{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:43:14Z","timestamp":1794084194122,"version":"4.8.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100008628","name":"Institut for Klinisk Medicin, Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008628","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Research Foundation of Central Denmark Region"},{"DOI":"10.13039\/501100009910","name":"Hartmann Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009910","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Carl og Ellen Hertz\u2019 Fond"},{"name":"Dansk Lymfom Gruppe"},{"DOI":"10.13039\/501100008267","name":"Kong Christian den Tiendes Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007436","name":"Torben og Alice Frimodts Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonden af 1870"},{"DOI":"10.13039\/501100010347","name":"Fabrikant Einar Willumsens Mindelegat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006426","name":"Eva og Henry Fr\u00e6nkels Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007460","name":"Arvid Nilssons Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008262","name":"Harboefonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008262","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Slagtermester Max W\u00f8rzner og hustru W\u00f8rzner\u2019s Mindelegat"},{"name":"A. P. M\u00f8ller Fonden: Fonden til L\u00e6gevidenskabens Fremme"},{"DOI":"10.13039\/501100021851","name":"William Demant Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-16218-8","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T20:57:45Z","timestamp":1755550665000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lymph node transcriptomic profiles suggest susceptibility to bleomycin-induced pulmonary toxicity in classic hodgkin lymphoma"],"prefix":"10.1038","volume":"15","author":[{"given":"Maja Dam","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Hairing","family":"Enemark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina Lystlund","family":"Lauridsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Jacques","family":"Hamilton-Dutoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Starklint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"d\u2019Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Ludvigsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kamper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"16218_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1177\/2040620711402414","volume":"2","author":"DJ Straus","year":"2011","unstructured":"Straus, D. J. Long-term survivorship at a price: late-term, therapy-associated toxicities in the adult hodgkin lymphoma patient. Ther. Adv. Hematol. 2, 111\u2013119 (2011).","journal-title":"Ther. Adv. Hematol."},{"key":"16218_CR2","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1002\/ajh.25856","volume":"95","author":"SM Ansell","year":"2020","unstructured":"Ansell, S. M. & Hodgkin lymphoma A 2020 update on diagnosis, risk-stratification, and management. Am. J. Hematol. 95, 978\u2013989 (2020).","journal-title":"Am. J. Hematol."},{"key":"16218_CR3","doi-asserted-by":"crossref","unstructured":"Canellos, G. & Duggan, D. How Important Is Bleomycin in the Adriamycin\u2009+\u2009Bleomycin\u2009+\u2009Vinblastine\u2009+\u2009Dacarbazine Regimen? In. (ed)^(eds), ; 1531\u20131532. (2004).","DOI":"10.1200\/JCO.2004.99.010"},{"key":"16218_CR4","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1200\/JCO.2003.12.086","volume":"21","author":"DB Duggan","year":"2003","unstructured":"Duggan, D. B. et al. Randomized comparison of ABVD and MOPP\/ABV hybrid for the treatment of advanced hodgkin\u2019s disease: report of an intergroup trial. J. Clin. Oncol. 21, 607\u2013614 (2003).","journal-title":"J. Clin. Oncol."},{"key":"16218_CR5","doi-asserted-by":"publisher","first-page":"7614","DOI":"10.1200\/JCO.2005.02.7243","volume":"23","author":"WG Martin","year":"2005","unstructured":"Martin, W. G. et al. Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with hodgkin\u2019s lymphoma. J. Clin. Oncol. 23, 7614\u20137620 (2005).","journal-title":"J. Clin. Oncol."},{"key":"16218_CR6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00277-010-1032-z","volume":"90","author":"J Ngeow","year":"2011","unstructured":"Ngeow, J. et al. Prognostic impact of bleomycin-induced pneumonitis on the outcome of hodgkin\u2019s lymphoma. Ann. Hematol. 90, 67\u201372 (2011).","journal-title":"Ann. Hematol."},{"key":"16218_CR7","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1080\/10428194.2018.1515939","volume":"60","author":"MD Andersen","year":"2019","unstructured":"Andersen, M. D. et al. The incidence of bleomycin induced lung toxicity is increased in hodgkin lymphoma patients over 45 years exposed to granulocyte-colony stimulating growth factor (\u2020). Leuk. Lymphoma. 60, 927\u2013933 (2019).","journal-title":"Leuk. Lymphoma"},{"key":"16218_CR8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1378\/chest.120.2.617","volume":"120","author":"S Sleijfer","year":"2001","unstructured":"Sleijfer, S. Bleomycin-induced pneumonitis. Chest 120, 617\u2013624 (2001).","journal-title":"Chest"},{"key":"16218_CR9","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0954-6111(99)90080-X","volume":"93","author":"LJ Couderc","year":"1999","unstructured":"Couderc, L. J. et al. Pulmonary toxicity of chemotherapy and G\/GM-CSF: A report of five cases. Respir. Med. 93, 65\u201368 (1999).","journal-title":"Respir. Med."},{"key":"16218_CR10","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.ijrobp.2016.08.018","volume":"96","author":"Z Abou Yehia","year":"2016","unstructured":"Abou Yehia, Z. et al. Does bleomycin lung toxicity increase the risk of radiation pneumonitis in hodgkin lymphoma? Int. J. Radiat. Oncol. Biol. Phys. 96, 951\u2013958 (2016).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"16218_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/annonc\/mdg020","volume":"14","author":"JM O\u2019Sullivan","year":"2003","unstructured":"O\u2019Sullivan, J. M. et al. Predicting the risk of bleomycin lung toxicity in patients with germ-cell tumours. Ann. Oncol. 14, 91\u201396 (2003).","journal-title":"Ann. Oncol."},{"key":"16218_CR12","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1080\/10428194.2019.1663419","volume":"61","author":"K Taparra","year":"2020","unstructured":"Taparra, K. et al. Bleomycin use in the treatment of hodgkin lymphoma (HL): toxicity and outcomes in the modern era. Leuk. Lymphoma. 61, 298\u2013308 (2020).","journal-title":"Leuk. Lymphoma"},{"key":"16218_CR13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41568-021-00347-z","volume":"21","author":"KJ Hiam-Galvez","year":"2021","unstructured":"Hiam-Galvez, K. J., Allen, B. M. & Spitzer, M. H. Systemic immunity in cancer. Nat. Rev. Cancer. 21, 345\u2013359 (2021).","journal-title":"Nat. Rev. Cancer"},{"key":"16218_CR14","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1182\/blood-2008-07-168096","volume":"113","author":"B Chetaille","year":"2009","unstructured":"Chetaille, B. et al. Molecular profiling of classical hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome. Blood 113, 2765\u20133775 (2009).","journal-title":"Blood"},{"key":"16218_CR15","doi-asserted-by":"publisher","first-page":"102995","DOI":"10.1016\/j.copbio.2023.102995","volume":"84","author":"SE Pilley","year":"2023","unstructured":"Pilley, S. E., Esparza, E. & Mullen, P. J. The aging tumor metabolic microenvironment. Curr. Opin. Biotechnol. 84, 102995 (2023).","journal-title":"Curr. Opin. Biotechnol."},{"key":"16218_CR16","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1200\/JCO.2010.32.8401","volume":"29","author":"C Steidl","year":"2011","unstructured":"Steidl, C., Connors, J. M. & Gascoyne, R. D. Molecular pathogenesis of hodgkin\u2019s lymphoma: increasing evidence of the importance of the microenvironment. J. Clin. Oncol. 29, 1812\u20131826 (2011).","journal-title":"J. Clin. Oncol."},{"key":"16218_CR17","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1046\/j.1365-2559.2001.01083.x","volume":"38","author":"K Ohshima","year":"2001","unstructured":"Ohshima, K. et al. Interleukin-13 and interleukin-13 receptor in hodgkin\u2019s disease: possible autocrine mechanism and involvement in fibrosis. Histopathology 38, 368\u2013375 (2001).","journal-title":"Histopathology"},{"key":"16218_CR18","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1002\/1097-0142(19870515)59:10<1717::AID-CNCR2820591007>3.0.CO;2-U","volume":"59","author":"HJ Ree","year":"1987","unstructured":"Ree, H. J., Crowley, J. P. & Dinarello, C. A. Anti-interleukin-1 reactive cells in hodgkin\u2019s disease. Cancer 59, 1717\u20131720 (1987).","journal-title":"Cancer"},{"key":"16218_CR19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1046\/j.1365-2141.2002.03575.x","volume":"118","author":"GM Reynolds","year":"2002","unstructured":"Reynolds, G. M. et al. Interleukin 6 expression by Hodgkin\/Reed-Sternberg cells is associated with the presence of \u2018B\u2019 symptoms and failure to achieve complete remission in patients with advanced hodgkin\u2019s disease. Br. J. Haematol. 118, 195\u2013201 (2002).","journal-title":"Br. J. Haematol."},{"key":"16218_CR20","doi-asserted-by":"publisher","first-page":"102631","DOI":"10.1016\/j.ebiom.2020.102631","volume":"52","author":"L Wang","year":"2020","unstructured":"Wang, L. et al. Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes. EBioMedicine 52, 102631 (2020).","journal-title":"EBioMedicine"},{"key":"16218_CR21","doi-asserted-by":"publisher","first-page":"6328","DOI":"10.1038\/s41598-021-85948-2","volume":"11","author":"S Nakamoto","year":"2021","unstructured":"Nakamoto, S. et al. Systemic immunity markers associated with lymphocytes predict the survival benefit from Paclitaxel plus bevacizumab in HER2 negative advanced breast cancer. Sci. Rep. 11, 6328 (2021).","journal-title":"Sci. Rep."},{"key":"16218_CR22","doi-asserted-by":"crossref","unstructured":"Ishida, Y. et al. Immune Mechanisms of Pulmonary Fibrosis with Bleomycin. Int J. Mol. Sci. 24(4), 3149 (2023).","DOI":"10.3390\/ijms24043149"},{"key":"16218_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0157999","volume":"11","author":"B Arboe","year":"2016","unstructured":"Arboe, B. et al. The Danish National lymphoma registry: coverage and data quality. PLoS ONE. 11, 1\u201312 (2016).","journal-title":"PLoS ONE"},{"key":"16218_CR24","doi-asserted-by":"publisher","first-page":"577","DOI":"10.2147\/CLEP.S99470","volume":"8","author":"B Arboe","year":"2016","unstructured":"Arboe, B. et al. Danish National lymphoma registry. Clin. Epidemiol. 8, 577\u2013581 (2016).","journal-title":"Clin. Epidemiol."},{"key":"16218_CR25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2147\/CLEP.S9908","volume":"2","author":"R Erichsen","year":"2010","unstructured":"Erichsen, R. et al. Existing data sources for clinical epidemiology: the Danish National pathology registry and data bank. Clin. Epidemiol. 2, 51\u201356 (2010).","journal-title":"Clin. Epidemiol."},{"key":"16218_CR26","unstructured":"Swerdlow, S. H. et al. ,. WHO classification of tumours of haematopoietic and lymphoid tissues, Revised 4th Edition. Lyon, France: IARC Press ; 2. (2017)."},{"key":"16218_CR27","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1080\/10428194.2018.1515939","volume":"60","author":"MD Andersen","year":"2019","unstructured":"Andersen, M. D. et al. The incidence of bleomycin induced lung toxicity is increased in hodgkin lymphoma patients over 45 years exposed to granulocyte-colony stimulating growth factor. Leuk. Lymphoma. 60, 927\u2013933 (2019).","journal-title":"Leuk. Lymphoma"},{"key":"16218_CR28","doi-asserted-by":"crossref","unstructured":"Andersen, M. D. et al. Proteomic profiling identifies classic Hodgkin lymphoma patients at risk of bleomycin pulmonary toxicity. Leukemia & Lymphoma 66(4), 656\u2013667 (2024).","DOI":"10.1080\/10428194.2024.2434170"},{"key":"16218_CR29","doi-asserted-by":"publisher","first-page":"109105","DOI":"10.1016\/j.clim.2022.109105","volume":"243","author":"X Wang","year":"2022","unstructured":"Wang, X. et al. A novel immune-related epigenetic signature based on the transcriptome for predicting the prognosis and therapeutic response of patients with diffuse large B-cell lymphoma. Clin. Immunol. 243, 109105 (2022).","journal-title":"Clin. Immunol."},{"key":"16218_CR30","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk, D. et al. STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47, D607\u2013D613 (2019).","journal-title":"Nucleic Acids Res."},{"key":"16218_CR31","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","volume":"18","author":"NT Doncheva","year":"2019","unstructured":"Doncheva, N. T. et al. Cytoscape stringapp: network analysis and visualization of proteomics data. J. Proteome Res. 18, 623\u2013632 (2019).","journal-title":"J. Proteome Res."},{"key":"16218_CR32","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk, D. et al. The STRING database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res. 49, D605\u2013D612 (2021).","journal-title":"Nucleic Acids Res."},{"key":"16218_CR33","doi-asserted-by":"crossref","unstructured":"Andersen Maja, D. et al., Proteomic Profiling of Lymph Nodes Differentiates Classic Hodgkin Lymphoma With and Without Skeletal Involvement. European J. Haematol. 114, 173\u2013185 (2024).","DOI":"10.1111\/ejh.14326"},{"key":"16218_CR34","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/ejh.12583","volume":"96","author":"MD Andersen","year":"2016","unstructured":"Andersen, M. D. et al. Tumour-associated mast cells in classical hodgkin\u2019s lymphoma: correlation with histological subtype, other tumour-infiltrating inflammatory cell subsets and outcome. Eur. J. Haematol. 96, 252\u2013259 (2016).","journal-title":"Eur. J. Haematol."},{"key":"16218_CR35","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","volume":"37","author":"AM Newman","year":"2019","unstructured":"Newman, A. M. et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat. Biotechnol. 37, 773\u2013782 (2019).","journal-title":"Nat. Biotechnol."},{"key":"16218_CR36","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1182\/blood-2006-04-017434","volume":"108","author":"Y Han","year":"2006","unstructured":"Han, Y. et al. Loss of SHP1 enhances JAK3\/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK\u2009+\u2009anaplastic large-cell lymphoma. Blood 108, 2796\u20132803 (2006).","journal-title":"Blood"},{"key":"16218_CR37","doi-asserted-by":"crossref","unstructured":"Vadivel, C. K. et al. JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL). Cancers (Basel) 13, 280 (2021).","DOI":"10.3390\/cancers13020280"},{"key":"16218_CR38","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1242\/jcs.00963","volume":"117","author":"JS Rawlings","year":"2004","unstructured":"Rawlings, J. S., Rosler, K. M. & Harrison, D. A. The JAK\/STAT signaling pathway. J. Cell. Sci. 117, 1281\u20131283 (2004).","journal-title":"J. Cell. Sci."},{"key":"16218_CR39","doi-asserted-by":"crossref","unstructured":"Liu, J., Wang, F. & Luo, F. The role of JAK\/STAT pathway in fibrotic diseases: molecular and cellular mechanisms. Biomolecules 13(1) (2023).","DOI":"10.3390\/biom13010119"},{"key":"16218_CR40","doi-asserted-by":"crossref","unstructured":"Montero, P. et al. Role of JAK\/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms. Int J. Mol. Sci.  22(12), 6211 (2021).","DOI":"10.3390\/ijms22126211"},{"key":"16218_CR41","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12931-018-0728-9","volume":"19","author":"J Milara","year":"2018","unstructured":"Milara, J. et al. The JAK2 pathway is activated in idiopathic pulmonary fibrosis. Respir. Res. 19, 24 (2018).","journal-title":"Respir. Res."},{"key":"16218_CR42","doi-asserted-by":"publisher","first-page":"115254","DOI":"10.1016\/j.bmc.2019.115254","volume":"28","author":"Y Zhu","year":"2020","unstructured":"Zhu, Y. et al. Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis. Bioorg. Med. Chem. 28, 115254 (2020).","journal-title":"Bioorg. Med. Chem."},{"key":"16218_CR43","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41698-024-00522-z","volume":"8","author":"S Wang","year":"2024","unstructured":"Wang, S. et al. Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance. NPJ Precis Oncol. 8, 31 (2024).","journal-title":"NPJ Precis Oncol."},{"key":"16218_CR44","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1158\/0008-5472.CAN-05-4005","volume":"66","author":"CE Lewis","year":"2006","unstructured":"Lewis, C. E. & Pollard, J. W. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66, 605\u2013612 (2006).","journal-title":"Cancer Res."},{"key":"16218_CR45","doi-asserted-by":"publisher","first-page":"15025","DOI":"10.1038\/npjbcancer.2015.25","volume":"2","author":"CB Williams","year":"2016","unstructured":"Williams, C. B., Yeh, E. S. & Soloff, A. C. Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy. NPJ Breast Cancer. 2, 15025 (2016).","journal-title":"NPJ Breast Cancer"},{"key":"16218_CR46","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ccell.2015.02.015","volume":"27","author":"B Ruffell","year":"2015","unstructured":"Ruffell, B. & Coussens, L. M. Macrophages and therapeutic resistance in cancer. Cancer Cell. 27, 462\u2013472 (2015).","journal-title":"Cancer Cell."},{"key":"16218_CR47","doi-asserted-by":"publisher","first-page":"e87066","DOI":"10.1371\/journal.pone.0087066","volume":"9","author":"YW Koh","year":"2014","unstructured":"Koh, Y. W. et al. CD163 expression was associated with angiogenesis and shortened survival in patients with uniformly treated classical hodgkin lymphoma. PLoS One. 9, e87066 (2014).","journal-title":"PLoS One"},{"key":"16218_CR48","doi-asserted-by":"publisher","first-page":"6443","DOI":"10.1007\/s11033-021-06646-w","volume":"48","author":"SM Zhang","year":"2021","unstructured":"Zhang, S. M. et al. M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1\/2, and STAT3 signaling pathways. Mol. Biol. Rep. 48, 6443\u20136456 (2021).","journal-title":"Mol. Biol. Rep."},{"key":"16218_CR49","doi-asserted-by":"publisher","first-page":"110070","DOI":"10.1016\/j.intimp.2023.110070","volume":"118","author":"Q Luo","year":"2023","unstructured":"Luo, Q. et al. TREM2 insufficiency protects against pulmonary fibrosis by inhibiting M2 macrophage polarization. Int. Immunopharmacol. 118, 110070 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"16218_CR50","doi-asserted-by":"publisher","first-page":"108271","DOI":"10.1016\/j.intimp.2021.108271","volume":"101","author":"S Li","year":"2021","unstructured":"Li, S. et al. Clevudine attenuates bleomycin-induced early pulmonary fibrosis via regulating M2 macrophage polarization. Int. Immunopharmacol. 101, 108271 (2021).","journal-title":"Int. Immunopharmacol."},{"key":"16218_CR51","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s00262-017-2023-x","volume":"66","author":"W van der Touw","year":"2017","unstructured":"van der Touw, W. et al. LILRB receptor-mediated regulation of myeloid cell maturation and function. Cancer Immunol. Immunother. 66, 1079\u20131087 (2017).","journal-title":"Cancer Immunol. Immunother"},{"key":"16218_CR52","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1038\/s43018-021-00262-0","volume":"2","author":"G Wu","year":"2021","unstructured":"Wu, G. et al. LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2-cFLIP-NF-\u03baB signaling axis. Nat. Cancer. 2, 1170\u20131184 (2021).","journal-title":"Nat. Cancer"},{"key":"16218_CR53","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1165\/rcmb.2012-0329OC","volume":"48","author":"D Karo-Atar","year":"2013","unstructured":"Karo-Atar, D. et al. Paired immunoglobulin-like receptor-B inhibits pulmonary fibrosis by suppressing profibrogenic properties of alveolar macrophages. Am. J. Respir Cell. Mol. Biol. 48, 456\u2013464 (2013).","journal-title":"Am. J. Respir Cell. Mol. Biol."},{"key":"16218_CR54","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.immuni.2014.02.012","volume":"40","author":"N Joller","year":"2014","unstructured":"Joller, N. et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit Proinflammatory Th1 and Th17 cell responses. Immunity 40, 569\u2013581 (2014).","journal-title":"Immunity"},{"key":"16218_CR55","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.4049\/jimmunol.1003081","volume":"186","author":"N Joller","year":"2011","unstructured":"Joller, N. et al. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J. Immunol. 186, 1338\u20131342 (2011).","journal-title":"J. Immunol."},{"key":"16218_CR56","unstructured":"Nanostring, T. MAN-10083-01 nCounter\u00aeGene Expression PanelsOverview [Accessed September 2024]."},{"key":"16218_CR57","doi-asserted-by":"crossref","unstructured":"Kulkarni, M. M. Digital Multiplexed Gene Expression Analysis Using the NanoString nCounter System. Current Protocols in Molecular Biology ; 94: 25B.10.21-25B.10.17. (2011).","DOI":"10.1002\/0471142727.mb25b10s94"},{"key":"16218_CR58","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/978-1-4939-9904-0_10","volume":"2079","author":"A Goytain","year":"2020","unstructured":"Goytain, A. & Ng, T. NanoString nCounter technology: High-Throughput RNA validation. Methods Mol. Biol. 2079, 125\u2013139 (2020).","journal-title":"Methods Mol. Biol."},{"key":"16218_CR59","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1472-6750-11-46","volume":"11","author":"PP Reis","year":"2011","unstructured":"Reis, P. P. et al. mRNA transcript quantification in archival samples using multiplexed, color-coded probes. BMC Biotechnol. 11, 46 (2011).","journal-title":"BMC Biotechnol."},{"key":"16218_CR60","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1158\/0008-5472.CAN-15-0262","volume":"75","author":"MH Veldman-Jones","year":"2015","unstructured":"Veldman-Jones, M. H. et al. Evaluating robustness and sensitivity of the NanoString technologies nCounter platform to enable multiplexed gene expression analysis of clinical samples. Cancer Res. 75, 2587\u20132593 (2015).","journal-title":"Cancer Res."},{"key":"16218_CR61","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.cancergen.2022.10.143","volume":"268\u2013269","author":"C-M Zheng","year":"2022","unstructured":"Zheng, C-M. et al. Study on the use of Nanostring nCounter to analyze RNA extracted from formalin-fixed-paraffin-embedded and fresh frozen bladder cancer tissues. Cancer Genet. 268\u2013269, 137\u2013143 (2022).","journal-title":"Cancer Genet."},{"key":"16218_CR62","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1080\/14737159.2019.1623672","volume":"19","author":"JM Eastel","year":"2019","unstructured":"Eastel, J. M. et al. Application of NanoString technologies in companion diagnostic development. Expert Rev. Mol. Diagn. 19, 591\u2013598 (2019).","journal-title":"Expert Rev. Mol. Diagn."},{"key":"16218_CR63","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"16218_CR64","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kramer","year":"2014","unstructured":"Kramer, A. et al. Causal analysis approaches in ingenuity pathway analysis. Bioinformatics 30, 523\u2013530 (2014).","journal-title":"Bioinformatics"},{"key":"16218_CR65","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. 9, 559 (2008).","journal-title":"BMC Bioinform."},{"key":"16218_CR66","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1182\/bloodadvances.2021006189","volume":"6","author":"K Karihtala","year":"2022","unstructured":"Karihtala, K. et al. Checkpoint protein expression in the tumor microenvironment defines the outcome of classical hodgkin lymphoma patients. Blood Adv. 6, 1919\u20131931 (2022).","journal-title":"Blood Adv."},{"key":"16218_CR67","doi-asserted-by":"crossref","unstructured":"Leivonen, S. K. et al. Characterization and clinical impact of the tumor microenvironment in post-transplant aggressive B-cell lymphomas. Haematologica 108(11), (2023).","DOI":"10.3324\/haematol.2023.282831"},{"key":"16218_CR68","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.3390\/cancers16203553","volume":"16","author":"MH Enemark","year":"2024","unstructured":"Enemark, M. H. et al. Impact of the immune landscape in follicular lymphoma: insights into histological transformation in the rituximab era. Cancers 16, 3553 (2024).","journal-title":"Cancers"},{"key":"16218_CR69","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman, A. M. et al. Robust enumeration of cell subsets from tissue expression profiles. Nat. Methods. 12, 453\u2013457 (2015).","journal-title":"Nat. Methods"},{"key":"16218_CR70","doi-asserted-by":"publisher","first-page":"116116","DOI":"10.1016\/j.biopha.2023.116116","volume":"171","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. The role of matrix metalloproteinase 9 in fibrosis diseases and its molecular mechanisms. Biomed. Pharmacother. 171, 116116 (2024).","journal-title":"Biomed. Pharmacother"},{"key":"16218_CR71","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1055\/s-0043-1768166","volume":"10","author":"D Kalali","year":"2023","unstructured":"Kalali, D. The role of the matrix Metalloproteinase-9 gene in tumor development and metastasis: A narrative review. Glob Med. Genet. 10, 48\u201353 (2023).","journal-title":"Glob Med. Genet."},{"key":"16218_CR72","doi-asserted-by":"crossref","unstructured":"Stainer, A. et al. Molecular Biomarkers in Idiopathic Pulmonary Fibrosis: State of the Art and Future Directions. Int J. Mol. Sci. 22(12), 6255 (2021).","DOI":"10.3390\/ijms22126255"},{"key":"16218_CR73","doi-asserted-by":"publisher","first-page":"4403","DOI":"10.1182\/blood.V124.21.4403.4403","volume":"124","author":"L Yang","year":"2014","unstructured":"Yang, L. et al. Expression of c-MYC and MMP9 in alternatively activated macrophages (M2) of classical hodgkin lymphoma. Blood 124, 4403\u20134403 (2014).","journal-title":"Blood"},{"key":"16218_CR74","first-page":"353","volume":"152","author":"CM Giachelli","year":"1998","unstructured":"Giachelli, C. M. et al. Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Am. J. Pathol. 152, 353\u2013358 (1998).","journal-title":"Am. J. Pathol."},{"key":"16218_CR75","doi-asserted-by":"crossref","unstructured":"Chen, Y. et al. EBV promotes TCR-T-cell therapy resistance by inducing CD163\u2009+\u2009M2 macrophage polarization and MMP9 secretion. J. Immunother Cancer 12, e008375 (2024).","DOI":"10.1136\/jitc-2023-008375"},{"key":"16218_CR76","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.3390\/biomedicines9121747","volume":"9","author":"L Lis-L\u00f3pez","year":"2021","unstructured":"Lis-L\u00f3pez, L. et al. Is the macrophage phenotype determinant for fibrosis development? Biomedicines 9, 1747 (2021).","journal-title":"Biomedicines"},{"key":"16218_CR77","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/s41576-020-0258-4","volume":"21","author":"C Buccitelli","year":"2020","unstructured":"Buccitelli, C. & Selbach, M. mRNAs, proteins and the emerging principles of gene expression control. Nat. Rev. Genet. 21, 630\u2013644 (2020).","journal-title":"Nat. Rev. Genet."},{"key":"16218_CR78","doi-asserted-by":"publisher","first-page":"e1005535","DOI":"10.1371\/journal.pcbi.1005535","volume":"13","author":"A Franks","year":"2017","unstructured":"Franks, A., Airoldi, E. & Slavov, N. Post-transcriptional regulation across human tissues. PLoS Comput. Biol. 13, e1005535 (2017).","journal-title":"PLoS Comput. Biol."},{"key":"16218_CR79","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1182\/blood-2002-04-1128","volume":"101","author":"JF Garc\u00eda","year":"2003","unstructured":"Garc\u00eda, J. F. et al. Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays. Blood 101, 681\u2013689 (2003).","journal-title":"Blood"},{"key":"16218_CR80","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3324\/haematol.2010.031542","volume":"96","author":"P Kamper","year":"2011","unstructured":"Kamper, P. et al. Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical hodgkin\u2019s lymphoma. Haematologica 96, 269\u2013276 (2011).","journal-title":"Haematologica"},{"key":"16218_CR81","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1182\/blood-2015-11-681064","volume":"127","author":"B B\u00f6ll","year":"2016","unstructured":"B\u00f6ll, B. et al. Bleomycin in older early-stage favorable hodgkin lymphoma patients: analysis of the German hodgkin study group (GHSG) HD10 and HD13 trials. Blood 127, 2189\u20132192 (2016).","journal-title":"Blood"},{"key":"16218_CR82","doi-asserted-by":"crossref","unstructured":"Bauer, K. et al., Comparison of chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for patients with early unfavourable or advanced stage Hodgkin lymphoma. Cochrane Database Syst Rev 2011: Cd007941..","DOI":"10.1002\/14651858.CD007941.pub2"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16218-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16218-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16218-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T07:41:03Z","timestamp":1757403663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16218-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":82,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["16218"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-16218-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,18]]},"assertion":[{"value":"28 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30273"}}