{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:26:55Z","timestamp":1789165615490,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-17356-9","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T03:54:11Z","timestamp":1756180451000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Revealing the protective potential of D-(-)-Quinic acid against thioacetamide-induced hepatic encephalopathy in rats"],"prefix":"10.1038","volume":"15","author":[{"given":"Sedat","family":"Ciftel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-1326","authenticated-orcid":false,"given":"Betul","family":"Cicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Bolat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seval","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahadir","family":"Suleyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Qaniyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halis","family":"S\u00fcleyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"17356_CR1","doi-asserted-by":"publisher","first-page":"14848","DOI":"10.1038\/s41598-024-65690-1","volume":"14","author":"Q Ke","year":"2024","unstructured":"Ke, Q. et al. Safety and efficacy of interventional embolization in cirrhotic patients with refractory hepatic encephalopathy associated with spontaneous portosystemic shunts. Sci. Rep. 14, 14848 (2024).","journal-title":"Sci. Rep."},{"key":"17356_CR2","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s12072-017-9812-3","volume":"12","author":"A Hadjihambi","year":"2018","unstructured":"Hadjihambi, A., Arias, N., Sheikh, M. & Jalan, R. Hepatic encephalopathy: a critical current review. Hepatol. Int. 12, 135\u2013147 (2018).","journal-title":"Hepatol. Int."},{"key":"17356_CR3","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jceh.2018.08.001","volume":"8","author":"R Ochoa-Sanchez","year":"2018","unstructured":"Ochoa-Sanchez, R. & Rose, C. F. Pathogenesis of hepatic encephalopathy in chronic liver disease. J. Clin. Exp. Hepatol. 8, 262\u2013271 (2018).","journal-title":"J. Clin. Exp. Hepatol."},{"key":"17356_CR4","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3390\/biom13020396","volume":"13","author":"K Lu","year":"2023","unstructured":"Lu, K. Cellular pathogenesis of hepatic encephalopathy: an update. Biomolecules 13, 396 (2023).","journal-title":"Biomolecules"},{"key":"17356_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11011-012-9370-2","volume":"28","author":"TH Tranah","year":"2013","unstructured":"Tranah, T. H., Vijay, G. K., Ryan, J. M. & Shawcross, D. L. Systemic inflammation and ammonia in hepatic encephalopathy. Metab. Brain Dis. 28, 1\u20135 (2013).","journal-title":"Metab. Brain Dis."},{"key":"17356_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.abb.2013.03.016","volume":"536","author":"I Coltart","year":"2013","unstructured":"Coltart, I., Tranah, T. H. & Shawcross, D. L. Inflammation and hepatic encephalopathy. Arch. Biochem. Biophys. 536, 189\u2013196 (2013).","journal-title":"Arch. Biochem. Biophys."},{"key":"17356_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2021.12.011","volume":"178","author":"K Pierzchala","year":"2022","unstructured":"Pierzchala, K. et al. Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy. Free Radic Biol. Med. 178, 295\u2013307 (2022).","journal-title":"Free Radic Biol. Med."},{"key":"17356_CR8","first-page":"4529","volume":"19","author":"X Shi","year":"2019","unstructured":"Shi, X. et al. Research progress on the PI3K\/AKT signaling pathway in gynecological cancer (Review). Mol. Med. Rep. 19, 4529\u20134535 (2019).","journal-title":"Mol. Med. Rep."},{"key":"17356_CR9","doi-asserted-by":"publisher","first-page":"7963","DOI":"10.3390\/molecules27227963","volume":"27","author":"X Liu","year":"2022","unstructured":"Liu, X., Xiao, X., Han, X., Yao, L. & Lan, W. A new therapeutic trend: natural medicine for ameliorating ischemic stroke via PI3K\/Akt signaling pathway. Molecules 27, 7963 (2022).","journal-title":"Molecules"},{"key":"17356_CR10","doi-asserted-by":"publisher","first-page":"1389329","DOI":"10.3389\/fmed.2024.1389329","volume":"11","author":"E Shamsan","year":"2024","unstructured":"Shamsan, E. et al. The role of PI3k\/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review. Front. Med. (Lausanne). 11, 1389329 (2024).","journal-title":"Front. Med. (Lausanne)"},{"key":"17356_CR11","doi-asserted-by":"publisher","first-page":"104846","DOI":"10.1016\/j.yexmp.2022.104846","volume":"129","author":"A Goyal","year":"2023","unstructured":"Goyal, A., Agrawal, A., Verma, A. & Dubey, N. The PI3K-AKT pathway: A plausible therapeutic target in parkinson\u2019s disease. Exp. Mol. Pathol. 129, 104846 (2023).","journal-title":"Exp. Mol. Pathol."},{"key":"17356_CR12","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1007\/s12035-023-03264-4","volume":"60","author":"YM Arenas","year":"2023","unstructured":"Arenas, Y. M. & Felipo, V. Sustained hyperammonemia activates NF-\u03baB in purkinje neurons through activation of the TrkB-PI3K-AKT pathway by Microglia-Derived BDNF in a rat model of minimal hepatic encephalopathy. Mol. Neurobiol. 60, 3071\u20133085 (2023).","journal-title":"Mol. Neurobiol."},{"key":"17356_CR13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.neuro.2022.08.005","volume":"92","author":"RR Abdelaziz","year":"2022","unstructured":"Abdelaziz, R. R., Abdelrahman, R. S. & Abdelmageed, M. E. SB332235, a CXCR2 antagonist, ameliorates thioacetamide-induced hepatic encephalopathy through modulation of the PI3K\/AKT pathways in rats. Neurotoxicology 92, 110\u2013121 (2022).","journal-title":"Neurotoxicology"},{"key":"17356_CR14","doi-asserted-by":"crossref","unstructured":"Szyller, J. & Bil-Lula, I. Heat Shock Proteins in Oxidative Stress and Ischemia\/Reperfusion Injury and Benefits from Physical Exercises: A Review to the Current Knowledge. Oxid. Med. Cell. Longev. 6678457 (2021). (2021).","DOI":"10.1155\/2021\/6678457"},{"key":"17356_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1476-9255-11-19","volume":"11","author":"E Ferat-Osorio","year":"2014","unstructured":"Ferat-Osorio, E. et al. Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1\/constitutive heat shock element-binding factor-dependent mechanism. J. Inflamm. (Lond). 11, 19 (2014).","journal-title":"J. Inflamm. (Lond)"},{"key":"17356_CR16","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10695-016-0269-4","volume":"43","author":"H Hangzo","year":"2017","unstructured":"Hangzo, H., Banerjee, B., Saha, S. & Saha, N. Ammonia stress under high environmental ammonia induces Hsp70 and Hsp90 in the mud eel, monopterus Cuchia. Fish. Physiol. Biochem. 43, 77\u201388 (2017).","journal-title":"Fish. Physiol. Biochem."},{"key":"17356_CR17","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s12192-009-0109-x","volume":"14","author":"S Banerjee Mustafi","year":"2009","unstructured":"Banerjee Mustafi, S., Chakraborty, P. K., Dey, R. S. & Raha, S. Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt. Cell. Stress Chaperones. 14, 579\u2013589 (2009).","journal-title":"Cell. Stress Chaperones"},{"key":"17356_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jceh.2020.01.001","volume":"10","author":"AJ Ryu","year":"2020","unstructured":"Ryu, A. J., Rahimi, R. S. & Leise, M. D. The current hepatic encephalopathy pipeline. J. Clin. Exp. Hepatol. 10, 377\u2013385 (2020).","journal-title":"J. Clin. Exp. Hepatol."},{"key":"17356_CR19","doi-asserted-by":"crossref","unstructured":"Chaachouay, N. & Zidane, L. Plant-derived natural products: a source for drug discovery and development. Drugs and Drug Candidates 3, 184\u2013207 Hajipour, (2024).","DOI":"10.3390\/ddc3010011"},{"key":"17356_CR20","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3390\/brainsci13060944","volume":"13","author":"S Farbood","year":"2023","unstructured":"Farbood, S., Dianat, Y., Nesari, M., Sarkaki, A. & A. & Effect of Berberine against cognitive deficits in rat model of Thioacetamide-Induced liver cirrhosis and hepatic encephalopathy (Behavioral, biochemical, molecular and histological Evaluations). Brain Sci. 13, 944 (2023).","journal-title":"Brain Sci."},{"key":"17356_CR21","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s11011-022-00952-3","volume":"37","author":"U Okkay","year":"2022","unstructured":"Okkay, U., Okkay, F., Cicek, I., Aydin, B., Ozkaraca, M. & I. C. & Hepatoprotective and neuroprotective effect of taxifolin on hepatic encephalopathy in rats. Metab. Brain Dis. 37, 1541\u20131556 (2022).","journal-title":"Metab. Brain Dis."},{"key":"17356_CR22","doi-asserted-by":"crossref","unstructured":"Enev, V. 2.11 chiral pool synthesis: chiral pool synthesis from Quinic acid. Comprehensive Chirality. 2, 325\u2013345 (2012).","DOI":"10.1016\/B978-0-08-095167-6.00221-4"},{"key":"17356_CR23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/ptr.2628","volume":"23","author":"RW Pero","year":"2009","unstructured":"Pero, R. W., Lund, H. & Leanderson, T. Antioxidant metabolism induced by Quinic acid. Increased urinary excretion of Tryptophan and nicotinamide. Phytother Res. 23, 335\u2013346 (2009).","journal-title":"Phytother Res."},{"key":"17356_CR24","doi-asserted-by":"crossref","unstructured":"Liu, L. et al. Neuroprotective Effects of D-(-)-Quinic Acid on Aluminum Chloride-Induced Dementia in Rats. Evid. Based Complement. Alternat. Med. 5602597 (2020). (2020).","DOI":"10.1155\/2020\/5602597"},{"key":"17356_CR25","doi-asserted-by":"publisher","first-page":"e926","DOI":"10.1002\/iid3.926","volume":"11","author":"M Ghasemi-Dehnoo","year":"2023","unstructured":"Ghasemi-Dehnoo, M., Lorigooini, Z., Amini-Khoei, H., Sabzevary-Ghahfarokhi, M. & Rafieian-Kopaei, M. Quinic acid ameliorates ulcerative colitis in rats, through the Inhibition of two TLR4-NF-\u03baB and NF-\u03baB-INOS-NO signaling pathways. Immun. Inflamm. Dis. 11, e926 (2023).","journal-title":"Immun. Inflamm. Dis."},{"key":"17356_CR26","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s12967-024-05120-y","volume":"22","author":"Q Jin","year":"2024","unstructured":"Jin, Q. et al. Quinic acid regulated TMA\/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic. J. Transl Med. 22, 352 (2024).","journal-title":"J. Transl Med."},{"key":"17356_CR27","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248\u2013254 (1976).","journal-title":"Anal. Biochem."},{"key":"17356_CR28","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3390\/ph16020221","volume":"16","author":"B Cicek","year":"2023","unstructured":"Cicek, B. et al. Sorafenib alleviates inflammatory signaling of tumor microenvironment in precancerous lung injuries. Pharmaceuticals (Basel). 16, 221 (2023).","journal-title":"Pharmaceuticals (Basel)"},{"key":"17356_CR29","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.3390\/jcm10184050","volume":"10","author":"C Mangini","year":"2021","unstructured":"Mangini, C. & Montagnese, S. New therapies of liver diseases: hepatic encephalopathy. J. Clin. Med. 10, 4050 (2021).","journal-title":"J. Clin. Med."},{"key":"17356_CR30","doi-asserted-by":"publisher","first-page":"11396","DOI":"10.1038\/s41598-024-61639-6","volume":"14","author":"AA Sedik","year":"2024","unstructured":"Sedik, A. A., Hussein, D. T., Fathy, K. & Mowaad, N. A. Neuroprotective and cognitive enhancing effects of Herbecetin against thioacetamide induced hepatic encephalopathy in rats via upregulation of AMPK and SIRT1 signaling pathways. Sci. Rep. 14, 11396 (2024).","journal-title":"Sci. Rep."},{"key":"17356_CR31","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/j.1478-3231.2009.02009.x","volume":"29","author":"C Randolph","year":"2009","unstructured":"Randolph, C. et al. Neuropsychological assessment of hepatic encephalopathy: ISHEN practice guidelines. Liver Int. 29, 629\u2013635 (2009).","journal-title":"Liver Int."},{"key":"17356_CR32","doi-asserted-by":"publisher","first-page":"104093","DOI":"10.1016\/j.etap.2023.104093","volume":"99","author":"D Ezhilarasan","year":"2023","unstructured":"Ezhilarasan, D. Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models. Environ. Toxicol. Pharmacol. 99, 104093 (2023).","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"17356_CR33","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.toxrep.2021.04.011","volume":"8","author":"A Sepehrinezhad","year":"2021","unstructured":"Sepehrinezhad, A., Shahbazi, A., Sahab Negah, S., Joghataei, M. T. & Larsen, F. S. Drug-induced-acute liver failure: A critical appraisal of the thioacetamide model for the study of hepatic encephalopathy. Toxicol. Rep. 8, 962\u2013970 (2021).","journal-title":"Toxicol. Rep."},{"key":"17356_CR34","doi-asserted-by":"publisher","first-page":"114141","DOI":"10.1016\/j.jep.2021.114141","volume":"277","author":"HMA Khalil","year":"2021","unstructured":"Khalil, H. M. A. et al. Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of Nrf2\/HO-1 and mitigation of NF-\u03baB\/MAPK signaling pathways. J. Ethnopharmacol. 277, 114141 (2021).","journal-title":"J. Ethnopharmacol."},{"key":"17356_CR35","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.jceh.2021.11.004","volume":"12","author":"P Sharma","year":"2022","unstructured":"Sharma, P. Value of liver function tests in cirrhosis. J. Clin. Exp. Hepatol. 12, 948\u2013964 (2022).","journal-title":"J. Clin. Exp. Hepatol."},{"key":"17356_CR36","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.jhep.2019.01.008","volume":"73","author":"T Balzano","year":"2020","unstructured":"Balzano, T. et al. Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversed by anti-TNF-\u03b1 treatment. J. Hepatol. 73, 582\u2013592 (2020).","journal-title":"J. Hepatol."},{"key":"17356_CR37","doi-asserted-by":"publisher","first-page":"s1321","DOI":"10.2741\/1211","volume":"8","author":"JC Schiltz","year":"2003","unstructured":"Schiltz, J. C. & Sawchenko, P. E. Signaling the brain in systemic inflammation: the role of perivascular cells. Front. Biosci. 8, s1321\u20131329 (2003).","journal-title":"Front. Biosci."},{"key":"17356_CR38","doi-asserted-by":"publisher","first-page":"960327122111980","DOI":"10.1177\/09603271221119804","volume":"41","author":"J Dong","year":"2022","unstructured":"Dong, J. et al. Protective effect of D-(-)-quinic acid as food supplement in modulating AMP-activated protein kinase signalling pathway activation in HFD induced obesity. Hum. Exp. Toxicol. 41, 9603271221119804 (2022).","journal-title":"Hum. Exp. Toxicol."},{"key":"17356_CR39","doi-asserted-by":"publisher","first-page":"2374608","DOI":"10.1080\/19490976.2024.2374608","volume":"16","author":"S Li","year":"2024","unstructured":"Li, S. et al. Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3\/IKK\/NF-\u03baB signaling via gut microbial Tryptophan metabolites. Gut Microbes. 16, 2374608 (2024).","journal-title":"Gut Microbes"},{"key":"17356_CR40","doi-asserted-by":"publisher","first-page":"309","DOI":"10.4062\/biomolther.2023.184","volume":"32","author":"Y Park","year":"2024","unstructured":"Park, Y. et al. Quinic acid alleviates behavior impairment by reducing neuroinflammation and MAPK activation in LPS-Treated mice. Biomol. Ther. (Seoul). 32, 309\u2013318 (2024).","journal-title":"Biomol. Ther. (Seoul)"},{"key":"17356_CR41","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0973-6883(11)60126-6","volume":"1","author":"DK Atluri","year":"2011","unstructured":"Atluri, D. K., Prakash, R. & Mullen, K. D. Pathogenesis, diagnosis, and treatment of hepatic encephalopathy. J. Clin. Exp. Hepatol. 1, 77\u201386 (2011).","journal-title":"J. Clin. Exp. Hepatol."},{"key":"17356_CR42","first-page":"123","volume":"5","author":"M Khoubnasabjafari","year":"2015","unstructured":"Khoubnasabjafari, M., Ansarin, K. & Jouyban, A. Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders. Bioimpacts 5, 123\u2013127 (2015).","journal-title":"Bioimpacts"},{"key":"17356_CR43","doi-asserted-by":"crossref","unstructured":"El-Baz, F. K., Elgohary, R. & Salama, A. Amelioration of Hepatic Encephalopathy Using Dunaliella salina Microalgae in Rats: Modulation of Hyperammonemia\/TLR4. Biomed. Res. Int. 8843218 (2021). (2021).","DOI":"10.1155\/2021\/8843218"},{"key":"17356_CR44","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.3390\/ijms19123725","volume":"19","author":"K S\u00e1nchez-Alegr\u00eda","year":"2018","unstructured":"S\u00e1nchez-Alegr\u00eda, K., Flores-Le\u00f3n, M., Avila-Mu\u00f1oz, E., Rodr\u00edguez-Corona, N. & Arias, C. PI3K signaling in neurons: A central node for the control of multiple functions. Int. J. Mol. Sci. 19, 3725 (2018).","journal-title":"Int. J. Mol. Sci."},{"key":"17356_CR45","doi-asserted-by":"publisher","first-page":"111714","DOI":"10.1016\/j.fct.2020.111714","volume":"145","author":"SN Zarneshan","year":"2020","unstructured":"Zarneshan, S. N., Fakhri, S., Farzaei, M. H., Khan, H. & Saso, L. Astaxanthin targets PI3K\/Akt signaling pathway toward potential therapeutic applications. Food Chem. Toxicol. 145, 111714 (2020).","journal-title":"Food Chem. Toxicol."},{"key":"17356_CR46","doi-asserted-by":"publisher","first-page":"481","DOI":"10.3389\/fphar.2016.00481","volume":"7","author":"S Ghosh","year":"2016","unstructured":"Ghosh, S., Sarkar, A., Bhattacharyya, S. & Sil, P. C. Silymarin protects mouse liver and kidney from thioacetamide induced toxicity by scavenging reactive oxygen species and activating PI3K-Akt pathway. Front. Pharmacol. 7, 481 (2016).","journal-title":"Front. Pharmacol."},{"key":"17356_CR47","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.2147\/DDDT.S194787","volume":"13","author":"R Wang","year":"2019","unstructured":"Wang, R. et al. Salvianolic acid A attenuates CCl(4)-induced liver fibrosis by regulating the PI3K\/AKT\/mTOR, Bcl-2\/Bax and caspase-3\/cleaved caspase-3 signaling pathways. Drug Des. Devel Ther. 13, 1889\u20131900 (2019).","journal-title":"Drug Des. Devel Ther."},{"key":"17356_CR48","doi-asserted-by":"publisher","first-page":"3623","DOI":"10.1007\/s10571-023-01371-3","volume":"43","author":"Z Gong","year":"2023","unstructured":"Gong, Z. et al. Inhibiting PI3K\/Akt-Signaling pathway improves neurobehavior changes in Anti-NMDAR encephalitis mice by ameliorating Blood-Brain barrier disruption and neuronal damage. Cell. Mol. Neurobiol. 43, 3623\u20133637 (2023).","journal-title":"Cell. Mol. Neurobiol."},{"key":"17356_CR49","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.biopha.2016.06.036","volume":"83","author":"W Zhong","year":"2016","unstructured":"Zhong, W. et al. Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K\/AKT and NF-\u03baB related signaling. Biomed. Pharmacother. 83, 302\u2013313 (2016).","journal-title":"Biomed. Pharmacother"},{"key":"17356_CR50","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3390\/biom13040601","volume":"13","author":"K Zhao","year":"2023","unstructured":"Zhao, K. et al. HSP70 family in cancer: signaling mechanisms and therapeutic advances. Biomolecules 13, 601 (2023).","journal-title":"Biomolecules"},{"key":"17356_CR51","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jtemb.2018.07.019","volume":"50","author":"H Cheng","year":"2018","unstructured":"Cheng, H. et al. PI3K\/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure. J. Trace Elem. Med. Biol. 50, 332\u2013338 (2018).","journal-title":"J. Trace Elem. Med. Biol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-17356-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-17356-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-17356-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T16:42:41Z","timestamp":1757436161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-17356-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["17356"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-17356-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"18 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study protocol was approved by Erzincan Binali Y\u0131ld\u0131r\u0131m University Experimental Animal Ethics Committee with the decision dated 31.10.2024 and numbered 47. All experiments were carried out in accordance with European Parliament Directive 2010\/63\/EU (Approval Number 2016-24-199) and ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"31331"}}