{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:32:03Z","timestamp":1785187923166,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Changshu Municipal Health Commission Science and Technology Plan Project","award":["CSWSQ202105"],"award-info":[{"award-number":["CSWSQ202105"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-15682-6","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T11:01:24Z","timestamp":1758884484000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrative analysis of molecular mechanisms in prostate cancer via single-cell RNA sequencing and weighted gene co-expression network analysis"],"prefix":"10.1038","volume":"15","author":[{"given":"Jing","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanxiong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"15682_CR1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.eururo.2024.04.010","volume":"86","author":"D Tilki","year":"2024","unstructured":"Tilki, D. et al. EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on prostate cancer. Part II-2024 update: Treatment of relapsing and metastatic prostate cancer. Eur. Urol. 86, 164\u2013182. https:\/\/doi.org\/10.1016\/j.eururo.2024.04.010 (2024). EAU-EANM-ESTRO-ESUR-ISUP-SIOG.","journal-title":"Eur. Urol."},{"key":"15682_CR2","doi-asserted-by":"publisher","first-page":"424","DOI":"10.5694\/mja2.51722","volume":"217","author":"IS Williams","year":"2022","unstructured":"Williams, I. S. et al. Modern paradigms for prostate cancer detection and management. Med. J. Aust 217, 424\u2013433. https:\/\/doi.org\/10.5694\/mja2.51722 (2022).","journal-title":"Med. J. Aust"},{"key":"15682_CR3","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1097\/JU.0000000000003452","volume":"209","author":"W Lowrance","year":"2023","unstructured":"Lowrance, W. et al. Updates to advanced prostate cancer: AUA\/SUO guideline (2023). J. Urol. 209, 1082\u20131090. https:\/\/doi.org\/10.1097\/JU.0000000000003452 (2023).","journal-title":"J. Urol."},{"key":"15682_CR4","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41556-020-00613-6","volume":"23","author":"S Chen","year":"2021","unstructured":"Chen, S. et al. Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. Nat. Cell. Biol. 23, 87\u201398. https:\/\/doi.org\/10.1038\/s41556-020-00613-6 (2021).","journal-title":"Nat. Cell. Biol."},{"key":"15682_CR5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41467-021-27322-4","volume":"13","author":"H Song","year":"2022","unstructured":"Song, H. et al. Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell States. Nat. Commun. 13, 141. https:\/\/doi.org\/10.1038\/s41467-021-27322-4 (2022).","journal-title":"Nat. Commun."},{"key":"15682_CR6","doi-asserted-by":"publisher","first-page":"e2305724","DOI":"10.1002\/advs.202305724","volume":"11","author":"X Bian","year":"2024","unstructured":"Bian, X. et al. Integration analysis of single-cell multi-omics reveals prostate cancer heterogeneity. Adv. Sci. (Weinh) 11, e2305724. https:\/\/doi.org\/10.1002\/advs.202305724 (2024).","journal-title":"Adv. Sci. (Weinh)"},{"key":"15682_CR7","doi-asserted-by":"publisher","first-page":"9949","DOI":"10.1038\/s41467-024-54364-1","volume":"15","author":"A Kiviaho","year":"2024","unstructured":"Kiviaho, A. et al. Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer. Nat. Commun. 15, 9949. https:\/\/doi.org\/10.1038\/s41467-024-54364-1 (2024).","journal-title":"Nat. Commun."},{"key":"15682_CR8","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/s41698-024-00667-x","volume":"8","author":"S Cheng","year":"2024","unstructured":"Cheng, S. et al. Unveiling novel double-negative prostate cancer subtypes through single-cell RNA sequencing analysis. NPJ Precis Oncol. 8, 171. https:\/\/doi.org\/10.1038\/s41698-024-00667-x (2024).","journal-title":"NPJ Precis Oncol."},{"key":"15682_CR9","doi-asserted-by":"publisher","first-page":"e2322203121","DOI":"10.1073\/pnas.2322203121","volume":"121","author":"S Zaidi","year":"2024","unstructured":"Zaidi, S. et al. Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen-targeted therapies. Proc. Natl. Acad. Sci. U S A 121, e2322203121. https:\/\/doi.org\/10.1073\/pnas.2322203121 (2024).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"15682_CR10","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1126\/science.abn0478","volume":"377","author":"JM Chan","year":"2022","unstructured":"Chan, J. M. et al. Lineage plasticity in prostate cancer depends on JAK\/STAT inflammatory signaling. Science 377, 1180\u20131191. https:\/\/doi.org\/10.1126\/science.abn0478 (2022).","journal-title":"Science"},{"key":"15682_CR11","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12943-020-01264-9","volume":"19","author":"X Ma","year":"2020","unstructured":"Ma, X. et al. Identification of a distinct luminal subgroup diagnosing and stratifying early stage prostate cancer by tissue-based single-cell RNA sequencing. Mol. Cancer 19, 147. https:\/\/doi.org\/10.1186\/s12943-020-01264-9 (2020).","journal-title":"Mol. Cancer"},{"key":"15682_CR12","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s41592-021-01282-5","volume":"18","author":"T Stuart","year":"2021","unstructured":"Stuart, T., Srivastava, A., Madad, S., Lareau, C. A. & Satija, R. Single-cell chromatin state analysis with Signac. Nat. Methods 18, 1333\u20131341. https:\/\/doi.org\/10.1038\/s41592-021-01282-5 (2021).","journal-title":"Nat. Methods"},{"key":"15682_CR13","doi-asserted-by":"publisher","first-page":"828479","DOI":"10.3389\/fgene.2022.828479","volume":"13","author":"S Seth","year":"2022","unstructured":"Seth, S., Mallik, S., Bhadra, T. & Zhao, Z. Dimensionality reduction and Louvain agglomerative hierarchical clustering for cluster-specified frequent biomarker discovery in single-cell sequencing data. Front. Genet. 13, 828479. https:\/\/doi.org\/10.3389\/fgene.2022.828479 (2022).","journal-title":"Front. Genet."},{"key":"15682_CR14","doi-asserted-by":"publisher","unstructured":"Ruscitti, P. et al. Derivation and validation of four patient clusters in Still\u2019s disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry. RMD Open. 9 https:\/\/doi.org\/10.1136\/rmdopen-2023-003419 (2023).","DOI":"10.1136\/rmdopen-2023-003419"},{"key":"15682_CR15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12920-024-01867-x","volume":"17","author":"X Qin","year":"2024","unstructured":"Qin, X., Sun, H., Hu, S., Pan, Y. & Wang, S. A hypoxia-glycolysis-lactate-related gene signature for prognosis prediction in hepatocellular carcinoma. BMC Med. Genomics 17, 88. https:\/\/doi.org\/10.1186\/s12920-024-01867-x (2024).","journal-title":"BMC Med. Genomics"},{"key":"15682_CR16","doi-asserted-by":"publisher","first-page":"110472","DOI":"10.1016\/j.ygeno.2022.110472","volume":"114","author":"YX Wang","year":"2022","unstructured":"Wang, Y. X., Chen, H. F., Yin, Z. Y., Chen, W. L. & Lu, L. T. The genetic adaptations of toxoptera aurantii facilitated its rapid multiple plant hosts dispersal and invasion. Genomics 114, 110472. https:\/\/doi.org\/10.1016\/j.ygeno.2022.110472 (2022).","journal-title":"Genomics"},{"key":"15682_CR17","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3892\/ol.2024.14636","volume":"28","author":"N Lyu","year":"2024","unstructured":"Lyu, N. et al. Identification of feature genes and molecular mechanisms involved in cell communication in uveal melanoma through analysis of single\u2013cell sequencing data. Oncol. Lett. 28, 503. https:\/\/doi.org\/10.3892\/ol.2024.14636 (2024).","journal-title":"Oncol. Lett."},{"key":"15682_CR18","doi-asserted-by":"publisher","first-page":"100498","DOI":"10.1016\/j.crmeth.2023.100498","volume":"3","author":"S Morabito","year":"2023","unstructured":"Morabito, S., Reese, F., Rahimzadeh, N., Miyoshi, E. & Swarup, V. HdWGCNA identifies co-expression networks in high-dimensional transcriptomics data. Cell. Rep. Methods 3, 100498. https:\/\/doi.org\/10.1016\/j.crmeth.2023.100498 (2023).","journal-title":"Cell. Rep. Methods"},{"key":"15682_CR19","doi-asserted-by":"publisher","unstructured":"Wang, Y. et al. WGCNA analysis identifies the hub genes related to heat stress in seedling of rice (Oryza sativa L). Genes 13. https:\/\/doi.org\/10.3390\/genes13061020 (2022).","DOI":"10.3390\/genes13061020"},{"key":"15682_CR20","doi-asserted-by":"publisher","unstructured":"Xie, N. et al. Integrated transcriptomic and WGCNA analyses reveal candidate genes regulating mainly flavonoid biosynthesis in litsea Coreana var. Sinensis. BMC Plant Biol. 24 https:\/\/doi.org\/10.1186\/s12870-024-04949-1 (2024).","DOI":"10.1186\/s12870-024-04949-1"},{"key":"15682_CR21","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s13721-024-00470-5","volume":"13","author":"S Saha","year":"2024","unstructured":"Saha, S. et al. DeMoS: Dense module based gene signature detection through quasi-clique: An application to cervical cancer prognosis. Netw. Model. Anal. Health Inf. Bioinf. 13, 36. https:\/\/doi.org\/10.1007\/s13721-024-00470-5 (2024).","journal-title":"Netw. Model. Anal. Health Inf. Bioinf."},{"key":"15682_CR22","doi-asserted-by":"publisher","first-page":"1242909","DOI":"10.3389\/fimmu.2023.1242909","volume":"14","author":"W Xu","year":"2023","unstructured":"Xu, W. et al. Unveiling the role of regulatory T cells in the tumor microenvironment of pancreatic cancer through single-cell transcriptomics and in vitro experiments. Front. Immunol. 14, 1242909. https:\/\/doi.org\/10.3389\/fimmu.2023.1242909 (2023).","journal-title":"Front. Immunol."},{"key":"15682_CR23","doi-asserted-by":"publisher","first-page":"1179014","DOI":"10.3389\/fimmu.2023.1179014","volume":"14","author":"S Chen","year":"2023","unstructured":"Chen, S. et al. Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling. Front. Immunol. 14, 1179014. https:\/\/doi.org\/10.3389\/fimmu.2023.1179014 (2023).","journal-title":"Front. Immunol."},{"key":"15682_CR24","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y. & Ishiguro-Watanabe, M. KEGG: Biological systems database as a model of the real world. Nucleic Acids Res. 53, D672\u2013d677. https:\/\/doi.org\/10.1093\/nar\/gkae909 (2025).","journal-title":"Nucleic Acids Res."},{"key":"15682_CR25","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"15682_CR26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"15682_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/tox.24177","author":"S Chen","year":"2024","unstructured":"Chen, S. et al. Deciphering m6A signatures in hepatocellular carcinoma: Single-cell insights, immune landscape, and the protective role of IGFBP3. Environ. Toxicol. https:\/\/doi.org\/10.1002\/tox.24177 (2024).","journal-title":"Environ. Toxicol."},{"key":"15682_CR28","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.21037\/jgo-21-494","volume":"12","author":"S Chen","year":"2021","unstructured":"Chen, S. et al. Six mutator-derived LncRNA signature of genome instability for predicting the clinical outcome of colon cancer. J. Gastrointest. Oncol. 12, 2157\u20132171. https:\/\/doi.org\/10.21037\/jgo-21-494 (2021).","journal-title":"J. Gastrointest. Oncol."},{"key":"15682_CR29","doi-asserted-by":"publisher","first-page":"102","DOI":"10.21037\/jgo-21-833","volume":"13","author":"S Chen","year":"2022","unstructured":"Chen, S., Ben, X., Guo, L. & Li, X. Identification of LncRNAs based on different patterns of immune infiltration in gastric cancer. J. Gastrointest. Oncol. 13, 102\u2013116. https:\/\/doi.org\/10.21037\/jgo-21-833 (2022).","journal-title":"J. Gastrointest. Oncol."},{"key":"15682_CR30","doi-asserted-by":"publisher","first-page":"6570879","DOI":"10.1155\/2022\/6570879","volume":"2022","author":"M Li","year":"2022","unstructured":"Li, M. et al. IPO5 mediates EMT and promotes esophageal cancer development through the RAS-ERK pathway. Oxid. Med. Cell. Longev. 2022, 6570879. https:\/\/doi.org\/10.1155\/2022\/6570879 (2022).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"15682_CR31","doi-asserted-by":"publisher","first-page":"4315","DOI":"10.3390\/math11204315","volume":"11","author":"S Seth","year":"2023","unstructured":"Seth, S. et al. Identifying genetic signatures from single-cell RNA sequencing data by matrix imputation and reduced set gene clustering. Mathematics 11, 4315 (2023).","journal-title":"Mathematics"},{"key":"15682_CR32","first-page":"1931","volume":"26","author":"S Chen","year":"2021","unstructured":"Chen, S. et al. Characterization of the m6A-related LncRNA signature in predicting prognosis and immune response in patients with colon cancer. J. BUON 26, 1931\u20131941 (2021).","journal-title":"J. BUON"},{"key":"15682_CR33","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.2147\/IJGM.S343350","volume":"15","author":"Y Zhu","year":"2022","unstructured":"Zhu, Y., Shan, D., Guo, L., Chen, S. & Li, X. Immune-related LncRNA pairs clinical prognosis model construction for hepatocellular carcinoma. Int. J. Gen. Med. 15, 1919\u20131931. https:\/\/doi.org\/10.2147\/IJGM.S343350 (2022).","journal-title":"Int. J. Gen. Med."},{"key":"15682_CR34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41585-020-00400-w","volume":"18","author":"MC Haffner","year":"2021","unstructured":"Haffner, M. C. et al. Genomic and phenotypic heterogeneity in prostate cancer. Nat. Rev. Urol. 18, 79\u201392. https:\/\/doi.org\/10.1038\/s41585-020-00400-w (2021).","journal-title":"Nat. Rev. Urol."},{"key":"15682_CR35","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41586-019-1347-4","volume":"571","author":"A Parolia","year":"2019","unstructured":"Parolia, A. et al. Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. Nature 571, 413\u2013418. https:\/\/doi.org\/10.1038\/s41586-019-1347-4 (2019).","journal-title":"Nature"},{"key":"15682_CR36","doi-asserted-by":"publisher","unstructured":"Patergnani, S. et al. Various aspects of calcium signaling in the regulation of apoptosis, autophagy, cell proliferation, and cancer. Int. J. Mol. Sci. 21 https:\/\/doi.org\/10.3390\/ijms21218323 (2020).","DOI":"10.3390\/ijms21218323"},{"key":"15682_CR37","doi-asserted-by":"publisher","unstructured":"Xu, T. et al. Epithelial cell adhesion molecule\u2013targeting designed Ankyrin repeat protein\u2013toxin fusion Ec1\u2013LoPE exhibits potent cytotoxic action in prostate cancer cells. Oncol. Rep. 47 https:\/\/doi.org\/10.3892\/or.2022.8305 (2022).","DOI":"10.3892\/or.2022.8305"},{"key":"15682_CR38","doi-asserted-by":"publisher","first-page":"2393442","DOI":"10.1080\/2162402X.2024.2393442","volume":"13","author":"K Kainulainen","year":"2024","unstructured":"Kainulainen, K. et al. Secreted factors from M1 macrophages drive prostate cancer stem cell plasticity by upregulating NANOG, SOX2, and CD44 through NF\u03baB-signaling. Oncoimmunology 13, 2393442. https:\/\/doi.org\/10.1080\/2162402X.2024.2393442 (2024).","journal-title":"Oncoimmunology"},{"key":"15682_CR39","doi-asserted-by":"publisher","first-page":"16405","DOI":"10.1002\/cam4.6275","volume":"12","author":"D Li","year":"2023","unstructured":"Li, D. et al. Prostate cancer cells synergistically defend against CD8\u2009+\u2009T cells by secreting Exosomal PD-L1. Cancer Med. 12, 16405\u201316415. https:\/\/doi.org\/10.1002\/cam4.6275 (2023).","journal-title":"Cancer Med."},{"key":"15682_CR40","doi-asserted-by":"publisher","first-page":"17645","DOI":"10.18632\/oncotarget.24824","volume":"9","author":"S Ito","year":"2018","unstructured":"Ito, S. et al. CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells. Oncotarget 9, 17645\u201317655. https:\/\/doi.org\/10.18632\/oncotarget.24824 (2018).","journal-title":"Oncotarget"},{"key":"15682_CR41","doi-asserted-by":"publisher","first-page":"e18050","DOI":"10.1111\/jcmm.18050","volume":"28","author":"P Singh","year":"2024","unstructured":"Singh, P. et al. Calotropis procera extract inhibits prostate cancer through regulation of autophagy. J. Cell. Mol. Med. 28, e18050. https:\/\/doi.org\/10.1111\/jcmm.18050 (2024).","journal-title":"J. Cell. Mol. Med."},{"key":"15682_CR42","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1186\/s12935-021-02062-z","volume":"21","author":"D Yang","year":"2021","unstructured":"Yang, D. et al. Circular RNA-DPP4 serves an oncogenic role in prostate cancer progression through regulating miR-195\/cyclin D1 axis. Cancer Cell Int. 21, 379. https:\/\/doi.org\/10.1186\/s12935-021-02062-z (2021).","journal-title":"Cancer Cell Int."},{"key":"15682_CR43","doi-asserted-by":"publisher","first-page":"100146","DOI":"10.1016\/j.modpat.2023.100146","volume":"36","author":"R Mehra","year":"2023","unstructured":"Mehra, R. et al. Highly recurrent IDH1 mutations in prostate cancer with psammomatous calcification. Mod. Pathol. 36, 100146. https:\/\/doi.org\/10.1016\/j.modpat.2023.100146 (2023).","journal-title":"Mod. Pathol."},{"key":"15682_CR44","doi-asserted-by":"publisher","first-page":"148976","DOI":"10.1016\/j.gene.2024.148976","volume":"933","author":"R Yan","year":"2025","unstructured":"Yan, R. et al. NIPSNAP3A regulates cellular homeostasis by modulating mitochondrial dynamics. Gene 933, 148976. https:\/\/doi.org\/10.1016\/j.gene.2024.148976 (2025).","journal-title":"Gene"},{"key":"15682_CR45","doi-asserted-by":"publisher","first-page":"F378","DOI":"10.1152\/ajprenal.00634.2020","volume":"320","author":"AR Murillo-de-Ozores","year":"2021","unstructured":"Murillo-de-Ozores, A. R., Rodr\u00edguez-Gama, A., Carbajal-Contreras, H., Gamba, G. & Casta\u00f1eda-Bueno, M. WNK4 kinase: From structure to physiology. Am. J. Physiol. Ren. Physiol. 320, F378\u2013F403. https:\/\/doi.org\/10.1152\/ajprenal.00634.2020 (2021).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"15682_CR46","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1158\/1535-7163.Mct-21-0604","volume":"21","author":"AP Lombard","year":"2022","unstructured":"Lombard, A. P. et al. Olaparib-Induced senescence is bypassed through G2-M checkpoint override in olaparib-resistant prostate cancer. Mol. Cancer Ther. 21, 677\u2013685. https:\/\/doi.org\/10.1158\/1535-7163.Mct-21-0604 (2022).","journal-title":"Mol. Cancer Ther."},{"key":"15682_CR47","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.1038\/s41598-018-22289-7","volume":"8","author":"WY Mansour","year":"2018","unstructured":"Mansour, W. Y. et al. Loss of PTEN-assisted G2\/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer. Sci. Rep. 8, 3947. https:\/\/doi.org\/10.1038\/s41598-018-22289-7 (2018).","journal-title":"Sci. Rep."},{"key":"15682_CR48","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/s43018-023-00594-z","volume":"4","author":"D Brina","year":"2023","unstructured":"Brina, D. et al. The akt\/mtor and MNK\/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells. Nat. Cancer 4, 1102\u20131121. https:\/\/doi.org\/10.1038\/s43018-023-00594-z (2023).","journal-title":"Nat. Cancer"},{"key":"15682_CR49","doi-asserted-by":"publisher","unstructured":"Kumar, R. et al. A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60. J. Clin. Investig. 132 https:\/\/doi.org\/10.1172\/jci149906 (2022).","DOI":"10.1172\/jci149906"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15682-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15682-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15682-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T11:01:25Z","timestamp":1758884485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15682-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["15682"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-15682-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"6 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"33076"}}