784\u2013799e5 (2019).","journal-title":"Cell. Metab."},{"issue":"4","key":"14595_CR43","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1681\/ASN.2016030349","volume":"28","author":"SJ Han","year":"2017","unstructured":"Han, S. J. et al. Mitochondrial NADP(+)-Dependent isocitrate dehydrogenase deficiency exacerbates mitochondrial and cell damage after kidney Ischemia-Reperfusion injury. J. Am. Soc. Nephrol. 28 (4), 1200\u20131215 (2017).","journal-title":"J. Am. Soc. Nephrol."},{"key":"14595_CR44","doi-asserted-by":"publisher","first-page":"1047367","DOI":"10.3389\/fimmu.2022.1047367","volume":"13","author":"J Wu","year":"2022","unstructured":"Wu, J. et al. Identification of renal ischemia reperfusion injury subtypes and predictive strategies for delayed graft function and graft survival based on neutrophil extracellular trap-related genes. Front. Immunol. 13, 1047367 (2022).","journal-title":"Front. Immunol."},{"key":"14595_CR45","doi-asserted-by":"publisher","first-page":"800650","DOI":"10.3389\/fcell.2022.800650","volume":"10","author":"X Wei","year":"2022","unstructured":"Wei, X. et al. Identification of subtypes and a delayed graft function predictive signature based on ferroptosis in renal Ischemia-Reperfusion injury. Front. Cell. Dev. Biol. 10, 800650 (2022).","journal-title":"Front. Cell. Dev. Biol."},{"issue":"Suppl 4","key":"14595_CR46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/ajt.17207","volume":"22","author":"SC Jordan","year":"2022","unstructured":"Jordan, S. C. et al. Importance of IL-6 Inhibition in prevention and treatment of antibody-mediated rejection in kidney allografts. Am. J. Transpl. 22 (Suppl 4), 28\u201337 (2022).","journal-title":"Am. J. Transpl."},{"key":"14595_CR47","doi-asserted-by":"crossref","unstructured":"Santarsiero, D. & Aiello, S. The complement system in kidney transplantation. Cells, 12(5). (2023).","DOI":"10.3390\/cells12050791"},{"issue":"1","key":"14595_CR48","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/path.4553","volume":"237","author":"F Rascio","year":"2015","unstructured":"Rascio, F. et al. A type I interferon signature characterizes chronic antibody-mediated rejection in kidney transplantation. J. Pathol. 237 (1), 72\u201384 (2015).","journal-title":"J. Pathol."},{"key":"14595_CR49","doi-asserted-by":"publisher","first-page":"1122409","DOI":"10.3389\/fimmu.2023.1122409","volume":"14","author":"G van der Elst","year":"2023","unstructured":"van der Elst, G. et al. The mast cell: A Janus in kidney transplants. Front. Immunol. 14, 1122409 (2023).","journal-title":"Front. Immunol."},{"issue":"4","key":"14595_CR50","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1046\/j.1523-1755.2001.0590041374.x","volume":"59","author":"M Yamada","year":"2001","unstructured":"Yamada, M. et al. Mast cell chymase expression and mast cell phenotypes in human rejected kidneys. Kidney Int. 59 (4), 1374\u20131381 (2001).","journal-title":"Kidney Int."},{"issue":"7","key":"14595_CR51","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1681\/ASN.2016050573","volume":"28","author":"YY Wang","year":"2017","unstructured":"Wang, Y. Y. et al. Macrophage-to-Myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury. J. Am. Soc. Nephrol. 28 (7), 2053\u20132067 (2017).","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"14595_CR52","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/ki.2014.430","volume":"87","author":"Q Zhuang","year":"2015","unstructured":"Zhuang, Q. & Lakkis, F. G. Dendritic cells and innate immunity in kidney transplantation. Kidney Int. 87 (4), 712\u2013718 (2015).","journal-title":"Kidney Int."},{"issue":"11","key":"14595_CR53","doi-asserted-by":"publisher","first-page":"e2003732","DOI":"10.1002\/advs.202003732","volume":"8","author":"M Li","year":"2021","unstructured":"Li, M. et al. DDIT3 directs a dual mechanism to balance Glycolysis and oxidative phosphorylation during glutamine deprivation. Adv. Sci. (Weinh). 8 (11), e2003732 (2021).","journal-title":"Adv. Sci. (Weinh)"},{"issue":"9","key":"14595_CR54","doi-asserted-by":"publisher","first-page":"119074","DOI":"10.1016\/j.bbamcr.2021.119074","volume":"1868","author":"C Yang","year":"2021","unstructured":"Yang, C. et al. DDIT3\/CHOP promotes autophagy in chondrocytes via SIRT1-AKT pathway. Biochim. Biophys. Acta Mol. Cell. Res. 1868 (9), 119074 (2021).","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"issue":"6","key":"14595_CR55","doi-asserted-by":"publisher","first-page":"e65568","DOI":"10.1371\/journal.pone.0065568","volume":"8","author":"J Rao","year":"2013","unstructured":"Rao, J. et al. Lipopolysaccharide preconditioning protects hepatocytes from ischemia\/reperfusion injury (IRI) through inhibiting ATF4-CHOP pathway in mice. PLoS One. 8 (6), e65568 (2013).","journal-title":"PLoS One"},{"key":"14595_CR56","doi-asserted-by":"publisher","first-page":"951855","DOI":"10.3389\/fphys.2022.951855","volume":"13","author":"S He","year":"2022","unstructured":"He, S. et al. Identification of hub genes associated with acute kidney injury induced by renal ischemia-reperfusion injury in mice. Front. Physiol. 13, 951855 (2022).","journal-title":"Front. Physiol."},{"issue":"12","key":"14595_CR57","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1080\/03601234.2020.1816092","volume":"55","author":"S Li","year":"2020","unstructured":"Li, S. et al. miR-96-5p attenuates malathion-induced apoptosis of human kidney cells by targeting the ER stress marker DDIT3. J. Environ. Sci. Health B. 55 (12), 1080\u20131086 (2020).","journal-title":"J. Environ. Sci. Health B"},{"issue":"24","key":"14595_CR58","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1101\/gad.1250704","volume":"18","author":"SJ Marciniak","year":"2004","unstructured":"Marciniak, S. J. et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed Endoplasmic reticulum. Genes Dev. 18 (24), 3066\u20133077 (2004).","journal-title":"Genes Dev."},{"key":"14595_CR59","doi-asserted-by":"publisher","first-page":"834187","DOI":"10.3389\/fendo.2022.834187","volume":"13","author":"GD Zhao","year":"2022","unstructured":"Zhao, G. D. et al. Endoplasmic reticulum stress mediates renal tubular vacuolation in BK Polyomavirus-Associated nephropathy. Front. Endocrinol. (Lausanne). 13, 834187 (2022).","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"3","key":"14595_CR60","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s00018-022-04172-x","volume":"79","author":"I Pereira-Castro","year":"2022","unstructured":"Pereira-Castro, I. et al. MCL1 alternative polyadenylation is essential for cell survival and mitochondria morphology. Cell. Mol. Life Sci. 79 (3), 164 (2022).","journal-title":"Cell. Mol. Life Sci."},{"issue":"11","key":"14595_CR61","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.4161\/auto.26168","volume":"9","author":"RL Thomas","year":"2013","unstructured":"Thomas, R. L. & Gustafsson, A. B. MCL1 is critical for mitochondrial function and autophagy in the heart. Autophagy 9 (11), 1902\u20131903 (2013).","journal-title":"Autophagy"},{"issue":"21","key":"14595_CR62","doi-asserted-by":"publisher","first-page":"13731","DOI":"10.1074\/jbc.272.21.13731","volume":"272","author":"MC Hollander","year":"1997","unstructured":"Hollander, M. C. et al. Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. J. Biol. Chem. 272 (21), 13731\u201313737 (1997).","journal-title":"J. Biol. Chem."},{"issue":"11","key":"14595_CR63","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/2211-5463.13484","volume":"12","author":"M Marton","year":"2022","unstructured":"Marton, M. et al. A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon Endoplasmic reticulum stress. FEBS Open. Bio. 12 (11), 2065\u20132082 (2022).","journal-title":"FEBS Open. Bio"},{"issue":"5","key":"14595_CR64","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2217\/epi-2018-0189","volume":"11","author":"S Huang","year":"2019","unstructured":"Huang, S. et al. Comprehensive and combined omics analysis reveals factors of ischemia-reperfusion injury in liver transplantation. Epigenomics 11 (5), 527\u2013542 (2019).","journal-title":"Epigenomics"},{"issue":"2","key":"14595_CR65","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1681\/ASN.2022060644","volume":"34","author":"A Kidwell","year":"2023","unstructured":"Kidwell, A. et al. Translation rescue by targeting Ppp1r15a through its upstream open reading frame in Sepsis-Induced acute kidney injury in a murine model. J. Am. Soc. Nephrol. 34 (2), 220\u2013240 (2023).","journal-title":"J. Am. Soc. Nephrol."},{"issue":"11","key":"14595_CR66","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.2217\/fon.13.114","volume":"9","author":"C Guo","year":"2013","unstructured":"Guo, C., Liu, S. & Sun, M. Z. Potential role of Anxa1 in cancer. Future Oncol. 9 (11), 1773\u20131793 (2013).","journal-title":"Future Oncol."},{"issue":"12","key":"14595_CR67","doi-asserted-by":"publisher","first-page":"4416","DOI":"10.21037\/tcr-22-1544","volume":"11","author":"L Zheng","year":"2022","unstructured":"Zheng, L. et al. Annexin A1 affects tumor metastasis through epithelial-mesenchymal transition: a narrative review. Transl Cancer Res. 11 (12), 4416\u20134433 (2022).","journal-title":"Transl Cancer Res."},{"key":"14595_CR68","doi-asserted-by":"crossref","unstructured":"Sheikh, M. H. & Solito, E. Annexin A1: Uncovering the many talents of an old protein. Int. J. Mol. Sci., 19(4). (2018).","DOI":"10.3390\/ijms19041045"},{"issue":"1","key":"14595_CR69","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/00003246-200301000-00011","volume":"31","author":"O Schroder","year":"2003","unstructured":"Schroder, O. et al. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. Crit. Care Med. 31 (1), 73\u201379 (2003).","journal-title":"Crit. Care Med."},{"issue":"5","key":"14595_CR70","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.sjbs.2019.04.002","volume":"26","author":"Y Luan","year":"2019","unstructured":"Luan, Y. et al. Isorhamnetin in Tsoong blocks Hsp70 expression to promote apoptosis of colon cancer cells. Saudi J. Biol. Sci. 26 (5), 1011\u20131022 (2019).","journal-title":"Saudi J. Biol. Sci."},{"issue":"22","key":"14595_CR71","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1007\/s00018-006-6192-6","volume":"63","author":"XB Qiu","year":"2006","unstructured":"Qiu, X. B. et al. The diversity of the DnaJ\/Hsp40 family, the crucial partners for Hsp70 chaperones. Cell. Mol. Life Sci. 63 (22), 2560\u20132570 (2006).","journal-title":"Cell. Mol. Life Sci."},{"issue":"4\u20135","key":"14595_CR72","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.jmb.2012.02.003","volume":"421","author":"JF Abisambra","year":"2012","unstructured":"Abisambra, J. F. et al. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of Tau. J. Mol. Biol. 421 (4\u20135), 653\u2013661 (2012).","journal-title":"J. Mol. Biol."},{"issue":"Suppl 1","key":"14595_CR73","doi-asserted-by":"publisher","first-page":"i109","DOI":"10.1136\/ard.2010.140533","volume":"70","author":"HB Schonthaler","year":"2011","unstructured":"Schonthaler, H. B., Guinea-Viniegra, J. & Wagner, E. F. Targeting inflammation by modulating the Jun\/AP-1 pathway. Ann. Rheum. Dis. 70 (Suppl 1), i109\u2013i112 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"14595_CR74","doi-asserted-by":"crossref","unstructured":"Ishikawa, Y., Yokoo, T. & Kitamura, M. c-Jun\/AP-1, but not NF-kappa B, is a mediator for oxidant-initiated apoptosis in glomerular mesangial cells. Biochem Biophys Res Commun, 240(2): pp. 496\u2013501. (1997).","DOI":"10.1006\/bbrc.1997.7665"},{"issue":"3","key":"14595_CR75","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.cellsig.2013.12.002","volume":"26","author":"K Huang","year":"2014","unstructured":"Huang, K. et al. AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose. Cell. Signal. 26 (3), 629\u2013638 (2014).","journal-title":"Cell. Signal."},{"key":"14595_CR76","doi-asserted-by":"publisher","first-page":"p5717913","DOI":"10.1155\/2018\/5717913","volume":"2018","author":"A Reznik","year":"2018","unstructured":"Reznik, A. et al. Reperfusion activates AP-1 and heat shock response in donor kidney parenchyma after warm ischemia. Biomed. Res. Int. 2018, p5717913 (2018).","journal-title":"Biomed. Res. Int."},{"issue":"11","key":"14595_CR77","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1681\/ASN.2009121306","volume":"21","author":"SB Gurley","year":"2010","unstructured":"Gurley, S. B. et al. Renal actions of RGS2 control blood pressure. J. Am. Soc. Nephrol. 21 (11), 1847\u20131851 (2010).","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"14595_CR78","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/jcp.24470","volume":"229","author":"A Adebiyi","year":"2014","unstructured":"Adebiyi, A. RGS2 regulates Urotensin II-induced intracellular Ca2\u2009+\u2009elevation and contraction in glomerular mesangial cells. J. Cell. Physiol. 229 (4), 502\u2013511 (2014).","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"14595_CR79","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1681\/ASN.2007010032","volume":"18","author":"AM Zuber","year":"2007","unstructured":"Zuber, A. M. et al. Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-\/- mice. J. Am. Soc. Nephrol. 18 (6), 1672\u20131678 (2007).","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"14595_CR80","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1600-065X.2008.00742.x","volume":"228","author":"AM Gilfillan","year":"2009","unstructured":"Gilfillan, A. M. & Rivera, J. The tyrosine kinase network regulating mast cell activation. Immunol. Rev. 228 (1), 149\u2013169 (2009).","journal-title":"Immunol. Rev."},{"key":"14595_CR81","doi-asserted-by":"crossref","unstructured":"Nagata, K. & Nishiyama, C. IL-10 in Mast Cell-Mediated Immune Responses: Anti-Inflammatory and Proinflammatory Roles. Int J Mol Sci, 22(9). (2021).","DOI":"10.3390\/ijms22094972"},{"key":"14595_CR82","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1600-065X.2007.00503.x","volume":"217","author":"U Blank","year":"2007","unstructured":"Blank, U. et al. Mast cells and inflammatory kidney disease. Immunol. Rev. 217, 79\u201395 (2007).","journal-title":"Immunol. Rev."},{"issue":"6","key":"14595_CR83","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/ki.2012.211","volume":"82","author":"SA Summers","year":"2012","unstructured":"Summers, S. A. et al. Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction. Kidney Int. 82 (6), 676\u2013685 (2012).","journal-title":"Kidney Int."},{"issue":"1","key":"14595_CR84","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/imr.12626","volume":"282","author":"P Bradding","year":"2018","unstructured":"Bradding, P. & Pejler, G. The controversial role of mast cells in fibrosis. Immunol. Rev. 282 (1), 198\u2013231 (2018).","journal-title":"Immunol. Rev."},{"issue":"2","key":"14595_CR85","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.immuni.2015.01.020","volume":"42","author":"DMW Zaiss","year":"2015","unstructured":"Zaiss, D. M. W. et al. Emerging functions of Amphiregulin in orchestrating immunity, inflammation, and tissue repair. Immunity 42 (2), 216\u2013226 (2015).","journal-title":"Immunity"},{"issue":"1","key":"14595_CR86","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/ptr.7599","volume":"37","author":"Q Wang","year":"2023","unstructured":"Wang, Q. et al. Quercetin inhibits the amphiregulin\/egfr signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy. Phytother Res. 37 (1), 111\u2013123 (2023).","journal-title":"Phytother Res."},{"issue":"6","key":"14595_CR87","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/ki.2015.324","volume":"88","author":"HM Perry","year":"2015","unstructured":"Perry, H. M. & Okusa, M. D. Driving change: kidney proximal tubule CSF-1 polarizes macrophages. Kidney Int. 88 (6), 1219\u20131221 (2015).","journal-title":"Kidney Int."},{"issue":"9","key":"14595_CR88","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1093\/ndt\/gfw026","volume":"31","author":"MD Sanchez-Nino","year":"2016","unstructured":"Sanchez-Nino, M. D., Sanz, A. B. & Ortiz, A. Chronicity following ischaemia-reperfusion injury depends on tubular-macrophage crosstalk involving two tubular cell-derived CSF-1R activators: CSF-1 and IL-34. Nephrol. Dial Transpl. 31 (9), 1409\u20131416 (2016).","journal-title":"Nephrol. Dial Transpl."},{"issue":"3","key":"14595_CR89","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.ajpath.2011.05.037","volume":"179","author":"MA Alikhan","year":"2011","unstructured":"Alikhan, M. A. et al. Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. Am. J. Pathol. 179 (3), 1243\u20131256 (2011).","journal-title":"Am. J. Pathol."},{"issue":"10","key":"14595_CR90","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1681\/ASN.2018080810","volume":"30","author":"KA Zimmerman","year":"2019","unstructured":"Zimmerman, K. A. et al. Tissue-Resident macrophages promote renal cystic disease. J. Am. Soc. Nephrol. 30 (10), 1841\u20131856 (2019).","journal-title":"J. Am. Soc. Nephrol."},{"key":"14595_CR91","doi-asserted-by":"publisher","first-page":"107823","DOI":"10.1016\/j.intimp.2021.107823","volume":"97","author":"M Arabpour","year":"2021","unstructured":"Arabpour, M., Saghazadeh, A. & Rezaei, N. Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes. Int. Immunopharmacol. 97, 107823 (2021).","journal-title":"Int. Immunopharmacol."},{"key":"14595_CR92","doi-asserted-by":"crossref","unstructured":"Bhatia, D. et al. Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis. JCI Insight, 4(23). (2019).","DOI":"10.1172\/jci.insight.132826"},{"issue":"2","key":"14595_CR93","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1681\/ASN.2009060615","volume":"22","author":"S Lee","year":"2011","unstructured":"Lee, S. et al. Distinct macrophage phenotypes contribute to kidney injury and repair. J. Am. Soc. Nephrol. 22 (2), 317\u2013326 (2011).","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14595-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14595-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14595-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T15:27:57Z","timestamp":1757345277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14595-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":93,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["14595"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-14595-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"15 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors state that they do not have any conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"28772"}}