{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:40:14Z","timestamp":1759174814923,"version":"3.44.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Interreg Italy-Croatia, European Union","award":["BIOBASED - Development support of blue biorefinery in the Adriatic Sea"],"award-info":[{"award-number":["BIOBASED - Development support of blue biorefinery in the Adriatic Sea"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["NextGenerationEU (Award Number: Project code CN_00000033)"],"award-info":[{"award-number":["NextGenerationEU (Award Number: Project code CN_00000033)"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-14884-2","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:13:20Z","timestamp":1759169600000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of the low-density lipoprotein receptors family and identification of vitellogenin receptors in Mugil cephalus"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-7229","authenticated-orcid":false,"given":"Andrea","family":"Miccoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basilio","family":"Randazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"14884_CR1","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1002\/j.1460-2075.1988.tb03306.x","volume":"7","author":"J Herz","year":"1988","unstructured":"Herz, J. et al. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 7, 4119\u20134127 (1988).","journal-title":"EMBO J."},{"key":"14884_CR2","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1146\/annurev.bi.63.070194.003125","volume":"63","author":"M Krieger","year":"1994","unstructured":"Krieger, M. & Krieger, J. Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 63, 601\u2013637 (1994).","journal-title":"Annu. Rev. Biochem."},{"key":"14884_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10695-023-01169-6","volume":"49","author":"L Babio","year":"2023","unstructured":"Babio, L., Damsteegt, E. L. & Lokman, P. M. Lipoprotein receptors in ovary of eel, Anguilla australis: Molecular characterisation of putative vitellogenin receptors. Fish. Physiol. Biochem. 49, 117\u2013137 (2023).","journal-title":"Fish. Physiol. Biochem."},{"key":"14884_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0074-7696(08)62507-3","volume":"166","author":"WJ Schneider","year":"1996","unstructured":"Schneider, W. J. Vitellogenin receptors: Oocyte-specific members of the low-density lipoprotein receptor supergene family. Int. Rev. Cytol. 166, 103\u2013137 (1996).","journal-title":"Int. Rev. Cytol."},{"key":"14884_CR5","doi-asserted-by":"publisher","unstructured":"Babin, P. J., Carnevali, O., Lubzens, E. & Schneider, W. J. Molecular aspects of oocyte vitellogenesis in fish. in The Fish Oocyte: From Basic Studies to Biotechnological Applications (2007). https:\/\/doi.org\/10.1007\/978-1-4020-6235-3_2","DOI":"10.1007\/978-1-4020-6235-3_2"},{"key":"14884_CR6","doi-asserted-by":"publisher","unstructured":"Sullivan, C. V. & Yilmaz, O. Vitellogenesis and yolk proteins, Fish. in Encyclopedia of Reproduction 266\u2013277 (Elsevier, 2018). https:\/\/doi.org\/10.1016\/B978-0-12-809633-8.20567-0","DOI":"10.1016\/B978-0-12-809633-8.20567-0"},{"key":"14884_CR7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/jez.1402720105","volume":"272","author":"T Matsubara","year":"1995","unstructured":"Matsubara, T. & Sawano, K. Proteolytic cleavage of vitellogenin and yolk proteins during vitellogenin uptake and oocyte maturation in barfin flounder (Verasper moseri). J. Exp. Zool. 272, 34\u201345 (1995).","journal-title":"J. Exp. Zool."},{"key":"14884_CR8","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0300-9629(96)00055-2","volume":"115","author":"N Hiramatsu","year":"1996","unstructured":"Hiramatsu, N. & Hara, A. Relationship between vitellogenin and its related egg yolk proteins in Sakhalin Taimen (Hucho perryi). Comp. Biochem. Physiol. Part. Physiol. 115, 243\u2013251 (1996).","journal-title":"Comp. Biochem. Physiol. Part. Physiol."},{"key":"14884_CR9","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1242\/dev.004408","volume":"134","author":"TE Willnow","year":"2007","unstructured":"Willnow, T. E., Hammes, A. & Eaton, S. Lipoproteins and their receptors in embryonic development: more than cholesterol clearance. Development 134, 3239\u20133249 (2007).","journal-title":"Development"},{"key":"14884_CR10","doi-asserted-by":"publisher","unstructured":"Biology Ecology and Culture of Grey Mullets (Mugilidae). Biology, Ecology and Culture of Grey Mullets (Mugilidae) (CRC, 2015). https:\/\/doi.org\/10.1201\/b19927","DOI":"10.1201\/b19927"},{"key":"14884_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1051\/alr\/2018026","volume":"32","author":"I Ben Khemis","year":"2019","unstructured":"Ben Khemis, I., Hamza, N. & Sadok, S. Nutritional quality of the fresh and processed grey mullet (Mugilidae) products: A short review including data concerning fish from freshwater. Aquat. Living Resour. 32, 2 (2019).","journal-title":"Aquat. Living Resour."},{"key":"14884_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1201\/b19927-14","volume-title":"Biology, Ecology and Culture of Grey Mullets (Mugilidae)","author":"M Gonz\u00e1lez-Castro","year":"2015","unstructured":"Gonz\u00e1lez-Castro, M. & Minos, G. Sexuality and reproduction of Mugilidae. in Biology, Ecology and Culture of Grey Mullets (Mugilidae) (eds Crosetti, D. & Blaber, S. J. M.) 237\u2013273 (CRC, 2015). https:\/\/doi.org\/10.1201\/b19927-14"},{"key":"14884_CR13","unstructured":"Yousif, O., Fatah, A., Krishna Kumar, K., Minh, D. & Hung, B. Induced spawning and larviculture of grey mullet, Mugil cephalus (Linnaeus 1758) in the Emirate of Abu Dhabi. in Aquaculture Asia 41\u201343 (2010)."},{"key":"14884_CR14","first-page":"265","volume-title":"Aquaculture of Grey Mullets","author":"C Nash","year":"1981","unstructured":"Nash, C. & Koningsberger, R. Artificial propagation. in Aquaculture of Grey Mullets (ed. Oren, O.)  265\u2013312 (Cambridge University Press, 1981)."},{"key":"14884_CR15","first-page":"214","volume":"49","author":"D De Monbrison","year":"1997","unstructured":"De Monbrison, D. et al. Acceleration of gonadal development and spawning induction in the mediterranean grey mullet, Mugil cephalus: Preliminary studies. Isr. J. Aquac - Bamidgeh. 49, 214\u2013221 (1997).","journal-title":"Isr. J. Aquac - Bamidgeh"},{"key":"14884_CR16","unstructured":"El-Greisy, Z. A. & Shaheen, A. A. Comparative difference between the effects of Lhrh-a, 17 \u0391-Methyltestosterone pellets and Hcg on reproductive performance of Mugil cephalus. J Appl. Sci. Res. 3(9), 890\u2013895 (2007)."},{"key":"14884_CR17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/0044-8486(72)90046-4","volume":"1","author":"CM Kuo","year":"1972","unstructured":"Kuo, C. M., Shehadeh, Z. H. & Nash, C. E. Induced spawning of captive grey mullet (Mugil cephalus L.) females by injection of human chorionic gonadotropin (HCG). Aquaculture 1, 429\u2013432 (1972).","journal-title":"Aquaculture"},{"key":"14884_CR18","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ygcen.2005.01.002","volume":"142","author":"J Aizen","year":"2005","unstructured":"Aizen, J., Meiri, I., Tzchori, I., Levavi-Sivan, B. & Rosenfeld, H. Enhancing spawning in the grey mullet (Mugil cephalus) by removal of dopaminergic Inhibition. Gen. Comp. Endocrinol. 142, 212\u2013221 (2005).","journal-title":"Gen. Comp. Endocrinol."},{"key":"14884_CR19","doi-asserted-by":"publisher","first-page":"736418","DOI":"10.1016\/j.aquaculture.2021.736418","volume":"536","author":"S Ramos-J\u00fadez","year":"2021","unstructured":"Ramos-J\u00fadez, S. et al. Providing Recombinant gonadotropin-based therapies that induce oogenesis from previtellogenic oocytes to produce viable larvae in a teleost, the Flathead grey mullet (Mugil cephalus). Aquaculture 536, 736418 (2021).","journal-title":"Aquaculture"},{"key":"14884_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-013-9828-0","author":"P Das","year":"2014","unstructured":"Das, P., Pramanick, K., Mukherjee, D. & Maiti, B. R. In vitro induction of oocyte maturation and steroidogenesis by gonadotropins, insulin, calcitonin and growth factor in an estuarine flat head grey mullet, Mugil cephalus L. Fish. Physiol. Biochem. https:\/\/doi.org\/10.1007\/s10695-013-9828-0 (2014).","journal-title":"Fish. Physiol. Biochem."},{"key":"14884_CR21","unstructured":"Meseda, M. E. G. & Samira, S. A. Spawning induction in the mediterranean grey mullet Mugil cephalus and larval developmental stages. African J. Biotechnol. 5 (19), 1836\u20131845 (2006)."},{"key":"14884_CR22","unstructured":"Karim, E., Hasan, J. & Hoq, E. Hormone induced artificial breeding of a commercially important marine finfish, striped mullet (Mugil cephalus L.) in Bangladesh. Turkish J. Fish. Aquat. Sci 16, 135\u2013140 (2016)."},{"key":"14884_CR23","first-page":"35","volume":"4","author":"M Yousefian","year":"2009","unstructured":"Yousefian, M., Ghanei, M., Pourgolam, R. & Rostami, H. K. H. Gonad development and hormonal induction in artificial propagation of grey mullet, Mugil cephalus L. Res. J. Fish. Hydrobiol. 4, 35\u201340 (2009).","journal-title":"Res. J. Fish. Hydrobiol."},{"key":"14884_CR24","unstructured":"Vazirzadeh, A. & Ezhdehakoshpour, A. The effects of different hormonal treatments on the oocyte maturation in wild grey mullet (Mugil cephalus) collected from the Iranian coastal waters of the Oman sea. Iran J. Ichthyol. 1(1), 17\u201322 (2014)."},{"key":"14884_CR25","doi-asserted-by":"publisher","first-page":"3722","DOI":"10.1038\/s41467-025-59035-3","volume":"16","author":"L Zhang","year":"2025","unstructured":"Zhang, L. et al. Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish. Nat. Commun. 16, 3722 (2025).","journal-title":"Nat. Commun."},{"key":"14884_CR26","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1007\/s00227-007-0768-z","volume":"152","author":"H Amano","year":"2007","unstructured":"Amano, H. et al. Purification of multiple vitellogenins in grey mullet (Mugil cephalus). Mar. Biol. 152, 1215\u20131225 (2007).","journal-title":"Mar. Biol."},{"key":"14884_CR27","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/jez.388","volume":"307A","author":"H Amano","year":"2007","unstructured":"Amano, H. et al. Egg yolk proteins in grey mullet (Mugil cephalus): Purification and classification of multiple Lipovitellins and other vitellogenin-derived yolk proteins and molecular cloning of the parent vitellogenin genes. J. Exp. Zool. Part. Ecol. Genet. Physiol. 307A, 324\u2013341 (2007).","journal-title":"J. Exp. Zool. Part. Ecol. Genet. Physiol."},{"key":"14884_CR28","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1002\/mrd.20864","volume":"75","author":"H Amano","year":"2008","unstructured":"Amano, H. et al. Multiple vitellogenin-derived yolk proteins in Gray mullet (Mugil cephalus): Disparate proteolytic patterns associated with ovarian follicle maturation. Mol. Reprod. Dev. 75, 1307\u20131317 (2008).","journal-title":"Mol. Reprod. Dev."},{"key":"14884_CR29","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ygcen.2018.10.020","volume":"271","author":"H Amano","year":"2019","unstructured":"Amano, H. et al. Development of specific chemiluminescent immunoassays for three subtypes of vitellogenin in grey mullet (Mugil cephalus). Gen. Comp. Endocrinol. 271, 30\u201338 (2019).","journal-title":"Gen. Comp. Endocrinol."},{"key":"14884_CR30","doi-asserted-by":"publisher","first-page":"D458","DOI":"10.1093\/nar\/gkaa937","volume":"49","author":"I Letunic","year":"2021","unstructured":"Letunic, I., Khedkar, S. & Bork, P. SMART: Recent updates, new developments and status in 2020. Nucleic Acids Res. 49, D458\u2013D460 (2021).","journal-title":"Nucleic Acids Res."},{"key":"14884_CR31","doi-asserted-by":"publisher","unstructured":"Gasteiger, E. et al. Protein identification and analysis tools on the ExPASy server. in The Proteomics Protocols Handbook 571\u2013607 (Humana Press, 2005). https:\/\/doi.org\/10.1385\/1-59259-890-0:571","DOI":"10.1385\/1-59259-890-0:571"},{"key":"14884_CR32","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper, J. et al. Highly accurate protein structure prediction with alphafold. Nature 596, 583\u2013589 (2021).","journal-title":"Nature"},{"key":"14884_CR33","doi-asserted-by":"publisher","first-page":"W438","DOI":"10.1093\/nar\/gky439","volume":"46","author":"Q Wu","year":"2018","unstructured":"Wu, Q., Peng, Z., Zhang, Y. & Yang, J. COACH-D: Improved protein\u2013ligand binding sites prediction with refined ligand-binding poses through molecular Docking. Nucleic Acids Res. 46, W438\u2013W442 (2018).","journal-title":"Nucleic Acids Res."},{"key":"14884_CR34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/bioinformatics\/btz502","volume":"36","author":"J Wang","year":"2020","unstructured":"Wang, J. et al. iCn3D, a web-based 3D viewer for sharing 1D\/2D\/3D representations of biomolecular structures. Bioinformatics 36, 131\u2013135 (2020).","journal-title":"Bioinformatics"},{"key":"14884_CR35","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/1471-2105-10-421","volume":"10","author":"C Camacho","year":"2009","unstructured":"Camacho, C. et al. BLAST+: Architecture and applications. BMC Bioinform. 10, 421 (2009).","journal-title":"BMC Bioinform."},{"key":"14884_CR36","doi-asserted-by":"publisher","first-page":"6968","DOI":"10.1038\/s41467-022-34630-w","volume":"13","author":"RC Edgar","year":"2022","unstructured":"Edgar, R. C. Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny. Nat. Commun. 13, 6968 (2022).","journal-title":"Nat. Commun."},{"key":"14884_CR37","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/sysbio\/syu084","volume":"64","author":"T Flouri","year":"2015","unstructured":"Flouri, T. et al. The phylogenetic likelihood library. Syst. Biol. 64, 356\u2013362 (2015).","journal-title":"Syst. Biol."},{"key":"14884_CR38","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/molbev\/msz189","volume":"37","author":"D Darriba","year":"2020","unstructured":"Darriba, D. et al. ModelTest-NG: A new and scalable tool for the selection of DNA and protein evolutionary models. Mol. Biol. Evol. 37, 291\u2013294 (2020).","journal-title":"Mol. Biol. Evol."},{"key":"14884_CR39","doi-asserted-by":"publisher","first-page":"4453","DOI":"10.1093\/bioinformatics\/btz305","volume":"35","author":"AM Kozlov","year":"2019","unstructured":"Kozlov, A. M., Darriba, D., Flouri, T., Morel, B. & Stamatakis, A. RAxML-NG: A fast, scalable and user-friendly tool for maximum likelihood phylogenetic inference. Bioinformatics 35, 4453\u20134455 (2019).","journal-title":"Bioinformatics"},{"key":"14884_CR40","doi-asserted-by":"publisher","unstructured":"Miller, M. A., Pfeiffer, W. & Schwartz, T. Creating the CIPRES Science Gateway for inference of large phylogenetic trees. in 2010 Gateway Computing Environments Workshop (GCE) 1\u20138 (IEEE, 2010). https:\/\/doi.org\/10.1109\/GCE.2010.5676129","DOI":"10.1109\/GCE.2010.5676129"},{"key":"14884_CR41","doi-asserted-by":"publisher","first-page":"W78","DOI":"10.1093\/nar\/gkae268","volume":"52","author":"I Letunic","year":"2024","unstructured":"Letunic, I. & Bork, P. Interactive tree of life (iTOL) v6: Recent updates to the phylogenetic tree display and annotation tool. Nucleic Acids Res. 52, W78\u2013W82 (2024).","journal-title":"Nucleic Acids Res."},{"key":"14884_CR42","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cbpb.2013.07.005","volume":"166","author":"H Mizuta","year":"2013","unstructured":"Mizuta, H. et al. Ovarian expression and localization of a vitellogenin receptor with eight ligand binding repeats in the cutthroat trout (Oncorhynchus clarki). Comp. Biochem. Physiol. - B Biochem. Mol. Biol. 166, 81\u201390 (2013).","journal-title":"Comp. Biochem. Physiol. - B Biochem. Mol. Biol."},{"key":"14884_CR43","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1095\/biolreprod58.5.1146","volume":"58","author":"F Prat","year":"1998","unstructured":"Prat, F., Coward, K., Sumpter, J. P. & Tyler, C. R. Molecular characterization and expression of two ovarian lipoprotein receptors in the rainbow trout, Oncorhynchus Mykiss. Biol. Reprod. 58, 1146\u20131153 (1998).","journal-title":"Biol. Reprod."},{"key":"14884_CR44","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.1073\/pnas.85.12.4335","volume":"85","author":"K Kozarsky","year":"1988","unstructured":"Kozarsky, K., Kingsley, D. & Krieger, M. Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors. Proc. Natl. Acad. Sci. 85, 4335\u20134339 (1988).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"14884_CR45","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S0014-5793(99)00494-9","volume":"451","author":"J Magran\u00e9","year":"1999","unstructured":"Magran\u00e9, J., Casaroli-Marano, R. P., Reina, M., G\u00e5fvels, M. & Vilar\u00f3, S. The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell. FEBS Lett. 451, 56\u201362 (1999).","journal-title":"FEBS Lett."},{"key":"14884_CR46","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1194\/jlr.M050286","volume":"55","author":"BJ Reading","year":"2014","unstructured":"Reading, B. J. et al. Lrp13 is a novel vertebrate lipoprotein receptor that binds vitellogenins in teleost fishes. J. Lipid Res. 55, 2287\u20132295 (2014).","journal-title":"J. Lipid Res."},{"key":"14884_CR47","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1002\/mrd.22579","volume":"82","author":"Y Mushirobira","year":"2015","unstructured":"Mushirobira, Y. et al. Molecular cloning and partial characterization of a low-density lipoprotein receptor\u2010related protein 13 (Lrp13) involved in vitellogenin uptake in the cutthroat trout (Oncorhynchus clarki). Mol. Reprod. Dev. 82, 986\u20131000 (2015).","journal-title":"Mol. Reprod. Dev."},{"key":"14884_CR48","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1002\/mrd.22881","volume":"84","author":"\u00d8 Andersen","year":"2017","unstructured":"Andersen, \u00d8. et al. Resolving the complexity of vitellogenins and their receptors in the tetraploid Atlantic salmon (Salmo salar): Ancient origin of the phosvitin-less VtgC in chondrichthyean fishes. Mol. Reprod. Dev. 84, 1191\u20131202 (2017).","journal-title":"Mol. Reprod. Dev."},{"key":"14884_CR49","doi-asserted-by":"publisher","first-page":"114479","DOI":"10.1016\/j.ygcen.2024.114479","volume":"351","author":"O Yilmaz","year":"2024","unstructured":"Yilmaz, O., Sullivan, C. V., Bobe, J. & Norberg, B. The role of multiple vitellogenins in early development of fishes. Gen. Comp. Endocrinol. 351, 114479 (2024).","journal-title":"Gen. Comp. Endocrinol."},{"key":"14884_CR50","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/S0022-2275(20)32491-3","volume":"39","author":"B Davail","year":"1998","unstructured":"Davail, B. et al. Evolution of oogenesis: The receptor for vitellogenin from the rainbow trout. J. Lipid Res. 39, 1929\u20131937 (1998).","journal-title":"J. Lipid Res."},{"key":"14884_CR51","doi-asserted-by":"publisher","first-page":"23546","DOI":"10.1074\/jbc.270.40.23546","volume":"270","author":"H Bujo","year":"1995","unstructured":"Bujo, H. et al. Chicken oocytes and somatic cells express different splice variants of a multifunctional receptor. J. Biol. Chem. 270, 23546\u201323551 (1995).","journal-title":"J. Biol. Chem."},{"key":"14884_CR52","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1006\/bbrc.1996.1040","volume":"224","author":"K Okabayashi","year":"1996","unstructured":"Okabayashi, K. et al. cDNA cloning and expression of thexenopus laevisvitellogenin receptor. Biochem. Biophys. Res. Commun. 224, 406\u2013413 (1996).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"14884_CR53","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10695-012-9612-6","volume":"39","author":"N Hiramatsu","year":"2013","unstructured":"Hiramatsu, N. et al. Multiple ovarian lipoprotein receptors in teleosts. Fish. Physiol. Biochem. 39, 29\u201332 (2013).","journal-title":"Fish. Physiol. Biochem."},{"key":"14884_CR54","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/jez.1402690509","volume":"269","author":"PM Lancaster","year":"1994","unstructured":"Lancaster, P. M. & Tyler, C. R. Developmental expression and modulation of the vitellogenin receptor in ovarian follicles of the rainbow trout,oncorhynchus Mykiss. J. Exp. Zool. 269, 458\u2013466 (1994).","journal-title":"J. Exp. Zool."},{"key":"14884_CR55","doi-asserted-by":"crossref","unstructured":"Tyler, C. R. & Lubberink, K. Identification of four ovarian receptor proteins that bind vitellogenin but not other homologous plasma lipoproteins in the rainbow trout, Oncorhynchus Mykiss. J Comp. Physiol. B 166, 11-20 (1996).","DOI":"10.1007\/BF00264634"},{"key":"14884_CR56","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/(SICI)1097-010X(19960215)274:3<163::AID-JEZ3>3.0.CO;2-M","volume":"274","author":"JN Rodriguez","year":"1996","unstructured":"Rodriguez, J. N., Bon, E. & Le Menn, F. Vitellogenin receptors during vitellogenesis in the rainbow trout Oncorhynchus Mykiss. J. Exp. Zool. 274, 163\u2013170 (1996).","journal-title":"J. Exp. Zool."},{"key":"14884_CR57","first-page":"5","volume":"52","author":"N Hiramatsu","year":"2001","unstructured":"Hiramatsu, N., Fukada, H., Sullivan, C. & Hara, A. Simple and sensitive detection of vitellogenin receptor(s) in Sakhalin Taimen (Hucho perryi). Bull. Fish. Sci. Hokkaido Univ. 52, 5\u20139 (2001).","journal-title":"Bull. Fish. Sci. Hokkaido Univ."},{"key":"14884_CR58","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1051\/rnd:19970106","volume":"37","author":"E Ma\u00f1an\u00f3s","year":"1997","unstructured":"Ma\u00f1an\u00f3s, E., N\u00fa\u00f1ez Rodr\u00edguez, J., Le Menn, F., Zanuy, S. & Carrillo, M. Identification of vitellogenin receptors in the ovary of a teleost fish, the mediterranean sea bass (Dicentrarchus labrax). Reprod. Nutr. Dev. 37, 51\u201361 (1997).","journal-title":"Reprod. Nutr. Dev."},{"key":"14884_CR59","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0005-2760(90)90130-P","volume":"1045","author":"S Stifani","year":"1990","unstructured":"Stifani, S., Menn, F., Le, Rodriguez, J. N. & Schneider, W. J. Regulation of oogenesis: The piscine receptor for vitellogenin. Biochim. Biophys. Acta - Lipids Lipid Metab. 1045, 271\u2013279 (1990).","journal-title":"Biochim. Biophys. Acta - Lipids Lipid Metab."},{"key":"14884_CR60","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1095\/biolreprod.110.087981","volume":"84","author":"BJ Reading","year":"2011","unstructured":"Reading, B. J., Hiramatsu, N. & Sullivan, C. V. Disparate binding of three types of vitellogenin to multiple forms of vitellogenin receptor in white perch. Biol. Reprod. 84, 392\u2013399 (2011).","journal-title":"Biol. Reprod."},{"key":"14884_CR61","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3354\/meps237217","volume":"237","author":"R Finn","year":"2002","unstructured":"Finn, R., Wamboldt, M. & Fyhn, H. Differential processing of yolk proteins during oocyte hydration in marine fishes (Labridae) that spawn benthic and pelagic eggs. Mar. Ecol. Prog Ser. 237, 217\u2013226 (2002).","journal-title":"Mar. Ecol. Prog Ser."},{"key":"14884_CR62","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/jez.1859","volume":"321","author":"VN Williams","year":"2014","unstructured":"Williams, V. N. et al. Proportional accumulation of yolk proteins derived from multiple vitellogenins is precisely regulated during vitellogenesis in striped bass (Morone saxatilis). J. Exp. Zool. Part. Ecol. Genet. Physiol. 321, 301\u2013315 (2014).","journal-title":"J. Exp. Zool. Part. Ecol. Genet. Physiol."},{"key":"14884_CR63","doi-asserted-by":"crossref","unstructured":"Reading, B. J. & Sullivan, C. V. The reproductive organs and processes | Vitellogenesis in Fishes. Encyclopedia of Fish Physiology 1 (Elsevier Inc., 2011).","DOI":"10.1016\/B978-0-12-374553-8.00257-4"},{"key":"14884_CR64","doi-asserted-by":"publisher","unstructured":"Reading, B. J., Sullivan, C. V. & Schilling, J. Vitellogenesis in Fishes. in Reference Module in Life Sciences (2017). https:\/\/doi.org\/10.1016\/b978-0-12-809633-8.03076-4","DOI":"10.1016\/b978-0-12-809633-8.03076-4"},{"key":"14884_CR65","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1515\/bc.2010.129","volume":"391","author":"M Dieckmann","year":"2010","unstructured":"Dieckmann, M., Dietrich, M. F. & Herz, J. Lipoprotein receptors-an evolutionarily ancient multifunctional receptor family. Biol. Chem. 391, 1341\u20131363 (2010).","journal-title":"Biol. Chem."},{"key":"14884_CR66","doi-asserted-by":"crossref","unstructured":"Cao, Y., Wang, H., Jin, P., Ma, F. & Zhou, X. Identification and characterization of the very-low-density lipoprotein receptor gene from Branchiostoma belcheri: Insights into the origin and evolution of the low-density lipoprotein receptor gene family. Animals 13, (2023).","DOI":"10.3390\/ani13132193"},{"key":"14884_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jmb.2004.10.038","volume":"345","author":"MT Uhlik","year":"2005","unstructured":"Uhlik, M. T. et al. Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J. Mol. Biol. 345, 1\u201320 (2005).","journal-title":"J. Mol. Biol."},{"key":"14884_CR68","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1006\/jmbi.1993.1305","volume":"231","author":"P Bork","year":"1993","unstructured":"Bork, P. & Beckmann, G. The CUB domain. J. Mol. Biol. 231, 539\u2013545 (1993).","journal-title":"J. Mol. Biol."},{"key":"14884_CR69","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.neuron.2014.08.005","volume":"83","author":"C Lane-Donovan","year":"2014","unstructured":"Lane-Donovan, C., Philips, G. T. & Herz, J. More than cholesterol transporters: Lipoprotein receptors in CNS function and neurodegeneration. Neuron 83, 771\u2013787 (2014).","journal-title":"Neuron"},{"key":"14884_CR70","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s13195-021-00921-5","volume":"13","author":"I Cuchillo-Iba\u00f1ez","year":"2021","unstructured":"Cuchillo-Iba\u00f1ez, I. et al. The Apolipoprotein receptor LRP3 compromises APP levels. Alzheimers Res. Ther. 13, 181 (2021).","journal-title":"Alzheimers Res. Ther."},{"key":"14884_CR71","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.aquatox.2013.11.014","volume":"153","author":"S Short","year":"2014","unstructured":"Short, S., Yang, G., Kille, P. & Ford, A. T. Vitellogenin is not an appropriate biomarker of feminisation in a crustacean. Aquat. Toxicol. 153, 89\u201397 (2014).","journal-title":"Aquat. Toxicol."},{"key":"14884_CR72","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.aquatox.2016.04.010","volume":"176","author":"E Legrand","year":"2016","unstructured":"Legrand, E. et al. Transcriptome analysis of the copepod eurytemora affinis upon exposure to endocrine disruptor pesticides: Focus on reproduction and development. Aquat. Toxicol. 176, 64\u201375 (2016).","journal-title":"Aquat. Toxicol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14884-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14884-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14884-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:05:01Z","timestamp":1759172701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-14884-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["14884"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-14884-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"17 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"33481"}}