{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T14:19:05Z","timestamp":1794665945936,"version":"4.9.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/14087-0"],"award-info":[{"award-number":["2013\/14087-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/24105-3"],"award-info":[{"award-number":["2012\/24105-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Levy-Longenbaugh Donor-Advised Fund"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["443816\/2014-0"],"award-info":[{"award-number":["443816\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-16761-4","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:45:59Z","timestamp":1759171559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Leishmania amazonensis impairs phagosome acidification in B-1 phagocytes as an unrecognized parasite infection and proliferation mechanism"],"prefix":"10.1038","volume":"15","author":[{"given":"Natalia S.","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalita C. S.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael P.","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Brandt-Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela I.","family":"Staquicini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane B.","family":"de Assis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian C.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Wandilson Barboza Duarte","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Claser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Flavia","family":"Popi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Pasqualini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wadih","family":"Arap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Cortez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"16761_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S1473-3099(07)70209-8","volume":"7","author":"R Reithinger","year":"2007","unstructured":"Reithinger, R. et al. Cutaneous leishmaniasis. Lancet Infect. Dis. 7, 581\u2013596 (2007).","journal-title":"Lancet Infect. Dis."},{"key":"16761_CR2","first-page":"159","volume":"26","author":"J Convit","year":"1993","unstructured":"Convit, J. & Ulrich, M. Antigen-specific immunodeficiency and its relation to the spectrum of American cutaneous leishmaniasis. Biol. Res. 26, 159\u2013166 (1993).","journal-title":"Biol. Res."},{"key":"16761_CR3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/1756-3305-5-276","volume":"5","author":"A Dostalova","year":"2012","unstructured":"Dostalova, A. & Volf, P. Leishmania development in sand flies: Parasite-vector interactions overview. Parasit. Vectors. 5, 276 (2012).","journal-title":"Parasit. Vectors"},{"key":"16761_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1462-5822.2000.00037.x","volume":"2","author":"JF Dermine","year":"2000","unstructured":"Dermine, J. F., Scianimanico, S., Prive, C., Descoteaux, A. & Desjardins, M. Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis. Cell. Microbiol. 2, 115\u2013126 (2000).","journal-title":"Cell. Microbiol."},{"key":"16761_CR5","doi-asserted-by":"publisher","first-page":"e1000628","DOI":"10.1371\/journal.ppat.1000628","volume":"5","author":"AF Vinet","year":"2009","unstructured":"Vinet, A. F., Fukuda, M., Turco, S. J. & Descoteaux, A. The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V. PLoS Pathog. 5, e1000628 (2009).","journal-title":"PLoS Pathog"},{"key":"16761_CR6","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1111\/j.1462-5822.2010.01483.x","volume":"12","author":"B Ndjamen","year":"2010","unstructured":"Ndjamen, B., Kang, B. H., Hatsuzawa, K. & Kima, P. E. Leishmania parasitophorous vacuoles interact continuously with the host cell\u2019s Endoplasmic reticulum; parasitophorous vacuoles are hybrid compartments. Cell. Microbiol. 12, 1480\u20131494 (2010).","journal-title":"Cell. Microbiol."},{"key":"16761_CR7","doi-asserted-by":"publisher","first-page":"e1000179","DOI":"10.1371\/journal.ppat.1000179","volume":"4","author":"J Wilson","year":"2008","unstructured":"Wilson, J. et al. Control of parasitophorous vacuole expansion by lyst\/beige restricts the intracellular growth of Leishmania amazonensis. PLoS Pathog. 4, e1000179 (2008).","journal-title":"PLoS Pathog"},{"key":"16761_CR8","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/978-3-319-17121-0_99","volume":"854","author":"X Ji","year":"2016","unstructured":"Ji, X., Chang, B., Naggert, J. K. & Nishina, P. M. Lysosomal trafficking regulator (LYST). Adv. Exp. Med. Biol. 854, 745\u2013750 (2016).","journal-title":"Adv. Exp. Med. Biol."},{"key":"16761_CR9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.chom.2011.04.014","volume":"9","author":"M Cortez","year":"2011","unstructured":"Cortez, M. et al. Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200. Cell. Host Microbe. 9, 463\u2013471 (2011).","journal-title":"Cell. Host Microbe"},{"issue":"10","key":"16761_CR10","doi-asserted-by":"publisher","first-page":"e126207","DOI":"10.1172\/jci.insight.126207","volume":"4","author":"IP Sauter","year":"2019","unstructured":"Sauter, I. P. et al. TLR9\/MyD88\/TRIF signaling activates host immune inhibitory CD200 in Leishmania infection. JCI Insight. 4 (10), e126207 (2019).","journal-title":"JCI Insight"},{"key":"16761_CR11","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.molimm.2021.01.008","volume":"132","author":"IV Rossi","year":"2021","unstructured":"Rossi, I. V. et al. Extracellular vvesicles during tritryps infection: complexity and future challenges. Mol. Immunol. 132, 172\u2013183 (2021).","journal-title":"Mol. Immunol."},{"key":"16761_CR12","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/nrmicro2608","volume":"9","author":"P Kaye","year":"2011","unstructured":"Kaye, P. & Scott, P. Leishmaniasis: complexity at the host-pathogen interface. Nat. Rev. Microbiol. 9, 604\u2013615 (2011).","journal-title":"Nat. Rev. Microbiol."},{"key":"16761_CR13","doi-asserted-by":"publisher","first-page":"e0007152","DOI":"10.1371\/journal.pntd.0007152","volume":"13","author":"SM Christensen","year":"2019","unstructured":"Christensen, S. M. et al. Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis. PLoS Negl. Trop. Dis. 13, e0007152 (2019).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"16761_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00281-004-0182-2","volume":"26","author":"N Baumgarth","year":"2005","unstructured":"Baumgarth, N., Tung, J. W. & Herzenberg, L. A. Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion. Springer Semin Immunopathol. 26, 347\u2013362 (2005).","journal-title":"Springer Semin Immunopathol."},{"key":"16761_CR15","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.it.2006.07.005","volume":"27","author":"E Montecino-Rodriguez","year":"2006","unstructured":"Montecino-Rodriguez, E. & Dorshkind, K. New perspectives in B-1 B cell development and function. Trends Immunol. 27, 428\u2013433 (2006).","journal-title":"Trends Immunol."},{"key":"16761_CR16","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/eji.1830220314","volume":"22","author":"A O\u2019Garra","year":"1992","unstructured":"O\u2019Garra, A. et al. Ly-1 B (B-1) cells are the main source of B cell-derived Interleukin 10. Eur. J. Immunol. 22, 711\u2013717 (1992).","journal-title":"Eur. J. Immunol."},{"key":"16761_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/nyas.12760","volume":"1362","author":"KM Haas","year":"2015","unstructured":"Haas, K. M. B-1 lymphocytes in mice and nonhuman primates. Ann. N Y Acad. Sci. Dec. 1362, 98\u2013109 (2015).","journal-title":"Ann. N Y Acad. Sci. Dec."},{"key":"16761_CR18","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.8332901","volume":"261","author":"DJ Rawlings","year":"1993","unstructured":"Rawlings, D. J. et al. Mutation of unique region of bruton\u2019s tyrosine kinase in immunodeficient XID mice. Science 261, 358\u2013361 (1993).","journal-title":"Science"},{"key":"16761_CR19","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1046\/j.1365-2567.2003.01624.x","volume":"108","author":"J Riggs","year":"2003","unstructured":"Riggs, J. et al. X-chromosome-linked immune-deficient mice have B-1b cells. Immunology 108, 440\u2013451 (2003).","journal-title":"Immunology"},{"key":"16761_CR20","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1093\/intimm\/13.9.1193","volume":"13","author":"SR Almeida","year":"2001","unstructured":"Almeida, S. R. et al. Mouse B-1 cell-derived mononuclear phagocyte, a novel cellular component of acute non-specific inflammatory exudate. Int. Immunol. 13, 1193\u20131201 (2001).","journal-title":"Int. Immunol."},{"key":"16761_CR21","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1365-2567.2008.02883.x","volume":"126","author":"AF Popi","year":"2009","unstructured":"Popi, A. F. et al. Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro. Immunology 126, 114\u2013122 (2009).","journal-title":"Immunology"},{"key":"16761_CR22","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3389\/fmicb.2017.00978","volume":"8","author":"AF Arcanjo","year":"2017","unstructured":"Arcanjo, A. F. et al. Dependency of B-1 cells in the maintenance of Splenic interleukin-10 producing cells and impairment of macrophage resistance in visceral leishmaniasis. Front. Microbiol. 8, 978 (2017).","journal-title":"Front. Microbiol."},{"key":"16761_CR23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.4331\/wjbc.v8.i2.151","volume":"8","author":"AF Arcanjo","year":"2017","unstructured":"Arcanjo, A. F. et al. B-1 cells modulate the murine macrophage response to Leishmania major infection. World J. Biol. Chem. 8, 151\u2013162 (2017).","journal-title":"World J. Biol. Chem."},{"key":"16761_CR24","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1645\/16-145","volume":"103","author":"WFKM Gonzaga","year":"2017","unstructured":"Gonzaga, W. F. K. M. et al. Evaluation of experimental infection with L. (L.) amazonensis in X-linked immunodeficient mice. J. Parasitol. 103, 708\u2013717 (2017).","journal-title":"J. Parasitol."},{"key":"16761_CR25","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/pim.12324","volume":"38","author":"MM Geraldo","year":"2016","unstructured":"Geraldo, M. M. et al. In vivo and in vitro phagocytosis of Leishmania (Leishmania) amazonensis promastigotes by B-1 cells. Parasite Immunol. 38, 365\u2013376 (2016).","journal-title":"Parasite Immunol."},{"key":"16761_CR26","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1017\/S0031182015000943","volume":"142","author":"WF Gonzaga","year":"2015","unstructured":"Gonzaga, W. F., Xavier, V., Vivanco, B. C., Lopes, J. D. & Xander, P. B-1 cells contribute to susceptibility in experimental infection with Leishmania (Leishmania) Chagasi. Parasitology 142, 1506\u20131515 (2015).","journal-title":"Parasitology"},{"issue":"23","key":"16761_CR27","doi-asserted-by":"publisher","first-page":"5741","DOI":"10.3390\/molecules25235741","volume":"5","author":"TCS Ferreira","year":"2020","unstructured":"Ferreira, T. C. S. et al. Effect of DODAB nano-sized cationic bilayer fragments against Leishmania amazonensis. Molecules 5 (23), 5741 (2020).","journal-title":"Molecules"},{"key":"16761_CR28","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/jhet.4217","volume":"58","author":"A Luczywo","year":"2021","unstructured":"Luczywo, A. et al. Microwave-assisted synthesis of 2\u2010styrylquinoline\u20104\u2010carboxylic acid derivatives to improve the toxic effect against Leishmania (Leishmania) amazonensis. J. Heterocycl. Chem. 58, 822\u2013832 (2021).","journal-title":"J. Heterocycl. Chem."},{"key":"16761_CR29","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) method. Methods 25, 402\u2013408 (2001).","journal-title":"Methods"},{"key":"16761_CR30","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1242\/jcs.115.11.2303","volume":"115","author":"N Courret","year":"2002","unstructured":"Courret, N. et al. Biogenesis of Leishmania-harbouring parasitophorous vacuoles following phagocytosis of the metacyclic promastigote or amastigote stages of the parasites. J. Cell. Sci. 115, 2303\u20132316 (2002).","journal-title":"J. Cell. Sci."},{"key":"16761_CR31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.chom.2011.03.011","volume":"9","author":"CL Forestier","year":"2011","unstructured":"Forestier, C. L., Machu, C., Loussert, C., Pescher, P. & Spath, G. F. Imaging host cell-Leishmania interaction dynamics implicates parasite motility, lysosome recruitment, and host cell wounding in the infection process. Cell. Host Microbe. 9, 319\u2013330 (2011).","journal-title":"Cell. Host Microbe"},{"key":"16761_CR32","doi-asserted-by":"publisher","first-page":"e19000","DOI":"10.1371\/journal.pone.0019000","volume":"6","author":"NE Rodriguez","year":"2011","unstructured":"Rodriguez, N. E., Gaur Dixit, U., Allen, L. A. & Wilson, M. E. Stage-specific pathways of Leishmania infantum Chagasi entry and phagosome maturation in macrophages. PLoS One. 6, e19000 (2011).","journal-title":"PLoS One"},{"key":"16761_CR33","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1111\/j.1346-8138.2005.tb00795.x","volume":"32","author":"H Uezato","year":"2005","unstructured":"Uezato, H. et al. The attachment and entry of Leishmania (Leishmania) major into macrophages: observation by scanning electron microscope. J. Dermatol. 32, 534\u2013540 (2005).","journal-title":"J. Dermatol."},{"key":"16761_CR34","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/j.1365-2567.2004.01969.x","volume":"113","author":"AF Popi","year":"2004","unstructured":"Popi, A. F., Lopes, J. D. & Mariano, M. Interleukin-10 secreted by B-1 cells modulates the phagocytic activity of murine macrophages in vitro. Immunology 113, 348\u2013354 (2004).","journal-title":"Immunology"},{"key":"16761_CR35","first-page":"570","volume":"69","author":"FY Liew","year":"1990","unstructured":"Liew, F. Y., Parkinson, C., Millott, S., Severn, A. & Carrier, M. Tumour necrosis factor (TNF alpha) in leishmaniasis. I. TNF alpha mediates host protection against cutaneous leishmaniasis. Immunology 69, 570\u2013573 (1990).","journal-title":"Immunology"},{"key":"16761_CR36","doi-asserted-by":"publisher","first-page":"e1518","DOI":"10.1371\/journal.pntd.0001518","volume":"6","author":"F Real","year":"2012","unstructured":"Real, F. & Mortara, R. A. The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging. PLoS Negl. Trop. Dis. 6, e1518 (2012).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"16761_CR37","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1034\/j.1600-0854.2000.011102.x","volume":"1","author":"DM Ward","year":"2000","unstructured":"Ward, D. M., Griffiths, G. M., Stinchcombe, J. C. & Kaplan, J. Analysis of the lysosomal storage disease Chediak-Higashi syndrome. Traffic 1, 816\u2013822 (2000).","journal-title":"Traffic"},{"key":"16761_CR38","doi-asserted-by":"publisher","first-page":"8424","DOI":"10.1074\/jbc.M116.772160","volume":"292","author":"Q Cao","year":"2017","unstructured":"Cao, Q., Yang, Y., Zhong, X. Z. & Dong, X. P. The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin. J. Biol. Chem. 292, 8424\u20138435 (2017).","journal-title":"J. Biol. Chem."},{"key":"16761_CR39","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/sj.embor.7400495","volume":"6","author":"C Huynh","year":"2005","unstructured":"Huynh, C. & Andrews, N. W. The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. EMBO Rep. 6, 843\u2013847 (2005).","journal-title":"EMBO Rep."},{"key":"16761_CR40","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.it.2012.03.003","volume":"33","author":"GD Fairn","year":"2012","unstructured":"Fairn, G. D. & Grinstein, S. How nascent phagosomes mature to become phagolysosomes. Trends Immunol. 33, 397\u2013405 (2012).","journal-title":"Trends Immunol."},{"key":"16761_CR41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1051\/medsci\/2010263227","volume":"26","author":"AF Vinet","year":"2010","unstructured":"Vinet, A. F. & A Descoteaux Leishmania donovani induit Un D\u00e9faut d\u2019acidification du phagosome [Leishmania donovani delays phagolysosomal acidification]. Med. Sci. (Paris). 26, 227\u2013228 (2010).","journal-title":"Med. Sci. (Paris)"},{"key":"16761_CR42","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.imbio.2008.12.007","volume":"214","author":"AF Popi","year":"2009","unstructured":"Popi, A. F., Zamboni, D. S., Mortara, R. A. & Mariano, M. Microbicidal property of B1 cell derived mononuclear phagocyte. Immunobiology 214, 664\u2013673 (2009).","journal-title":"Immunobiology"},{"key":"16761_CR43","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3389\/fimmu.2019.00492","volume":"10","author":"F Afrin","year":"2019","unstructured":"Afrin, F., Khan, I. & Hemeg, H. A. Leishmania-host interactions - An epigenetic paradigm. Front. Immunol. 10, 492 (2019).","journal-title":"Front. Immunol."},{"key":"16761_CR44","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1084\/jem.20121368","volume":"210","author":"B Mittra","year":"2013","unstructured":"Mittra, B. et al. Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels. J. Exp. Med. 210, 401\u2013416 (2013).","journal-title":"J. Exp. Med."},{"key":"16761_CR45","doi-asserted-by":"publisher","first-page":"e0226837","DOI":"10.1371\/journal.pone.0226837","volume":"14","author":"S Santos-Pereira","year":"2019","unstructured":"Santos-Pereira, S., Cardoso, F. O., Calabrese, K. S. & do Valle, T. Zaverucha. Leishmania amazonensis resistance in murine macrophages: Analysis of possible mechanisms. PLoS One 14, e0226837 (2019).","journal-title":"PLoS One"},{"key":"16761_CR46","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3389\/fimmu.2019.00188","volume":"10","author":"JR Foote","year":"2019","unstructured":"Foote, J. R., Patel, A. A., Yona, S. & Segal, A. W. Variations in the phagosomal environment of human neutrophils and mononuclear phagocyte subsets. Front. Immunol. 10, 188 (2019).","journal-title":"Front. Immunol."},{"key":"16761_CR47","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1161\/CIRCRESAHA.117.311327","volume":"121","author":"M DeBerge","year":"2017","unstructured":"DeBerge, M. et al. MerTK cleavage on resident cardiac macrophages compromises repair after myocardial ischemia reperfusion injury. Circ. Res. 121, 930\u2013940 (2017).","journal-title":"Circ. Res."},{"key":"16761_CR48","doi-asserted-by":"publisher","first-page":"e1005669","DOI":"10.1371\/journal.ppat.1005669","volume":"12","author":"K Okuda","year":"2016","unstructured":"Okuda, K. et al. Leishmania amazonensis engages CD36 to drive parasitophorous vacuole maturation. PLoS Pathog. 12, e1005669 (2016).","journal-title":"PLoS Pathog"},{"key":"16761_CR49","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.chom.2012.10.015","volume":"12","author":"AO Barry","year":"2012","unstructured":"Barry, A. O. et al. Impaired stimulation of p38\u03b1-MAPK\/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes. Cell. Host Microbe. 12, 751\u2013763 (2012).","journal-title":"Cell. Host Microbe"},{"key":"16761_CR50","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.devcel.2020.12.010","volume":"56","author":"G Miao","year":"2021","unstructured":"Miao, G. et al. ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. Dev. Cell. 56, 427\u2013442 (2021).","journal-title":"Dev. Cell."},{"key":"16761_CR51","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1016\/j.cell.2020.10.039","volume":"183","author":"S Ghosh","year":"2020","unstructured":"Ghosh, S. et al. \u03b2-coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway. Cell 183, 1520\u20131535 (2020).","journal-title":"Cell"},{"issue":"Suppl 2","key":"16761_CR52","doi-asserted-by":"publisher","first-page":"S340","DOI":"10.1086\/374747","volume":"187","author":"A Aderem","year":"2003","unstructured":"Aderem, A. Phagocytosis and the inflammatory response. J. Infect. Dis. 187 (Suppl 2), S340\u2013345 (2003).","journal-title":"J. Infect. Dis."},{"key":"16761_CR53","doi-asserted-by":"publisher","first-page":"14166","DOI":"10.1074\/jbc.M114.628891","volume":"290","author":"S Kissing","year":"2015","unstructured":"Kissing, S. et al. Vacuolar ATPase in phagosome-lysosome fusion. J. Biol. Chem. 290, 14166\u201314180 (2015).","journal-title":"J. Biol. Chem."},{"key":"16761_CR54","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.tcb.2019.05.003","volume":"8","author":"GT Saffi","year":"2019","unstructured":"Saffi, G. T. & Botelho, R. J. Lysosome fission: planning for an exit. Trends Cell. Biol. 8, 635\u2013646 (2019).","journal-title":"Trends Cell. Biol."},{"key":"16761_CR55","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.1074\/jbc.M116.743047","volume":"292","author":"N Vashi","year":"2017","unstructured":"Vashi, N., Andrabi, S. B., Ghanwat, S., Suar, M. & Kumar, D. Ca2+-dependent focal exocytosis of Golgi-derived vesicles helps phagocytic uptake in macrophages. J. Biol. Chem. 292, 5144\u20135165 (2017).","journal-title":"J. Biol. Chem."},{"key":"16761_CR56","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/nature09076","volume":"465","author":"L Yu","year":"2010","unstructured":"Yu, L. et al. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 465, 942\u2013946 (2010).","journal-title":"Nature"},{"key":"16761_CR57","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.micinf.2011.05.014","volume":"13","author":"CH Hsiao","year":"2011","unstructured":"Hsiao, C. H. et al. The effects of macrophage source on the mechanism of phagocytosis and intracellular survival of Leishmania. Microbes Infect. 13, 1033\u20131044 (2011).","journal-title":"Microbes Infect."},{"key":"16761_CR58","doi-asserted-by":"publisher","first-page":"8991","DOI":"10.1038\/ncomms9991","volume":"6","author":"EE Waffarn","year":"2015","unstructured":"Waffarn, E. E. et al. Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation. Nat. Commun. 6, 8991 (2015).","journal-title":"Nat. Commun."},{"key":"16761_CR59","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/pim.12312","volume":"38","author":"CF Cunha","year":"2016","unstructured":"Cunha, C. F. et al. Cytotoxic cell involvement in human cutaneous leishmaniasis: assessments in active disease, under therapy and after clinical cure. Parasite Immunol. 38, 244\u2013254 (2016).","journal-title":"Parasite Immunol."},{"key":"16761_CR60","doi-asserted-by":"publisher","first-page":"e36595","DOI":"10.1371\/journal.pone.0036595","volume":"7","author":"J Franca-Costa","year":"2012","unstructured":"Franca-Costa, J. et al. Exposure of phosphatidylserine on Leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity. PLoS One. 7, e36595 (2012).","journal-title":"PLoS One"},{"key":"16761_CR61","doi-asserted-by":"publisher","first-page":"e844","DOI":"10.1371\/journal.pntd.0000844","volume":"4","author":"G Tasew","year":"2010","unstructured":"Tasew, G. et al. Systemic FasL and TRAIL neutralisation reduce leishmaniasis induced skin ulceration. PLoS Negl. Trop. Dis. 4, e844 (2010).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"16761_CR62","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/nyas.12804","volume":"1362","author":"N Baumgarth","year":"2015","unstructured":"Baumgarth, N., Waffarn, E. E. & Nguyen, T. T. Natural and induced B-1 cell immunity to infections raises questions of nature versus nurture. Ann. N Y Acad. Sci. 1362, 188\u2013199 (2015).","journal-title":"Ann. N Y Acad. Sci."},{"key":"16761_CR63","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.4049\/jimmunol.1403246","volume":"196","author":"SA Geherin","year":"2016","unstructured":"Geherin, S. A. et al. IL-10+ innate-like B cells are part of the skin immune system and require alpha4beta1 integrin to migrate between the peritoneum and inflamed skin. J. Immunol. 196, 2514\u20132525 (2016).","journal-title":"J. Immunol."},{"key":"16761_CR64","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S1074-7613(01)00129-7","volume":"14","author":"F Martin","year":"2001","unstructured":"Martin, F., Oliver, A. M. & Kearney, J. F. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14, 617\u2013629 (2001).","journal-title":"Immunity"},{"key":"16761_CR65","doi-asserted-by":"publisher","first-page":"8419","DOI":"10.1158\/0008-5472.CAN-08-1242","volume":"68","author":"FI Staquicini","year":"2008","unstructured":"Staquicini, F. I. et al. A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule\/MUC18-dependent interaction: evidence from mice and humans. Cancer Res. 68, 8419\u20138428 (2008).","journal-title":"Cancer Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16761-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16761-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16761-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T03:30:23Z","timestamp":1759548623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16761-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["16761"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-16761-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"23 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"R.P. and W.A. are founders and equity shareholders of PhageNova Bio. R.P. is the Chief Scientific Officer of and serves as a paid consultant for PhageNova Bio. R.P. and W.A. are founders and equity shareholders of and serve as paid consultants for MBrace Therapeutics. R.P. and W.A. have Sponsored Research Agreements (SRAs) in place with PhageNova Bio and with MBrace Therapeutics. These arrangements are managed in accordance with the established institutional conflict-of-interest policies of Rutgers, The State University of New Jersey. This particular study falls outside of the scope of these SRAs. The subject matter of this publication falls outside of SRAs of PhageNova Bio and MBrace Therapeutics. All the remaining authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"33650"}}