{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:50:33Z","timestamp":1757627433418,"version":"3.44.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-18112-9","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T10:53:05Z","timestamp":1756723985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of CD14 rs2569190 and rs2569191 polymorphisms with tuberculosis susceptibility in the Kurdish population of Iran"],"prefix":"10.1038","volume":"15","author":[{"given":"Iraj","family":"Ahmadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enayat","family":"Anvari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiyad","family":"Bastaminejad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Sakhaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morteza","family":"Ghazanfari Jajin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abolfazl","family":"Fateh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"18112_CR1","unstructured":"Global tuberculosis report. World Health Organization; 2024. License: CC BY-NC-SA 3.0 IGO, (2024)."},{"key":"18112_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-024-00504-2","volume":"10","author":"K Dheda","year":"2024","unstructured":"Dheda, K. et al. Multidrug-resistant tuberculosis. Nat. Rev. Dis. Primers. 10, 22 (2024).","journal-title":"Nat. Rev. Dis. Primers."},{"key":"18112_CR3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.tig.2012.02.001","volume":"28","author":"CC Khor","year":"2012","unstructured":"Khor, C. C. & Hibberd, M. L. Host\u2013pathogen interactions revealed by human genome-wide surveys. Trends Genet. 28, 233\u2013243 (2012).","journal-title":"Trends Genet."},{"key":"18112_CR4","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/s41467-023-36282-w","volume":"14","author":"J Phelan","year":"2023","unstructured":"Phelan, J. et al. Genome-wide host-pathogen analyses reveal genetic interaction points in tuberculosis disease. Nat. Commun. 14, 549 (2023).","journal-title":"Nat. Commun."},{"key":"18112_CR5","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/ng.639","volume":"42","author":"T Thye","year":"2010","unstructured":"Thye, T. et al. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11. 2. Nat. Genet. 42, 739\u2013741 (2010).","journal-title":"Nat. Genet."},{"key":"18112_CR6","doi-asserted-by":"publisher","first-page":"e0147543","DOI":"10.1371\/journal.pone.0147543","volume":"11","author":"D Souza de Lima","year":"2016","unstructured":"Souza de Lima, D. et al. Alleles of HLA-DRB1* 04 associated with pulmonary tuberculosis in Amazon Brazilian population. PLoS ONE 11, e0147543 (2016).","journal-title":"PLoS ONE"},{"key":"18112_CR7","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/jhg.2017.82","volume":"62","author":"Y Omae","year":"2017","unstructured":"Omae, Y. et al. Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis. J. Hum. Genet. 62, 1015\u20131022 (2017).","journal-title":"J. Hum. Genet."},{"key":"18112_CR8","doi-asserted-by":"crossref","unstructured":"Anas, A., van der Poll, T. & de Vos, A. F. Role of CD14 in lung inflammation and infection. In: Yearbook of Intensive Care and Emergency Medicine, 2010, 129\u2013140 (2010).","DOI":"10.1007\/978-3-642-10286-8_13"},{"key":"18112_CR9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S1286-4579(00)00298-7","volume":"2","author":"R Landmann","year":"2000","unstructured":"Landmann, R., M\u00fcller, B. & Zimmerli, W. CD14, new aspects of ligand and signal diversity. Microbes Infect. 2, 295\u2013304 (2000).","journal-title":"Microbes Infect."},{"key":"18112_CR10","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0928-8244(03)00369-9","volume":"40","author":"E Pacheco","year":"2004","unstructured":"Pacheco, E. et al. CD14 gene promoter polymorphism in different clinical forms of tuberculosis. FEMS Immunol. Med. Microbiol. 40, 207\u2013213 (2004).","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"18112_CR11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1399-0039.2012.01958.x","volume":"80","author":"Y Xue","year":"2012","unstructured":"Xue, Y. et al. Polymorphisms in the promoter of the CD14 gene and their associations with susceptibility to pulmonary tuberculosis. Tissue Antigens 80, 437\u2013443 (2012).","journal-title":"Tissue Antigens"},{"key":"18112_CR12","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.4238\/2012.September.25.11","volume":"11","author":"M Zhao","year":"2012","unstructured":"Zhao, M. et al. Association of CD 14 G (-1145) A and C (-159) T polymorphisms with reduced risk for tuberculosis in a Chinese Han population. Genet. Mol. Res. 11, 3425\u20133431 (2012).","journal-title":"Genet. Mol. Res."},{"key":"18112_CR13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1046\/j.1365-2370.2003.00414.x","volume":"30","author":"A Heinzmann","year":"2003","unstructured":"Heinzmann, A., Dietrich, H., Jerkic, S. P., Kurz, T. & Deichmann, K. Promoter polymorphisms of the CD14 gene are not associated with bronchial asthma in Caucasian children. Eur. J. Immunogenet. 30, 345\u2013348 (2003).","journal-title":"Eur. J. Immunogenet."},{"key":"18112_CR14","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.5588\/ijtld.11.0827","volume":"16","author":"R Alavi-Naini","year":"2012","unstructured":"Alavi-Naini, R. et al. Association between the CD14 gene C-159T polymorphism and serum soluble CD14 with pulmonary tuberculosis. Int. J. Tuberc. Lung Dis. 16, 1383\u20131387 (2012).","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"18112_CR15","doi-asserted-by":"publisher","first-page":"e64747","DOI":"10.1371\/journal.pone.0064747","volume":"8","author":"M Areeshi","year":"2013","unstructured":"Areeshi, M., Mandal, R. K., Panda, A. K., Bisht, S. C. & Haque, S. CD14\u2212159 C> T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis. PLoS ONE 8, e64747 (2013).","journal-title":"PLoS ONE"},{"key":"18112_CR16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jmii.2012.05.008","volume":"46","author":"E Ayaslioglu","year":"2013","unstructured":"Ayaslioglu, E. et al. The role of CD14 gene promoter polymorphism in tuberculosis susceptibility. J. Microbiol. Immunol. Infect. 46, 158\u2013163 (2013).","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"18112_CR17","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1097\/CCM.0b013e318180b1ed","volume":"36","author":"W Gu","year":"2008","unstructured":"Gu, W. et al. Functional significance of CD14 promoter polymorphisms and their clinical relevance in a Chinese Han population. Crit. Care Med. 36, 2274\u20132280 (2008).","journal-title":"Crit. Care Med."},{"key":"18112_CR18","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1086\/314492","volume":"178","author":"NP Juffermans","year":"1998","unstructured":"Juffermans, N. P. et al. Serum concentrations of lipopolysaccharide activity\u2014modulating proteins during tuberculosis. J. Infect. Dis. 178, 1839\u20131842 (1998).","journal-title":"J. Infect. Dis."},{"key":"18112_CR19","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1378\/chest.108.6.1614","volume":"108","author":"G Hoheisel","year":"1995","unstructured":"Hoheisel, G., Zheng, L., Teschler, H., Striz, I. & Costabel, U. Increased soluble CD14 levels in BAL fluid in pulmonary tuberculosis. Chest 108, 1614\u20131616 (1995).","journal-title":"Chest"},{"key":"18112_CR20","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0928-8244(03)00039-7","volume":"36","author":"H Shams","year":"2003","unstructured":"Shams, H. et al. The CD14 receptor does not mediate entry of Mycobacterium tuberculosis into human mononuclear phagocytes. FEMS Immunol. Med. Microbiol. 36, 63\u201369 (2003).","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"18112_CR21","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1159\/000053658","volume":"124","author":"D Vercelli","year":"2001","unstructured":"Vercelli, D., Baldini, M. & Martinez, F. The monocyte\/IgE connection: May polymorphisms in the CD14 gene teach us about IgE regulation?. Int. Arch. Allergy Immunol. 124, 20\u201324 (2001).","journal-title":"Int. Arch. Allergy Immunol."},{"key":"18112_CR22","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ijporl.2006.07.024","volume":"70","author":"HJ Kang","year":"2006","unstructured":"Kang, H. J. et al. Polymorphism of the CD14 gene in perennial allergic rhinitis. Int. J. Pediatr. Otorhinolaryngol. 70, 2081\u20132085 (2006).","journal-title":"Int. J. Pediatr. Otorhinolaryngol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-18112-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-18112-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-18112-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T02:25:15Z","timestamp":1757471115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-18112-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["18112"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-18112-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"assertion":[{"value":"25 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32127"}}