{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:48:57Z","timestamp":1793638137136,"version":"4.5.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007465","name":"UiT The Arctic University of Norway","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>The relationship between alcohol consumption levels and carotid atherosclerosis remains controversial. We investigated this association in 2357 general population participants and 272 in-patients treated for alcohol-related disorders (narcology patients) aged 35\u201369 years in Arkhangelsk, Russia (Know Your Heart study, 2015\u20132017). Participants were categorized as non-drinking, non-problem drinking, hazardous drinking, harmful drinking, and narcology patients. Carotid atherosclerosis was assessed via carotid intima-media thickness (CIMT), plaque score (0\u20136 points), and presence of stenosis\u2009\u2265\u200950%. We used quantile regression for CIMT, linear regression for plaque score, and logistic regression for stenosis. Models were adjusted for sociodemographic factors and dysmetabolic conditions (abdominal obesity, dyslipidemia, hypertension, diabetes, and systemic inflammation). Compared to non-problem drinking, narcology patients had significantly higher CIMT (+\u20090.05\u00a0mm), plaque score (+\u20090.57 points), and odds of stenosis (OR\u2009=\u20092.10) independent of dysmetabolic conditions. Hazardous drinking participants had higher CIMT (+\u20090.03\u00a0mm) and plaque score (+\u20090.15 points), which became non-significant after adjusting for hypertension. Harmful drinking participants did not differ in atherosclerosis markers from those with non-problem drinking. Non-drinking participants had higher CIMT (+\u20090.02\u00a0mm) and plaque score (+\u20090.30 points). These findings in a middle-aged Russian population suggest that chronic severe alcohol consumption can affect carotid artery walls directly, while hazardous drinking is linked to atherosclerosis through hypertensive mechanisms.<\/jats:p>","DOI":"10.1038\/s41598-025-16290-0","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:23:05Z","timestamp":1756326185000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between alcohol consumption and carotid atherosclerosis in Russia"],"prefix":"10.1038","volume":"15","author":[{"given":"Nikita A.","family":"Mitkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Ryabikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Mirolyubova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulker G.","family":"Guseinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Solovieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Soloviev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Malyutina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Kudryavtsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"16290_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/life13081783","author":"C Imtiaz","year":"2023","unstructured":"Imtiaz, C. et al. Focused ultrasound, an emerging tool for atherosclerosis treatment: A comprehensive review. Life (Basel) https:\/\/doi.org\/10.3390\/life13081783 (2023).","journal-title":"Life (Basel)"},{"key":"16290_CR2","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrcardio.2016.179","volume":"14","author":"FG Fowkes","year":"2017","unstructured":"Fowkes, F. G. et al. Peripheral artery disease: Epidemiology and global perspectives. Nat. Rev. Cardiol. 14, 156\u2013170. https:\/\/doi.org\/10.1038\/nrcardio.2016.179 (2017).","journal-title":"Nat. Rev. Cardiol."},{"key":"16290_CR3","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","volume":"116","author":"MH Criqui","year":"2015","unstructured":"Criqui, M. H. & Aboyans, V. Epidemiology of peripheral artery disease. Circ. Res. 116, 1509\u20131526. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303849 (2015).","journal-title":"Circ. Res."},{"key":"16290_CR4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s10654-015-0092-8","volume":"31","author":"M Bobak","year":"2016","unstructured":"Bobak, M. et al. Alcohol, drinking pattern and all-cause, cardiovascular and alcohol-related mortality in Eastern Europe. Eur. J. Epidemiol. 31, 21\u201330. https:\/\/doi.org\/10.1007\/s10654-015-0092-8 (2016).","journal-title":"Eur. J. Epidemiol."},{"key":"16290_CR5","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/S0140-6736(02)11470-X","volume":"360","author":"S Malyutina","year":"2002","unstructured":"Malyutina, S. et al. Relation between heavy and binge drinking and all-cause and cardiovascular mortality in Novosibirsk, Russia: A prospective cohort study. Lancet 360, 1448\u20131454. https:\/\/doi.org\/10.1016\/S0140-6736(02)11470-X (2002).","journal-title":"Lancet"},{"key":"16290_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.fshw.2022.07.013","volume":"12","author":"Q Kang","year":"2023","unstructured":"Kang, Q., Sun, J., Wang, B. & Sun, B. Wine, beer and Chinese Baijiu in relation to cardiovascular health: The impact of moderate drinking. Food Sci. Human Wellness 12, 1\u201313 (2023).","journal-title":"Food Sci. Human Wellness"},{"key":"16290_CR7","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.3390\/nu14112183","volume":"14","author":"LK McEvoy","year":"2022","unstructured":"McEvoy, L. K. et al. Moderate alcohol use is associated with reduced cardiovascular risk in middle-aged men independent of health, behavior, psychosocial, and earlier life factors. Nutrients 14, 2183 (2022).","journal-title":"Nutrients"},{"key":"16290_CR8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12916-021-02040-2","volume":"19","author":"C Ding","year":"2021","unstructured":"Ding, C., O\u2019Neill, D., Bell, S., Stamatakis, E. & Britton, A. Association of alcohol consumption with morbidity and mortality in patients with cardiovascular disease: original data and meta-analysis of 48,423 men and women. BMC Med. 19, 167. https:\/\/doi.org\/10.1186\/s12916-021-02040-2 (2021).","journal-title":"BMC Med."},{"key":"16290_CR9","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.atherosclerosis.2011.07.129","volume":"219","author":"S Kohsaka","year":"2011","unstructured":"Kohsaka, S. et al. Alcohol consumption and atherosclerotic burden in the proximal thoracic aorta. Atherosclerosis 219, 794\u2013798. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2011.07.129 (2011).","journal-title":"Atherosclerosis"},{"key":"16290_CR10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d636","volume":"342","author":"SE Brien","year":"2011","unstructured":"Brien, S. E., Ronksley, P. E., Turner, B. J., Mukamal, K. J. & Ghali, W. A. Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies. BMJ 342, d636. https:\/\/doi.org\/10.1136\/bmj.d636 (2011).","journal-title":"BMJ"},{"key":"16290_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.drugalcdep.2017.09.034","volume":"181","author":"NE Kelso-Chichetto","year":"2017","unstructured":"Kelso-Chichetto, N. E. et al. The impact of long-term moderate and heavy alcohol consumption on incident atherosclerosis among persons living with HIV. Drug. Alcohol. Depend. 181, 235\u2013241. https:\/\/doi.org\/10.1016\/j.drugalcdep.2017.09.034 (2017).","journal-title":"Drug. Alcohol. Depend."},{"key":"16290_CR12","doi-asserted-by":"publisher","DOI":"10.37532\/icrj.2020.9(4).406","author":"AA Getu","year":"2020","unstructured":"Getu, A. A. & S. G.,. Regular moderate alcohol consumption reduces the incidence of cardiovascular diseases: Review of evidences and plausible mechanisms. Int. J. Cardiovasc. Res. https:\/\/doi.org\/10.37532\/icrj.2020.9(4).406 (2020).","journal-title":"Int. J. Cardiovasc. Res."},{"key":"16290_CR13","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/s41430-018-0091-4","volume":"72","author":"R Golan","year":"2018","unstructured":"Golan, R. et al. Effect of wine on carotid atherosclerosis in type 2 diabetes: A 2-year randomized controlled trial. Eur. J. Clin. Nutr. 72, 871\u2013878. https:\/\/doi.org\/10.1038\/s41430-018-0091-4 (2018).","journal-title":"Eur. J. Clin. Nutr."},{"key":"16290_CR14","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1373\/clinchem.2011.181628","volume":"58","author":"KJ Mukamal","year":"2012","unstructured":"Mukamal, K. J. Understanding the mechanisms that link alcohol and lower risk of coronary heart disease. Clin. Chem. 58, 664\u2013666. https:\/\/doi.org\/10.1373\/clinchem.2011.181628 (2012).","journal-title":"Clin. Chem."},{"key":"16290_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/biom10070987","author":"C Rosales","year":"2020","unstructured":"Rosales, C., Gillard, B. K., Gotto, A. M. Jr. & Pownall, H. J. The Alcohol-High-Density Lipoprotein Athero-Protective Axis. Biomolecules https:\/\/doi.org\/10.3390\/biom10070987 (2020).","journal-title":"Biomolecules"},{"key":"16290_CR16","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12916-023-02907-6","volume":"21","author":"Y Tian","year":"2023","unstructured":"Tian, Y. et al. Alcohol consumption and all-cause and cause-specific mortality among US adults: Prospective cohort study. BMC Med. 21, 208 (2023).","journal-title":"BMC Med."},{"key":"16290_CR17","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/alcalc\/agad033","volume":"58","author":"T Norstrom","year":"2023","unstructured":"Norstrom, T. & Landberg, J. The association between population drinking and ischemic heart disease mortality in educational groups. Alcohol Alcohol 58, 385\u2013392. https:\/\/doi.org\/10.1093\/alcalc\/agad033 (2023).","journal-title":"Alcohol Alcohol"},{"key":"16290_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147822","volume":"11","author":"SG Kelly","year":"2016","unstructured":"Kelly, S. G. et al. Associations between tobacco, alcohol, and drug use with coronary artery plaque among HIV-infected and uninfected men in the multicenter AIDS cohort study. PLoS ONE 11, e0147822. https:\/\/doi.org\/10.1371\/journal.pone.0147822 (2016).","journal-title":"PLoS ONE"},{"key":"16290_CR19","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1111\/acer.14411","volume":"44","author":"J Gonzalez-Sanchez","year":"2020","unstructured":"Gonzalez-Sanchez, J. et al. The relationship between alcohol consumption with vascular structure and arterial stiffness in the Spanish population: EVA study. Alcohol Clin Exp Res 44, 1816\u20131824. https:\/\/doi.org\/10.1111\/acer.14411 (2020).","journal-title":"Alcohol Clin Exp Res"},{"key":"16290_CR20","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/nu14061207","volume":"14","author":"R Del Giorno","year":"2022","unstructured":"Del Giorno, R., Maddalena, A., Bassetti, S. & Gabutti, L. Association between alcohol intake and arterial stiffness in healthy adults: A systematic review. Nutrients 14, 12. https:\/\/doi.org\/10.3390\/nu14061207 (2022).","journal-title":"Nutrients"},{"key":"16290_CR21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/nu11102331","volume":"11","author":"J Langenau","year":"2019","unstructured":"Langenau, J., Boeing, H., Bergmann, M. M., Nothlings, U. & Oluwagbemigun, K. The association between alcohol consumption and serum metabolites and the modifying effect of smoking. Nutrients 11, 12. https:\/\/doi.org\/10.3390\/nu11102331 (2019).","journal-title":"Nutrients"},{"key":"16290_CR22","doi-asserted-by":"crossref","unstructured":"Liu, Y., Gou, M., Gu, S. & Guo, X. Alcohol consumption may be a risk factor for cerebrovascular stenosis. (2023).","DOI":"10.21203\/rs.3.rs-3741213\/v1"},{"key":"16290_CR23","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.atherosclerosis.2017.11.017","volume":"268","author":"H Mahajan","year":"2018","unstructured":"Mahajan, H. et al. Association of alcohol consumption and aortic calcification in healthy men aged 40\u201349 years for the ERA JUMP Study. Atherosclerosis 268, 84\u201391. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.11.017 (2018).","journal-title":"Atherosclerosis"},{"key":"16290_CR24","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1186\/s12889-024-20674-8","volume":"24","author":"NA Mitkin","year":"2024","unstructured":"Mitkin, N. A. et al. Alcohol and cause-specific mortality in Russia: the Know Your Heart Study 2015\u201323. BMC Public Health 24, 3128. https:\/\/doi.org\/10.1186\/s12889-024-20674-8 (2024).","journal-title":"BMC Public Health"},{"key":"16290_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276690","volume":"17","author":"C Sung","year":"2022","unstructured":"Sung, C. et al. Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study. PLoS ONE 17, e0276690. https:\/\/doi.org\/10.1371\/journal.pone.0276690 (2022).","journal-title":"PLoS ONE"},{"key":"16290_CR26","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1093\/ije\/dyu018","volume":"43","author":"M Roerecke","year":"2014","unstructured":"Roerecke, M. & Rehm, J. Cause-specific mortality risk in alcohol use disorder treatment patients: A systematic review and meta-analysis. Int J Epidemiol 43, 906\u2013919. https:\/\/doi.org\/10.1093\/ije\/dyu018 (2014).","journal-title":"Int J Epidemiol"},{"key":"16290_CR27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.numecd.2019.07.021","volume":"30","author":"PA Chevli","year":"2020","unstructured":"Chevli, P. A. et al. Alcohol consumption and subclinical atherosclerosis among South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Nutr. Metab. Cardiovasc. Dis. 30, 123\u2013131. https:\/\/doi.org\/10.1016\/j.numecd.2019.07.021 (2020).","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"16290_CR28","first-page":"262","volume":"20","author":"AIBTV Ershova","year":"2021","unstructured":"Ershova, A. I. B. T. V. et al. Prevalence of carotid and femoral artery atherosclerosis among the Ivanovo Oblast population: Data from the ATEROGEN-Ivanovo study. Cardiovasc. Therapy and Prevent. 20, 262\u2013270 (2021).","journal-title":"Cardiovasc. Therapy and Prevent."},{"key":"16290_CR29","doi-asserted-by":"publisher","first-page":"585","DOI":"10.2147\/RMHP.S388873","volume":"16","author":"M Kaneva","year":"2023","unstructured":"Kaneva, M. & Jakovljevic, M. Socioeconomic and behavioral determinants of cardiovascular risk in Russia: A structural equation modeling approach. Risk Manag Healthc Policy 16, 585\u2013605. https:\/\/doi.org\/10.2147\/RMHP.S388873 (2023).","journal-title":"Risk Manag Healthc Policy"},{"key":"16290_CR30","unstructured":"World Health Organization. Global status report on alcohol and health 2018. (World Health Organization, 2019)."},{"key":"16290_CR31","doi-asserted-by":"publisher","first-page":"67","DOI":"10.12688\/wellcomeopenres.14619.3","volume":"3","author":"S Cook","year":"2018","unstructured":"Cook, S. et al. Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35\u201369 years from two Russian cities, 2015\u201318. Wellcome Open Res. 3, 67. https:\/\/doi.org\/10.12688\/wellcomeopenres.14619.3 (2018).","journal-title":"Wellcome Open Res."},{"key":"16290_CR32","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1001\/jama.252.14.1905","volume":"252","author":"JA Ewing","year":"1984","unstructured":"Ewing, J. A. Detecting alcoholism. The CAGE questionnaire. JAMA 252, 1905\u20131907. https:\/\/doi.org\/10.1001\/jama.252.14.1905 (1984).","journal-title":"JAMA"},{"key":"16290_CR33","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1046\/j.1360-0443.1995.901013496.x","volume":"90","author":"KM Conigrave","year":"1995","unstructured":"Conigrave, K. M., Hall, W. D. & Saunders, J. B. The AUDIT questionnaire: choosing a cut-off score Alcohol Use Disorder Identification Test. Addiction 90, 1349\u20131356. https:\/\/doi.org\/10.1046\/j.1360-0443.1995.901013496.x (1995).","journal-title":"Addiction"},{"key":"16290_CR34","unstructured":"World Health Organization. (ed WHO. Department of Mental Health and Substance Dependence) (2001)."},{"key":"16290_CR35","doi-asserted-by":"publisher","first-page":"774","DOI":"10.7326\/0003-4819-115-10-774","volume":"115","author":"DG Buchsbaum","year":"1991","unstructured":"Buchsbaum, D. G., Buchanan, R. G., Centor, R. M., Schnoll, S. H. & Lawton, M. J. Screening for alcohol abuse using CAGE scores and likelihood ratios. Ann. Intern. Med. 115, 774\u2013777. https:\/\/doi.org\/10.7326\/0003-4819-115-10-774 (1991).","journal-title":"Ann. Intern. Med."},{"key":"16290_CR36","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014491","volume":"9","author":"O Iakunchykova","year":"2020","unstructured":"Iakunchykova, O. et al. Evidence for a Direct Harmful Effect of Alcohol on Myocardial Health: A large cross-sectional study of consumption patterns and cardiovascular disease risk biomarkers From Northwest Russia, 2015 to 2017. J. Am. Heart Assoc. 9, e014491. https:\/\/doi.org\/10.1161\/JAHA.119.014491 (2020).","journal-title":"J. Am. Heart Assoc."},{"key":"16290_CR37","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1038\/s41598-024-51962-3","volume":"14","author":"NA Mitkin","year":"2024","unstructured":"Mitkin, N. A. et al. The relationship between physical performance and alcohol consumption levels in Russian adults. Sci Rep 14, 1417. https:\/\/doi.org\/10.1038\/s41598-024-51962-3 (2024).","journal-title":"Sci Rep"},{"key":"16290_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20042905","author":"NA Mitkin","year":"2023","unstructured":"Mitkin, N. A., Unguryanu, T. N., Malyutina, S. & Kudryavtsev, A. V. Association between Alcohol Consumption and Body Composition in Russian Adults and Patients Treated for Alcohol-Related Disorders: The Know Your Heart Cross-Sectional Study. Int J Environ. Res. Public Health https:\/\/doi.org\/10.3390\/ijerph20042905 (2023).","journal-title":"Int J Environ. Res. Public Health"},{"key":"16290_CR39","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-036583","volume":"10","author":"Y Imahori","year":"2020","unstructured":"Imahori, Y. et al. Effect of adiposity on differences in carotid plaque burden in studies conducted in Norway and Russia: A cross-sectional analysis of two populations at very different risk of cardiovascular mortality. BMJ Open 10, e036583. https:\/\/doi.org\/10.1136\/bmjopen-2019-036583 (2020).","journal-title":"BMJ Open"},{"key":"16290_CR40","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.0583","volume":"8","author":"T Suzuki","year":"2025","unstructured":"Suzuki, T. et al. Lipid profiles after changes in alcohol consumption among adults undergoing annual Checkups. JAMA Netw. Open 8, e250583. https:\/\/doi.org\/10.1001\/jamanetworkopen.2025.0583 (2025).","journal-title":"JAMA Netw. Open"},{"key":"16290_CR41","doi-asserted-by":"publisher","first-page":"526","DOI":"10.9758\/cpn.22.1010","volume":"21","author":"A Senat","year":"2023","unstructured":"Senat, A., Kabadayi-Sahin, E., Sogut, I., Duymaz, T. & Erel, O. Evaluation of atherosclerotic risk by oxidative contributors in alcohol use disorder. Clin. Psychopharmacol. Neurosci. 21, 526\u2013533. https:\/\/doi.org\/10.9758\/cpn.22.1010 (2023).","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"16290_CR42","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agae055","author":"TC Durazzo","year":"2024","unstructured":"Durazzo, T. C., Kraybill, E. P., Stephens, L. H., May, A. C. & Meyerhoff, D. J. Pro-atherogenic medical conditions are associated with widespread regional brain metabolite abnormalities in those with alcohol use disorder. Alcohol Alcohol https:\/\/doi.org\/10.1093\/alcalc\/agae055 (2024).","journal-title":"Alcohol Alcohol"},{"key":"16290_CR43","doi-asserted-by":"publisher","first-page":"276","DOI":"10.52727\/2078-256X-2024-20-3-276-290","volume":"20","author":"UGMNA Guseinova","year":"2024","unstructured":"Guseinova, U. G. M. N. A. et al. Lipid metabolism parameters and alcohol consumption among men in Arkhangelsk, Russia: The Know Your Heart study. Ateroscleroz 20, 276\u2013290 (2024).","journal-title":"Ateroscleroz"},{"key":"16290_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13293-024-00584-5","volume":"15","author":"C Perpina-Clerigues","year":"2024","unstructured":"Perpina-Clerigues, C. et al. Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients. Biol Sex Differ 15, 10. https:\/\/doi.org\/10.1186\/s13293-024-00584-5 (2024).","journal-title":"Biol Sex Differ"},{"key":"16290_CR45","doi-asserted-by":"publisher","unstructured":"Triglyceride Coronary Disease Genetics, C. et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 375, 1634-1639, https:\/\/doi.org\/10.1016\/S0140-6736(10)60545-4 (2010).","DOI":"10.1016\/S0140-6736(10)60545-4"},{"key":"16290_CR46","unstructured":"Malyutina SK, S. G., Nikitin YuP. The incidence of coronary heart disease and cardiovascular mortality in the urban Siberian population: Gender specific findings from the 10-year cohort study. Heart Disease: Environment, Stress and Gender. NATO Science Series, Series I: Life and Behavioral Sciences 327, 69\u201379 (2002)."},{"key":"16290_CR47","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.3390\/antiox12101813","volume":"12","author":"JC Padovan","year":"2023","unstructured":"Padovan, J. C., Dourado, T. M., Pimenta, G. F., Bruder-Nascimento, T. & Tirapelli, C. R. Reactive oxygen species are central mediators of vascular dysfunction and hypertension induced by ethanol consumption. Antioxidants 12, 1813 (2023).","journal-title":"Antioxidants"},{"key":"16290_CR48","doi-asserted-by":"publisher","first-page":"245","DOI":"10.4330\/wjc.v6.i5.245","volume":"6","author":"K Husain","year":"2014","unstructured":"Husain, K., Ansari, R. A. & Ferder, L. Alcohol-induced hypertension: Mechanism and prevention. World J Cardiol 6, 245\u2013252. https:\/\/doi.org\/10.4330\/wjc.v6.i5.245 (2014).","journal-title":"World J Cardiol"},{"key":"16290_CR49","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2174\/157340211004150319122736","volume":"10","author":"CS Ceron","year":"2014","unstructured":"Ceron, C. S., Marchi, K. C., Muniz, J. J. & Tirapelli, C. R. Vascular oxidative stress: a key factor in the development of hypertension associated with ethanol consumption. Curr Hypertens Rev 10, 213\u2013222. https:\/\/doi.org\/10.2174\/157340211004150319122736 (2014).","journal-title":"Curr Hypertens Rev"},{"key":"16290_CR50","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12916-016-0656-9","volume":"14","author":"A Britton","year":"2016","unstructured":"Britton, A. et al. Twenty-year trajectories of alcohol consumption during midlife and atherosclerotic thickening in early old age: findings from two British population cohort studies. BMC Med 14, 111. https:\/\/doi.org\/10.1186\/s12916-016-0656-9 (2016).","journal-title":"BMC Med"},{"key":"16290_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.atherosclerosis.2023.06.012","volume":"377","author":"T Zhou","year":"2023","unstructured":"Zhou, T. et al. Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults. Atherosclerosis 377, 34\u201342. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2023.06.012 (2023).","journal-title":"Atherosclerosis"},{"key":"16290_CR52","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1161\/ATVBAHA.110.218057","volume":"31","author":"A Ryabikov","year":"2011","unstructured":"Ryabikov, A. et al. Prevalence and predictors of carotid wall triple line pattern in a general population sample. Arterioscler Thromb Vasc Biol 31, 1682\u20131688. https:\/\/doi.org\/10.1161\/ATVBAHA.110.218057 (2011).","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"16290_CR53","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00394-020-02220-5","volume":"60","author":"F Laguzzi","year":"2021","unstructured":"Laguzzi, F. et al. Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study. Eur. J. Nutr. 60(1), 123-134. https:\/\/doi.org\/10.1007\/s00394-020-02220-5 (2021).","journal-title":"Eur. J. Nutr."},{"key":"16290_CR54","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s00508-017-1235-6","volume":"129","author":"Y Huang","year":"2017","unstructured":"Huang, Y. et al. Moderate alcohol consumption and atherosclerosis\u202f: Meta-analysis of effects on lipids and inflammation. Wien Klin. Wochenschr 129, 835\u2013843. https:\/\/doi.org\/10.1007\/s00508-017-1235-6 (2017).","journal-title":"Wien Klin. Wochenschr"},{"key":"16290_CR55","doi-asserted-by":"crossref","unstructured":"Lamuela-Ravent\u00f3s, R. M. & Estruch, R. in Wine Safety, Consumer Preference, and Human Health (eds M. Victoria Moreno-Arribas & Bego\u00f1a Bartolom\u00e9 Su\u00e1ldea) 231-239 (Springer International Publishing, 2016).","DOI":"10.1007\/978-3-319-24514-0_11"},{"key":"16290_CR56","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s11886-018-0962-2","volume":"20","author":"S Goel","year":"2018","unstructured":"Goel, S., Sharma, A. & Garg, A. Effect of Alcohol Consumption on Cardiovascular Health. Curr. Cardiol. Rep. 20, 19. https:\/\/doi.org\/10.1007\/s11886-018-0962-2 (2018).","journal-title":"Curr. Cardiol. Rep."},{"key":"16290_CR57","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1111\/acer.14706","volume":"45","author":"NK Rajendran","year":"2021","unstructured":"Rajendran, N. K., Liu, W., Chu, C. C., Cahill, P. A. & Redmond, E. M. Moderate dose alcohol protects against serum amyloid protein A1-induced endothelial dysfunction via both notch-dependent and notch-independent pathways. Alcohol Clin. Exp. Res. 45, 2217\u20132230. https:\/\/doi.org\/10.1111\/acer.14706 (2021).","journal-title":"Alcohol Clin. Exp. Res."},{"key":"16290_CR58","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1111\/acer.14415","volume":"44","author":"W Liu","year":"2020","unstructured":"Liu, W. et al. Moderate Alcohol Consumption Targets S100beta(+) Vascular Stem Cells and Attenuates Injury-Induced Neointimal Hyperplasia. Alcohol Clin. Exp. Res. 44, 1734\u20131746. https:\/\/doi.org\/10.1111\/acer.14415 (2020).","journal-title":"Alcohol Clin. Exp. Res."},{"key":"16290_CR59","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12937-015-0011-6","volume":"14","author":"MJ Mathews","year":"2015","unstructured":"Mathews, M. J., Liebenberg, L. & Mathews, E. H. The mechanism by which moderate alcohol consumption influences coronary heart disease. Nutr. J. 14, 33. https:\/\/doi.org\/10.1186\/s12937-015-0011-6 (2015).","journal-title":"Nutr. J."},{"key":"16290_CR60","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.106.628875","volume":"115","author":"MW Lorenz","year":"2007","unstructured":"Lorenz, M. W., Markus, H. S., Bots, M. L., Rosvall, M. & Sitzer, M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 115, 459\u2013467. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.628875 (2007).","journal-title":"Circulation"},{"key":"16290_CR61","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ejvs.2022.04.011","volume":"65","author":"R Naylor","year":"2023","unstructured":"Naylor, R. et al. Editor\u2019s Choice - European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease. Eur. J. Vasc. Endovasc. Surg. 65, 7\u2013111. https:\/\/doi.org\/10.1016\/j.ejvs.2022.04.011 (2023).","journal-title":"Eur. J. Vasc. Endovasc. Surg."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16290-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16290-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16290-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T06:22:23Z","timestamp":1757485343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16290-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["16290"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-16290-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]},"assertion":[{"value":"23 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31646"}}