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To investigate the pathobiology of DMD, this study employed the Sprague-Dawley <jats:italic>Dmd<\/jats:italic>-mutated rat model (<jats:italic>DMD<\/jats:italic>\n            <jats:sup>\n              <jats:italic>mdx<\/jats:italic>\n            <\/jats:sup>) and analyzed gene expression profiles and pathological molecular pathways. The methods used included histopathological, biochemical, and transcriptomic analyses of dystrophic skeletal muscle from <jats:italic>DMD<\/jats:italic>\n            <jats:sup>\n              <jats:italic>mdx<\/jats:italic>\n            <\/jats:sup> and wild-type (WT) individuals. Histological analysis of skeletal muscle tissue from <jats:italic>DMD<\/jats:italic>\n            <jats:sup>\n              <jats:italic>mdx<\/jats:italic>\n            <\/jats:sup> rats revealed multifocal necrosis, fibrosis, and inflammation, whereas WT rats displayed normal muscle architecture. Biochemical analysis revealed significant alterations in plasma markers of muscle damage and metabolism in <jats:italic>DMD<\/jats:italic>\n            <jats:sup>\n              <jats:italic>mdx<\/jats:italic>\n            <\/jats:sup> rats compared to WT controls, including elevated AST, ALT, ALP, CPK, and LDH levels. Additionally, oxidative status measurements showed reduced antioxidant capacity and increased lipid peroxidation in dystrophic skeletal muscle, as evidenced by lower TAS, GR, GPx, and SOD activities and higher TBARS levels. RNA-seq analysis identified 3,615 differentially expressed genes between the two groups, associated with muscle contraction, extracellular matrix (ECM) organization, and cytoskeleton organization. Notably, <jats:italic>Dmd<\/jats:italic>, <jats:italic>Actc1<\/jats:italic>, <jats:italic>Col6a1<\/jats:italic>, and <jats:italic>Mmp2<\/jats:italic> were significantly downregulated. Gene ontology and pathway enrichment analyses indicated dystrophic changes in skeletal muscle, disruptions in calcium homeostasis, and alterations in actin cytoskeleton regulation. KEGG and Reactome pathway analyses revealed upregulation of the MAPK signaling and immune system pathways and downregulation of the ECM organization pathway. These findings support the hypothesis that targeting complex intracellular signaling pathways in DMD may represent a promising therapeutic strategy. Given that the <jats:italic>DMD<\/jats:italic>\n            <jats:sup>\n              <jats:italic>mdx<\/jats:italic>\n            <\/jats:sup> rat model closely mimics human DMD pathology compared to other animal models, it offers a more realistic platform for studying the molecular mechanisms of the disease and improving the translational potential of therapeutic approaches.<\/jats:p>","DOI":"10.1038\/s41598-025-14756-9","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T05:44:22Z","timestamp":1754891062000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transcriptomic profiling of skeletal muscle in the DMDmdx rat model of Duchenne muscular dystrophy"],"prefix":"10.1038","volume":"15","author":[{"given":"Abdolvahab Ebrahimpour","family":"Gorji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kliczkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Ollik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Le Guiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Wilczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Bielecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Ostaszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Shirali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Roudbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Sadkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"14756_CR1","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.4238\/2014.February.28.13","volume":"13","author":"LJ Tian","year":"2014","unstructured":"Tian, L. 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