{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:50:22Z","timestamp":1792785022141,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Foundation for Mary Elizabeth\u2019s hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-15769-0","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T14:55:01Z","timestamp":1755615301000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nationwide registry study of long term survival and comorbidities in total anomalous pulmonary venous connection in Denmark"],"prefix":"10.1038","volume":"15","author":[{"given":"Maj Beldring","family":"Henningsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Bohnstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese Risom","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Holdgaard","family":"Smerup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi Vejsig","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone Graff","family":"Stensballe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"issue":"1","key":"15769_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13019-023-02356-5","volume":"18","author":"J Huang","year":"2023","unstructured":"Huang, J. et al. Risk factors associated with prolonged intensive care unit stay following surgery for total anomalous pulmonary venous connection: a retrospective study. J. Cardiothorac. Surg. 18 (1), 257 (2023).","journal-title":"J. Cardiothorac. Surg."},{"issue":"7","key":"15769_CR2","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.7863\/ultra.33.7.1193","volume":"33","author":"S Ganesan","year":"2014","unstructured":"Ganesan, S. et al. Prenatal findings in total anomalous pulmonary venous return: a diagnostic road map starts with obstetric screening views. J. Ultrasound Med. 33 (7), 1193\u20131207 (2014).","journal-title":"J. Ultrasound Med."},{"issue":"25","key":"15769_CR3","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1161\/CIRCULATIONAHA.110.940825","volume":"122","author":"AN Seale","year":"2010","unstructured":"Seale, A. N. et al. Total anomalous pulmonary venous connection: morphology and outcome from an international population-based study. Circulation 122 (25), 2718\u20132726 (2010).","journal-title":"Circulation"},{"issue":"12","key":"15769_CR4","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","volume":"39","author":"JI Hoffman","year":"2002","unstructured":"Hoffman, J. I. & Kaplan, S. The incidence of congenital heart disease. J. Am. Coll. Cardiol. 39 (12), 1890\u20131900 (2002).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"15769_CR5","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1001\/jamacardio.2018.2009","volume":"3","author":"R Lytzen","year":"2018","unstructured":"Lytzen, R. et al. Live-born major congenital heart disease in denmark: incidence, detection rate, and termination of pregnancy rate from 1996 to 2013. JAMA Cardiol. 3 (9), 829\u2013837 (2018).","journal-title":"JAMA Cardiol."},{"issue":"3","key":"15769_CR6","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/uog.11093","volume":"40","author":"AN Seale","year":"2012","unstructured":"Seale, A. N. et al. Total anomalous pulmonary venous connection: impact of prenatal diagnosis. Ultrasound Obstet. Gynecol. 40 (3), 310\u2013318 (2012).","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"15769_CR7","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/0002-8703(60)90414-2","volume":"59","author":"JT Burroughs","year":"1960","unstructured":"Burroughs, J. T. & Edwards, J. E. Total anomalous pulmonary venous connection. Am. Heart J. 59, 913\u2013931 (1960).","journal-title":"Am. Heart J."},{"issue":"4 Suppl","key":"15769_CR8","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1016\/S0003-4975(99)01237-0","volume":"69","author":"JR Herlong","year":"2000","unstructured":"Herlong, J. R., Jaggers, J. J. & Ungerleider, R. M. Congenital heart surgery nomenclature and database project: pulmonary venous anomalies. Ann. Thorac. Surg. 69 (4 Suppl), S56\u201369 (2000).","journal-title":"Ann. Thorac. Surg."},{"issue":"1","key":"15769_CR9","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jtcvs.2007.08.028","volume":"135","author":"UK Chowdhury","year":"2008","unstructured":"Chowdhury, U. K. et al. Mixed total anomalous pulmonary venous connection: anatomic variations, surgical approach, techniques, and results. J. Thorac. Cardiovasc. Surg. 135 (1), 116 e1\u20135 (2008).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"4","key":"15769_CR10","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1017\/S104795110700073X","volume":"17","author":"UK Chowdhury","year":"2007","unstructured":"Chowdhury, U. K. et al. A suggested new surgical classification for mixed totally anomalous pulmonary venous connection. Cardiol. Young. 17 (4), 342\u2013353 (2007).","journal-title":"Cardiol. Young"},{"issue":"6","key":"15769_CR11","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/S0022-5223(96)70017-X","volume":"112","author":"RE Delius","year":"1996","unstructured":"Delius, R. E. et al. Mixed total pulmonary venous drainage: still a surgical challenge. J. Thorac. Cardiovasc. Surg. 112 (6), 1581\u20131588 (1996).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"6","key":"15769_CR12","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/S1010-7940(96)80111-4","volume":"10","author":"N Sinzobahamvya","year":"1996","unstructured":"Sinzobahamvya, N. et al. Early and long-term results for correction of total anomalous pulmonary venous drainage (TAPVD) in neonates and infants. Eur. J. Cardiothorac. Surg. 10 (6), 433\u2013438 (1996).","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"2","key":"15769_CR13","first-page":"254","volume":"39","author":"SY Hu","year":"2023","unstructured":"Hu, S. Y. et al. Total anomalous pulmonary venous connection: surgical outcomes and risk factors for postoperative pulmonary vein obstruction. Acta Cardiol. Sin. 39 (2), 254\u2013265 (2023).","journal-title":"Acta Cardiol. Sin"},{"key":"15769_CR14","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.xjon.2022.09.008","volume":"12","author":"A Schulz","year":"2022","unstructured":"Schulz, A. et al. Outcomes of total anomalous pulmonary venous drainage repair in neonates and the impact of pulmonary hypertension on survival. JTCVS Open. 12, 335\u2013343 (2022).","journal-title":"JTCVS Open."},{"key":"15769_CR15","doi-asserted-by":"publisher","first-page":"733253","DOI":"10.3389\/fcvm.2022.733253","volume":"9","author":"L Chen","year":"2022","unstructured":"Chen, L. et al. Clinical nomogram for predicting the prognosis of patients with pulmonary venous obstruction after total anomalous pulmonary venous connection repair. Front. Cardiovasc. Med. 9, 733253 (2022).","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"15769_CR16","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.athoracsur.2017.05.052","volume":"105","author":"JD St Louis","year":"2018","unstructured":"St Louis, J. D. et al. Long-Term Transplant-Free survival after repair of total anomalous pulmonary venous connection. Ann. Thorac. Surg. 105 (1), 186\u2013192 (2018).","journal-title":"Ann. Thorac. Surg."},{"issue":"9 Suppl","key":"15769_CR17","first-page":"II12","volume":"94","author":"K Bando","year":"1996","unstructured":"Bando, K. et al. Surgical management of total anomalous pulmonary venous connection. Thirty-year trends. Circulation 94 (9 Suppl), II12\u2013II16 (1996).","journal-title":"Circulation"},{"issue":"2","key":"15769_CR18","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.athoracsur.2004.07.005","volume":"79","author":"CL Hancock Friesen","year":"2005","unstructured":"Hancock Friesen, C. L. et al. Total anomalous pulmonary venous connection: an analysis of current management strategies in a single institution. Ann. Thorac. Surg. 79 (2), 596\u2013606 (2005).","journal-title":"Ann. Thorac. Surg."},{"issue":"12","key":"15769_CR19","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1161\/CIRCULATIONAHA.106.635441","volume":"115","author":"T Karamlou","year":"2007","unstructured":"Karamlou, T. et al. Factors associated with mortality and reoperation in 377 children with total anomalous pulmonary venous connection. Circulation 115 (12), 1591\u20131598 (2007).","journal-title":"Circulation"},{"issue":"9","key":"15769_CR20","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1136\/hrt.2007.122671","volume":"94","author":"J Billett","year":"2008","unstructured":"Billett, J. et al. Comorbidity, healthcare utilisation and process of care measures in patients with congenital heart disease in the UK: cross-sectional, population-based study with case\u2013control analysis. Heart 94 (9), 1194\u20131199 (2008).","journal-title":"Heart"},{"issue":"2","key":"15769_CR21","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3390\/jcm10020314","volume":"10","author":"SJ Maurer","year":"2021","unstructured":"Maurer, S. J. et al. Acquired comorbidities in adults with congenital heart disease: an analysis of the German National register for congenital heart defects. J. Clin. Med. 10 (2), 314 (2021).","journal-title":"J. Clin. Med."},{"key":"15769_CR22","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ijcard.2017.02.118","volume":"240","author":"I Bracher","year":"2017","unstructured":"Bracher, I. et al. Burden and impact of congenital syndromes and comorbidities among adults with congenital heart disease. Int. J. Cardiol. 240, 159\u2013164 (2017).","journal-title":"Int. J. Cardiol."},{"key":"15769_CR23","doi-asserted-by":"crossref","unstructured":"Nelson, E. C. et al. Patient focused registries can improve health, care, and science. Bmj, 354. (2016).","DOI":"10.1136\/bmj.i3319"},{"issue":"4","key":"15769_CR24","first-page":"A12220796","volume":"70","author":"ST S\u00f8rensen","year":"2023","unstructured":"S\u00f8rensen, S. T. et al. Health registries as research tools: a review of methodological key issues. Dan. Med. J. 70 (4), A12220796 (2023).","journal-title":"Dan. Med. J."},{"issue":"25","key":"15769_CR25","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1161\/CIRCULATIONAHA.116.023544","volume":"133","author":"JK Triedman","year":"2016","unstructured":"Triedman, J. K. & Newburger, J. W. Trends in congenital heart disease: the next decade. Circulation 133 (25), 2716\u20132733 (2016).","journal-title":"Circulation"},{"issue":"1","key":"15769_CR26","doi-asserted-by":"publisher","first-page":"12999","DOI":"10.1038\/s41598-024-63853-8","volume":"14","author":"PV Madsen","year":"2024","unstructured":"Madsen, P. V. et al. Pediatric health service utilization at tertiary hospitals in Denmark 2000\u20132018. Sci. Rep. 14 (1), 12999 (2024).","journal-title":"Sci. Rep."},{"issue":"12","key":"15769_CR27","doi-asserted-by":"publisher","first-page":"e0226045","DOI":"10.1371\/journal.pone.0226045","volume":"14","author":"A Jensen","year":"2019","unstructured":"Jensen, A. et al. Risk factors of post-discharge under-five mortality among Danish children 1997\u20132016: A register-based study. PLoS One. 14 (12), e0226045 (2019).","journal-title":"PLoS One"},{"key":"15769_CR28","unstructured":"NOMESCO. Classification of Surgical Procedures. http:\/\/norden.diva-portal.org\/smash\/get\/diva2:968721\/FULLTEXT01.pdf (2024)."},{"key":"15769_CR29","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/CLEP.S91125","volume":"7","author":"M Schmidt","year":"2015","unstructured":"Schmidt, M. et al. The Danish National patient registry: a review of content, data quality, and research potential. Clin. Epidemiol. 7, 449\u2013490 (2015).","journal-title":"Clin. Epidemiol."},{"issue":"1","key":"15769_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s10654-018-0356-1","volume":"33","author":"M Bliddal","year":"2018","unstructured":"Bliddal, M. et al. The Danish medical birth register. Eur. J. Epidemiol. 33 (1), 27\u201336 (2018).","journal-title":"Eur. J. Epidemiol."},{"issue":"8","key":"15769_CR31","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","volume":"29","author":"M Schmidt","year":"2014","unstructured":"Schmidt, M., Pedersen, L. & Sorensen, H. T. The Danish civil registration system as a tool in epidemiology. Eur. J. Epidemiol. 29 (8), 541\u2013549 (2014).","journal-title":"Eur. J. Epidemiol."},{"issue":"282","key":"15769_CR32","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EL Kaplan","year":"1958","unstructured":"Kaplan, E. L. & Meier, P. Nonparametric Estimation from incomplete observations. J. Am. Stat. Assoc. 53 (282), 457\u2013481 (1958).","journal-title":"J. Am. Stat. Assoc."},{"issue":"2","key":"15769_CR33","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"DR Cox","year":"1972","unstructured":"Cox, D. R. Regression models and Life-Tables. J. Royal Stat. Soc. Ser. B (Methodological). 34 (2), 187\u2013220 (1972).","journal-title":"J. Royal Stat. Soc. Ser. B (Methodological)"},{"key":"15769_CR34","unstructured":"Therneau, T. M. A Package for Survival Analysis in R. https:\/\/cran.r-project.org\/web\/packages\/survival\/vignettes\/survival.pdf (2023)."},{"key":"15769_CR35","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing). https:\/\/www.R-project.org\/ (2024)."},{"key":"15769_CR36","unstructured":"EU. General Data Protection Regulation (GDPR). https:\/\/gdpr.eu\/ (2025)."},{"key":"15769_CR37","unstructured":"Statistics Denmark. Rules for Data Safety under the Microdata Scheme: Rules for Transferring Analysis Results and Sanctions in Case of Data Breach. https:\/\/www.dst.dk\/Site\/Dst\/SingleFiles\/GetArchiveFile.aspx?fi=38014105383&fo=0&ext=forskning (2024)."},{"key":"15769_CR38","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00246-018-1948-y","volume":"40","author":"Y Wu","year":"2019","unstructured":"Wu, Y. et al. Is sutureless technique beneficial in the primary repair of total anomalous pulmonary venous connection? A systematic review and meta-analysis. Pediatr. Cardiol. 40, 881\u2013891 (2019).","journal-title":"Pediatr. Cardiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15769-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15769-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15769-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T07:32:57Z","timestamp":1757403177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-15769-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["15769"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-15769-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"6 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30408"}}