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While D-dimer is a widely used biomarker for thrombosis, its postoperative specificity is limited due to inflammatory interference. This study introduces a novel cumulative metric\u20147-day D-dimer exposure (7dDDE)\u2014to quantify perioperative coagulation burden. We retrospectively analyzed 525 patients undergoing gastrointestinal surgery, performed propensity score matching, and constructed a multivariable logistic regression model incorporating 7dDDE and other clinical variables. Model performance was evaluated using ROC curves, decision curve analysis, calibration plots, SHAP values, and a nomogram. Additionally, a linear mixed-effects model assessed D-dimer trajectories over time. The results demonstrated that 7dDDE was independently associated with postoperative DVT and was the most influential predictor in the model. The model showed good discrimination and clinical utility. Longitudinal analysis further revealed significant differences in D-dimer dynamics between DVT and non-DVT groups, even after adjustment for confounders. These findings support the use of 7dDDE as a robust biomarker for thrombotic risk stratification and highlight the importance of integrating temporal biomarker patterns into perioperative DVT prediction.<\/jats:p>","DOI":"10.1038\/s41598-025-14960-7","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T08:29:42Z","timestamp":1755073782000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrating 7-day D-dimer exposure into deep vein thrombosis risk prediction after gastrointestinal surgery"],"prefix":"10.1038","volume":"15","author":[{"given":"Shuwei","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoquan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"issue":"5","key":"14960_CR1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1182\/blood.2019000919","volume":"135","author":"JI Weitz","year":"2020","unstructured":"Weitz, J. 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