{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:12:22Z","timestamp":1792498342723,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-17447-7","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T05:19:29Z","timestamp":1756185569000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the protective effect of Benfotiamine against neurotoxic effects, depression and oxidative stress induced by noise exposure"],"prefix":"10.1038","volume":"15","author":[{"given":"Mahsa","family":"Gholami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3152-7062","authenticated-orcid":false,"given":"Seyed Ehsan","family":"Samaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Shaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siavash","family":"Etemadinezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Shokati","family":"Sayyad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"17447_CR1","first-page":"1","volume":"5","author":"F Salehpour","year":"2018","unstructured":"Salehpour, F., Mahmoudi, J. & Eyvazzadeh, N. Effects of acute and chronic noise stress on depressive-and anxiety-like behaviors in mice. J. Exp. Neurosci. 5, 1\u20136 (2018).","journal-title":"J. Exp. Neurosci."},{"key":"17447_CR2","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/ijerph15020379","volume":"15","author":"E Van Kempen","year":"2018","unstructured":"Van Kempen, E., Casas, M., Pershagen, G. & Foraster, M. WHO environmental noise guidelines for the European region: a systematic review on environmental noise and cardiovascular and metabolic effects: a summary. Int. J. Environ. Res. Public. Health. 15, 379. https:\/\/doi.org\/10.3390\/ijerph15020379 (2018).","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"17447_CR3","first-page":"426","volume":"181","author":"S Gongi","year":"2016","unstructured":"Gongi, S., Kaluyi, J. & Kanali, C. Industrial noise pollution and its health effects on wokers in Nairoby City. Int. J. Eng. Res. 181, 426\u2013435 (2016).","journal-title":"Int. J. Eng. Res."},{"key":"17447_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4103\/1463-1741.149565","volume":"17","author":"ER Koc","year":"2015","unstructured":"Koc, E. R., Ersoy, A., Ilhan, A., Erken, H. A. & Sah\u0131n, S. Is Rosuvastatin protective against on noise-induced oxidative stress in rat serum? Noise Health. 17, 11\u201316. https:\/\/doi.org\/10.4103\/1463-1741.149565 (2015).","journal-title":"Noise Health"},{"key":"17447_CR5","doi-asserted-by":"publisher","first-page":"4720","DOI":"10.1038\/s41598-017-04943-8","volume":"7","author":"Z Jafari","year":"2017","unstructured":"Jafari, Z. et al. The adverse effects of auditory stress on mouse uterus receptivity and behaviour. Sci. Rep. 7, 4720. https:\/\/doi.org\/10.1038\/s41598-017-04943-8 (2017).","journal-title":"Sci. Rep."},{"key":"17447_CR6","doi-asserted-by":"publisher","first-page":"058","DOI":"10.7324\/JAPS.2015.50609","volume":"5","author":"S Srinivasan","year":"2015","unstructured":"Srinivasan, S., Wankhar, W., Rathinasamy, S. & Rajan, R. Neuroprotective effects of indigofera tinctoria on noise stress affected Wistar albino rat brain. J. Appl. Pharm. Sci. 5, 058\u2013065. https:\/\/doi.org\/10.7324\/JAPS.2015.50609 (2015).","journal-title":"J. Appl. Pharm. Sci."},{"key":"17447_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4103\/nah.NAH_31_19","volume":"22","author":"AL Manukyan","year":"2020","unstructured":"Manukyan, A. L. et al. Adrenergic Alpha-2 receptor antagonists cease augmented oxidation of plasma proteins and anxiety of rats caused by chronic noise exposure. Noise Health. 22, 63\u201369. https:\/\/doi.org\/10.4103\/nah.NAH_31_19 (2020).","journal-title":"Noise Health"},{"key":"17447_CR8","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.sjbs.2021.09.018","volume":"29","author":"N Samad","year":"2022","unstructured":"Samad, N. et al. Vitamin D2 protects acute and repeated noise stress induced behavioral, biochemical, and histopathological alterations: possible antioxidant effect. Saudi J. Biol. Sci. 29, 601\u2013609. https:\/\/doi.org\/10.1016\/j.sjbs.2021.09.018 (2022).","journal-title":"Saudi J. Biol. Sci."},{"key":"17447_CR9","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.bbagen.2015.02.015","volume":"1850","author":"JI Romero","year":"2015","unstructured":"Romero, J. I. et al. Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia. Biochim. Biophys. Acta - Gen. Subj. 1850, 1274\u20131285 (2015).","journal-title":"Biochim. Biophys. Acta - Gen. Subj."},{"key":"17447_CR10","doi-asserted-by":"publisher","first-page":"499","DOI":"10.32598\/bcn.2021.2026.1","volume":"12","author":"Y Mahmoodzadeh","year":"2021","unstructured":"Mahmoodzadeh, Y., Mahmoudi, J., Gorgani-Firuzjaee, S., Mohtavinejad, N. & Namvaran, A. Effects of N-acetylcysteine on noise exposure-induced oxidative stress and depressive-and anxiety-like behaviors in adult male mice. Basic. Clin. Neurosci. 12, 499. https:\/\/doi.org\/10.32598\/bcn.2021.2026.1 (2021).","journal-title":"Basic. Clin. Neurosci."},{"key":"17447_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1080\/16583655.2018.1465275","volume":"12","author":"KF Azman","year":"2018","unstructured":"Azman, K. F., Zakaria, R., Othman, Z. & Abdul Aziz, C. B. Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress. J. Taibah Univ. Med. Sci. 12, 273\u2013284. https:\/\/doi.org\/10.1080\/16583655.2018.1465275 (2018).","journal-title":"J. Taibah Univ. Med. Sci."},{"key":"17447_CR12","doi-asserted-by":"publisher","unstructured":"Samad, N., Yasmin, F., Khaliq, S., Ahmad, S. & Mustafa, S. Diet supplements of banana fruit pulp mitigates repeated noise stress induced behavioral deficits and oxidative stress. Pak J. Pharm. Sci. 33 https:\/\/doi.org\/10.36721\/PJPS.2020.33.5.SUP.2293-2300.1 (2020).","DOI":"10.36721\/PJPS.2020.33.5.SUP.2293-2300.1"},{"key":"17447_CR13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.brainres.2016.01.050","volume":"1636","author":"SJ Molina","year":"2016","unstructured":"Molina, S. J., Capani, F. & Guelman, L. R. Noise exposure of immature rats can induce different age-dependent extra-auditory alterations that can be partially restored by rearing animals in an enriched environment. Brain Res. J. 1636, 52\u201361. https:\/\/doi.org\/10.1016\/j.brainres.2016.01.050 (2016).","journal-title":"Brain Res. J."},{"key":"17447_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/nure.12088","volume":"72","author":"M Hennebelle","year":"2014","unstructured":"Hennebelle, M., Champeil-Potokar, G., Lavialle, M., Vancassel, S. & Denis, I. Omega-3 polyunsaturated fatty acids and chronic stress-induced modulations of glutamatergic neurotransmission in the hippocampus. J. Biochem. Mol. Toxicol. 72, 99\u2013112. https:\/\/doi.org\/10.1111\/nure.12088 (2014).","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"17447_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fncir.2018.00031","volume":"12","author":"SE Motley","year":"2018","unstructured":"Motley, S. E. Relationship between neuromodulation and working memory in the prefrontal cortex: it\u2019s complicated. Front. Neural Circuits. 12, 31\u201337. https:\/\/doi.org\/10.3389\/fncir.2018.00031 (2018).","journal-title":"Front. Neural Circuits"},{"key":"17447_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jad.2014.07.032","volume":"169","author":"JJ Young","year":"2014","unstructured":"Young, J. J., Bruno, D. & Pomara, N. A review of the relationship between Proinflammatory cytokines and major depressive disorder. J. Affect. Disord. 169, 15\u201320. https:\/\/doi.org\/10.1016\/j.jad.2014.07.032 (2014).","journal-title":"J. Affect. Disord"},{"key":"17447_CR17","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.freeradbiomed.2010.02.031","volume":"48","author":"UC Yadav","year":"2010","unstructured":"Yadav, U. C., Kalariya, N. M., Srivastava, S. K. & Ramana, K. V. Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic Biol. Med. 48, 1423\u20131434. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.02.031 (2010).","journal-title":"Free Radic Biol. Med."},{"key":"17447_CR18","doi-asserted-by":"publisher","first-page":"e0232413","DOI":"10.1371\/journal.pone.0232413","volume":"15","author":"LA Ahmed","year":"2020","unstructured":"Ahmed, L. A., Hassan, O. F., Galal, O., Mansour, D. F. & El-Khatib, A. Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats. Plos One. 15, e0232413. https:\/\/doi.org\/10.1371\/journal.pone.0232413 (2020).","journal-title":"Plos One"},{"key":"17447_CR19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3389\/fncel.2015.00351","volume":"9","author":"I Bozic","year":"2015","unstructured":"Bozic, I. et al. Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells. Front. Cell. Neurosci. 9, 351. https:\/\/doi.org\/10.3389\/fncel.2015.00351 (2015).","journal-title":"Front. Cell. Neurosci."},{"key":"17447_CR20","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s10735-024-10237-x","volume":"55","author":"M Shokati Sayyad","year":"2024","unstructured":"Shokati Sayyad, M. et al. The protective effect of Benfotiamine on gastric ulcers in male rats: an experimental study. J. Mol. Histol. 55, 863\u2013874. https:\/\/doi.org\/10.1007\/s10735-024-10237-x (2024).","journal-title":"J. Mol. Histol."},{"key":"17447_CR21","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/00006676-200003000-00009","volume":"20","author":"A Demols","year":"2000","unstructured":"Demols, A. et al. N-acetylcysteine decreases severity of acute pancreatitis in mice. Pancreas 20, 161\u2013169 (2000).","journal-title":"Pancreas"},{"key":"17447_CR22","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.phanu.2017.10.003","volume":"5","author":"MM Ommati","year":"2017","unstructured":"Ommati, M. M. et al. N-acetylcysteine treatment blunts liver failure-associated impairment of locomotor activity. PharmaNutrition 5, 141\u2013147. https:\/\/doi.org\/10.1016\/j.phanu.2017.10.003 (2017).","journal-title":"PharmaNutrition"},{"key":"17447_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2010.11.013","volume":"201","author":"S Penugonda","year":"2011","unstructured":"Penugonda, S. & Ercal, N. Comparative evaluation of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) on glutamate and lead-induced toxicity in CD-1 mice. Toxicol. Lett. 201, 1\u20137. https:\/\/doi.org\/10.1016\/j.toxlet.2010.11.013 (2011).","journal-title":"Toxicol. Lett."},{"key":"17447_CR24","doi-asserted-by":"publisher","unstructured":"Yankelevitch-Yahav, R., Franko, M., Huly, A. & Doron, R. The forced swim test as a model of depressive-like behavior. J. Vis. Exp. e52587 https:\/\/doi.org\/10.3791\/52587 (2015).","DOI":"10.3791\/52587"},{"key":"17447_CR25","doi-asserted-by":"publisher","first-page":"e1958","DOI":"10.21769\/BioProtoc.1958","volume":"6","author":"T Serchov","year":"2016","unstructured":"Serchov, T., van Calker, D. & Biber, K. Sucrose preference test to measure anhedonic behaviour in mice. Bio Protoc. 6, e1958\u2013e1958. https:\/\/doi.org\/10.21769\/BioProtoc.1958 (2016).","journal-title":"Bio Protoc."},{"key":"17447_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248\u2013254. https:\/\/doi.org\/10.1016\/0003-2697(76)90527-3 (1976).","journal-title":"Anal. Biochem."},{"key":"17447_CR27","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1006\/abio.1996.0292","volume":"239","author":"IF Benzie","year":"1996","unstructured":"Benzie, I. F. & Strain, J. J. The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Anal. Biochem. 239, 70\u201376. https:\/\/doi.org\/10.1006\/abio.1996.0292 (1996).","journal-title":"Anal. Biochem."},{"key":"17447_CR28","first-page":"533","volume":"8","author":"M Dadgar","year":"2018","unstructured":"Dadgar, M. et al. Arbutin attenuates behavioral impairment and oxidative stress in an animal model of parkinson\u2019s disease. Avicenna J. Phytomed. 8, 533 (2018).","journal-title":"Avicenna J. Phytomed"},{"key":"17447_CR29","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","volume":"86","author":"M Uchiyama","year":"1978","unstructured":"Uchiyama, M. & Mihara, M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 86, 271\u2013278. https:\/\/doi.org\/10.1016\/0003-2697(78)90342-1 (1978).","journal-title":"Anal. Biochem."},{"key":"17447_CR30","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"Sedlak, J. & Lindsay, R. H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with ellman\u2019s reagent. Anal. Biochem. 25, 192\u2013205 (1968).","journal-title":"Anal. Biochem."},{"key":"17447_CR31","doi-asserted-by":"publisher","first-page":"e16160093","DOI":"10.1590\/1678-4324-2016160093","volume":"59","author":"M Koohsari","year":"2016","unstructured":"Koohsari, M., Shaki, F. & Jahani, D. Protective effects of Edaravone against methamphetamine-induced cardiotoxicity. Braz Arch. Biol. Technol. 59, e16160093. https:\/\/doi.org\/10.1590\/1678-4324-2016160093 (2016).","journal-title":"Braz Arch. Biol. Technol."},{"key":"17447_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13041-016-0229-z","volume":"9","author":"Y Dong","year":"2016","unstructured":"Dong, Y. et al. Dental noise exposed mice display depressive-like phenotypes. Brain Mol. 9, 1\u201310. https:\/\/doi.org\/10.1186\/s13041-016-0229-z (2016).","journal-title":"Brain Mol."},{"key":"17447_CR33","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.pnpbp.2003.11.012","volume":"28","author":"S Bulduk","year":"2004","unstructured":"Bulduk, S. & Canbeyli, R. Effect of inescapable tones on behavioral despair in Wistar rats. Prog Neuropsychopharmacol. Biol. Psychiatry. 28, 471\u2013475. https:\/\/doi.org\/10.1016\/j.pnpbp.2003.11.012 (2004).","journal-title":"Prog Neuropsychopharmacol. Biol. Psychiatry"},{"key":"17447_CR34","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S1734-1140(12)70731-4","volume":"64","author":"F Naqvi","year":"2012","unstructured":"Naqvi, F., Haider, S., Batool, Z., Perveen, T. & Haleem, D. J. Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behavior in rats. Pharmacol. Rep. 64, 64\u201369. https:\/\/doi.org\/10.1016\/S1734-1140(12)70731-4 (2012).","journal-title":"Pharmacol. Rep."},{"key":"17447_CR35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/1463-1741.153388","volume":"17","author":"KF Azman","year":"2015","unstructured":"Azman, K. F., Zakaria, R., AbdAziz, C., Othman, Z. & Al-Rahbi, B. Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress. Noise Health. 17, 83\u201389. https:\/\/doi.org\/10.4103\/1463-1741.153388 (2015).","journal-title":"Noise Health"},{"key":"17447_CR36","first-page":"61","volume":"6","author":"MJ Jafari","year":"2014","unstructured":"Jafari, M. J., Dehghani, A., Khavanin, A., Azari-Reza-Zade, M. & Dadashpourahangar, A. The impact of noise and formaldehyde exposure on oxidative stress indices in blood and liver tissue of rat. Int. J. Occup. Hyg. 6, 61\u201367 (2014).","journal-title":"Int. J. Occup. Hyg."},{"key":"17447_CR37","first-page":"55","volume":"7","author":"M Ghanbari","year":"2013","unstructured":"Ghanbari, M., Mortazavi, S. B., Khavanin, A. & Khazaei, M. Simultaneous effects of exposure to microwaves and noise on male rats\u2019 sperm parameters and total antioxidant capacity. Int. J. Fertil. Steril. 7, 55\u201356 (2013).","journal-title":"Int. J. Fertil. Steril."},{"key":"17447_CR38","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.3390\/microorganisms11092272","volume":"11","author":"Z Zhang","year":"2023","unstructured":"Zhang, Z., Wu, Y., Zhou, S., Fu, P. & Yan, H. Effects of music and white noise exposure on the gut microbiota, oxidative stress, and Immune-Related gene expression of mice. Microorganisms 11, 2272. https:\/\/doi.org\/10.3390\/microorganisms11092272 (2023).","journal-title":"Microorganisms"},{"key":"17447_CR39","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s00420-019-01444-1","volume":"92","author":"M Bagheri Hosseinabadi","year":"2019","unstructured":"Bagheri Hosseinabadi, M., Khanjani, N., Ebrahimi, M. H., Mirbadie, S. R. & Biganeh, J. The effects of industrial noise exposure on lipid peroxidation and antioxidant enzymes among workers. Int. Arch. Occup. Environ. Health. 92, 1041\u20131046. https:\/\/doi.org\/10.1007\/s00420-019-01444-1 (2019).","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"17447_CR40","doi-asserted-by":"publisher","first-page":"3318","DOI":"10.1007\/s11064-022-03683-0","volume":"47","author":"Y Cheng","year":"2022","unstructured":"Cheng, Y. et al. Noise induced Depression-Like behavior, neuroinflammation and synaptic plasticity impairments: the protective effects of Luteolin. Neurochem Res. 47, 3318\u20133330. https:\/\/doi.org\/10.1007\/s11064-022-03683-0 (2022).","journal-title":"Neurochem Res."},{"key":"17447_CR41","doi-asserted-by":"publisher","first-page":"107543","DOI":"10.1016\/j.neuropharm.2019.02.025","volume":"156","author":"A Gorlova","year":"2019","unstructured":"Gorlova, A. et al. Thiamine and Benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice. Neuropharmacology 156, 107543. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.02.025 (2019).","journal-title":"Neuropharmacology"},{"key":"17447_CR42","doi-asserted-by":"publisher","first-page":"5418","DOI":"10.3390\/ijms22115418","volume":"22","author":"M Sambon","year":"2021","unstructured":"Sambon, M., Wins, P. & Bettendorff, L. Neuroprotective effects of thiamine and precursors with higher bioavailability: focus on Benfotiamine and dibenzoylthiamine. Int. J. Mol. Sci. 22, 5418. https:\/\/doi.org\/10.3390\/ijms22115418 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"17447_CR43","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3233\/JAD-200896","volume":"78","author":"GE Gibson","year":"2020","unstructured":"Gibson, G. E. et al. Benfotiamine and cognitive decline in alzheimer\u2019s disease: results of a randomized placebo-controlled phase IIa clinical trial. J. Alzheimer\u2019s Dis. 78, 989\u20131010. https:\/\/doi.org\/10.3233\/JAD-200896 (2020).","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"17447_CR44","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.pnpbp.2016.11.001","volume":"75","author":"N Markova","year":"2017","unstructured":"Markova, N. et al. Thiamine and Benfotiamine improve cognition and ameliorate GSK-3\u03b2-associated stress-induced behaviours in mice. Prog Neuropsychopharmacol. Biol. Psychiatry. 75, 148\u2013156. https:\/\/doi.org\/10.1016\/j.pnpbp.2016.11.001 (2017).","journal-title":"Prog Neuropsychopharmacol. Biol. Psychiatry"},{"key":"17447_CR45","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1007\/s11064-020-03127-7","volume":"45","author":"S Haider","year":"2020","unstructured":"Haider, S. et al. Supplementation of taurine insulates against oxidative stress, confers neuroprotection and attenuates memory impairment in noise stress exposed male Wistar rats. Neurochem Res. 45, 2762\u20132774. https:\/\/doi.org\/10.1007\/s11064-020-03127-7 (2020).","journal-title":"Neurochem Res."},{"key":"17447_CR46","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/jbt.21501","volume":"27","author":"GI Harisa","year":"2013","unstructured":"Harisa, G. I. Benfotiamine enhances antioxidant defenses and protects against cisplatin-induced DNA damage in nephrotoxic rats. J. Biochem. Mol. Toxicol. 27, 398\u2013405. https:\/\/doi.org\/10.1002\/jbt.21501 (2013).","journal-title":"J. Biochem. Mol. Toxicol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-17447-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-17447-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-17447-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:32:27Z","timestamp":1757464347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-17447-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["17447"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-17447-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"9 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All experimental procedures adhered to the guidelines approved by the Research Ethics Committee of Mazandaran University of Medical Sciences, Iran (IR.MAZUMS.AEC.1402.045). URL:https:\/\/ethics.research.ac.ir\/ProposalCertificateEn.php?id=379992&Print=true&NoPrintHeader=true&NoPrintFooter=true&NoPrintPageBorder=true&LetterPrint=true.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All of the experimental procedures were approved by Animal Experimental Ethics Committee of Mazandaran University of Medical Sciences, Mazndaran, Iran (protocol number:1402.045).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors agree that this research work can be published.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"31336"}}