{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:01:21Z","timestamp":1757624481969,"version":"3.44.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170858","81170858","81170858","81170858"],"award-info":[{"award-number":["81170858","81170858","81170858","81170858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-15134-1","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T10:34:55Z","timestamp":1755945295000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomics on choroidal neovascularization based on itraq and the protective effect of TAB1 in CNV"],"prefix":"10.1038","volume":"15","author":[{"given":"Yong","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujia","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"issue":"5","key":"15134_CR1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/17441692.2011.634815","volume":"7","author":"A Gordois","year":"2012","unstructured":"Gordois, A. et al. An estimation of the worldwide economic and health burden of visual impairment. Glob. Public Health 7(5), 465\u2013481 (2012).","journal-title":"Glob. Public Health"},{"issue":"4","key":"15134_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.mam.2012.04.005","volume":"33","author":"I Bhutto","year":"2012","unstructured":"Bhutto, I. & Lutty, G. Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor\/retinal pigment epithelium\/Bruch\u2019s membrane\/choriocapillaris complex. Mol. Aspects Med. 33(4), 295\u2013317 (2012).","journal-title":"Mol. Aspects Med."},{"issue":"1\u20132","key":"15134_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10495-018-1490-7","volume":"24","author":"S Aashaq","year":"2019","unstructured":"Aashaq, S., Batool, A. & Andrabi, K. I. TAB1 mediates convergence of cellular signals for death and survival. Apoptosis 24(1\u20132), 3\u201320 (2019).","journal-title":"Apoptosis"},{"issue":"1\u20132","key":"15134_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s11010-017-3183-x","volume":"441","author":"X Fan","year":"2018","unstructured":"Fan, X., Gao, N., Li, J., Lei, J. & Kang, Q. Effects of VEGF levels on anti-VEGF therapy for patients with idiopathic choroidal neovascularization. Mol. Cell Biochem. 441(1\u20132), 173\u2013179 (2018).","journal-title":"Mol. Cell Biochem."},{"issue":"10","key":"15134_CR5","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1167\/iovs.17-23747","volume":"59","author":"Y Gao","year":"2018","unstructured":"Gao, Y., Yu, T., Zhang, Y. & Dang, G. Anti VEGF monotherapy versus photodynamic therapy and anti vegf combination treatment for neovascular age related macular degeneration a meta analysis. Invest Ophthalmol. Vis. Sci. 59(10), 4307\u20134317 (2018).","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"15134_CR6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.preteyeres.2017.10.005","volume":"63","author":"K Ohno-Matsui","year":"2018","unstructured":"Ohno-Matsui, K., Ikuno, Y., Lai, T. & Gemmy Cheung, C. M. Diagnosis and treatment guideline for myopic choroidal neovascularization due to pathologic myopia. Prog. Retin. Eye Res. 63, 92\u2013106 (2018).","journal-title":"Prog. Retin. Eye Res."},{"issue":"5","key":"15134_CR7","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.survophthal.2021.01.014","volume":"66","author":"M Lupidi","year":"2021","unstructured":"Lupidi, M. et al. The choroidal rupture: Current concepts and insights. Surv. Ophthalmol. 66(5), 761\u2013770 (2021).","journal-title":"Surv. Ophthalmol."},{"key":"15134_CR8","doi-asserted-by":"publisher","first-page":"100906","DOI":"10.1016\/j.preteyeres.2020.100906","volume":"82","author":"PS Mettu","year":"2021","unstructured":"Mettu, P. S., Allingham, M. J. & Cousins, S. W. Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities. Prog. Retin. Eye Res. 82, 100906 (2021).","journal-title":"Prog. Retin. Eye Res."},{"issue":"12","key":"15134_CR9","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1080\/14712598.2021.1830969","volume":"20","author":"D Ng","year":"2020","unstructured":"Ng, D., Fung, N., Yip, F. & Lai, T. Ranibizumab for myopic choroidal neovascularization. Expert Opin. Biol. Ther. 20(12), 1385\u20131393 (2020).","journal-title":"Expert Opin. Biol. Ther."},{"issue":"1","key":"15134_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/14740338.2021.1952979","volume":"21","author":"D Ng","year":"2022","unstructured":"Ng, D., Ho, M., Iu, L. & Lai, T. Safety review of anti-VEGF therapy in patients with myopic choroidal neovascularization. Expert Opin. Drug Saf. 21(1), 43\u201354 (2022).","journal-title":"Expert Opin. Drug Saf."},{"key":"15134_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jprot.2018.12.012","volume":"198","author":"C Monti","year":"2019","unstructured":"Monti, C., Zilocchi, M., Colugnat, I. & Alberio, T. Proteomics turns functional. J. Proteomics 198, 36\u201344 (2019).","journal-title":"J. Proteomics"},{"issue":"1","key":"15134_CR12","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1186\/s12967-023-04225-0","volume":"21","author":"W Bai","year":"2023","unstructured":"Bai, W. et al. Targeting FSCN1 with an oral small-molecule inhibitor for treating ocular neovascularization. J. Transl. Med. 21(1), 555 (2023).","journal-title":"J. Transl. Med."},{"issue":"8","key":"15134_CR13","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1002\/ctm2.1383","volume":"13","author":"S Hu","year":"2023","unstructured":"Hu, S. et al. Nme(2) Cas9-mediated therapeutic editing in inhibiting angiogenesis after wet age-related macular degeneration onset. Clin. Transl. Med. 13(8), 1383 (2023).","journal-title":"Clin. Transl. Med."},{"key":"15134_CR14","doi-asserted-by":"publisher","first-page":"1192464","DOI":"10.3389\/fncel.2023.1192464","volume":"17","author":"J Canonica","year":"2023","unstructured":"Canonica, J. et al. Delineating effects of angiopoietin-2 inhibition on vascular permeability and inflammation in models of retinal neovascularization and ischemia\/reperfusion. Front. Cell Neurosci. 17, 1192464 (2023).","journal-title":"Front. Cell Neurosci."},{"key":"15134_CR15","doi-asserted-by":"publisher","first-page":"155584","DOI":"10.1016\/j.metabol.2023.155584","volume":"144","author":"B Cui","year":"2023","unstructured":"Cui, B. et al. Exercise alleviates neovascular age-related macular degeneration by inhibiting AIM2 inflammasome in myeloid cells. Metabolism 144, 155584 (2023).","journal-title":"Metabolism"},{"issue":"3","key":"15134_CR16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s10456-021-09787-5","volume":"24","author":"L Zhu","year":"2021","unstructured":"Zhu, L. et al. TAK1 signaling is a potential therapeutic target for pathological angiogenesis. Angiogenesis 24(3), 453\u2013470 (2021).","journal-title":"Angiogenesis"},{"key":"15134_CR17","doi-asserted-by":"publisher","first-page":"608976","DOI":"10.3389\/fimmu.2020.608976","volume":"11","author":"YR Xu","year":"2020","unstructured":"Xu, Y. R. & Lei, C. Q. TAK1-TABs complex: A central signalosome in inflammatory responses. Front. Immunol. 11, 608976 (2020).","journal-title":"Front. Immunol."},{"issue":"10","key":"15134_CR18","doi-asserted-by":"publisher","first-page":"7359","DOI":"10.1074\/jbc.275.10.7359","volume":"275","author":"K Kishimoto","year":"2000","unstructured":"Kishimoto, K., Matsumoto, K. & Ninomiya-Tsuji, J. TAK1 mitogen-activated protein kinase is activated by autophosphorylation within its activation loop. J. Biol. Chem. 275(10), 7359\u20137364 (2000).","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"15134_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10495-018-1490-7","volume":"24","author":"S Aashaq","year":"2019","unstructured":"Aashaq, S., Batool, A. & Andrabi, K. I. TAK1 mediates convergence of cellular signals for death and survival. Apoptosis 24(1\u20132), 3\u201320 (2019).","journal-title":"Apoptosis"},{"issue":"9","key":"15134_CR20","doi-asserted-by":"publisher","first-page":"200099","DOI":"10.1098\/rsob.200099","volume":"10","author":"J Totzke","year":"2020","unstructured":"Totzke, J., Scarneo, S. A., Yang, K. W. & Haystead, T. TAK1: A potent tumor necrosis factor inhibitor for the treatment of inflammatory diseases. Open Biol. 10(9), 200099 (2020).","journal-title":"Open Biol."},{"issue":"1","key":"15134_CR21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41421-022-00423-0","volume":"8","author":"S Wei","year":"2022","unstructured":"Wei, S. et al. GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation. Cell Discov. 8(1), 77 (2022).","journal-title":"Cell Discov."},{"issue":"5","key":"15134_CR22","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1080\/15384047.2018.1539290","volume":"20","author":"Y Fan","year":"2019","unstructured":"Fan, Y. et al. Dual-target MDM2\/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1\/TAK1\/p38 MAPK pathway. Cancer Biol. Ther. 20(5), 617\u2013632 (2019).","journal-title":"Cancer Biol. Ther."},{"issue":"12","key":"15134_CR23","first-page":"15801","volume":"8","author":"J Zhu","year":"2015","unstructured":"Zhu, J., Li, Q., He, J. T. & Liu, G. Y. Expression of TAK1\/TAB1 expression in non-small cell lung carcinoma and adjacent normal tissues and their clinical significance. Int. J. Clin. Exp. Pathol. 8(12), 15801\u201315807 (2015).","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"7","key":"15134_CR24","doi-asserted-by":"publisher","first-page":"168142","DOI":"10.1172\/jci.insight.168142","volume":"8","author":"S Droho","year":"2023","unstructured":"Droho, S., Rajesh, A., Cuda, C. M., Perlman, H. & Lavine, J. A. CD11c+ macrophages are proangiogenic and necessary for experimental choroidal neovascularization. JCI Insight 8(7), 168142 (2023).","journal-title":"JCI Insight"},{"issue":"12","key":"15134_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.61.12.24","volume":"61","author":"JY Do","year":"2020","unstructured":"Do, J. Y. et al. Fursultiamine alleviates choroidal neovascularization by suppressing inflammation and metabolic reprogramming. Invest Ophthalmol. Vis. Sci. 61(12), 24 (2020).","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"15134_CR26","doi-asserted-by":"publisher","first-page":"110312","DOI":"10.1016\/j.biopha.2020.110312","volume":"129","author":"K Lai","year":"2020","unstructured":"Lai, K. et al. Triptolide attenuates laser-induced choroidal neovascularization via M2 macrophage in a mouse model. Biomed. Pharmacother. 129, 110312 (2020).","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"15134_CR27","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1167\/iovs.15-17264","volume":"56","author":"SL Doyle","year":"2015","unstructured":"Doyle, S. L. et al. IL-18 immunotherapy for neovascular AMD: Tolerability and efficacy in nonhuman primates. Invest Ophthalmol. Vis. Sci. 56(9), 5424\u20135430 (2015).","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"5","key":"15134_CR28","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/CIRCULATIONAHA.118.034532","volume":"139","author":"M Sabater-Lleal","year":"2019","unstructured":"Sabater-Lleal, M. et al. Genome-wide association transethnic meta-analyses identifies novel associations regulating coagulation factor viii and von willebrand factor plasma levels. Circulation 139(5), 620\u2013635 (2019).","journal-title":"Circulation"},{"issue":"8","key":"15134_CR29","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/s41418-022-00939-8","volume":"29","author":"L Yuan","year":"2022","unstructured":"Yuan, L. et al. EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma. Cell Death Differ. 29(8), 1513\u20131527 (2022).","journal-title":"Cell Death Differ."},{"issue":"8","key":"15134_CR30","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1038\/s41556-022-00962-4","volume":"24","author":"G Guo","year":"2022","unstructured":"Guo, G. et al. EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation. Nat. Cell Biol. 24(8), 1291\u20131305 (2022).","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"15134_CR31","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.3390\/cancers12082269","volume":"12","author":"A Batool","year":"2020","unstructured":"Batool, A., Liu, H., Liu, Y. X. & Chen, S. R. CD83, a novel MAPK signaling pathway interactor, determines ovarian cancer cell fate. Cancers 12(8), 2269 (2020).","journal-title":"Cancers"},{"issue":"10","key":"15134_CR32","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/ni.2981","volume":"15","author":"A Lanna","year":"2014","unstructured":"Lanna, A., Henson, S. M., Escors, D. & Akbar, A. N. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol. 15(10), 965\u2013972 (2014).","journal-title":"Nat Immunol."},{"issue":"1","key":"15134_CR33","first-page":"261","volume":"20","author":"Z Dong","year":"2019","unstructured":"Dong, Z., Li, B. & Wang, X. \u039cicroRNA-889 plays a suppressive role in cell proliferation and invasion by directly targeting TAB1 in non-small cell lung cancer. Mol. Med. Rep. 20(1), 261\u2013269 (2019).","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"15134_CR34","first-page":"1090","volume":"39","author":"H Gong","year":"2018","unstructured":"Gong, H. et al. miR-873 inhibits colorectal cancer cell proliferation by targeting TRAF5 and TAB1. Oncol. Rep. 39(3), 1090\u20131098 (2018).","journal-title":"Oncol. Rep."},{"issue":"1","key":"15134_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41419-022-05541-x","volume":"14","author":"F Meng","year":"2023","unstructured":"Meng, F. et al. Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1\/NF\u03baB pathway. Cell Death Dis. 14(1), 9 (2023).","journal-title":"Cell Death Dis."},{"key":"15134_CR36","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.3389\/fonc.2020.01780","volume":"10","author":"A Singh","year":"2020","unstructured":"Singh, A., Devkar, R. & Basu, A. Myeloid differentiation primary response 88-Cyclin D1 signaling in breast cancer cells regulates toll-like receptor 3-mediated cell proliferation. Front. Oncol. 10, 1780 (2020).","journal-title":"Front. Oncol."},{"key":"15134_CR37","doi-asserted-by":"publisher","first-page":"6366","DOI":"10.1016\/j.csbj.2021.11.034","volume":"19","author":"F Cossu","year":"2021","unstructured":"Cossu, F. et al. Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-\u03baB pathway. Comput. Struct. Biotechnol. J. 19, 6366\u20136374 (2021).","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"6","key":"15134_CR38","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1177\/1756287215597637","volume":"7","author":"D Kaushik","year":"2015","unstructured":"Kaushik, D., Vashistha, V., Isharwal, S., Sediqe, S. A. & Lin, M. F. Histone deacetylase inhibitors in castration-resistant prostate cancer: Molecular mechanism of action and recent clinical trials. Ther. Adv. Urol. 7(6), 388\u2013395 (2015).","journal-title":"Ther. Adv. Urol."},{"issue":"5","key":"15134_CR39","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3347\/kjp.2014.52.5.459","volume":"52","author":"KA Kim","year":"2014","unstructured":"Kim, K. A., Min, A., Lee, Y. A. & Shin, M. H. Degradation of the transcription factors NF-\u03baB, STAT3, and STAT5 is involved in Entamoeba histolytica-induced cell death in Caco-2 colonic epithelial cells. Korean. J. Parasitol. 52(5), 459\u2013469 (2014).","journal-title":"Korean. J. Parasitol."},{"key":"15134_CR40","doi-asserted-by":"publisher","first-page":"115120","DOI":"10.1016\/j.bcp.2022.115120","volume":"202","author":"Y Song","year":"2022","unstructured":"Song, Y. et al. Palmatine alleviates LPS-induced acute lung injury via interfering the interaction of TAK1 and TAB1. Biochem. Pharmacol. 202, 115120 (2022).","journal-title":"Biochem. Pharmacol."},{"issue":"120","key":"15134_CR41","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.fsi.2021.12.019","volume":"1","author":"Y Xu","year":"2022","unstructured":"Xu, Y. et al. TAK1 of blunt snout bream promotes NF-\u03baB activation via interaction with TAB1 in response to pathogenic bacteria. Fish Shellfish Immunol. 1(120), 481\u2013496 (2022).","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"15134_CR42","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","volume":"132","author":"MS Hayden","year":"2008","unstructured":"Hayden, M. S. & Ghosh, S. Shared principles in NF-\u03baB signaling. Cell 132(3), 344\u2013362 (2008).","journal-title":"Cell"},{"issue":"1","key":"15134_CR43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic. Acids Res. 28(1), 27\u201330 (2000).","journal-title":"Nucleic. Acids Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15134-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15134-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15134-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T13:55:01Z","timestamp":1757426101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15134-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["15134"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-15134-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"assertion":[{"value":"9 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Written informed consent was obtained from the donors before publishing this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent statement"}}],"article-number":"31037"}}