{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:31:18Z","timestamp":1767151878374,"version":"build-2238731810"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-16919-0","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T16:20:14Z","timestamp":1755879614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide identification of the cytochrome P450 superfamily in Trichoplusia ni and in-silico expression of resistance against HDAC inhibitors"],"prefix":"10.1038","volume":"15","author":[{"given":"Arsalan","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Sami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Zeshan","family":"Haider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Shafiq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahbaz","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qurban","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Arshad","family":"Javed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ashfaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoud","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"16919_CR1","doi-asserted-by":"publisher","first-page":"e31628","DOI":"10.7554\/eLife.31628","volume":"7","author":"Y Fu","year":"2018","unstructured":"Fu, Y. et al. The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology. Elife 7, e31628 (2018).","journal-title":"Elife"},{"key":"16919_CR2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/imb.12003","volume":"22","author":"J Simmons","year":"2013","unstructured":"Simmons, J., D\u2019Souza, O., Rheault, M. & Donly, C. Multidrug resistance protein gene expression in Trichoplusia ni caterpillars. Insect Mol. Biol. 22, 62\u201371 (2013).","journal-title":"Insect Mol. Biol."},{"key":"16919_CR3","unstructured":"Lingren, P. & Green, G. Suppression and management of cabbage looper populations. (1984)."},{"key":"16919_CR4","doi-asserted-by":"publisher","first-page":"13584","DOI":"10.1016\/S0021-9258(19)76468-0","volume":"262","author":"TN Hanzlik","year":"1987","unstructured":"Hanzlik, T. N. & Hammock, B. D. Characterization of affinity-purified juvenile hormone esterase from Trichoplusia ni. J. Biol. Chem. 262, 13584\u201313591 (1987).","journal-title":"J. Biol. Chem."},{"key":"16919_CR5","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/(SICI)1520-6327(1996)32:3\/4<429::AID-ARCH15>3.0.CO;2-E","volume":"32","author":"G Jones","year":"1996","unstructured":"Jones, G., Schelling, D. & Chhokar, V. Overview of the regulation of metamorphosis-associated genes in Trichoplusia ni. Archives Insect Biochem. Physiology: Published Collab. Entomol. Soc. Am. 32, 429\u2013437 (1996).","journal-title":"Archives Insect Biochem. Physiology: Published Collab. Entomol. Soc. Am."},{"key":"16919_CR6","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.peptides.2012.03.034","volume":"41","author":"F Lam","year":"2013","unstructured":"Lam, F., McNeil, J. N. & Donly, C. Octopamine receptor gene expression in three lepidopteran species of insect. Peptides 41, 66\u201373 (2013).","journal-title":"Peptides"},{"key":"16919_CR7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00442-011-2015-z","volume":"167","author":"MG Bidart-Bouzat","year":"2011","unstructured":"Bidart-Bouzat, M. G. & Kliebenstein, D. An ecological genomic approach challenging the paradigm of differential plant responses to specialist versus generalist insect herbivores. Oecologia 167, 677\u2013689 (2011).","journal-title":"Oecologia"},{"key":"16919_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ibmb.2014.03.013","volume":"50","author":"M Herde","year":"2014","unstructured":"Herde, M. & Howe, G. A. Host plant-specific remodeling of midgut physiology in the generalist insect herbivore Trichoplusia ni. Insect Biochem. Mol. Biol. 50, 58\u201367 (2014).","journal-title":"Insect Biochem. Mol. Biol."},{"key":"16919_CR9","doi-asserted-by":"publisher","first-page":"E9923","DOI":"10.1073\/pnas.1713385114","volume":"114","author":"M Pennington","year":"2017","unstructured":"Pennington, M. et al. (ed, J.) Contaminants of emerging concern affect Trichoplusia ni growth and development on artificial diets and a key host plant. Proc. Natl. Acad. Sci. 114 E9923\u2013E9931 (2017).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"16919_CR10","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jbiotec.2006.01.026","volume":"124","author":"R Bernhardt","year":"2006","unstructured":"Bernhardt, R. Cytochromes P450 as versatile biocatalysts. J. Biotechnol. 124, 128\u2013145 (2006).","journal-title":"J. Biotechnol."},{"key":"16919_CR11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/ps.2780430309","volume":"43","author":"R Feyereisen","year":"1995","unstructured":"Feyereisen, R., Andersen, J. F., Cari\u00f1o, F. A., Cohen, M. B. & Koener, J. F. Cytochrome P450 in the house fly: structure, catalytic activity and regulation of expression of CYP6 A1 in an insecticide-resistant strain. Pest. Sci. 43, 233\u2013239 (1995).","journal-title":"Pest. Sci."},{"key":"16919_CR12","doi-asserted-by":"crossref","unstructured":"Feyereisen, R. Insect Molecular Biology and Biochemistry 236\u2013316 (Elsevier, 2012).","DOI":"10.1016\/B978-0-12-384747-8.10008-X"},{"key":"16919_CR13","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1248\/bpb.35.838","volume":"35","author":"M Iga","year":"2012","unstructured":"Iga, M. & Kataoka, H. Recent studies on insect hormone metabolic pathways mediated by cytochrome P450 enzymes. Biol. Pharm. Bull. 35, 838\u2013843 (2012).","journal-title":"Biol. Pharm. Bull."},{"key":"16919_CR14","doi-asserted-by":"publisher","first-page":"685054","DOI":"10.3389\/fpls.2021.685054","volume":"12","author":"K Sun","year":"2021","unstructured":"Sun, K. et al. Genome-wide analysis of the cytochrome P450 gene family involved in salt tolerance in Gossypium hirsutum. Front. Plant Sci. 12, 685054 (2021).","journal-title":"Front. Plant Sci."},{"key":"16919_CR15","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0965-1748(99)00038-7","volume":"29","author":"JG Scott","year":"1999","unstructured":"Scott, J. G. Cytochromes P450 and insecticide resistance. Insect Biochem. Mol. Biol. 29, 757\u2013777 (1999).","journal-title":"Insect Biochem. Mol. Biol."},{"key":"16919_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-14-174","volume":"14","author":"F Zhu","year":"2013","unstructured":"Zhu, F., Moural, T. W., Shah, K. & Palli, S. R. Integrated analysis of cytochrome P450 gene superfamily in the red flour beetle, Tribolium castaneum. BMC Genom. 14, 1\u201312 (2013).","journal-title":"BMC Genom."},{"key":"16919_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cois.2020.11.010","volume":"43","author":"GJ Blomquist","year":"2021","unstructured":"Blomquist, G. J., Tittiger, C., MacLean, M. & Keeling, C. I. Cytochromes P450: terpene detoxification and pheromone production in bark beetles. Curr. Opin. Insect Sci. 43, 97\u2013102 (2021).","journal-title":"Curr. Opin. Insect Sci."},{"key":"16919_CR18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.pestbp.2015.01.006","volume":"120","author":"N Liu","year":"2015","unstructured":"Liu, N., Li, M., Gong, Y., Liu, F. & Li, T. Cytochrome P450s\u2013Their expression, regulation, and role in insecticide resistance. Pestic. Biochem. Physiol. 120, 77\u201381 (2015).","journal-title":"Pestic. Biochem. Physiol."},{"key":"16919_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.gene.2011.03.002","volume":"480","author":"J Ai","year":"2011","unstructured":"Ai, J. et al. Genome-wide analysis of cytochrome P450 monooxygenase genes in the silkworm, Bombyx mori. Gene 480, 42\u201350 (2011).","journal-title":"Gene"},{"key":"16919_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-019-5837-4","volume":"20","author":"B Antony","year":"2019","unstructured":"Antony, B. et al. Global transcriptome profiling and functional analysis reveal that tissue-specific constitutive overexpression of cytochrome P450s confers tolerance to imidacloprid in palm weevils in date palm fields. BMC Genom. 20, 1\u201323 (2019).","journal-title":"BMC Genom."},{"key":"16919_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-7364-4-1-59","volume":"4","author":"DR Nelson","year":"2009","unstructured":"Nelson, D. R. The cytochrome p450 homepage. Hum. Genomics. 4, 1\u20137 (2009).","journal-title":"Hum. Genomics"},{"key":"16919_CR22","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.3390\/ijms24065899","volume":"24","author":"P Qin","year":"2023","unstructured":"Qin, P., Zheng, H., Tao, Y., Zhang, Y. & Chu, D. Genome-wide identification and expression analysis of the cytochrome P450 gene family in Bemisia tabaci MED and their roles in the insecticide resistance. Int. J. Mol. Sci. 24, 5899 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"16919_CR23","doi-asserted-by":"publisher","first-page":"20421","DOI":"10.1038\/srep20421","volume":"6","author":"F Zhu","year":"2016","unstructured":"Zhu, F., Moural, T. W., Nelson, D. R. & Palli, S. R. A specialist herbivore pest adaptation to xenobiotics through up-regulation of multiple cytochrome P450s. Sci. Rep. 6, 20421 (2016).","journal-title":"Sci. Rep."},{"key":"16919_CR24","doi-asserted-by":"publisher","first-page":"W6","DOI":"10.1093\/nar\/gkl164","volume":"34","author":"J Ye","year":"2006","unstructured":"Ye, J., McGinnis, S. & Madden, T. L. BLAST: improvements for better sequence analysis. Nucleic Acids Res. 34, W6\u2013W9 (2006).","journal-title":"Nucleic Acids Res."},{"key":"16919_CR25","first-page":"349","volume":"2","author":"FS Brinkman","year":"2001","unstructured":"Brinkman, F. S. & Leipe, D. D. Phylogenetic analysis. Bioinformatics: Practical Guide Anal. Genes Proteins. 2, 349 (2001).","journal-title":"Bioinformatics: Practical Guide Anal. Genes Proteins"},{"key":"16919_CR26","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1093\/molbev\/msab120","volume":"38","author":"K Tamura","year":"2021","unstructured":"Tamura, K., Stecher, G. & Kumar, S. MEGA11: molecular evolutionary genetics analysis version 11. Mol. Biol. Evol. 38, 3022\u20133027 (2021).","journal-title":"Mol. Biol. Evol."},{"key":"16919_CR27","doi-asserted-by":"publisher","first-page":"W293","DOI":"10.1093\/nar\/gkab301","volume":"49","author":"I Letunic","year":"2021","unstructured":"Letunic, I. & Bork, P. Interactive tree of life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Nucleic Acids Res. 49, W293\u2013W296 (2021).","journal-title":"Nucleic Acids Res."},{"key":"16919_CR28","doi-asserted-by":"publisher","first-page":"D222","DOI":"10.1093\/nar\/gku1221","volume":"CDD","author":"A Marchler-Bauer","year":"2015","unstructured":"Marchler-Bauer, A. et al. NCBI\u2019s conserved domain database. Nucleic Acids Res. 43. CDD, D222\u2013D226 (2015).","journal-title":"Nucleic Acids Res. 43"},{"key":"16919_CR29","unstructured":"Horton, P., Park, K. J., Obayashi, T. & Nakai, K. In Proceedings of the 4th Asia-Pacific bioinformatics conference. 39\u201348 (World Scientific)."},{"key":"16919_CR30","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/bioinformatics\/btu817","volume":"31","author":"B Hu","year":"2015","unstructured":"Hu, B. et al. GSDS 2.0: an upgraded gene feature visualization server. Bioinformatics 31, 1296\u20131297 (2015).","journal-title":"Bioinformatics"},{"key":"16919_CR31","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.molp.2020.06.009","volume":"13","author":"C Chen","year":"2020","unstructured":"Chen, C. et al. TBtools: an integrative toolkit developed for interactive analyses of big biological data. Mol. Plant. 13, 1194\u20131202 (2020).","journal-title":"Mol. Plant"},{"key":"16919_CR32","doi-asserted-by":"publisher","first-page":"D1040","DOI":"10.1093\/nar\/gkab1090","volume":"50","author":"Y Mei","year":"2022","unstructured":"Mei, Y. et al. InsectBase 2.0: a comprehensive gene resource for insects. Nucleic Acids Res. 50, D1040\u2013D1045 (2022).","journal-title":"Nucleic Acids Res."},{"key":"16919_CR33","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ymeth.2007.09.005","volume":"44","author":"DE Kuhn","year":"2008","unstructured":"Kuhn, D. E. et al. Experimental validation of MiRNA targets. Methods 44, 47\u201354 (2008).","journal-title":"Methods"},{"key":"16919_CR34","doi-asserted-by":"publisher","first-page":"i9","DOI":"10.1093\/bioinformatics\/btu259","volume":"30","author":"CG Ghiurcuta","year":"2014","unstructured":"Ghiurcuta, C. G. & Moret, B. M. Evaluating synteny for improved comparative studies. Bioinformatics 30, i9\u2013i18 (2014).","journal-title":"Bioinformatics"},{"key":"16919_CR35","doi-asserted-by":"publisher","first-page":"e0293075","DOI":"10.1371\/journal.pone.0293075","volume":"18","author":"DJ Somers","year":"2023","unstructured":"Somers, D. J. et al. Epigenetic weapons in plant-herbivore interactions: Sulforaphane disrupts histone deacetylases, gene expression, and larval development in spodoptera Exigua while the specialist feeder trichoplusia Ni is largely resistant to these effects. Plos One. 18, e0293075 (2023).","journal-title":"Plos One"},{"key":"16919_CR36","doi-asserted-by":"publisher","first-page":"100579","DOI":"10.1016\/j.stress.2024.100579","volume":"14","author":"A Ahmad","year":"2024","unstructured":"Ahmad, A. et al. Genome-wide identification of cytochrome P450 gene in fall armyworm (Spodoptera frugiperda) in response to insecticide resistance. Plant. Stress. 14, 100579 (2024).","journal-title":"Plant. Stress"},{"key":"16919_CR37","doi-asserted-by":"crossref","unstructured":"Myzak, M. C., Karplus, P. A., Chung, F.-L. & Dashwood, R. H. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res. 64, 5767\u20135774 (2004).","DOI":"10.1158\/0008-5472.CAN-04-1326"},{"key":"16919_CR38","doi-asserted-by":"crossref","unstructured":"Ho, E., Clarke, J. D. & Dashwood, R. H. Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. The Journal of Nutrition 139(12), 2393\u20132396 (2009).","DOI":"10.3945\/jn.109.113332"},{"key":"16919_CR39","doi-asserted-by":"crossref","unstructured":"Kaufman-Szymczyk, A., Majewski, G., Lubecka-Pietruszewska, K. & Fabianowska-Majewska, K. The role of sulforaphane in epigenetic mechanisms, including interdependence between histone modification and DNA methylation. Int. J. Mol. Sci. 16(12), 29732\u201329743 (2015)","DOI":"10.3390\/ijms161226195"},{"key":"16919_CR40","doi-asserted-by":"crossref","unstructured":"Tortorella, S. M., Royce, S. G., Licciardi, P. V. & Karagiannis, T. C. Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition. Antioxid Redox Signal 22(16), 1382\u20131424 (2015).","DOI":"10.1089\/ars.2014.6097"},{"key":"16919_CR41","doi-asserted-by":"crossref","unstructured":"Bagnall, N. H. et al. Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina. Int J Parasitol Drugs Drug Resis. 7(1), 51\u201360 (2017).","DOI":"10.1016\/j.ijpddr.2017.01.001"},{"key":"16919_CR42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/jcb.20179","volume":"93","author":"N Sengupta","year":"2004","unstructured":"Sengupta, N. & Seto, E. Regulation of histone deacetylase activities. J. Cell. Biochem. 93, 57\u201367 (2004).","journal-title":"J. Cell. Biochem."},{"key":"16919_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-9994-9-25","volume":"9","author":"K Mukherjee","year":"2012","unstructured":"Mukherjee, K., Fischer, R. & Vilcinskas, A. Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection. Front. Zool. 9, 1\u201312 (2012).","journal-title":"Front. Zool."},{"key":"16919_CR44","doi-asserted-by":"publisher","first-page":"5767","DOI":"10.1158\/0008-5472.CAN-04-1326","volume":"64","author":"MC Myzak","year":"2004","unstructured":"Myzak, M. C., Karplus, P. A., Chung, F. L. & Dashwood, R. H. A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase. Cancer Res. 64, 5767\u20135774 (2004).","journal-title":"Cancer Res."},{"key":"16919_CR45","unstructured":"Ahn, E. Histone deacetylase inhibitors trichostatin A (tsa) and sulforaphane (sfn) modulate vitamin D responsive Cyp24 gene expression in 3t3-l1 preadipocytes. (2013)."},{"key":"16919_CR46","doi-asserted-by":"crossref","unstructured":"Fatima, S. et al. The genome-wide bioinformatics analysis of 1-aminocyclopropane-1-carboxylate synthase (acs), 1-aminocyclopropane-1-carboxylate oxidase (aco) and ethylene overproducer 1 (eto1) gene family of fragaria vesca (woodland strawberry). Bull. Biol. Allied Sci. Res. 2023, 38\u201338 (2023).","DOI":"10.54112\/bbasr.v2023i1.38"},{"key":"16919_CR47","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.pestbp.2009.06.009","volume":"97","author":"M Giraudo","year":"2010","unstructured":"Giraudo, M., Unnithan, G. C., Le Goff, G. & Feyereisen, R. Regulation of cytochrome P450 expression in drosophila: genomic insights. Pestic. Biochem. Physiol. 97, 115\u2013122 (2010).","journal-title":"Pestic. Biochem. Physiol."},{"key":"16919_CR48","doi-asserted-by":"publisher","first-page":"e100059","DOI":"10.1371\/journal.pone.0100059","volume":"9","author":"A Kawashima","year":"2014","unstructured":"Kawashima, A. & Satta, Y. Substrate-dependent evolution of cytochrome P450: rapid turnover of the detoxification-type and conservation of the biosynthesis-type. PLoS One. 9, e100059 (2014).","journal-title":"PLoS One"},{"key":"16919_CR49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cois.2020.11.004","volume":"43","author":"K Lu","year":"2021","unstructured":"Lu, K., Song, Y. & Zeng, R. The role of cytochrome P450-mediated detoxification in insect adaptation to xenobiotics. Curr. Opin. Insect Sci. 43, 103\u2013107 (2021).","journal-title":"Curr. Opin. Insect Sci."},{"key":"16919_CR50","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1093\/jee\/toaa233","volume":"114","author":"CR Perini","year":"2021","unstructured":"Perini, C. R. et al. Transcriptome analysis of pyrethroid-resistant Chrysodeixis includens (Lepidoptera: Noctuidae) reveals overexpression of metabolic detoxification genes. J. Econ. Entomol. 114, 274\u2013283 (2021).","journal-title":"J. Econ. Entomol."},{"key":"16919_CR51","doi-asserted-by":"crossref","unstructured":"Fu, Y. et al. The genome of Trichoplusia ni, an agricultural pest and novel model for small RNA biology. bioRxiv, 183921 (2017).","DOI":"10.1101\/183921"},{"key":"16919_CR52","doi-asserted-by":"publisher","first-page":"98","DOI":"10.54112\/bbasr.v2025i1.98","volume":"2025","author":"A Zahid","year":"2025","unstructured":"Zahid, A. et al. Chemical fingerprint of Azadirachta indica: unraveling the bioactive profile and therapeutic potential. Bull. Biol. Allied Sci. Res. 2025, 98\u201398 (2025).","journal-title":"Bull. Biol. Allied Sci. Res."},{"key":"16919_CR53","doi-asserted-by":"crossref","unstructured":"Malik, A. et al. Exploring beclin-1 therapeutic potential in neurodegenerative diseases: focus on multiple sclerosis. Bull. Biol. Allied Sci. Res. 2025, 95\u201395 (2025).","DOI":"10.54112\/bbasr.v2025i1.95"},{"key":"16919_CR54","doi-asserted-by":"crossref","unstructured":"Ali, J. et al. Comparative nutritional and minerals composition of Azadirachta indica, Eucalyptus globules and Melia azedarach. J. Life and Soc. Sci. 2025, 39 (2024).","DOI":"10.64013\/bbasrjlifess.v2025i1.39"},{"key":"16919_CR55","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/B978-0-12-394387-3.00002-1","volume":"116","author":"JH Lee","year":"2012","unstructured":"Lee, J. H., Choy, M. L. & Marks, P. A. Mechanisms of resistance to histone deacetylase inhibitors. Adv. Cancer Res. 116, 39\u201386 (2012).","journal-title":"Adv. Cancer Res."},{"key":"16919_CR56","doi-asserted-by":"crossref","unstructured":"Zahid, A. et al. Chlorophyll degradation under smog exposure: unveiling the molecular and ecological consequences. Bull. Biol. Allied Sci. Res. 2025, 96\u201396 (2025).","DOI":"10.54112\/bbasr.v2025i1.96"},{"key":"16919_CR57","doi-asserted-by":"crossref","unstructured":"Kayani, R. et al. Chlorophytum comosum-mediated iron nanoparticles: an eco-friendly approach for antimicrobial and dye degradation applications. Bull. Biol. Allied Sci. Res. 2025, 94\u201394 (2025).","DOI":"10.54112\/bbasr.v2025i1.94"},{"key":"16919_CR58","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.bbaexp.2007.07.002","volume":"1769","author":"M Schnekenburger","year":"2007","unstructured":"Schnekenburger, M., Peng, L. & Puga, A. HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with ah receptor-mediated trans-activation. Biochim. Et Biophys. Acta (BBA)-Gene Struct. Expression. 1769, 569\u2013578 (2007).","journal-title":"Biochim. Et Biophys. Acta (BBA)-Gene Struct. Expression"},{"key":"16919_CR59","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1007\/s00204-016-1887-4","volume":"91","author":"O Zapletal","year":"2017","unstructured":"Zapletal, O. et al. Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo [a] pyrene via its histone deacetylase activity in colon epithelial cell models. Arch. Toxicol. 91, 2135\u20132150 (2017).","journal-title":"Arch. Toxicol."},{"key":"16919_CR60","doi-asserted-by":"publisher","unstructured":"Ahmad, A. & Shakeel, M. Assessing the efficacy of eco-friendly insecticides against the Spodoptera litura (Tobacco cutworm) population. Bull. Biol. Allied Sci. Res. 2024, 62. https:\/\/doi.org\/10.54112\/bbasr.v2024i1.62 (2024).","DOI":"10.54112\/bbasr.v2024i1.62"},{"key":"16919_CR61","doi-asserted-by":"publisher","unstructured":"Raza, A., Ayub, M. & Abbas, A. Genome-wide identification and characterization of pbs3 plant-specific transcription factor gene family in Carrot species (Daucus Carota L). J. Phys. Biomedical Biol. Sci. 2025, 39. https:\/\/doi.org\/10.64013\/jpbab.v2025i1.39 (2025).","DOI":"10.64013\/jpbab.v2025i1.39"},{"key":"16919_CR62","doi-asserted-by":"publisher","unstructured":"Safdar, A. et al. Identification of exon 12 mutations in the Cftr gene using a cost-effective capillary electrophoresis (CE) assay. Bull. Biol. Allied Sci. Res. 2025, 103. https:\/\/doi.org\/10.64013\/bbasr.v2025i1.103 (2025).","DOI":"10.64013\/bbasr.v2025i1.103"},{"key":"16919_CR63","doi-asserted-by":"publisher","first-page":"104666","DOI":"10.1016\/j.pestbp.2020.104666","volume":"170","author":"J Vontas","year":"2020","unstructured":"Vontas, J., Katsavou, E. & Mavridis, K. Cytochrome P450-based metabolic insecticide resistance in Anopheles and Aedes mosquito vectors: muddying the waters. Pestic. Biochem. Physiol. 170, 104666 (2020).","journal-title":"Pestic. Biochem. Physiol."}],"updated-by":[{"DOI":"10.1038\/s41598-025-30222-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16919-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16919-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16919-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T18:06:12Z","timestamp":1766167572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-16919-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["16919"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-16919-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"assertion":[{"value":"21 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-025-30222-y","URL":"https:\/\/doi.org\/10.1038\/s41598-025-30222-y","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30934"}}